{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:42:21Z","timestamp":1792082541703,"version":"4.4.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Seventh Batch of National Traditional Chinese Medicine Experts Academic Experience Inheritance Project by the National Administration of Traditional Chinese Medicine","award":["34022025"],"award-info":[{"award-number":["34022025"]}]},{"name":"The Seventh Batch of National Traditional Chinese Medicine Experts Academic Experience Inheritance Project by the National Administration of Traditional Chinese Medicine","award":["34022025"],"award-info":[{"award-number":["34022025"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82405081 and 82274294"],"award-info":[{"award-number":["82405081 and 82274294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2021A1515011271, 2023A1515011686 and 2025A1515011267"],"award-info":[{"award-number":["2021A1515011271, 2023A1515011686 and 2025A1515011267"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2021A1515011271, 2023A1515011686 and 2025A1515011267"],"award-info":[{"award-number":["2021A1515011271, 2023A1515011686 and 2025A1515011267"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National postdoctoral research program","award":["GZC20230979"],"award-info":[{"award-number":["GZC20230979"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2023TQ0135, 2024M751136"],"award-info":[{"award-number":["2023TQ0135, 2024M751136"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangzhou Basic and Applied Basic Research","award":["2025A04J3397"],"award-info":[{"award-number":["2025A04J3397"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["21624362"],"award-info":[{"award-number":["21624362"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Sixth Batch of National Training Program for Outstanding Clinical Talents in Traditional Chinese Medicine"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"DOI":"10.1186\/s13048-026-02052-7","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:23:23Z","timestamp":1773411803000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quercetin ameliorates cyclophosphamide-induced premature ovarian insufficiency by modulating SIRT1\/HIF-1\u03b1 pathway"],"prefix":"10.1186","volume":"19","author":[{"given":"Mei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxi","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingliang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"3","key":"2052_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.34172\/apb.2024.059","volume":"14","author":"Y Yahyavi","year":"2024","unstructured":"Yahyavi Y, Kheradi N, Karimi A, Ebrahimi-Kalan A, Ramezani F, Yousefi S, et al. Novel Advances in Cell-Free Therapy for Premature Ovarian Failure (POF): A Comprehensive Review. Adv Pharm Bull. 2024;14(3):543\u201357.","journal-title":"Adv Pharm Bull"},{"key":"2052_CR2","doi-asserted-by":"publisher","first-page":"1194575","DOI":"10.3389\/frph.2023.1194575","volume":"5","author":"M Moustaki","year":"2023","unstructured":"Moustaki M, Kontogeorgi A, Tsangkalova G, Tzoupis H, Makrigiannakis A, Vryonidou A, et al. Biological therapies for premature ovarian insufficiency: what is the evidence? Front Reprod Health. 2023;5:1194575.","journal-title":"Front Reprod Health"},{"issue":"2","key":"2052_CR3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4103\/jhrs.jhrs_28_23","volume":"16","author":"S Hazarika","year":"2023","unstructured":"Hazarika S, Dasari P, Chanu SM, Basu S. Factors Associated with Poor Ovarian Reserve in Young Infertile Women: A Hospital-based Cohort Study. J Hum Reprod Sci. 2023;16(2):140\u20137.","journal-title":"J Hum Reprod Sci"},{"key":"2052_CR4","doi-asserted-by":"crossref","unstructured":"Tan Z, Gong X, Wang CC, Zhang T, Huang J. Diminished Ovarian Reserve in Endometriosis: Insights from In Vitro, In Vivo, and Human Studies-A Systematic Review. Int J Mol Sci. 2023;24(21).","DOI":"10.3390\/ijms242115967"},{"key":"2052_CR5","doi-asserted-by":"publisher","first-page":"1397279","DOI":"10.3389\/fendo.2024.1397279","volume":"15","author":"JS Younis","year":"2024","unstructured":"Younis JS, Taylor HS. The impact of ovarian endometrioma and endometriotic cystectomy on anti-M\u00fcllerian hormone, and antral follicle count: a contemporary critical appraisal of systematic reviews. Front Endocrinol (Lausanne). 2024;15:1397279.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2052_CR6","doi-asserted-by":"crossref","unstructured":"Kapoor E. Premature Ovarian Insufficiency. Curr Opin Endocr Metab Res. 2023;28.","DOI":"10.1016\/j.coemr.2023.100435"},{"key":"2052_CR7","unstructured":"Vogt EC, Russell HNB, \u00d8ksnes M, Lund A. [Premature ovarian insufficiency]. Tidsskr Nor Laegeforen. 