{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:39:37Z","timestamp":1783431577871,"version":"3.54.6"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Postdoctoral fellowships from the Mathematics of Information Technology and Complex Systems"},{"name":"Montreal Reproductive and Regenerative Foundation"},{"name":"Canada First Research Excellence Fund (CFREF) and Food From Thought"},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01648-9","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T05:35:43Z","timestamp":1743485743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model"],"prefix":"10.1186","volume":"18","author":[{"given":"Fereshteh","family":"Esfandiarinezhad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshu","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seang Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"1648_CR1","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.3390\/jcm12041454","volume":"12","author":"S Singh","year":"2023","unstructured":"Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, et al. Polycystic ovary syndrome: etiology, current management, and future therapeutics. J Clin Med. 2023;12:1454.","journal-title":"J Clin Med"},{"key":"1648_CR2","doi-asserted-by":"publisher","first-page":"100937","DOI":"10.1016\/j.molmet.2020.01.001","volume":"35","author":"MA Sanchez-Garrido","year":"2020","unstructured":"Sanchez-Garrido MA, Tena-Sempere M. Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies. Mol Metab. 2020;35:100937.","journal-title":"Mol Metab"},{"key":"1648_CR3","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.3390\/jcm12041500","volume":"12","author":"Y Che","year":"2023","unstructured":"Che Y, Yu J, Li Y-S, Zhu Y-C, Tao T. Polycystic ovary syndrome: challenges and possible solutions. J Clin Med. 2023;12:1500.","journal-title":"J Clin Med"},{"key":"1648_CR4","doi-asserted-by":"crossref","unstructured":"Kumar R, Minerva S, Shah R, Bhat A, Verma S, Chander G et al. Role of genetic, environmental, and hormonal factors in the progression of PCOS: A review. J Reprod Health Med. 2022;3.","DOI":"10.25259\/JRHM_16_2021"},{"key":"1648_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13287-015-0004-6","volume":"6","author":"D Lai","year":"2015","unstructured":"Lai D, Xu M, Zhang Q, Chen Y, Li T, Wang Q, et al. Identification and characterization of epithelial cells derived from human ovarian follicular fluid. Stem Cell Res Ther. 2015;6:13.","journal-title":"Stem Cell Res Ther"},{"key":"1648_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-021-02045-w","volume":"4","author":"LE Carter","year":"2021","unstructured":"Carter LE, Cook DP, McCloskey CW, Grondin MA, Landry DA, Dang T, et al. Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium. Commun Biol. 2021;4:1\u201311.","journal-title":"Commun Biol"},{"key":"1648_CR7","doi-asserted-by":"crossref","unstructured":"Wang J, Liu C, He L, Xie Z, Bai L, Yu W et al. Selective YAP activation in Procr cells is essential for ovarian stem\/progenitor expansion and epithelium repair. Postovit L-M, Azziz R, editors. eLife. 2022;11:e75449.","DOI":"10.7554\/eLife.75449"},{"key":"1648_CR8","doi-asserted-by":"crossref","unstructured":"Rodriguez Paris V, Wong XYD, Solon-Biet SM, Edwards MC, Aflatounian A, Gilchrist RB et al. The interplay between PCOS pathology and diet on gut microbiota in a mouse model. Gut Microbes. 14:2085961.","DOI":"10.1080\/19490976.2022.2085961"},{"key":"1648_CR9","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"X Qi","year":"2019","unstructured":"Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, et al. Gut microbiota\u2013bile acid\u2013interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019;25:1225\u201333.","journal-title":"Nat Med"},{"key":"1648_CR10","doi-asserted-by":"publisher","first-page":"121739","DOI":"10.1016\/j.biomaterials.2022.121739","volume":"288","author":"M Cao","year":"2022","unstructured":"Cao M, Zhao Y, Chen T, Zhao Z, Zhang B, Yuan C, et al. Adipose mesenchymal stem cell-derived Exosomal MicroRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances. Biomaterials. 2022;288:121739.","journal-title":"Biomaterials"},{"key":"1648_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12964-022-00876-6","volume":"20","author":"J Cao","year":"2022","unstructured":"Cao J, Huo P, Cui K, Wei H, Cao J, Wang J, et al. Follicular fluid-derived Exosomal miR-143-3p\/miR-155-5p regulate follicular dysplasia by modulating Glycolysis in granulosa cells in polycystic ovary syndrome. Cell Commun Signal. 