{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:27:16Z","timestamp":1793053636801,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274573"],"award-info":[{"award-number":["82274573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH255"],"award-info":[{"award-number":["ZR2021MH255"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202103182"],"award-info":[{"award-number":["tsqn202103182"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["National Letter of TCM Practitioners No. 1 [2022]"],"award-info":[{"award-number":["National Letter of TCM Practitioners No. 1 [2022]"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Traditional Chinese Medicine Science and Technology Program","award":["Z-2023094"],"award-info":[{"award-number":["Z-2023094"]}]},{"name":"Jinan Science and Technology Program","award":["202328044"],"award-info":[{"award-number":["202328044"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01683-6","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:19:15Z","timestamp":1747354755000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p\/ESR1 axis"],"prefix":"10.1186","volume":"18","author":[{"given":"Li","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haicui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghua","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rugen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"1683_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12958-024-01321-8","volume":"22","author":"X Li","year":"2024","unstructured":"Li X, Wu X, Zhang H, Liu P, Xia L, Zhang N, Tian L, Li Z, Lu J, Zhao Y, Tan J. Analysis of single-cell RNA sequencing in human oocytes with diminished ovarian reserve uncovers mitochondrial dysregulation and translation deficiency. Reprod Biol Endocrinol. 2024;22:146.","journal-title":"Reprod Biol Endocrinol"},{"key":"1683_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000535508","volume":"8","author":"Y Wang","year":"2023","unstructured":"Wang Y, Jiang J, Zhang J, Fan P, Xu J. Research progress on the etiology and treatment of premature ovarian insufficiency. Biomed Hub. 2023;8:97\u2013107.","journal-title":"Biomed Hub"},{"key":"1683_CR3","doi-asserted-by":"crossref","unstructured":"Turathum B, Gao EM, Chian RC. The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization. Cells 2021, 10.","DOI":"10.3390\/cells10092292"},{"key":"1683_CR4","doi-asserted-by":"crossref","unstructured":"Deng J, Tang Y, Li L, Huang R, Wang Z, Ye T, Xiao Z, Hu M, Wei S, Wang Y et al. miR-143-3p promotes ovarian granulosa cell senescence and inhibits estradiol synthesis by targeting UBE2E3 and LHCGR. Int J Mol Sci 2023, 24.","DOI":"10.3390\/ijms241612560"},{"key":"1683_CR5","first-page":"844","volume":"16","author":"P Li","year":"2024","unstructured":"Li P, Dou Q, Zhang D, Xiang Y, Tan L. Melatonin regulates autophagy in granulosa cells from patients with premature ovarian insufficiency via activating Foxo3a. Aging. 2024;16:844\u201356.","journal-title":"Aging"},{"key":"1683_CR6","doi-asserted-by":"crossref","unstructured":"Yang Z, Hong W, Zheng K, Feng J, Hu C, Tan J, Zhong Z, Zheng Y. Chitosan Oligosaccharides Alleviate H(2)O(2)-stimulated Granulosa Cell Damage via HIF-1\u03b1 Signaling Pathway. Oxid Med Cell Longev 2022, 2022:4247042.","DOI":"10.1155\/2022\/4247042"},{"key":"1683_CR7","doi-asserted-by":"publisher","first-page":"111930","DOI":"10.1016\/j.plantsci.2023.111930","volume":"339","author":"C Guan","year":"2024","unstructured":"Guan C, Li W, Wang G, Yang R, Zhang J, Zhang J, Wu B, Gao R, Jia C. Transcriptomic analysis of NcRNAs and mRNAs interactions during drought stress in Switchgrass. Plant Sci. 2024;339:111930.","journal-title":"Plant