2022;142(11)."},{"key":"2052_CR8","doi-asserted-by":"crossref","unstructured":"Xu D, Hu MJ, Wang YQ, Cui YL. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules. 2019;24(6).","DOI":"10.3390\/molecules24061123"},{"key":"2052_CR9","doi-asserted-by":"publisher","first-page":"19095","DOI":"10.1038\/srep19095","volume":"6","author":"Z Liu","year":"2016","unstructured":"Liu Z, Zhao J, Li W, Shen L, Huang S, Tang J, et al. Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine. Sci Rep. 2016;6:19095.","journal-title":"Sci Rep"},{"issue":"1","key":"2052_CR10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s13048-022-01080-3","volume":"15","author":"Y Chen","year":"2022","unstructured":"Chen Y, Zhao Y, Miao C, Yang L, Wang R, Chen B, et al. Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells. J Ovarian Res. 2022;15(1):138.","journal-title":"J Ovarian Res"},{"issue":"4","key":"2052_CR11","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.fertnstert.2013.01.129","volume":"99","author":"A Uyar","year":"2013","unstructured":"Uyar A, Torrealday S, Seli E. Cumulus and granulosa cell markers of oocyte and embryo quality. Fertil Steril. 2013;99(4):979\u201397.","journal-title":"Fertil Steril"},{"key":"2052_CR12","doi-asserted-by":"publisher","first-page":"108759","DOI":"10.1016\/j.cbi.2019.108759","volume":"310","author":"X Wang","year":"2019","unstructured":"Wang X, Fan G, Wei F, Bu Y, Huang W. Hyperoside protects rat ovarian granulosa cells against hydrogen peroxide-induced injury by sonic hedgehog signaling pathway. Chem Biol Interact. 2019;310:108759.","journal-title":"Chem Biol Interact"},{"issue":"6771","key":"2052_CR13","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/35001622","volume":"403","author":"S Imai","year":"2000","unstructured":"Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000;403(6771):795\u2013800.","journal-title":"Nature"},{"issue":"1","key":"2052_CR14","doi-asserted-by":"publisher","first-page":"4194","DOI":"10.1038\/s41467-018-06459-9","volume":"9","author":"MJ Vazquez","year":"2018","unstructured":"Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, et al. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nat Commun. 2018;9(1):4194.","journal-title":"Nat Commun"},{"issue":"4a","key":"2052_CR15","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","volume":"62","author":"FK Marcondes","year":"2002","unstructured":"Marcondes FK, Bianchi FJ, Tanno AP. Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol. 2002;62(4a):609\u201314.","journal-title":"Braz J Biol"},{"issue":"1","key":"2052_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13048-024-01536-8","volume":"17","author":"H Miao","year":"2024","unstructured":"Miao H, Miao C, Li N, Han J. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2\/HO-1 pathway. J Ovarian Res. 2024;17(1):224.","journal-title":"J Ovarian Res"},{"key":"2052_CR17","unstructured":"An Online Catalog of Human Genes and Genetic Disorders. Johns Hopkins University. 1966. http:\/\/www.omim.org\/. Accessed 30 Dec 2024."},{"key":"2052_CR18","unstructured":"GeneCards. Weizmann Institute of Science. 1996. https:\/\/www.genecards.org\/. Accessed 2 Jan 2025."},{"key":"2052_CR19","unstructured":"SwissTargetPrediction. The Swiss Institute of Bioinformatics. 2013. http:\/\/www.swisstargetprediction.ch\/. Accessed 5 Jan 2025."},{"key":"2052_CR20","unstructured":"Super -PRED. Institute of Physiology Charit\u00e9-University Medicine Berlin. 2015. https:\/\/prediction.charite.de\/. Accessed 8 Jan 2025."},{"key":"2052_CR21","unstructured":"STRING database. Swiss Institute of Bioinformatics. 2003. https:\/\/string-db.org\/. Accessed 10 Jan 2025."},{"issue":"D1","key":"2052_CR22","doi-asserted-by":"publisher","first-page":"D419","DOI":"10.1093\/nar\/gky1038","volume":"47","author":"H Mi","year":"2019","unstructured":"Mi H, Muruganujan A, Ebert D, Huang X, Thomas PD. PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 2019;47(D1):D419\u201326.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2052_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2052_CR24","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1038\/s41467-020-15795-8","volume":"11","author":"ML Weng","year":"2020","unstructured":"Weng ML, Chen WK, Chen XY, Lu H, Sun ZR, Yu Q, et al. Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT\/mTOR\/HIF1\u03b1 pathway suppression. Nat Commun. 