{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:46Z","timestamp":1787837446389,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82360158"],"award-info":[{"award-number":["82360158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Reproductive Obstetrics and Gynecology Clinical Center of Yunnan Province","award":["zx2019-01-01"],"award-info":[{"award-number":["zx2019-01-01"]}]},{"name":"Social development projects of Yunnan Province","award":["202302AA310044"],"award-info":[{"award-number":["202302AA310044"]}]},{"name":"Special Project for \u201cFamous Doctor\u201d of Yunnan Ten Thousand Talents Plan","award":["YNWR-MY-2019-020"],"award-info":[{"award-number":["YNWR-MY-2019-020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-025-01855-4","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T16:19:53Z","timestamp":1763137193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of ferroptosis- and mitochondrial metabolism-related biomarkers and the potential molecular mechanisms of poor ovarian response"],"prefix":"10.1186","volume":"18","author":[{"given":"Yunying","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"1855_CR1","doi-asserted-by":"publisher","first-page":"263349412110620","DOI":"10.1177\/26334941211062026","volume":"16","author":"F Di Guardo","year":"2022","unstructured":"Di Guardo F, Blockeel C, De Vos M, et al. Poor ovarian response and the possible role of natural and modified natural cycles. Ther Adv Reprod Health. 2022;16:26334941211062026. https:\/\/doi.org\/10.1177\/26334941211062026. Published 2022 Jan 14.","journal-title":"Ther Adv Reprod Health"},{"issue":"6","key":"1855_CR2","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.18632\/aging.203972","volume":"14","author":"Y Cakiroglu","year":"2022","unstructured":"Cakiroglu Y, Yuceturk A, Karaosmanoglu O, et al. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging. 2022;14(6):2513\u201323. https:\/\/doi.org\/10.18632\/aging.203972.","journal-title":"Aging"},{"issue":"4","key":"1855_CR3","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1093\/humrep\/deae038","volume":"39","author":"G Barrenetxea","year":"2024","unstructured":"Barrenetxea G, Celis R, Barrenetxea J, et al. Intraovarian platelet-rich plasma injection and IVF outcomes in patients with poor ovarian response: a double-blind randomized controlled trial. Hum Reprod. 2024;39(4):760\u20139. https:\/\/doi.org\/10.1093\/humrep\/deae038.","journal-title":"Hum Reprod"},{"issue":"4","key":"1855_CR4","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.fertnstert.2022.02.026","volume":"117","author":"MI Cedars","year":"2022","unstructured":"Cedars MI. Managing poor ovarian response in the patient with diminished ovarian reserve. Fertil Steril. 2022;117(4):655\u20136. https:\/\/doi.org\/10.1016\/j.fertnstert.2022.02.026.","journal-title":"Fertil Steril"},{"issue":"5","key":"1855_CR5","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s00404-023-06922-z","volume":"308","author":"J Luo","year":"2023","unstructured":"Luo J, Sun Z. MicroRNAs in POI, DOR and POR. Arch Gynecol Obstet. 2023;308(5):1419\u201330. https:\/\/doi.org\/10.1007\/s00404-023-06922-z.","journal-title":"Arch Gynecol Obstet"},{"key":"1855_CR6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.theriogenology.2023.04.009","volume":"205","author":"CA Martinez","year":"2023","unstructured":"Martinez CA, Rizos D, Rodriguez-Martinez H, et al. Oocyte-cumulus cells crosstalk: new comparative insights. Theriogenology. 2023;205:87\u201393. https:\/\/doi.org\/10.1016\/j.theriogenology.2023.04.009.","journal-title":"Theriogenology"},{"key":"1855_CR7","doi-asserted-by":"publisher","first-page":"1346842","DOI":"10.3389\/fendo.2024.1346842","volume":"15","author":"J Huang","year":"2024","unstructured":"Huang J, Fan H, Li C, et al. Dysregulation of ferroptosis-related genes in granulosa cells associates with impaired oocyte quality in polycystic ovary syndrome. Front Endocrinol (Lausanne). 2024;15:1346842. https:\/\/doi.org\/10.3389\/fendo.2024.1346842. Published 2024 Feb 6.