2022;20:61.","journal-title":"Cell Commun Signal"},{"key":"1648_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1757-2215-6-36","volume":"6","author":"MM Hossain","year":"2013","unstructured":"Hossain MM, Cao M, Wang Q, Kim JY, Schellander K, Tesfaye D, et al. Altered expression of MiRNAs in a dihydrotestosterone-induced rat PCOS model. J Ovarian Res. 2013;6:36.","journal-title":"J Ovarian Res"},{"key":"1648_CR13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s13048-023-01318-8","volume":"16","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wang J, Li Q, Xuan R, Guo Y, He P, et al. Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period. J Ovarian Res. 2023;16:234.","journal-title":"J Ovarian Res"},{"key":"1648_CR14","doi-asserted-by":"crossref","unstructured":"Qi X, Yun C, Pang Y, Qiao J. The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut Microbes. 13:1894070.","DOI":"10.1080\/19490976.2021.1894070"},{"key":"1648_CR15","doi-asserted-by":"publisher","first-page":"1104550","DOI":"10.3389\/fimmu.2023.1104550","volume":"14","author":"R Salehi","year":"2023","unstructured":"Salehi R, Asare-Werehene M, Wyse BA, Abedini A, Pan B, Gutsol A, et al. Granulosa cell-derived miR-379-5p regulates macrophage polarization in polycystic ovarian syndrome. Front Immunol. 2023;14:1104550.","journal-title":"Front Immunol"},{"key":"1648_CR16","doi-asserted-by":"publisher","first-page":"1101519","DOI":"10.3389\/fnut.2023.1101519","volume":"10","author":"X Zhan","year":"2023","unstructured":"Zhan X, Fletcher L, Huyben D, Cai H, Dingle S, Qi N, et al. Choline supplementation regulates gut Microbiome diversity, gut epithelial activity, and the cytokine gene expression in gilts. Front Nutr. 2023;10:1101519.","journal-title":"Front Nutr"},{"key":"1648_CR17","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/bioinformatics\/btq041","volume":"26","author":"DH Parks","year":"2010","unstructured":"Parks DH, Beiko RG. Identifying biologically relevant differences between metagenomic communities. Bioinformatics. 2010;26:715\u201321.","journal-title":"Bioinformatics"},{"key":"1648_CR18","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","volume":"30","author":"DH Parks","year":"2014","unstructured":"Parks DH, Tyson GW, Hugenholtz P, Beiko RG. STAMP: statistical analysis of taxonomic and functional profiles. Bioinformatics. 2014;30:3123\u20134.","journal-title":"Bioinformatics"},{"key":"1648_CR19","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1210\/en.2013-1001","volume":"154","author":"JY Kim","year":"2013","unstructured":"Kim JY, Xue K, Cao M, Wang Q, Liu J-Y, Leader A, et al. Chemerin suppresses ovarian follicular development and its potential involvement in follicular arrest in rats treated chronically with dihydrotestosterone. Endocrinology. 2013;154:2912\u201323.","journal-title":"Endocrinology"},{"key":"1648_CR20","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1210\/en.2007-0168","volume":"148","author":"L Manner\u00e5s","year":"2007","unstructured":"Manner\u00e5s L, Cajander S, Holm\u00e4ng A, Seleskovic Z, Lystig T, L\u00f6nn M, et al. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology. 2007;148:3781\u201391.","journal-title":"Endocrinology"},{"key":"1648_CR21","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s41598-020-57672-w","volume":"10","author":"R Salehi","year":"2020","unstructured":"Salehi R, Mazier HL, Nivet A-L, Reunov AA, Lima P, Wang Q, et al. Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome. Sci Rep. 2020;10:1021.","journal-title":"Sci Rep"},{"key":"1648_CR22","doi-asserted-by":"publisher","first-page":"10272","DOI":"10.1038\/s41598-017-09880-0","volume":"7","author":"JJ Lim","year":"2017","unstructured":"Lim JJ, Lima PDA, Salehi R, Lee DR, Tsang BK. Regulation of androgen receptor signaling by ubiquitination during folliculogenesis and its possible dysregulation in polycystic ovarian syndrome. Sci Rep. 2017;7:10272.","journal-title":"Sci Rep"},{"key":"1648_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cois.2018.07.001","volume":"31","author":"Y Yoshinari","year":"2019","unstructured":"Yoshinari Y, Kurogi Y, Ameku T, Niwa R. Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. Curr Opin Insect Sci. 2019;31:14\u20139.","journal-title":"Curr Opin Insect Sci"},{"key":"1648_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev-cellbio-101512-122331","volume":"29","author":"D Gancz","year":"2013","unstructured":"Gancz D, Gilboa L. Hormonal control of stem cell systems. Annu Rev Cell Dev Biol. 2013;29:137\u201362.