{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:45:06Z","timestamp":1792817106144,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Collaborative Innovation Program of Shanghai Municipal Health Commission","award":["2020CXJQ01"],"award-info":[{"award-number":["2020CXJQ01"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82001649"],"award-info":[{"award-number":["82001649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81871140"],"award-info":[{"award-number":["81871140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC2702504"],"award-info":[{"award-number":["2022YFC2702504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01606-5","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:19:47Z","timestamp":1738754387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF"],"prefix":"10.1186","volume":"18","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"1606_CR1","unstructured":"Obesity W, World Obesity. Atlas 2024 2024 [updated 2024-03-01. Available from: https:\/\/www.worldobesity.org\/"},{"issue":"6","key":"1606_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S2213-8587(21)00045-0","volume":"9","author":"XF Pan","year":"2021","unstructured":"Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol. 2021;9(6):373\u201392.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"1606_CR3","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1111\/dom.15238","volume":"25","author":"K Chen","year":"2023","unstructured":"Chen K, Shen Z, Gu W, Lyu Z, Qi X, Mu Y, et al. Prevalence of obesity and associated complications in China: a cross-sectional, real-world study in 15.8 million adults. Diabetes Obes Metab. 2023;25(11):3390\u20139.","journal-title":"Diabetes Obes Metab"},{"issue":"9468","key":"1606_CR4","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","volume":"365","author":"RH Eckel","year":"2005","unstructured":"Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415\u201328.","journal-title":"Lancet"},{"issue":"9492","key":"1606_CR5","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","volume":"366","author":"DW Haslam","year":"2005","unstructured":"Haslam DW, James WP. Obes Lancet. 2005;366(9492):1197\u2013209.","journal-title":"Obes Lancet"},{"issue":"10","key":"1606_CR6","doi-asserted-by":"publisher","first-page":"e13603","DOI":"10.1111\/obr.13603","volume":"24","author":"T Muhammad","year":"2023","unstructured":"Muhammad T, Wan Y, Lv Y, Li H, Naushad W, Chan WY, et al. Maternal obesity: a potential disruptor of female fertility and current interventions to reduce associated risks. Obes Rev. 2023;24(10):e13603.","journal-title":"Obes Rev"},{"issue":"1","key":"1606_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/AOG.0b013e31821fd360","volume":"118","author":"DK Shah","year":"2011","unstructured":"Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet Gynecol. 2011;118(1):63\u201370.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"1606_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI92035","volume":"127","author":"AR Saltiel","year":"2017","unstructured":"Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017;127(1):1\u20134.","journal-title":"J Clin Invest"},{"issue":"3","key":"1606_CR9","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.fertnstert.2016.07.1069","volume":"106","author":"JK Riley","year":"2016","unstructured":"Riley JK, Jungheim ES. Is there a role for diet in ameliorating the reproductive sequelae associated with chronic low-grade inflammation in polycystic ovary syndrome and obesity? Fertil Steril. 2016;106(3):520\u20137.","journal-title":"Fertil Steril"},{"issue":"4","key":"1606_CR10","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/obr.12133","volume":"15","author":"T Pecht","year":"2014","unstructured":"Pecht T, Gutman-Tirosh A, Bashan N, Rudich A. Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans. Obes Rev. 2014;15(4):322\u201337.","journal-title":"Obes Rev"},{"issue":"6","key":"1606_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41577-021-00635-7","volume":"22","author":"WV Trim","year":"2022","unstructured":"Trim WV, Lynch L. Immune and non-immune functions of adipose tissue leukocytes. Nat Rev Immunol. 