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5 Pt 2","key":"1855_CR8","first-page":"S214","volume":"35","author":"V Machelon","year":"2006","unstructured":"Machelon V. Cellules de La granulosa et indicateur de La qualit\u00e9 ovocytaire [Granulosa cells as indicators of oocyte quality]. J Gynecol Obstet Biol Reprod (Paris). 2006;35(5 Pt 2):S214\u20138.","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"4","key":"1855_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382. https:\/\/doi.org\/10.1038\/s41580-020-00324-8.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"1855_CR10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.fertnstert.2023.05.165","volume":"120","author":"J Zhou","year":"2023","unstructured":"Zhou J, Lin L, Liu L, Wang J, Xia G, Wang C. The transcriptome reveals the molecular regulatory network of primordial follicle depletion in obese mice. Fertil Steril. 2023;120(4):899\u2013910. https:\/\/doi.org\/10.1016\/j.fertnstert.2023.05.165.","journal-title":"Fertil Steril"},{"issue":"1","key":"1855_CR11","doi-asserted-by":"publisher","first-page":"4463","DOI":"10.1038\/s41598-023-31712-7","volume":"13","author":"R Du","year":"2023","unstructured":"Du R, Cheng X, Ji J, et al. Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin. Sci Rep. 2023;13(1):4463. https:\/\/doi.org\/10.1038\/s41598-023-31712-7. Published 2023 Mar 17.","journal-title":"Sci Rep"},{"key":"1855_CR12","doi-asserted-by":"publisher","first-page":"109561","DOI":"10.1016\/j.abb.2023.109561","volume":"738","author":"X Chen","year":"2023","unstructured":"Chen X, Song QL, Li ZH, et al. Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2\/HO-1 pathway. Arch Biochem Biophys. 2023;738:109561. https:\/\/doi.org\/10.1016\/j.abb.2023.109561.","journal-title":"Arch Biochem Biophys"},{"issue":"10","key":"1855_CR13","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1210\/en.2019-00441","volume":"160","author":"D Tiosano","year":"2019","unstructured":"Tiosano D, Mears JA, Buchner DA. Mitochondrial dysfunction in primary ovarian insufficiency. Endocrinology. 2019;160(10):2353\u201366. https:\/\/doi.org\/10.1210\/en.2019-00441.","journal-title":"Endocrinology"},{"issue":"12","key":"1855_CR14","doi-asserted-by":"publisher","first-page":"7966","DOI":"10.1002\/jcp.30468","volume":"236","author":"L Wang","year":"2021","unstructured":"Wang L, Tang J, Wang L, et al. Oxidative stress in oocyte aging and female reproduction. J Cell Physiol. 2021;236(12):7966\u201383. https:\/\/doi.org\/10.1002\/jcp.30468.","journal-title":"J Cell Physiol"},{"key":"1855_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2023.04.002","volume":"203","author":"H Xu","year":"2023","unstructured":"Xu H, Mao X, Nie Z, Li Y. Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free Radic Biol Med. 2023;203:102\u201313. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.04.002.","journal-title":"Free Radic Biol Med"},{"key":"1855_CR16","doi-asserted-by":"publisher","first-page":"1172481","DOI":"10.3389\/fendo.2023.1172481","volume":"14","author":"YQ Shi","year":"2023","unstructured":"Shi YQ, Zhu XT, Zhang SN, et al. Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants. Front Endocrinol (Lausanne). 2023;14:1172481. https:\/\/doi.org\/10.3389\/fendo.2023.1172481. Published 2023 Aug 1.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1855_CR17","doi-asserted-by":"publisher","first-page":"1297484","DOI":"10.3389\/fimmu.2023.1297484","volume":"14","author":"L Qi","year":"2023","unstructured":"Qi L, Li Y, Zhang L, et al. Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptome. Front Immunol. 2023;14:1297484. https:\/\/doi.org\/10.3389\/fimmu.2023.1297484. Published 2023 Dec 4.","journal-title":"Front Immunol"},{"key":"1855_CR18","doi-asserted-by":"publisher","unstructured":"Lu G, Li HX, Song ZW, et al. Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy. Stem Cell Res Ther. 2024;15(1):102.\u00a0https:\/\/doi.org\/10.1186\/s13287-024-03709-0. Published 2024 Apr 8.","DOI":"10.1186\/s13287-024-03709-0"},{"issue":"10","key":"1855_CR19","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1093\/humrep\/deae170","volume":"39","author":"RM Yildirim","year":"2024","unstructured":"Yildirim RM, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Hum Reprod. 