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1648_CR25","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.4252\/wjsc.v7.i9.1150","volume":"7","author":"C Hadjimichael","year":"2015","unstructured":"Hadjimichael C, Chanoumidou K, Papadopoulou N, Arampatzi P, Papamatheakis J, Kretsovali A. Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells. 2015;7:1150.","journal-title":"World J Stem Cells"},{"key":"1648_CR26","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/stem.1352","volume":"31","author":"A Rizzino","year":"2013","unstructured":"Rizzino A. The Sox2-Oct4 connection: critical players in a much larger interdependent network integrated at multiple levels. Stem Cells. 2013;31:1033.","journal-title":"Stem Cells"},{"key":"1648_CR27","doi-asserted-by":"publisher","first-page":"305","DOI":"10.4252\/wjsc.v6.i3.305","volume":"6","author":"S Zhang","year":"2014","unstructured":"Zhang S, Cui W. Sox2, a key factor in the regulation of pluripotency and neural differentiation. World J Stem Cells. 2014;6:305.","journal-title":"World J Stem Cells"},{"key":"1648_CR28","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1369\/jhc.3A6241.2004","volume":"52","author":"L Cui","year":"2004","unstructured":"Cui L, Johkura K, Yue F, Ogiwara N, Okouchi Y, Asanuma K, et al. Spatial distribution and initial changes of SSEA-1 and other cell Adhesion-related molecules on mouse embryonic stem cells before and during differentiation. J Histochem Cytochem. 2004;52:1447\u201357.","journal-title":"J Histochem Cytochem"},{"key":"1648_CR29","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3168\/jds.S0022-0302(99)75262-8","volume":"82","author":"S-J Choi","year":"1999","unstructured":"Choi S-J, Shim H, Anderson GB. Short communication: lack of Stage-Specific embryonic Antigen-1 expression by bovine embryos and primordial germ cells. J Dairy Sci. 1999;82:516\u20139.","journal-title":"J Dairy Sci"},{"key":"1648_CR30","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.stem.2007.09.003","volume":"1","author":"S Liedtke","year":"2007","unstructured":"Liedtke S, Enczmann J, Waclawczyk S, Wernet P, K\u00f6gler G. Oct4 and its pseudogenes confuse stem cell research. Cell Stem Cell. 2007;1:364\u20136.","journal-title":"Cell Stem Cell"},{"key":"1648_CR31","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S0896-6273(03)00497-5","volume":"39","author":"V Graham","year":"2003","unstructured":"Graham V, Khudyakov J, Ellis P, Pevny L. SOX2 functions to maintain neural progenitor identity. Neuron. 2003;39:749\u201365.","journal-title":"Neuron"},{"key":"1648_CR32","doi-asserted-by":"crossref","unstructured":"Fujisaka S, Watanabe Y, Tobe K. The gut microbiome: a core regulator of metabolism. 2023.","DOI":"10.1530\/JOE-22-0111"},{"key":"1648_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41392-024-01746-y","volume":"9","author":"D Semo","year":"2024","unstructured":"Semo D, Reinecke H, Godfrey R. Gut Microbiome regulates inflammation and insulin resistance: a novel therapeutic target to improve insulin sensitivity. Signal Transduct Target Ther. 2024;9:35.","journal-title":"Signal Transduct Target Ther"},{"key":"1648_CR34","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1080\/10408398.2018.1517725","volume":"59","author":"Q Zhai","year":"2019","unstructured":"Zhai Q, Feng S, Arjan N, Chen W. A next generation probiotic, Akkermansia muciniphila. Crit Rev Food Sci Nutr. 2019;59:3227\u201336.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1648_CR35","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.3390\/nu16203440","volume":"16","author":"E Liu","year":"2024","unstructured":"Liu E, Ji X, Zhou K. Akkermansia muciniphila for the prevention of type 2 diabetes and obesity: A Meta-Analysis of animal studies. Nutrients. 2024;16:3440.","journal-title":"Nutrients"},{"key":"1648_CR36","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","volume":"25","author":"C Depommier","year":"2019","unstructured":"Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25:1096\u2013103.","journal-title":"Nat Med"},{"key":"1648_CR37","doi-asserted-by":"publisher","first-page":"2295394","DOI":"10.1080\/19490976.2023.2295394","volume":"16","author":"F Huang","year":"2024","unstructured":"Huang F, Cao Y, Liang J, Tang R, Wu S, Zhang P, et al. The influence of the gut Microbiome on ovarian aging. Gut Microbes. 