{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:05:05Z","timestamp":1749614705409,"version":"3.41.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012681","name":"Universit\u00e4tsklinikum K\u00f6ln","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012681","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>In a recent publication (Reprod. Biomed. Online, 2024) it was presented point of view that, for post-cancer patients, in vitro fertilization (IVF) is a more effective method than ovarian tissue cryopreservation (OTC). In their commentary, Andersen et al. (Reprod. Biomed. Online, 2024) present nine distinct arguments advocating for the use of OTC. We fully agree with all these points. In support of the clinical application of the OTC procedure, we introduce two additional arguments. First, the transplantation of cryopreserved ovarian tissue can be considered as a form of tissue therapy. Moreover, OTC inherently serves as an activator of oogenesis. Second, during tissue dissection prior to OTC, a significant number of germinal vesicle (GV) oocytes can be retrieved, matured to the metaphase II (MII) stage, cryopreserved, and later used in IVF procedures.<\/jats:p>","DOI":"10.1186\/s13048-025-01680-9","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:48:14Z","timestamp":1749545294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cryopreservation and transplantation of ovarian tissue as post-cancer tissue therapy and an activator of oogenesis"],"prefix":"10.1186","volume":"18","author":[{"given":"Volodimir","family":"Isachenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Morgenstern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Plamen","family":"Todorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Isachenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Nawroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Quassdorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Salama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Mallmann-Gottschalk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Merzenich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Skala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gohar","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"1680_CR1","first-page":"03939","volume":"49","author":"KT Macklon","year":"2024","unstructured":"Macklon KT, De Vos M. Cryopreservation of ovarian tissue for fertility preservation in breast cancer patients: time to stop? Reprod BioMed Online. 2024;49:03939.","journal-title":"Reprod BioMed Online"},{"key":"1680_CR2","doi-asserted-by":"crossref","first-page":"104442","DOI":"10.1016\/j.rbmo.2024.104442","volume":"50","author":"CY Andersen","year":"2025","unstructured":"Andersen CY, Donnez J, Ernst E, Gook D, Pellicer A, Von Wolff M, Suzuki N, Roux C, Dolmans MM. Ovarian tissue cryopreservation in breast cancer patients: glass half empty or glass half full? Reprod Biomed Online. 2025;50:104442.","journal-title":"Reprod Biomed Online"},{"key":"1680_CR3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13048-020-00713-9","volume":"13","author":"V Isachenko","year":"2020","unstructured":"Isachenko V, Morgenstern B, Todorov P, Isachenko E, Mallmann P, Hanstein B, Rahimi G. Patient with ovarian insufficiency: baby born after anticancer therapy and re-transplantation of cryopreserved ovarian tissue. J Ovarian Res. 2020;13:118\u201323.","journal-title":"J Ovarian Res"},{"key":"1680_CR4","first-page":"213","volume-title":"Concept of human ovarian tissue cryobanking","author":"V Isachenko","year":"2010","unstructured":"Isachenko V, Gagsteiger F, Isachenko E, Weiss J, Kreienberg R. In: Fertility Cryopreservation R-C, Chian P, Quinn, editors. Concept of human ovarian tissue cryobanking. New York: Cambrydge Univerity; 2010. pp. 213\u201317."},{"key":"1680_CR5","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.3727\/096368912X658827","volume":"22","author":"V Isachenko","year":"2013","unstructured":"Isachenko V, Isachenko E, Mallmann P, Rahimi G. Increasing follicular and stromal cell proliferation in cryopreserved human ovarian tissue after long-term precooling prior to freezing: in vitro versus Chorioallantoic membrane (CAM) xenotransplantation. Cell Transpl. 2013;22:2053\u201361.","journal-title":"Cell Transpl"},{"key":"1680_CR6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1472-6483(10)61102-9","volume":"8","author":"E Isachenko","year":"2004","unstructured":"Isachenko E, Rahimi G, Isachenko V, Nawroth F. In-vitro maturation of germinal-vesicle oocytes and cryopreservation in metaphase I\/II: a possible additional option to preserve fertility during ovarian tissue cryopreservation. Reprod Biomed Online. 2004;8:553\u20137.","journal-title":"Reprod Biomed Online"},{"key":"1680_CR7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(10)60355-8","volume":"376","author":"M De Vos","year":"2010","unstructured":"De Vos M, Devroey P, Fauser BC. Primary ovarian insufficiency. Lancet. 2010;376:911\u201321.","journal-title":"Lancet"},{"key":"1680_CR8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJMra1614676","volume":"377","author":"J Donnez","year":"2017","unstructured":"Donnez J, Dolmans MM. Fertility preservation in women. N Engl J Med. 2017;377:1657\u201365.","journal-title":"N Engl J Med"},{"key":"1680_CR9","doi-asserted-by":"crossref","first-page":"10280","DOI":"10.1073\/pnas.1001198107","volume":"107","author":"J Li","year":"2010","unstructured":"Li J, Kawamura K, Cheng Y, Liu S, Klein C, Liu S, et al. Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci USA. 2010;107:10280\u201384.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1680_CR10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dev.045500","volume":"138","author":"G Halder","year":"2011","unstructured":"Halder G, Johnson RL. Hippo signaling: growth control and beyond. 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Cryobiology. 2024;116:104910.","journal-title":"Cryobiology"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01680-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01680-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01680-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:48:17Z","timestamp":1749545297000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01680-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1680"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01680-9","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"25 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Ethics Committee of Cologne University (applications 999,184 and 13\u2013147) and by the Bulgarian Ethics Committee. Informed consent was obtained from patients whose ovarian tissue was collected for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"128"}}