2022;22(6):371\u201386.","journal-title":"Nat Rev Immunol"},{"key":"1606_CR12","doi-asserted-by":"publisher","first-page":"1131893","DOI":"10.3389\/fimmu.2023.1131893","volume":"14","author":"A Gihring","year":"2023","unstructured":"Gihring A, Gartner F, Mayer L, Roth A, Abdelrasoul H, Kornmann M, et al. Influence of bariatric surgery on the peripheral blood immune system of female patients with morbid obesity revealed by high-dimensional mass cytometry. Front Immunol. 2023;14:1131893.","journal-title":"Front Immunol"},{"issue":"2","key":"1606_CR13","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1210\/er.2018-00075","volume":"40","author":"DM Duffy","year":"2019","unstructured":"Duffy DM, Ko C, Jo M, Brannstrom M, Curry TE. Ovulation: parallels with inflammatory processes. Endocr Rev. 2019;40(2):369\u2013416.","journal-title":"Endocr Rev"},{"issue":"2","key":"1606_CR14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/humupd\/dmm040","volume":"14","author":"RB Gilchrist","year":"2008","unstructured":"Gilchrist RB, Lane M, Thompson JG. Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update. 2008;14(2):159\u201377.","journal-title":"Hum Reprod Update"},{"key":"1606_CR15","doi-asserted-by":"crossref","unstructured":"Turathum B, Gao EM, Chian RC. The function of Cumulus cells in Oocyte Growth and Maturation and in subsequent ovulation and fertilization. Cells. 2021;10(9).","DOI":"10.3390\/cells10092292"},{"issue":"2","key":"1606_CR16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/humupd\/dmh011","volume":"10","author":"R Wu","year":"2004","unstructured":"Wu R, Van der Hoek KH, Ryan NK, Norman RJ, Robker RL. Macrophage contributions to ovarian function. Hum Reprod Update. 2004;10(2):119\u201333.","journal-title":"Hum Reprod Update"},{"key":"1606_CR17","doi-asserted-by":"publisher","first-page":"1109122","DOI":"10.3389\/fimmu.2023.1109122","volume":"14","author":"M Dai","year":"2023","unstructured":"Dai M, Xu Y, Gong G, Zhang Y. Roles of immune microenvironment in the female reproductive maintenance and regulation: novel insights into the crosstalk of immune cells. Front Immunol. 2023;14:1109122.","journal-title":"Front Immunol"},{"key":"1606_CR18","doi-asserted-by":"crossref","unstructured":"Wu H, Zhu R, Zheng B, Liao G, Wang F, Ding J et al. Single-cell sequencing reveals an intrinsic heterogeneity of the Preovulatory Follicular Microenvironment. Biomolecules. 2022;12(2).","DOI":"10.3390\/biom12020231"},{"issue":"11","key":"1606_CR19","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1002\/mrd.22231","volume":"80","author":"J Nteeba","year":"2013","unstructured":"Nteeba J, Ortinau LC, Perfield JW 2nd, Keating AF. Diet-induced obesity alters immune cell infiltration and expression of inflammatory cytokine genes in mouse ovarian and peri-ovarian adipose depot tissues. Mol Reprod Dev. 2013;80(11):948\u201358.","journal-title":"Mol Reprod Dev"},{"key":"1606_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jnutbio.2018.03.011","volume":"57","author":"M Pae","year":"2018","unstructured":"Pae M, Baek Y, Lee S, Wu D. Loss of ovarian function in association with a high-fat diet promotes insulin resistance and disturbs adipose tissue immune homeostasis. J Nutr Biochem. 2018;57:93\u2013102.","journal-title":"J Nutr Biochem"},{"key":"1606_CR21","doi-asserted-by":"crossref","unstructured":"Artini PG, Scarfo G, Marzi I, Fusi J, Obino ME, Franzoni F et al. Oxidative Stress-Related Signaling Pathways Predict Oocytes\u2019 Fertilization In Vitro and Embryo Quality. Int J Mol Sci. 2022;23(21).","DOI":"10.3390\/ijms232113442"},{"key":"1606_CR22","doi-asserted-by":"crossref","unstructured":"Tariq A, Seekford ZK, Bromfield JJ. Inflammation during oocyte maturation reduces developmental competence and increases apoptosis in blastocysts. Biol Reprod. 2024.","DOI":"10.1093\/biolre\/ioae180"},{"issue":"3","key":"1606_CR23","doi-asserted-by":"publisher","first-page":"E383","DOI":"10.1152\/ajpendo.00401.2018","volume":"316","author":"ML Ruebel","year":"2019","unstructured":"Ruebel ML, Piccolo BD, Mercer KE, Pack L, Moutos D, Shankar K, et al. Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization. Am J Physiol Endocrinol Metab. 2019;316(3):E383\u201396.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"1606_CR24","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.rbmo.2021.07.001","volume":"43","author":"BA Wyse","year":"2021","unstructured":"Wyse BA, Fuchs Weizman N, Defer M, Montbriand J, Szaraz P, Librach C. The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes. Reprod Biomed Online. 