Sci"},{"key":"1683_CR8","doi-asserted-by":"publisher","first-page":"1341999","DOI":"10.3389\/fcell.2024.1341999","volume":"12","author":"Z Tang","year":"2024","unstructured":"Tang Z, Li X, Zheng Y, Liu J, Liu C, Li X. The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets. Front Cell Dev Biol. 2024;12:1341999.","journal-title":"Front Cell Dev Biol"},{"key":"1683_CR9","doi-asserted-by":"crossref","unstructured":"Wu W, Cao L, Jia Y, Xiao Y, Zhang X, Gui S. Emerging roles of MiRNA, LncRNA, circrna, and their Cross-Talk in pituitary adenoma. Cells 2022, 11.","DOI":"10.3390\/cells11182920"},{"key":"1683_CR10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/biolre\/ioac200","volume":"108","author":"Y Yang","year":"2023","unstructured":"Yang Y, Xiong Y, Pan Z. Role of CeRNAs in non-tumor female reproductive diseases\u2020. Biol Reprod. 2023;108:363\u201381.","journal-title":"Biol Reprod"},{"key":"1683_CR11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s40364-022-00419-8","volume":"10","author":"J Shen","year":"2022","unstructured":"Shen J, Liang C, Su X, Wang Q, Ke Y, Fang J, Zhang D, Duan S. Dysfunction and CeRNA network of the tumor suppressor miR-637 in cancer development and prognosis. Biomark Res. 2022;10:72.","journal-title":"Biomark Res"},{"key":"1683_CR12","doi-asserted-by":"publisher","first-page":"110589","DOI":"10.1016\/j.mce.2019.110589","volume":"499","author":"D Zhang","year":"2020","unstructured":"Zhang D, Tang HY, Tan L, Zhao DM. MALAT1 is involved in the pathophysiological process of PCOS by modulating TGF\u03b2 signaling in granulosa cells. Mol Cell Endocrinol. 2020;499:110589.","journal-title":"Mol Cell Endocrinol"},{"key":"1683_CR13","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1007\/s43032-022-01051-5","volume":"30","author":"Y Yao","year":"2023","unstructured":"Yao Y, Wang Y, Wang F, Meng C, Niu J, Guo M, Sizhu S, Xu Y. BMP15 modulates the H19\/miR-26b\/SMAD1 Axis influences Yak granulosa cell proliferation, autophagy, and apoptosis. Reprod Sci. 2023;30:1266\u201380.","journal-title":"Reprod Sci"},{"key":"1683_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13048-022-01053-6","volume":"15","author":"L Dong","year":"2022","unstructured":"Dong L, Xin X, Chang HM, Leung PCK, Yu C, Lian F, Wu H. Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing. J Ovarian Res. 2022;15:119.","journal-title":"J Ovarian Res"},{"key":"1683_CR15","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/humrep\/der092","volume":"26","author":"AP Ferraretti","year":"2011","unstructured":"Ferraretti AP, La Marca A, Fauser BCJM, Tarlatzis B, Nargund G, Gianaroli L. ESHRE consensus on the definition of \u2018poor response\u2019 to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26:1616\u201324.","journal-title":"Hum Reprod"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12958-024-01189-8","volume":"22","author":"W Ju","year":"2024","unstructured":"Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S. miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4. Reprod Biol Endocrinol. 2024;22:17.","journal-title":"Reprod Biol Endocrinol"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"17593","DOI":"10.1002\/jcb.29027","volume":"120","author":"A Liu","year":"2019","unstructured":"Liu A, Zhang D, Yang X, Song Y. Estrogen receptor alpha activates MAPK signaling pathway to promote the development of endometrial cancer. J Cell Biochem. 