2024;39(10):2147\u201359. https:\/\/doi.org\/10.1093\/humrep\/deae170.","journal-title":"Hum Reprod"},{"issue":"9","key":"1855_CR20","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.7150\/ijbs.83348","volume":"19","author":"J Li","year":"2023","unstructured":"Li J, Jia YC, Ding YX, et al. The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks. Int J Biol Sci. 2023;19(9):2756\u201371. https:\/\/doi.org\/10.7150\/ijbs.83348. Published 2023 May 21.","journal-title":"Int J Biol Sci"},{"key":"1855_CR21","doi-asserted-by":"publisher","unstructured":"Battaglia AM, Chirillo R, Aversa I et al. Ferroptosis and cancer: mitochondria meet the iron maiden cell death. Cells. 2020;9(6):1505.\u00a0https:\/\/doi.org\/10.3390\/cells9061505. Published 2020 Jun 20.","DOI":"10.3390\/cells9061505"},{"key":"1855_CR22","doi-asserted-by":"publisher","unstructured":"Chen H, Nie P, Li J et al. Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction. J Ovarian Res. 2024;17(1):107.\u00a0https:\/\/doi.org\/10.1186\/s13048-024-01434-z.\u00a0Published 2024 May 18.","DOI":"10.1186\/s13048-024-01434-z"},{"issue":"2","key":"1855_CR23","doi-asserted-by":"publisher","first-page":"114524","DOI":"10.1016\/j.yexcr.2025.114524","volume":"447","author":"H Ruan","year":"2025","unstructured":"Ruan H, Xiang H, Liu Y, et al. FSP1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation. Exp Cell Res. 2025;447(2):114524. https:\/\/doi.org\/10.1016\/j.yexcr.2025.114524.","journal-title":"Exp Cell Res"},{"issue":"1","key":"1855_CR24","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1186\/s12967-023-04611-8","volume":"21","author":"Y Kong","year":"2023","unstructured":"Kong Y, Liu Y, Li X, et al. Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis. J Transl Med. 2023;21(1):826. https:\/\/doi.org\/10.1186\/s12967-023-04611-8. Published 2023 Nov 17.","journal-title":"J Transl Med"},{"issue":"12","key":"1855_CR25","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"1855_CR26","doi-asserted-by":"publisher","unstructured":"Xie ZW, He Y, Feng YX et al. Identification of programmed cell death-related genes and diagnostic biomarkers in endometriosis using a machine learning and Mendelian randomization approach. Front Endocrinol (Lausanne). 2024;15:1372221.\u00a0https:\/\/doi.org\/10.3389\/fendo.2024.1372221.\u00a0Published 2024 Aug 1.","DOI":"10.3389\/fendo.2024.1372221"},{"issue":"18","key":"1855_CR27","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","volume":"32","author":"Z Gu","year":"2016","unstructured":"Gu Z, Eils R, Schlesner M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016;32(18):2847\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btw313.","journal-title":"Bioinformatics"},{"issue":"3","key":"1855_CR28","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, et al. ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov (Camb). 2021;2(3):100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141. Published 2021 Jul 1.","journal-title":"Innov (Camb)"},{"key":"1855_CR29","doi-asserted-by":"publisher","first-page":"112766","DOI":"10.1016\/j.intimp.2024.112766","volume":"139","author":"Z Ran","year":"2024","unstructured":"Ran Z, Mu BR, Zhu T, et al. Predicting biomarkers related to idiopathic pulmonary fibrosis: robust ranking aggregation analysis and animal experiment verification. Int Immunopharmacol. 2024;139:112766. https:\/\/doi.org\/10.1016\/j.intimp.2024.112766.","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"1855_CR30","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","volume":"26","author":"MD Wilkerson","year":"2010","unstructured":"Wilkerson MD, Hayes DN. ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Bioinformatics. 2010;26(12):1572\u20133. https:\/\/doi.org\/10.1093\/bioinformatics\/btq170.","journal-title":"Bioinformatics"},{"issue":"5","key":"1855_CR31","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, et al. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"issue":"18","key":"1855_CR32","doi-asserted-by":"publisher","first-page":"427","DOI":"10.21037\/atm.2019.08.113","volume":"7","author":"C Zhang","year":"2019","unstructured":"Zhang C, Zheng Y, Li X, et al. Genome-wide mutation profiling and related risk signature for prognosis of papillary renal cell carcinoma. Ann Transl Med. 2019;7(18):427. https:\/\/doi.org\/10.21037\/atm.2019.08.113.","journal-title":"Ann Transl Med"},{"issue":"2","key":"1855_CR33","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva NT, Morris JH, Gorodkin J, et al. Cytoscape stringapp: network analysis and visualization of proteomics data. J Proteome Res. 2019;18(2):623\u201332. https:\/\/doi.org\/10.1021\/acs.jproteome.8b00702.","journal-title":"J Proteome Res"},{"issue":"1","key":"1855_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v033.i01","volume":"33","author":"J Friedman","year":"2010","unstructured":"Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33(1):1\u201322.","journal-title":"J Stat Softw"},{"issue":"1","key":"1855_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3760\/cma.j.cn112150-20220117-00063","volume":"57","author":"LJ Xi","year":"2023","unstructured":"Xi LJ, Guo ZY, Yang XK, Ping ZG, Zhonghua. Yu Fang Yi Xue Za Zhi. 2023;57(1):107\u201311. https:\/\/doi.org\/10.3760\/cma.j.cn112150-20220117-00063.","journal-title":"Yu Fang Yi Xue Za Zhi"},{"issue":"7","key":"1855_CR36","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/bioinformatics\/btw771","volume":"33","author":"M Cinelli","year":"2017","unstructured":"Cinelli M, Sun Y, Best K, et al. Feature selection using a one dimensional na\u00efve bayes\u2019 classifier increases the accuracy of support vector machine classification of CDR3 repertoires. Bioinformatics. 2017;33(7):951\u20135. https:\/\/doi.org\/10.1093\/bioinformatics\/btw771.","journal-title":"Bioinformatics"},{"issue":"1","key":"1855_CR37","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1186\/s12859-018-2451-4","volume":"19","author":"H Sanz","year":"2018","unstructured":"Sanz H, Valim C, Vegas E, Oller JM, Reverter F. SVM-RFE: selection and visualization of the most relevant features through non-linear kernels. BMC Bioinformatics. 2018;19(1):432. https:\/\/doi.org\/10.1186\/s12859-018-2451-4. Published 2018 Nov 19.","journal-title":"BMC Bioinformatics"},{"key":"1855_CR38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S\u2009+\u2009to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77. https:\/\/doi.org\/10.1186\/1471-2105-12-77. Published 2011 Mar 17.","journal-title":"BMC Bioinformatics"},{"issue":"11","key":"1855_CR39","doi-asserted-by":"publisher","first-page":"e21147","DOI":"10.1016\/j.heliyon.2023.e21147","volume":"9","author":"J Xu","year":"2023","unstructured":"Xu J, Yang T, Wu F, et al. A nomogram for predicting prognosis of patients with cervical cerclage. Heliyon. 2023;9(11):e21147. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e21147. Published 2023 Oct 18.","journal-title":"Heliyon"},{"key":"1855_CR40","doi-asserted-by":"publisher","first-page":"879326","DOI":"10.3389\/fonc.2022.879326","volume":"12","author":"Z Sui","year":"2022","unstructured":"Sui Z, Wu X, Du L, et al. Characterization of the immune cell infiltration landscape in esophageal squamous cell carcinoma. Front Oncol. 2022;12:879326. https:\/\/doi.org\/10.3389\/fonc.2022.879326. Published 2022 Jul 7.","journal-title":"Front Oncol"},{"issue":"18","key":"1855_CR41","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.21037\/atm-22-4303","volume":"10","author":"Y Huang","year":"2022","unstructured":"Huang Y, Cai L, Liu X, et al. Exploring biomarkers and transcriptional factors in type 2 diabetes by comprehensive bioinformatics analysis on RNA-Seq and scRNA-Seq data. Ann Transl Med. 2022;10(18):1017. https:\/\/doi.org\/10.21037\/atm-22-4303.","journal-title":"Ann Transl Med"},{"issue":"1","key":"1855_CR42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/ani12010060","volume":"12","author":"LE Robles-Jimenez","year":"2021","unstructured":"Robles-Jimenez LE, Aranda-Aguirre E, Castelan-Ortega OA, et al. Worldwide traceability of antibiotic residues from livestock in wastewater and soil: A systematic review. Anim (Basel). 