2021;43(4):738\u201346.","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"1606_CR25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1055\/s-0035-1554928","volume":"33","author":"CE Boots","year":"2015","unstructured":"Boots CE, Jungheim ES. Inflammation and human ovarian Follicular dynamics. Semin Reprod Med. 2015;33(4):270\u20135.","journal-title":"Semin Reprod Med"},{"issue":"2","key":"1606_CR26","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jri.2011.01.008","volume":"88","author":"RL Robker","year":"2011","unstructured":"Robker RL, Wu LL, Yang X. Inflammatory pathways linking obesity and ovarian dysfunction. J Reprod Immunol. 2011;88(2):142\u20138.","journal-title":"J Reprod Immunol"},{"issue":"6","key":"1606_CR27","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1210\/jc.2016-3524","volume":"102","author":"ML Ruebel","year":"2017","unstructured":"Ruebel ML, Cotter M, Sims CR, Moutos DM, Badger TM, Cleves MA, et al. Obesity modulates inflammation and lipid metabolism oocyte gene expression: a single-cell transcriptome perspective. J Clin Endocrinol Metab. 2017;102(6):2029\u201338.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"1606_CR28","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1097\/CM9.0000000000002992","volume":"137","author":"D Zheng","year":"2024","unstructured":"Zheng D, Wang Y, Chen L, Zeng L, Li R. Association between body mass index and in vitro fertilization\/intra-cytoplasmic sperm injection outcomes: an analysis of 15,124 normal ovarian responders in China. Chin Med J (Engl). 2024;137(7):837\u201345.","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"1606_CR29","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1093\/humrep\/dead042","volume":"38","author":"F Rafael","year":"2023","unstructured":"Rafael F, Rodrigues MD, Bellver J, Canelas-Pais M, Garrido N, Garcia-Velasco JA, et al. The combined effect of BMI and age on ART outcomes. Hum Reprod. 2023;38(5):886\u201394.","journal-title":"Hum Reprod"},{"issue":"1","key":"1606_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12958-023-01183-6","volume":"22","author":"J Shang","year":"2024","unstructured":"Shang J, Wang S, Wang A, Li F, Zhang J, Wang J, et al. Intra-ovarian inflammatory states and their associations with embryo quality in normal-BMI PCOS patients undergoing IVF treatment. Reprod Biol Endocrinol. 2024;22(1):11.","journal-title":"Reprod Biol Endocrinol"},{"issue":"5","key":"1606_CR31","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1210\/jc.2008-2648","volume":"94","author":"RL Robker","year":"2009","unstructured":"Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533\u201340.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"1606_CR32","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1093\/humrep\/dei240","volume":"20","author":"MP Smith","year":"2005","unstructured":"Smith MP, Flannery GR, Randle BJ, Jenkins JM, Holmes CH. Leukocyte origin and profile in follicular aspirates at oocyte retrieval. Hum Reprod. 2005;20(12):3526\u201331.","journal-title":"Hum Reprod"},{"issue":"7564","key":"1606_CR33","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1136\/bmj.333.7564.362","volume":"333","author":"Y Wu","year":"2006","unstructured":"Wu Y. Overweight and obesity in China. BMJ. 2006;333(7564):362\u20133.","journal-title":"BMJ"},{"issue":"2","key":"1606_CR34","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S0015-0282(16)54141-7","volume":"55","author":"RT Scott Jr","year":"1991","unstructured":"Scott RT Jr., Hofmann GE, Veeck LL, Jones HW Jr., Muasher SJ. Embryo quality and pregnancy rates in patients attempting pregnancy through in vitro fertilization. Fertil Steril. 1991;55(2):426\u20138.","journal-title":"Fertil Steril"},{"issue":"8","key":"1606_CR35","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.cmet.2022.07.002","volume":"34","author":"T Hagglof","year":"2022","unstructured":"Hagglof T, Vanz C, Kumagai A, Dudley E, Ortega V, Siller M, et al. T-bet(+) B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity. Cell Metab. 