2019;120:17593\u2013601.","journal-title":"J Cell Biochem"},{"key":"1683_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13048-021-00769-1","volume":"14","author":"G Yao","year":"2021","unstructured":"Yao G, Kong Y, Yang G, Kong D, Xu Y, He J, Xu Z, Bai Y, Fan H, He Q, Sun Y. Lnc-GULP1-2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization. J Ovarian Res. 2021;14:16.","journal-title":"J Ovarian Res"},{"key":"1683_CR19","doi-asserted-by":"publisher","first-page":"5162","DOI":"10.1002\/jcp.30222","volume":"236","author":"F Wang","year":"2021","unstructured":"Wang F, Chen X, Sun B, Ma Y, Niu W, Zhai J, Sun Y. Hypermethylation-mediated downregulation of LncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. J Cell Physiol. 2021;236:5162\u201375.","journal-title":"J Cell Physiol"},{"key":"1683_CR20","doi-asserted-by":"crossref","unstructured":"Jia Y, Liu L, Gong S, Li H, Zhang X, Zhang R, Wang A, Jin Y, Lin P. Hand2os1 regulates the secretion of progesterone in mice Corpus luteum. Vet Sci 2022, 9.","DOI":"10.3390\/vetsci9080404"},{"key":"1683_CR21","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1042\/EBC20200010","volume":"64","author":"Y Wang","year":"2020","unstructured":"Wang Y, Chen LL. Organization and function of paraspeckles. Essays Biochem. 2020;64:875\u201382.","journal-title":"Essays Biochem"},{"key":"1683_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fcell.2018.00078","volume":"6","author":"EH Ernst","year":"2018","unstructured":"Ernst EH, Nielsen J, Ipsen MB, Villesen P, Lykke-Hartmann K. Transcriptome analysis of long Non-coding RNAs and genes encoding paraspeckle proteins during human ovarian follicle development. Front Cell Dev Biol. 2018;6:78.","journal-title":"Front Cell Dev Biol"},{"key":"1683_CR23","doi-asserted-by":"publisher","first-page":"4618","DOI":"10.1242\/dev.110544","volume":"141","author":"S Nakagawa","year":"2014","unstructured":"Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, Fujita Y, Fujimori T, Standaert L, Marine JC, Hirose T. The LncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. Development. 2014;141:4618\u201327.","journal-title":"Development"},{"key":"1683_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3892\/etm.2020.9197","volume":"20","author":"M Li","year":"2020","unstructured":"Li M, Peng J, Zeng Z. Overexpression of long non-coding RNA nuclear enriched abundant transcript 1 inhibits the expression of p53 and improves premature ovarian failure. Exp Ther Med. 2020;20:69.","journal-title":"Exp Ther Med"},{"key":"1683_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.ncrna.2023.02.008","volume":"8","author":"AA ElMonier","year":"2023","unstructured":"ElMonier AA, El-Boghdady NA, Fahim SA, Sabry D, Elsetohy KA, Shaheen AA. LncRNA NEAT1 and MALAT1 are involved in polycystic ovary syndrome pathogenesis by functioning as competing endogenous RNAs to control the expression of PCOS-related target genes. Noncoding RNA Res. 2023;8:263\u201371.","journal-title":"Noncoding RNA Res"},{"key":"1683_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3892\/etm.2022.11731","volume":"25","author":"P Zhang","year":"2023","unstructured":"Zhang P, Gao J, Lin S, Lin G, Wang W, Tan C, Liu X, Li X, Zhang L. Long non\u2013coding RNA NEAT1 promotes mouse granulosa cell proliferation and estradiol synthesis by sponging miR\u2013874\u20133p. Exp Ther Med. 2023;25:32.","journal-title":"Exp Ther Med"},{"key":"1683_CR27","doi-asserted-by":"publisher","first-page":"113473","DOI":"10.1016\/j.yexcr.2023.113473","volume":"424","author":"YX Liu","year":"2023","unstructured":"Liu YX, Ke Y, Qiu P, Gao J, Deng GP. LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654\/STC2-mediated MAPK signaling pathway. Exp Cell Res. 2023;424:113473.","journal-title":"Exp Cell Res"},{"key":"1683_CR28","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s13577-020-00461-4","volume":"34","author":"J Xiao","year":"2021","unstructured":"Xiao J, Wang R, Zhou W, Cai X, Ye Z. LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p. Hum Cell. 2021;34:372\u201382.","journal-title":"Hum Cell"},{"key":"1683_CR29","doi-asserted-by":"publisher","first-page":"105843","DOI":"10.1016\/j.jsbmb.2021.105843","volume":"209","author":"A Shetty","year":"2021","unstructured":"Shetty A, Suresh PS. A synergy of estradiol with leptin modulates the long non-coding RNA NEAT1\/ mmu-miR-204-5p\/IGF1 axis in the uterus of high-fat-diet-induced obese ovariectomized mice. J Steroid Biochem Mol Biol. 2021;209:105843.