2021;12(1):60. https:\/\/doi.org\/10.3390\/ani12010060. Published 2021 Dec 28.","journal-title":"Anim (Basel)"},{"issue":"17","key":"1855_CR43","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1093\/nar\/gku631","volume":"42","author":"Y Ru","year":"2014","unstructured":"Ru Y, Kechris KJ, Tabakoff B, et al. The MultiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Res. 2014;42(17):e133. https:\/\/doi.org\/10.1093\/nar\/gku631.","journal-title":"Nucleic Acids Res"},{"key":"1855_CR44","doi-asserted-by":"publisher","unstructured":"Khan SA, Ilies MA. The phospholipase A2 superfamily: structure, isozymes, catalysis, physiologic and pathologic roles. Int J Mol Sci. 2023;24(2):1353.\u00a0https:\/\/doi.org\/10.3390\/ijms24021353.\u00a0Published 2023 Jan 10.","DOI":"10.3390\/ijms24021353"},{"issue":"4","key":"1855_CR45","doi-asserted-by":"publisher","first-page":"e13127","DOI":"10.1111\/acel.13127","volume":"19","author":"M Saare","year":"2020","unstructured":"Saare M, Tserel L, Haljasm\u00e4gi L, et al. Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. Aging Cell. 2020;19(4):e13127. https:\/\/doi.org\/10.1111\/acel.13127.","journal-title":"Aging Cell"},{"issue":"1","key":"1855_CR46","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/path.2463","volume":"217","author":"D Montenegro","year":"2009","unstructured":"Montenegro D, Romero R, Kim SS, et al. Expression patterns of MicroRNAs in the chorioamniotic membranes: a role for MicroRNAs in human pregnancy and parturition. J Pathol. 2009;217(1):113\u201321. https:\/\/doi.org\/10.1002\/path.2463.","journal-title":"J Pathol"},{"key":"1855_CR47","doi-asserted-by":"publisher","unstructured":"Shahid K, Khan K, Badshah Y et al. Pathogenicity of PKC\u03b3 genetic variants-possible function as a non-invasive diagnostic biomarker in ovarian cancer. Genes (Basel). 2023;14(1):236.\u00a0https:\/\/doi.org\/10.3390\/genes14010236.\u00a0Published 2023 Jan 16.","DOI":"10.3390\/genes14010236"},{"issue":"20","key":"1855_CR48","doi-asserted-by":"publisher","first-page":"6644","DOI":"10.7150\/jca.100911","volume":"15","author":"F Abid","year":"2024","unstructured":"Abid F, Khan K, Ashraf NM, et al. Genetic variants at PRKCG splice and UTR sites promote cancer susceptibility by disrupting epigenetic and MiRNA regulatory network. J Cancer. 2024;15(20):6644\u201357. https:\/\/doi.org\/10.7150\/jca.100911. Published 2024 Oct 28.","journal-title":"J Cancer"},{"key":"1855_CR49","doi-asserted-by":"publisher","first-page":"1129988","DOI":"10.3389\/fgene.2023.1129988","volume":"14","author":"R Sun","year":"2023","unstructured":"Sun R, Tang X, Cao X, Shao X, Sun H. Novel mutation in exon11 of PRKCG (SCA14): A case report. Front Genet. 2023;14:1129988. https:\/\/doi.org\/10.3389\/fgene.2023.1129988. Published 2023 Mar 8.","journal-title":"Front Genet"},{"key":"1855_CR50","doi-asserted-by":"publisher","unstructured":"Huang Y, Chen C, Liu Y et al. Downregulation of tRF-Cys-GCA-029 by hyperglycemia promotes tumorigenesis and glycolysis of diabetic breast cancer through upregulating PRKCG translation. Breast Cancer Res. 2024;26(1):117. https:\/\/doi.org\/10.1186\/s13058-024-01870-1.\u00a0Published 2024 Jul 22.","DOI":"10.1186\/s13058-024-01870-1"},{"issue":"1","key":"1855_CR51","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12920-023-01457-3","volume":"16","author":"Z Xu","year":"2023","unstructured":"Xu Z, Li Q, Shen X. AZU1 (HBP\/CAP37) and PRKCG (PKC-gamma) May be candidate genes affecting the severity of acute mountain sickness. BMC Med Genomics. 2023;16(1):28. https:\/\/doi.org\/10.1186\/s12920-023-01457-3. Published 2023 Feb 20.","journal-title":"BMC Med Genomics"},{"key":"1855_CR52","doi-asserted-by":"publisher","first-page":"116307","DOI":"10.1016\/j.bcp.2024.116307","volume":"225","author":"NH Sarg","year":"2024","unstructured":"Sarg NH, Zaher DM, Abu Jayab NN, Mostafa SH, Ismail HH, Omar HA. The interplay of p38 MAPK signaling and mitochondrial metabolism, a dynamic target in cancer and pathological contexts. Biochem Pharmacol. 