{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:39:33Z","timestamp":1787020773942,"version":"build-2736575974"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jinshan District Health Commission of Shanghai","award":["JSKJ-KTMS-2021-07"],"award-info":[{"award-number":["JSKJ-KTMS-2021-07"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872121"],"award-info":[{"award-number":["81872121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1408900"],"award-info":[{"award-number":["23ZR1408900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01758-4","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T13:44:27Z","timestamp":1753796667000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SLC4A11 is a targetable marker correlated with therapeutic responses in ovarian cancer"],"prefix":"10.1186","volume":"18","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencai","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0148-2702","authenticated-orcid":false,"given":"Jihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-8754","authenticated-orcid":false,"given":"Guoxiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"1758_CR1","doi-asserted-by":"publisher","first-page":"100629","DOI":"10.1016\/j.ctarc.2022.100629","volume":"33","author":"S Sambasivan","year":"2022","unstructured":"Sambasivan S. Epithelial ovarian cancer: review Article. Cancer Treat Res Commun. 2022;33:100629. https:\/\/doi.org\/10.1016\/j.ctarc.2022.100629.","journal-title":"Cancer Treat Res Commun"},{"issue":"1","key":"1758_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A. Cancer statistics, 2025. CA Cancer J Clin. 2025;75(1):10\u201345. https:\/\/doi.org\/10.3322\/caac.21871.","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"1758_CR3","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/s43018-023-00617-9","volume":"4","author":"PA Konstantinopoulos","year":"2023","unstructured":"Konstantinopoulos PA, Matulonis UA. Clinical and translational advances in ovarian cancer therapy. Nat Cancer. 2023;4(9):1239\u201357. https:\/\/doi.org\/10.1038\/s43018-023-00617-9.","journal-title":"Nat Cancer"},{"issue":"10","key":"1758_CR4","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.annonc.2023.07.011","volume":"34","author":"A Gonzalez-Martin","year":"2023","unstructured":"Gonzalez-Martin A, Harter P, Leary A, Lorusso D, Miller RE, Pothuri B, et al. Newly diagnosed and relapsed epithelial ovarian cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34(10):833\u201348. https:\/\/doi.org\/10.1016\/j.annonc.2023.07.011.","journal-title":"Ann Oncol"},{"issue":"5","key":"1758_CR5","doi-asserted-by":"publisher","first-page":"C735","DOI":"10.1152\/ajpcell.00078.2016","volume":"311","author":"SK Loganathan","year":"2016","unstructured":"Loganathan SK, Schneider HP, Morgan PE, Deitmer JW, Casey JR. Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies. Am J Physiol Cell Physiol. 2016;311(5):C735\u201348. https:\/\/doi.org\/10.1152\/ajpcell.00078.2016.","journal-title":"Am J Physiol Cell Physiol"},{"key":"1758_CR6","doi-asserted-by":"publisher","unstructured":"Yousaf K, Naz S, Mushtaq A, Wohler E, Sobreira N, Ho BM, et al. Exome sequencing reveals SLC4A11 variant underlying congenital hereditary endothelial dystrophy (CHED2) misdiagnosed as congenital Glaucoma. Genes (Basel). 2023;14(2). https:\/\/doi.org\/10.3390\/genes14020310.","DOI":"10.3390\/genes14020310"},{"issue":"11","key":"1758_CR7","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1136\/bjophthalmol-2019-314377","volume":"104","author":"H Moazzeni","year":"2020","unstructured":"Moazzeni H, Javadi MA, Asgari D, Khani M, Emami M, Moghadam A, et al. Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family. Br J Ophthalmol. 2020;104(11):1621\u20138. https:\/\/doi.org\/10.1136\/bjophthalmol-2019-314377.","journal-title":"Br J Ophthalmol"},{"issue":"22","key":"1758_CR8","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1093\/hmg\/ddt307","volume":"22","author":"GL Vilas","year":"2013","unstructured":"Vilas GL, Loganathan SK, Liu J, Riau AK, Young JD, Mehta JS, et al. Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. Hum Mol Genet. 2013;22(22):4579\u201390. https:\/\/doi.org\/10.1093\/hmg\/ddt307.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"1758_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s10038-020-00834-5","volume":"66","author":"N Tananuvat","year":"2021","unstructured":"Tananuvat N, Tananuvat R, Chartapisak W, Mahanupab P, Hokierti C, Srikummool M, et al. Harboyan syndrome: novel SLC4A11 mutation, clinical manifestations, and outcome of corneal transplantation. J Hum Genet. 2021;66(2):193\u2013203. https:\/\/doi.org\/10.1038\/s10038-020-00834-5.","journal-title":"J Hum Genet"},{"issue":"5","key":"1758_CR10","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1093\/hmg\/ddm337","volume":"17","author":"EN Vithana","year":"2008","unstructured":"Vithana EN, Morgan PE, Ramprasad V, Tan DT, Yong VH, Venkataraman D, et al. SLC4A11 mutations in Fuchs endothelial corneal dystrophy. Hum Mol Genet. 2008;17(5):656\u201366. https:\/\/doi.org\/10.1093\/hmg\/ddm337.","journal-title":"Hum Mol Genet"},{"key":"1758_CR11","doi-asserted-by":"publisher","unstructured":"Bonanno JA, Shyam R, Choi M, Ogando DG. The H(+) transporter SLC4A11: roles in metabolism, oxidative stress and mitochondrial uncoupling. Cells. 2022;11(2). https:\/\/doi.org\/10.3390\/cells11020197.","DOI":"10.3390\/cells11020197"},{"key":"1758_CR12","doi-asserted-by":"publisher","unstructured":"Elaimy AL, El-Derany MO, James J, Wang Z, Pearson AN, Holcomb EA, et al. SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma. JCI Insight. 2024;9(21). https:\/\/doi.org\/10.1172\/jci.insight.184826.","DOI":"10.1172\/jci.insight.184826"},{"issue":"10","key":"1758_CR13","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1158\/0008-5472.CAN-23-0673","volume":"84","author":"Y Wang","year":"2024","unstructured":"Wang Y, Cheng C, Lu Y, Lian Z, Liu Q, Xu Y, et al. beta-Catenin activation reprograms Ammonia metabolism to promote senescence resistance in hepatocellular carcinoma. Cancer Res. 2024;84(10):1643\u201358. https:\/\/doi.org\/10.1158\/0008-5472.CAN-23-0673.","journal-title":"Cancer Res"},{"issue":"8","key":"1758_CR14","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1245\/s10434-023-13594-1","volume":"30","author":"E Shinto","year":"2023","unstructured":"Shinto E, Oki E, Shimokawa M, Yamaguchi S, Ishiguro M, Hasegawa S, et al. Enhanced clinical utility of molecular budding signature as a recurrence risk determinant in stage II and III Colon cancer patients. Ann Surg Oncol. 2023;30(8):5239\u201347. https:\/\/doi.org\/10.1245\/s10434-023-13594-1.","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"1758_CR15","doi-asserted-by":"publisher","first-page":"e0187385","DOI":"10.1371\/journal.pone.0187385","volume":"12","author":"L Qin","year":"2017","unstructured":"Qin L, Li T, Liu Y, High. SLC4A11 expression is an independent predictor for poor overall survival in grade 3\/4 serous ovarian cancer. PLoS ONE. 2017;12(11):e0187385. https:\/\/doi.org\/10.1371\/journal.pone.0187385.","journal-title":"PLoS ONE"},{"key":"1758_CR16","doi-asserted-by":"publisher","first-page":"2505812","DOI":"10.1155\/sci\/2505812","volume":"2025","author":"K Zhou","year":"2025","unstructured":"Zhou K, Ma X, Yan T, Zheng H, Xie S, Guo L, et al. Stemness-Relevant gene signature for chemotherapeutic response and prognosis prediction in ovarian Cancer. Stem Cells Int. 2025;2025:2505812. https:\/\/doi.org\/10.1155\/sci\/2505812.","journal-title":"Stem Cells Int"},{"issue":"W1","key":"1758_CR17","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98\u2013102. https:\/\/doi.org\/10.1093\/nar\/gkx247.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"1758_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401\u20134. https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0095.","journal-title":"Cancer Discov"},{"issue":"7","key":"1758_CR19","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. https:\/\/doi.org\/10.1093\/nar\/gkv007.