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1683_CR30","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1002\/cam4.5077","volume":"12","author":"F Yang","year":"2023","unstructured":"Yang F, Bian Z, Xu P, Sun S, Huang Z. MicroRNA-204-5p: A pivotal tumor suppressor. Cancer Med. 2023;12:3185\u2013200.","journal-title":"Cancer Med"},{"key":"1683_CR31","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1038\/s41388-019-0862-y","volume":"38","author":"X Chen","year":"2019","unstructured":"Chen X, Mangala LS, Mooberry L, Bayraktar E, Dasari SK, Ma S, Ivan C, Court KA, Rodriguez-Aguayo C, Bayraktar R, et al. Identifying and targeting angiogenesis-related MicroRNAs in ovarian cancer. Oncogene. 2019;38:6095\u2013108.","journal-title":"Oncogene"},{"key":"1683_CR32","doi-asserted-by":"publisher","first-page":"s51","DOI":"10.1177\/0963689719877372","volume":"28","author":"L Hu","year":"2019","unstructured":"Hu L, Kolibaba H, Zhang S, Cao M, Niu H, Mei H, Hao Y, Xu Y, Yin Q. MicroRNA-204-5p inhibits ovarian Cancer cell proliferation by Down-Regulating USP47. Cell Transpl. 2019;28:s51\u20138.","journal-title":"Cell Transpl"},{"key":"1683_CR33","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/biolre\/ioaa091","volume":"103","author":"P Zhong","year":"2020","unstructured":"Zhong P, Liu J, Li H, Lin S, Zeng L, Luo L, Wu M, Zhang W. MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium\u2020. Biol Reprod. 2020;103:608\u201319.","journal-title":"Biol Reprod"},{"key":"1683_CR34","doi-asserted-by":"publisher","first-page":"15","DOI":"10.15586\/aei.v51i3.676","volume":"51","author":"Y Cai","year":"2023","unstructured":"Cai Y, Tian J, Su Y, Shi X. MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via mediating Wnt\/\u03b2-catenin signaling pathway. Allergol Immunopathol (Madr). 2023;51:15\u201324.","journal-title":"Allergol Immunopathol (Madr)"},{"key":"1683_CR35","doi-asserted-by":"publisher","first-page":"194","DOI":"10.5653\/cerm.2019.03412","volume":"47","author":"SY Lee","year":"2020","unstructured":"Lee SY, Kang YJ, Kwon J, Nishi Y, Yanase T, Lee KA, Koong MK. miR-4463 regulates aromatase expression and activity for 17\u03b2-estradiol synthesis in response to follicle-stimulating hormone. Clin Exp Reprod Med. 2020;47:194\u2013206.","journal-title":"Clin Exp Reprod Med"},{"key":"1683_CR36","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1507\/endocrj.EJ21-0653","volume":"69","author":"YT Sun","year":"2022","unstructured":"Sun YT, Cai JH, Bao S. Overexpression of LncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the Musashi RNA-binding protein 2\/oestrogen receptor alpha 1 axis. Endocr J. 2022;69:1117\u201329.","journal-title":"Endocr J"},{"key":"1683_CR37","doi-asserted-by":"crossref","unstructured":"Baddela VS, Michaelis M, Tao X, Koczan D, Vanselow J. ERK1\/2-SOX9\/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular-luteal transition. Life Sci Alliance 2023, 6.","DOI":"10.26508\/lsa.202302100"},{"key":"1683_CR38","doi-asserted-by":"publisher","first-page":"114980","DOI":"10.1016\/j.ecoenv.2023.114980","volume":"258","author":"Q Liu","year":"2023","unstructured":"Liu