2024;16:2295394.","journal-title":"Gut Microbes"},{"key":"1648_CR38","doi-asserted-by":"publisher","first-page":"14671","DOI":"10.1038\/s41598-017-13250-1","volume":"7","author":"M Naji","year":"2017","unstructured":"Naji M, Aleyasin A, Nekoonam S, Arefian E, Mahdian R, Amidi F. Differential expression of miR-93 and miR-21 in granulosa cells and follicular fluid of polycystic ovary syndrome associating with different phenotypes. Sci Rep. 2017;7:14671.","journal-title":"Sci Rep"},{"key":"1648_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1530\/JME-21-0162","volume":"68","author":"RE Hilker","year":"2021","unstructured":"Hilker RE, Pan B, Zhan X, Li J. MicroRNA-21 enhances estradiol production by inhibiting WT1 expression in granulosa cells. J Mol Endocrinol. 2021;68:11\u201322.","journal-title":"J Mol Endocrinol"},{"key":"1648_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mce.2018.05.011","volume":"477","author":"Bo Pan null","year":"2018","unstructured":"Bo Pan null. Julang Li null. MicroRNA-21 up-regulates metalloprotease by down-regulating TIMP3 during cumulus cell-oocyte complex in vitro maturation. Mol Cell Endocrinol. 2018;477:29\u201338.","journal-title":"Mol Cell Endocrinol"},{"key":"1648_CR41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13293-024-00630-2","volume":"15","author":"S Rezq","year":"2024","unstructured":"Rezq S, Huffman AM, Basnet J, Alsemeh AE, do Carmo JM, Yanes Cardozo LL, et al. MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome. Biol Sex Differ. 2024;15:53.","journal-title":"Biol Sex Differ"},{"key":"1648_CR42","doi-asserted-by":"publisher","first-page":"E525","DOI":"10.1152\/ajpendo.00480.2014","volume":"308","author":"B Pan","year":"2015","unstructured":"Pan B, Toms D, Shen W, Li J. MicroRNA-378 regulates oocyte maturation via the suppression of aromatase in Porcine cumulus cells. Am J Physiol - Endocrinol Metabolism. 2015;308:E525.","journal-title":"Am J Physiol - Endocrinol Metabolism"},{"key":"1648_CR43","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12958-021-00754-9","volume":"19","author":"HL Khan","year":"2021","unstructured":"Khan HL, Bhatti S, Abbas S, Kaloglu C, Isa AM, Younas H, et al. Extracellular MicroRNAs: key players to explore the outcomes of in vitro fertilization. Reprod Biol Endocrinol. 2021;19:72.","journal-title":"Reprod Biol Endocrinol"},{"key":"1648_CR44","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3324\/haematol.2019.236927","volume":"106","author":"M Hu","year":"2020","unstructured":"Hu M, Lu Y, Zeng H, Zhang Z, Chen S, Qi Y, et al. MicroRNA-21 maintains hematopoietic stem cell homeostasis through sustaining the nuclear factor-B signaling pathway in mice. Haematologica. 2020;106:412\u201323.","journal-title":"Haematologica"},{"key":"1648_CR45","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1002\/stem.2081","volume":"33","author":"T Wu","year":"2015","unstructured":"Wu T, Liu Y, Fan Z, Xu J, Jin L, Gao Z, et al. miR-21 modulates the immunoregulatory function of bone marrow mesenchymal stem cells through the PTEN\/Akt\/TGF-\u03b21 pathway. Stem Cells. 2015;33:3281\u201390.","journal-title":"Stem Cells"},{"key":"1648_CR46","doi-asserted-by":"publisher","first-page":"108623","DOI":"10.1016\/j.biopha.2019.108623","volume":"112","author":"J Ma","year":"2019","unstructured":"Ma J, Wu D, Yi J, Yi Y, Zhu X, Qiu H, et al. MiR-378 promoted cell proliferation and inhibited apoptosis by enhanced stem cell properties in chronic myeloid leukemia K562 cells. Biomed Pharmacother. 2019;112:108623.","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01648-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01648-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01648-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T12:53:37Z","timestamp":1743684817000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01648-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1648"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01648-9","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"21 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were carried out in accordance with the Guidelines for the Care and Use of Laboratory Animals, Canadian Council on Animal Care, and were approved by the University of Ottawa Animal Care Committee (OHRIe-3708 [Replacing OHRIe-1624]-R2).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This manuscript does not contain any individual person\u2019s data in any form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Benjamin K Tsang is an Editor-in-Chief, Julang Li is an Associate Editor, and Fereshteh Esfandiarinezhad is a member of the Editorial Board of the Journal of Ovarian Research. All decisions on this manuscript were made by another senior editor. The author(s) declare that they have no other competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"66"}}