{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:13:29Z","timestamp":1793121209213,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Diminished ovarian reserve (DOR), a common female disease, results in reduced fertility and menstrual disorders. Patients without timely treatment often suffer from infertility, ovarian insufficiency, premature ovarian failure and early onset or worsened perimenopausal symptoms caused by estrogen fluctuation or deficiency. However, there is a lack of effective methods to improve ovarian reserve function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>Here, we report a case of a 13-year-old female with 2-year menstrual disorder. The anti-mullerian hormone (AMH) levels were test twice, with interval of 2 months, yielding results of 0.41 ng\/mL and 0.50 ng\/mL, respectively. Colour Doppler ultrasound examination showed that there were 4\u20136 antral follicles bilaterally. The patient was diagnosed with DOR. She was treated with Heyan Kuntai capsule (HYKT) combined with hormonal therapy (HT). Post treament, her AMH level, follicle stimulating hormone level and AFC normalized. Discontinuation of HYKT and continuation of HT alone for 5 months proved ineffective. Consequently, HYKT in combination with HT was continued, leading to normal ovarian reserve function restoration. No adverse reactions were observed during the 4-year follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This case highlights the importance of including DOR as a diagnostic consideration in adolescents with menstrual disorders during clinical evaluation. AND combining HYKT with HT might contribute to potential improvements in ovarian function in DOR patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13048-025-01716-0","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T10:07:18Z","timestamp":1751537238000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment of Heyan Kuntai capsule combined with hormonal therapy in an adolescent with diminished ovarian reserve: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Xue","family":"Ao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"issue":"6","key":"1716_CR1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.fertnstert.2020.09.134","volume":"114","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2020","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Electronic address aao, practice committee of the American society for reproductive M: testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2020;114(6):1151\u20137.","journal-title":"Fertil Steril"},{"issue":"4","key":"1716_CR2","first-page":"425","volume":"31","author":"Expert Group of Consensus on Clinical Diagnosis &","year":"2022","unstructured":"Expert Group of Consensus on Clinical Diagnosis &. Management of diminished ovarian reserve, reproductive endocrinology & fertility preservation section of Chinese society on fertility preservation under Chinese preventive medicine association: consensus on clinical diagnosis and management of diminished ovarian reserve. 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A novel de Novo partial Xq duplication in a Girl with short stature, nonverbal learning disability and diminished ovarian reserve - effect of growth hormone treatment and fertility preservation strategies: a case report and up-to-date review. Int J Pediatr Endocrinol. 2020;2020:1.","journal-title":"Int J Pediatr Endocrinol"},{"issue":"2","key":"1716_CR7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/ijgo.15284","volume":"165","author":"H Bareghamyan","year":"2024","unstructured":"Bareghamyan H, Chopikyan A, Petrosyan M, Shahverdyan N, Harutyunyan A. Influence of ovarian cysts on ovarian reserve and fertility: A case-control study. Int J Gynaecol Obstet. 2024;165(2):424\u201330.","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"1716_CR8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s11655-021-3353-2","volume":"29","author":"QL Zhang","year":"2023","unstructured":"Zhang QL, Lei YL, Deng Y, Ma RL, Ding XS, Xue W, Sun AJ. 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This patient signed informed consent for participation in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"143"}}