Q, Liu Y, Li X, Wang D, Zhang A, Pang J, He J, Chen X, Tang NJ. Perfluoroalkyl substances promote breast cancer progression via ER\u03b1 and GPER mediated PI3K\/Akt and MAPK\/Erk signaling pathways. Ecotoxicol Environ Saf. 2023;258:114980.","journal-title":"Ecotoxicol Environ Saf"},{"key":"1683_CR39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41389-021-00327-w","volume":"10","author":"WB Ou","year":"2021","unstructured":"Ou WB, Lundberg MZ, Zhu S, Bahri N, Kyriazoglou A, Xu L, Chen T, Mari\u00f1o-Enriquez A, Fletcher JA. YWHAE-NUTM2 oncoprotein regulates proliferation and Cyclin D1 via RAF\/MAPK and Hippo pathways. Oncogenesis. 2021;10:37.","journal-title":"Oncogenesis"},{"key":"1683_CR40","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.7314\/APJCP.2014.15.15.6247","volume":"15","author":"JQ Sui","year":"2014","unstructured":"Sui JQ, Xie KP, Zou W, Xie MJ. Emodin inhibits breast cancer cell proliferation through the ER\u03b1-MAPK\/Akt-cyclin D1\/Bcl-2 signaling pathway. Asian Pac J Cancer Prev. 2014;15:6247\u201351.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1683_CR41","doi-asserted-by":"crossref","unstructured":"Safdar M, Liang A, Rajput SA, Abbas N, Zubair M, Shaukat A, Rehman AU, Jamil H, Guo Y, Ullah F, Yang L. Orexin-A regulates follicular growth, proliferation, cell cycle and apoptosis in mouse primary granulosa cells via the AKT\/ERK signaling pathway. Molecules 2021, 26.","DOI":"10.3390\/molecules26185635"},{"key":"1683_CR42","doi-asserted-by":"crossref","unstructured":"Huang Z, Tian Z, Zhao Y, Zhu F, Liu W, Wang X. MAPK signaling pathway is essential for female reproductive regulation in the cabbage beetle, Colaphellus bowringi. Cells 2022, 11.","DOI":"10.3390\/cells11101602"},{"key":"1683_CR43","first-page":"1997","volume":"19","author":"YJ Guo","year":"2020","unstructured":"Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y, Hu LL. ERK\/MAPK signalling pathway and tumorigenesis. Exp Ther Med. 2020;19:1997\u20132007.","journal-title":"Exp Ther Med"},{"key":"1683_CR44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.taap.2014.05.008","volume":"279","author":"J Guo","year":"2014","unstructured":"Guo J, Yuan Y, Lu D, Du B, Xiong L, Shi J, Yang L, Liu W, Yuan X, Zhang G, Wang F. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3\u03b2,5\u03b1,8\u03b1-triol, inhibit the biosynthesis of Estrogen in human ovarian granulosa cells by aromatase (CYP19). Toxicol Appl Pharmacol. 2014;279:23\u201332.","journal-title":"Toxicol Appl Pharmacol"},{"key":"1683_CR45","doi-asserted-by":"crossref","unstructured":"Wu H, Sun P, Lv C, Zhao X, Liu M, Zhou Q, Tang J, Yang L, Liang A. Effects of IL-11\/IL-11 receptor alpha on proliferation and steroidogenesis in ovarian granulosa cells of dairy cows. Cells 2023, 12.","DOI":"10.3390\/cells12040673"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01683-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01683-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01683-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:19:29Z","timestamp":1747354769000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01683-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01683-6","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"3 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Reproductive Medicine of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Ref: 2021-103-KY). Written informed consent was obtained from all participants prior to oocyte retrieval, and the protocol strictly adhered to the Declaration of Helsinki. As this study was not a clinical trial, Clinical trial number: not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"102"}}