2022;34(8):1121\u201336. e6.","journal-title":"Cell Metab"},{"issue":"1","key":"1606_CR36","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12979-023-00372-6","volume":"20","author":"P Prechtl","year":"2023","unstructured":"Prechtl P, Schmitz T, Pochert N, Traidl-Hoffmann C, Linseisen J, Meisinger C, et al. Association between body fat distribution and B-lymphocyte subsets in peripheral blood. Immun Ageing. 2023;20(1):47.","journal-title":"Immun Ageing"},{"issue":"5","key":"1606_CR37","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1161\/ATVBAHA.119.312467","volume":"40","author":"P Srikakulapu","year":"2020","unstructured":"Srikakulapu P, McNamara CA. B lymphocytes and adipose tissue inflammation. Arterioscler Thromb Vasc Biol. 2020;40(5):1110\u201322.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"1606_CR38","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.cmet.2024.01.015","volume":"36","author":"L Yu","year":"2024","unstructured":"Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski AA, et al. IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline. Cell Metab. 2024;36(4):793\u2013e8075.","journal-title":"Cell Metab"},{"key":"1606_CR39","doi-asserted-by":"publisher","first-page":"103994","DOI":"10.1016\/j.cellimm.2019.103994","volume":"348","author":"D Frasca","year":"2020","unstructured":"Frasca D, Diaz A, Romero M, Blomberg BB. Leptin induces immunosenescence in human B cells. Cell Immunol. 2020;348:103994.","journal-title":"Cell Immunol"},{"key":"1606_CR40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jri.2018.08.005","volume":"130","author":"MB Gonzalez","year":"2018","unstructured":"Gonzalez MB, Lane M, Knight EJ, Robker RL. Inflammatory markers in human follicular fluid correlate with lipid levels and body Mass Index. J Reprod Immunol. 2018;130:25\u20139.","journal-title":"J Reprod Immunol"},{"issue":"12","key":"1606_CR41","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1161\/ATVBAHA.114.304636","volume":"34","author":"T McLaughlin","year":"2014","unstructured":"McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, et al. T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans. Arterioscler Thromb Vasc Biol. 2014;34(12):2637\u201343.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1606_CR42","doi-asserted-by":"publisher","first-page":"6634532","DOI":"10.1155\/2021\/6634532","volume":"2021","author":"F Cai","year":"2021","unstructured":"Cai F, Jin S, Chen G. The effect of lipid metabolism on CD4(+) T cells. Mediators Inflamm. 2021;2021:6634532.","journal-title":"Mediators Inflamm"},{"issue":"8","key":"1606_CR43","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3945\/jn.114.194407","volume":"144","author":"MJ Allen","year":"2014","unstructured":"Allen MJ, Fan YY, Monk JM, Hou TY, Barhoumi R, McMurray DN, et al. n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4(+) T cells. J Nutr. 2014;144(8):1306\u201313.","journal-title":"J Nutr"},{"key":"1606_CR44","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1477-7827-12-13","volume":"12","author":"SD Valckx","year":"2014","unstructured":"Valckx SD, Arias-Alvarez M, De Pauw I, Fievez V, Vlaeminck B, Fransen E, et al. Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study. Reprod Biol Endocrinol. 2014;12:13.","journal-title":"Reprod Biol Endocrinol"},{"key":"1606_CR45","doi-asserted-by":"crossref","unstructured":"Lu Y, Yao Y, Zhai S, Ni F, Wang J, Chen F et al. The role of immune cell signatures in the pathogenesis of ovarian-related diseases: a causal inference based on mendelian randomization. Int J Surg. 2024.","DOI":"10.1097\/JS9.0000000000001814"},{"issue":"1","key":"1606_CR46","doi-asserted-by":"publisher","first-page":"6040","DOI":"10.1038\/s41598-019-42631-x","volume":"9","author":"Z Li","year":"2019","unstructured":"Li Z, Peng A, Feng Y, Zhang X, Liu F, Chen C, et al. Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome. Sci Rep. 2019;9(1):6040.","journal-title":"Sci Rep"},{"issue":"4","key":"1606_CR47","doi-asserted-by":"publisher","first-page":"e13522","DOI":"10.1111\/aji.13522","volume":"87","author":"N Zhao","year":"2022","unstructured":"Zhao N, Zhang C, Ding J, Wu H, Cheng W, Li M, et al. Altered T lymphocyte subtypes and cytokine profiles in follicular fluid associated with diminished ovary reserve. Am J Reprod Immunol. 