2024;225:116307. https:\/\/doi.org\/10.1016\/j.bcp.2024.116307.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1855_CR53","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12964-023-01170-9","volume":"21","author":"X Wang","year":"2023","unstructured":"Wang X, Tan X, Zhang J, Wu J, Shi H. The emerging roles of MAPK-AMPK in ferroptosis regulatory network. Cell Commun Signal. 2023;21(1):200. https:\/\/doi.org\/10.1186\/s12964-023-01170-9. Published 2023 Aug 14.","journal-title":"Cell Commun Signal"},{"issue":"3","key":"1855_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","volume":"14","author":"Y Chen","year":"2023","unstructured":"Chen Y, Fang ZM, Yi X, Wei X, Jiang DS. The interaction between ferroptosis and inflammatory signaling pathways. Cell Death Dis. 2023;14(3):205. https:\/\/doi.org\/10.1038\/s41419-023-05716-0. Published 2023 Mar 21.","journal-title":"Cell Death Dis"},{"issue":"2","key":"1855_CR55","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41591-022-02194-3","volume":"29","author":"H Ke","year":"2023","unstructured":"Ke H, Tang S, Guo T, et al. Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med. 2023;29(2):483\u201392. https:\/\/doi.org\/10.1038\/s41591-022-02194-3.","journal-title":"Nat Med"},{"issue":"12","key":"1855_CR56","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1007\/s40618-024-02385-4","volume":"47","author":"J Ma","year":"2024","unstructured":"Ma J, Li Z, Xu J, et al. PRDM1 promotes the ferroptosis and immune escape of thyroid cancer by regulating USP15-mediated SELENBP1 deubiquitination. J Endocrinol Invest. 2024;47(12):2981\u201397. https:\/\/doi.org\/10.1007\/s40618-024-02385-4.","journal-title":"J Endocrinol Invest"},{"key":"1855_CR57","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","volume":"133","author":"R Kang","year":"2019","unstructured":"Kang R, Kroemer G, Tang D. The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med. 2019;133:162\u20138. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.05.074.","journal-title":"Free Radic Biol Med"},{"key":"1855_CR58","doi-asserted-by":"publisher","unstructured":"Wu R, Chen H, Chang N, Xu Y, Jiao J, Zhang H. Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications. Published correction appears in Chemistry. Chemistry. 2020;26(32):7330. https:\/\/doi.org\/10.1002\/chem.202001859.\u00a0","DOI":"10.1002\/chem.202001859"},{"issue":"5","key":"1855_CR59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s12032-022-01701-3","volume":"39","author":"A Polisety","year":"2022","unstructured":"Polisety A, Misra G, Rajawat J, Katiyar A, Singh H, Bhatt AN. Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation. Med Oncol. 2022;39(5):100. https:\/\/doi.org\/10.1007\/s12032-022-01701-3. Published 2022 May 23.","journal-title":"Med Oncol"},{"key":"1855_CR60","doi-asserted-by":"publisher","unstructured":"Adel K, Amor M, Alaeddine R et al. Comparative computational analysis of dirithromycin and Azithromycin in search for a potent drug against COVID-19 caused by SARS-CoV-2: evidence from molecular Docking and dynamic simulation. Cell mol biol (Noisy-le-grand). 2022;67(5):371\u201386.\u00a0https:\/\/doi.org\/10.14715\/cmb\/2021.67.5.50.\u00a0Published 2022 Feb 4.","DOI":"10.14715\/cmb\/2021.67.5.50"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01855-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-025-01855-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-025-01855-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T01:04:03Z","timestamp":1763168643000},"score":1,"resource":{"primary":{"URL":"https:\/\/ovarianresearch.biomedcentral.com\/articles\/10.1186\/s13048-025-01855-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1855"],"URL":"https:\/\/doi.org\/10.1186\/s13048-025-01855-4","relation":{},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"17 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The First People\u2019s Hospital Medical Ethics Committee of Yunnan Province approved the study (No: KYLL2024-KY039). Written informed consent was obtained from the individuals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"260"}}