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"1758_CR20","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216\u201321. https:\/\/doi.org\/10.1093\/nar\/gkac194.","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"1758_CR21","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.1038\/psp.2013.56","volume":"2","author":"K Ito","year":"2013","unstructured":"Ito K, Murphy D. Application of ggplot2 to pharmacometric graphics. CPT Pharmacometrics Syst Pharmacol. 2013;2(10):e79. https:\/\/doi.org\/10.1038\/psp.2013.56.","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"issue":"3","key":"1758_CR22","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov (N Y). 2021;2(3):100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141.","journal-title":"Innov (N Y)"},{"issue":"9","key":"1758_CR23","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1016\/j.celrep.2018.10.096","volume":"25","author":"E Papp","year":"2018","unstructured":"Papp E, Hallberg D, Konecny GE, Bruhm DC, Adleff V, Noe M, et al. Integrated genomic, epigenomic, and expression analyses of ovarian Cancer cell lines. Cell Rep. 2018;25(9):2617\u201333. https:\/\/doi.org\/10.1016\/j.celrep.2018.10.096.","journal-title":"Cell Rep"},{"issue":"4","key":"1758_CR24","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1261\/rna.2192803","volume":"9","author":"SA Stewart","year":"2003","unstructured":"Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, et al. Lentivirus-delivered stable gene Silencing by RNAi in primary cells. RNA. 2003;9(4):493\u2013501. https:\/\/doi.org\/10.1261\/rna.2192803.","journal-title":"RNA"},{"issue":"1 Suppl","key":"1758_CR25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2144\/000112517","volume":"43","author":"TJ Collins","year":"2007","unstructured":"Collins TJ. ImageJ for microscopy. Biotechniques. 2007;43(1 Suppl):25\u201330. https:\/\/doi.org\/10.2144\/000112517.","journal-title":"Biotechniques"},{"issue":"30","key":"1758_CR26","doi-asserted-by":"publisher","first-page":"4906","DOI":"10.1038\/s41388-021-01891-6","volume":"40","author":"J Zhang","year":"2021","unstructured":"Zhang J, Guan W, Xu X, Wang F, Li X, Xu G. A novel homeostatic loop of Sorcin drives paclitaxel-resistance and malignant progression via Smad4\/ZEB1\/miR-142-5p in human ovarian cancer. Oncogene. 2021;40(30):4906\u201318. https:\/\/doi.org\/10.1038\/s41388-021-01891-6.","journal-title":"Oncogene"},{"key":"1758_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","volume":"1711","author":"B Chen","year":"2018","unstructured":"Chen B, Khodadoust MS, Liu CL, Newman AM, Alizadeh AA. Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol. 2018;1711:243\u201359. https:\/\/doi.org\/10.1007\/978-1-4939-7493-1_12.","journal-title":"Methods Mol Biol"},{"key":"1758_CR28","doi-asserted-by":"publisher","unstructured":"Liu CJ, Hu FF, Xie GY, Miao YR, Li XW, Zeng Y, et al. GSCA: an integrated platform for gene set cancer analysis at genomic, Pharmacogenomic and Immunogenomic levels. Brief Bioinform. 2023;24(1). https:\/\/doi.org\/10.1093\/bib\/bbac558.","DOI":"10.1093\/bib\/bbac558"},{"issue":"24","key":"1758_CR29","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1080\/15384101.2017.1383577","volume":"16","author":"SL Liu","year":"2017","unstructured":"Liu SL, Liu Z, Zhang LD, Zhu HQ, Guo JH, Zhao M, et al. GSK3beta-dependent Cyclin D1 and Cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0\/G1 arrest in neuroblastoma cells. Cell Cycle. 2017;16(24):2386\u201395. https:\/\/doi.org\/10.1080\/15384101.2017.1383577.","journal-title":"Cell Cycle"},{"issue":"16","key":"1758_CR30","doi-asserted-by":"publisher","first-page":"6565","DOI":"10.1158\/0008-5472.CAN-09-0913","volume":"69","author":"CP Masamha","year":"2009","unstructured":"Masamha CP, Benbrook DM. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of Cyclin E2 in ovarian cancer cells. Cancer Res. 2009;69(16):6565\u201372. https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-0913.","journal-title":"Cancer Res"},{"issue":"8","key":"1758_CR31","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.biocel.2003.12.005","volume":"36","author":"T Moroy","year":"2004","unstructured":"Moroy T, Geisen C, Cyclin E, Int. J Biochem Cell Biol. 2004;36(8):1424\u201339. https:\/\/doi.org\/10.1016\/j.biocel.2003.12.005.","journal-title":"J Biochem Cell Biol"},{"issue":"27","key":"1758_CR32","doi-asserted-by":"publisher","first-page":"18236","DOI":"10.1074\/jbc.M109.002584","volume":"284","author":"H Wang","year":"2009","unstructured":"Wang H, Zhang X, Geng L, Teng L, Legerski RJ. Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of Cyclin E. J Biol Chem. 2009;284(27):18236\u201343. https:\/\/doi.org\/10.1074\/jbc.M109.002584.","journal-title":"J Biol Chem"},{"key":"1758_CR33","doi-asserted-by":"publisher","unstructured":"Zahra A, Hall M, Chatterjee J, Sisu C, Karteris E. In Silico study to predict the structural and functional consequences of SNPs on biomarkers of ovarian Cancer (OC) and BPA Exposure-Associated OC. Int J Mol Sci. 2022;23(3). https:\/\/doi.org\/10.3390\/ijms23031725.","DOI":"10.3390\/ijms23031725"},{"issue":"4","key":"1758_CR34","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1007\/s10147-021-02104-6","volume":"27","author":"M Yamadera","year":"2022","unstructured":"Yamadera M, Shinto E, Nagata K, Shiraishi T, Kajiwara Y, Mochizuki S, et al. Proposal for a tumor budding predictive score derived from endoscopic biopsy samples in colorectal cancer. Int J Clin Oncol. 2022;27(4):756\u201364. https:\/\/doi.org\/10.1007\/s10147-021-02104-6.","journal-title":"Int J Clin Oncol"},{"issue":"12","key":"1758_CR35","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1158\/1535-7163.MCT-23-0099","volume":"22","author":"S Shimoyama","year":"2023","unstructured":"Shimoyama S, Okada K, Kimura T, Morohashi Y, Nakayama S, Kemmochi S, et al. FF-10850, a novel liposomal Topotecan achieves superior antitumor activity via Macrophage- and Ammonia-Mediated payload release in the tumor microenvironment. Mol Cancer Ther. 2023;22(12):1454\u201364. https:\/\/doi.org\/10.1158\/1535-7163.MCT-23-0099.","journal-title":"Mol Cancer Ther"},{"key":"1758_CR36","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ebiom.2017.01.004","volume":"16","author":"W Zhang","year":"2017","unstructured":"Zhang W, Li H, Ogando DG, Li S, Feng M, Price FW Jr, et al. Glutaminolysis is essential for energy production and ion transport in human corneal endothelium. EBioMedicine. 2017;16:292\u2013301. https:\/\/doi.org\/10.1016\/j.ebiom.2017.01.004.","journal-title":"EBioMedicine"},{"issue":"9","key":"1758_CR37","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1167\/iovs.17-21781","volume":"58","author":"W Zhang","year":"2017","unstructured":"Zhang W, Ogando DG, Kim ET, Choi MJ, Li H, Tenessen JM, et al. Conditionally immortal Slc4a11-\/- mouse corneal endothelial cell line recapitulates disrupted Glutaminolysis seen in Slc4a11-\/- mouse model. Invest Ophthalmol Vis Sci. 2017;58(9):3723\u201331. https:\/\/doi.org\/10.1167\/iovs.17-21781.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1758_CR38","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1097\/ICO.0000000000000421","volume":"34","author":"S Roy","year":"2015","unstructured":"Roy S, Praneetha DC, Vendra VP. Mutations in the corneal endothelial Dystrophy-Associated gene SLC4A11 render the cells more vulnerable to oxidative insults. Cornea. 2015;34(6):668\u201374. https:\/\/doi.org\/10.1097\/ICO.0000000000000421.","journal-title":"Cornea"},{"key":"1758_CR39","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.freeradbiomed.2021.03.006","volume":"167","author":"S Guha","year":"2021","unstructured":"Guha S, Roy S. Enhanced expression of SLC4A11 by tert-Butylhydroquinone is mediated by direct binding of Nrf2 to the promoter of SLC4A11. Free Radic Biol Med. 2021;167:299\u2013306. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.03.006.","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"1758_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/iovs.62.12.15","volume":"62","author":"R Shyam","year":"2021","unstructured":"Shyam R, Ogando DG, Choi M, Liton PB, Bonanno JA. Mitochondrial ROS induced lysosomal dysfunction and autophagy impairment in an animal model of congenital hereditary endothelial dystrophy. Invest Ophthalmol Vis Sci. 2021;62(12):15. https:\/\/doi.org\/10.1167\/iovs.62.12.15.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"1758_CR41","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1172\/JCI69600","volume":"123","author":"CT Hensley","year":"2013","unstructured":"Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest. 2013;123(9):3678\u201384. https:\/\/doi.org\/10.1172\/JCI69600.","journal-title":"J Clin Invest"},{"issue":"10","key":"1758_CR42","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nrc.2016.71","volume":"16","author":"BJ Altman","year":"2016","unstructured":"Altman BJ, Stine ZE, Dang CV. From Krebs to clinic: glutamine metabolism to cancer therapy. Nat Rev Cancer. 2016;16(10):619\u201334. https:\/\/doi.org\/10.1038\/nrc.2016.71.","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"1758_CR43","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/bjc.2017.113","volume":"116","author":"ER Still","year":"2017","unstructured":"Still ER, Yuneva MO. Hopefully devoted to Q: targeting glutamine addiction in cancer. Br J Cancer. 2017;116(11):1375\u201381. https:\/\/doi.org\/10.1038\/bjc.2017.113.","journal-title":"Br J Cancer"},{"key":"1758_CR44","doi-asserted-by":"publisher","first-page":"1537483","DOI":"10.3389\/fimmu.2025.1537483","volume":"16","author":"Y Wu","year":"2025","unstructured":"Wu Y, Li Z, Xi P, Wang Y, Guo H, Yin H, et al. The ammonia-Slc4a11 axis in T cells alleviates LPS-induced mastitis. Front Immunol. 2025;16:1537483. https:\/\/doi.org\/10.3389\/fimmu.2025.1537483.","journal-title":"Front Immunol"},{"issue":"2","key":"1758_CR45","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s13402-024-00992-0","volume":"48","author":"M Ryba-Stanislawowska","year":"2025","unstructured":"Ryba-Stanislawowska M. Unraveling Th subsets: insights into their role in immune checkpoint inhibitor therapy. Cell Oncol (Dordr). 2025;48(2):295\u2013312. https:\/\/doi.org\/10.1007\/s13402-024-00992-0.","journal-title":"Cell Oncol (Dordr)"},{"issue":"4","key":"1758_CR46","doi-asserted-by":"publisher","first-page":"e1604","DOI":"10.1002\/ctm2.1604","volume":"14","author":"F Neuhaus","year":"2024","unstructured":"Neuhaus F, Lieber S, Shinkevich V, Steitz AM, Raifer H, Roth K, et al. Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells. Clin Transl Med. 2024;14(4):e1604. https:\/\/doi.org\/10.1002\/ctm2.1604.","journal-title":"Clin Transl Med"},{"issue":"2","key":"1758_CR47","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41416-022-02056-2","volume":"128","author":"D Jacenik","year":"2023","unstructured":"Jacenik D, Karagiannidis I, Beswick EJ. Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. Br J Cancer. 2023;128(2):387\u201397. https:\/\/doi.org\/10.1038\/s41416-022-02056-2.","journal-title":"Br J Cancer"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01758-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01758-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01758-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T02:14:43Z","timestamp":1753928083000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01758-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1758"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01758-4","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical approval of the study for human subjects was approved by the Ethics Committee of Jinshan Hospital of Fudan University (approval no. JIEC-2022-S10). The written informed consent was obtained from the patients. Animal studies were approved by the Laboratory Animal Welfare and Ethics Committee of the Shanghai Public Health Clinical Center of Fudan University (approval no. 2022-A041-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"167"}}