2022;87(4):e13522.","journal-title":"Am J Reprod Immunol"},{"issue":"4","key":"1606_CR48","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/humrep\/deg156","volume":"18","author":"JY Kwak-Kim","year":"2003","unstructured":"Kwak-Kim JY, Chung-Bang HS, Ng SC, Ntrivalas EI, Mangubat CP, Beaman KD, et al. Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum Reprod. 2003;18(4):767\u201373.","journal-title":"Hum Reprod"},{"issue":"1","key":"1606_CR49","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1159\/000230515","volume":"41","author":"A Gecse","year":"1971","unstructured":"Gecse A, Zsilinszky E, Lonovics J, West GB. C-phenylglycine-n-heptyl ester as an inhibitor of mediators of allergic reactions. Int Arch Allergy Appl Immunol. 1971;41(1):174\u20139.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"1606_CR50","doi-asserted-by":"crossref","unstructured":"Adamczak R, Ukleja-Sokolowska N, Lis K, Dubiel M. Function of follicular cytokines: roles played during maturation, development and implantation of embryo. Med (Kaunas). 2021;57(11).","DOI":"10.3390\/medicina57111251"},{"issue":"1","key":"1606_CR51","doi-asserted-by":"publisher","first-page":"113002","DOI":"10.1016\/j.yexcr.2021.113002","volume":"412","author":"Y Han","year":"2022","unstructured":"Han Y, Yao R, Yang Z, Li S, Meng W, Zhang Y, et al. Interleukin-4 activates the PI3K\/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells. Exp Cell Res. 2022;412(1):113002.","journal-title":"Exp Cell Res"},{"key":"1606_CR52","doi-asserted-by":"publisher","first-page":"986893","DOI":"10.3389\/fimmu.2022.986893","volume":"13","author":"L Wu","year":"2022","unstructured":"Wu L, Fang X, Lu F, Zhang Y, Wang Y, Kwak-Kim J. Anticardiolipin and\/or anti-beta2-glycoprotein-I antibodies are associated with adverse IVF outcomes. Front Immunol. 2022;13:986893.","journal-title":"Front Immunol"},{"issue":"6","key":"1606_CR53","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0015-0282(03)00344-3","volume":"79","author":"A Gallinelli","year":"2003","unstructured":"Gallinelli A, Ciaccio I, Giannella L, Salvatori M, Marsella T, Volpe A. Correlations between concentrations of interleukin-12 and interleukin-13 and lymphocyte subsets in the follicular fluid of women with and without polycystic ovary syndrome. Fertil Steril. 2003;79(6):1365\u201372.","journal-title":"Fertil Steril"},{"issue":"1","key":"1606_CR54","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/humrep\/deu276","volume":"30","author":"C Leary","year":"2015","unstructured":"Leary C, Leese HJ, Sturmey RG. Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod. 2015;30(1):122\u201332.","journal-title":"Hum Reprod"},{"issue":"5","key":"1606_CR55","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/humupd\/dmm017","volume":"13","author":"A Maheshwari","year":"2007","unstructured":"Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology\u2013a systematic review. Hum Reprod Update. 2007;13(5):433\u201344.","journal-title":"Hum Reprod Update"},{"key":"1606_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2015.11.002","volume":"34","author":"MJ Hubler","year":"2016","unstructured":"Hubler MJ, Kennedy AJ. Role of lipids in the metabolism and activation of immune cells. J Nutr Biochem. 2016;34:1\u20137.","journal-title":"J Nutr Biochem"},{"issue":"5","key":"1606_CR57","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41589-022-01017-3","volume":"18","author":"SA Lim","year":"2022","unstructured":"Lim SA, Su W, Chapman NM, Chi H. Lipid metabolism in T cell signaling and function. Nat Chem Biol. 2022;18(5):470\u201381.","journal-title":"Nat Chem Biol"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01606-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01606-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01606-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:43:37Z","timestamp":1738763017000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01606-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1606"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01606-5","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed following the ethical guidelines of the Declaration of Helsinki and was approved by the Ethical Committee of Shanghai JiAi Genetics and IVF Institute (Approval number: JIAI E2021-27). All patients provided signed informed consent forms prior to the commencement the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}