{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:38:37Z","timestamp":1760524717306,"version":"3.38.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The standard treatment for Pregnancy-Associated Breast Cancer (PABC) includes surgery and neoadjuvant chemotherapy, which can impair fertility, emphasizing the critical need for fertility preservation in these patients. This case report discusses a breast cancer patient who was found to be pregnant shortly after starting treatment. Despite the pregnancy and increased levels of \u03b2HCG and progesterone, the ovarian stimulation cycle yielded a satisfactory number of mature oocytes and high-quality embryos.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 40-year-old woman, G1Ab1 (Gravida1Abortion1), who was diagnosed with Invasive Ductal Carcinoma with negative receptors (Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2) was referred to the oncofertility unit of the Royan Infertility Center for fertility preservation prior to the commencement of chemotherapy. Following necessary consultations and procedures, and confirming a negative pregnancy test, a random start letrozole-based protocol was initiated for ovarian stimulation. During the cycle, a positive pregnancy test was encountered. Despite the positive test, the cycle continued, and on day 13 of the cycle, triggering was performed with a GnRH agonist. A puncture was performed 36\u00a0h later, yielding 12 oocytes and 8 embryos.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case highlights the feasibility of adapting random-start ovarian stimulation protocols during pregnancy, warranting further investigation in similar clinical scenarios.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13048-025-01615-4","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:53:03Z","timestamp":1740563583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring new frontiers in oncofertility preservation: a case of ovarian stimulation during pregnancy"],"prefix":"10.1186","volume":"18","author":[{"given":"Parisa","family":"Pirooznia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmat Mashhadi","family":"Meighani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firouzeh","family":"Ghaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"3","key":"1615_CR1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/09513590.2018.1522298","volume":"35","author":"N Pereira","year":"2019","unstructured":"Pereira N, Kligman I, Hunt R, Kopparam R, Wahmann B, Rosenwaks Z. Fertility preservation with random-start controlled ovarian stimulation and embryo cryopreservation for early pregnancy-associated breast cancer. Gynecol Endocrinology: Official J Int Soc Gynecol Endocrinol. 2019;35(3):214\u20136.","journal-title":"Gynecol Endocrinology: Official J Int Soc Gynecol Endocrinol"},{"issue":"1","key":"1615_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00404-017-4595-2","volume":"297","author":"M von Wolff","year":"2018","unstructured":"von Wolff M, Germeyer A, Liebenthron J, Korell M, Nawroth F. Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part II: fertility preservation techniques. 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The efficacy of dydrogesterone use to suppress premature luteinizing hormone surge on cycle outcomes in controlled ovarian stimulation. J Turkish German Gynecol Association. 2021;22(4):293\u20139.","journal-title":"J Turkish German Gynecol Association"},{"issue":"2","key":"1615_CR10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.rbmo.2019.03.212","volume":"39","author":"A La Marca","year":"2019","unstructured":"La Marca A, Capuzzo M. Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era? Reprod Biomed Online. 2019;39(2):321\u201331.","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"1615_CR11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/humupd\/dmaa040","volume":"27","author":"B Ata","year":"2021","unstructured":"Ata B, Capuzzo M, Turkgeldi E, Yildiz S, La Marca A. 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Eur J Obstet Gynecol Reprod Biol. 2017;218:92\u20138.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"1615_CR18","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13048-021-00929-3","volume":"14","author":"J Cheng","year":"2021","unstructured":"Cheng J, Ruan X, Du J, Jin F, Li Y, Liu X, et al. Ovarian tissue cryopreservation in a patient with breast cancer during pregnancy: a case report. 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The treatment process for this particular patient was also conducted in accordance with these approved protocols. An exhaustive consultation regarding fertility preservation was conducted with the patient and her spouse by a specialist in infertility. The patient was meticulously informed about the procedure, including the potential risks associated with this situation. Subsequently, she provided her informed consent for the intervention to proceed. After obtaining written consent from both the patient and her spouse, the option of embryo cryopreservation was selected.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication has been obtained from the individual whose data is included in this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39"}}