2020;11(1):1869.","journal-title":"Nat Commun"},{"issue":"1","key":"2052_CR25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s13046-024-03184-8","volume":"43","author":"P Geng","year":"2024","unstructured":"Geng P, Ye F, Dou P, Hu C, He J, Zhao J, et al. HIF-1\u03b1-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma. J Exp Clin Cancer Res. 2024;43(1):269.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"2052_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s40164-023-00419-w","volume":"12","author":"F Zhou","year":"2023","unstructured":"Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, et al. Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK\/MAPK\/ HIF-1\u03b1 axis and activating wnt signaling pathway. Exp Hematol Oncol. 2023;12(1):61.","journal-title":"Exp Hematol Oncol"},{"issue":"5","key":"2052_CR27","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1182\/blood-2011-08-375014","volume":"119","author":"D Fl\u00fcgel","year":"2012","unstructured":"Fl\u00fcgel D, G\u00f6rlach A, Kietzmann T. GSK-3\u03b2 regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1\u03b1. Blood. 2012;119(5):1292\u2013301.","journal-title":"Blood"},{"key":"2052_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.imlet.2020.12.007","volume":"230","author":"L Lin","year":"2021","unstructured":"Lin L, Wang Q, Xu F, Luo X, Xu J, Yan L, et al. BML-111, the lipoxin A(4) agonist, modulates VEGF or CoCl(2)-induced migration, angiogenesis and permeability in tumor-derived endothelial cells. Immunol Lett. 2021;230:27\u201335.","journal-title":"Immunol Lett"},{"issue":"2","key":"2052_CR29","doi-asserted-by":"publisher","first-page":"599","DOI":"10.7150\/ijbs.67816","volume":"18","author":"L Gao","year":"2022","unstructured":"Gao L, Xu QH, Ma LN, Luo J, Muyayalo KP, Wang LL, et al. Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC\/LDHA Signaling in Early Pregnancy. Int J Biol Sci. 2022;18(2):599\u2013616.","journal-title":"Int J Biol Sci"},{"issue":"6","key":"2052_CR30","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.immuni.2020.05.001","volume":"52","author":"J Ni","year":"2020","unstructured":"Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, B\u00fchler L, et al. Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1\u03b1 Unleashes NK Cell Activity. Immunity. 2020;52(6):1075\u2013e878.","journal-title":"Immunity"},{"issue":"5","key":"2052_CR31","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/biof.1979","volume":"49","author":"Z Sarlak","year":"2023","unstructured":"Sarlak Z, Eidi A, Ghorbanzadeh V, Moghaddasi M, Mortazavi P. miR-34a\/SIRT1\/HIF-1\u03b1 axis is involved in cardiac angiogenesis of type 2 diabetic rats: The protective effect of sodium butyrate combined with treadmill exercise. BioFactors. 2023;49(5):1085\u201398.","journal-title":"BioFactors"},{"key":"2052_CR32","doi-asserted-by":"publisher","first-page":"1099134","DOI":"10.3389\/fendo.2023.1099134","volume":"14","author":"K Wu","year":"2023","unstructured":"Wu K, Li B, Ma Y, Tu T, Lin Q, Zhu J, et al. Nicotinamide mononucleotide attenuates HIF-1\u03b1 activation and fibrosis in hypoxic adipose tissue via NAD(+)\/SIRT1 axis. Front Endocrinol (Lausanne). 2023;14:1099134.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2052_CR33","doi-asserted-by":"crossref","unstructured":"Shelling AN, Ahmed Nasef N. The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency. Antioxid (Basel). 2023;12(8).","DOI":"10.3390\/antiox12081601"},{"key":"2052_CR34","doi-asserted-by":"publisher","first-page":"626924","DOI":"10.3389\/fendo.2021.626924","volume":"12","author":"B Ishizuka","year":"2021","unstructured":"Ishizuka B. Current Understanding of the Etiology, Symptomatology, and Treatment Options in Premature Ovarian Insufficiency (POI). Front Endocrinol (Lausanne). 2021;12:626924.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"51","key":"2052_CR35","doi-asserted-by":"publisher","first-page":"eade1846","DOI":"10.1126\/sciadv.ade1846","volume":"8","author":"Y Luan","year":"2022","unstructured":"Luan Y, Yu SY, Abazarikia A, Dong R, Kim SY. TAp63 determines the fate of oocytes against DNA damage. Sci Adv. 2022;8(51):eade1846.","journal-title":"Sci Adv"},{"issue":"2","key":"2052_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1089\/bio.2021.0159","volume":"21","author":"RS Barberino","year":"2023","unstructured":"Barberino RS, Silva RLS, Palheta Junior RC, Smitz JEJ, Matos MHT. Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity. Biopreserv Biobank. 2023;21(2):121\u201341.","journal-title":"Biopreserv Biobank"},{"issue":"2","key":"2052_CR37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.14715\/cmb\/2024.70.2.36","volume":"70","author":"Q Wan","year":"2024","unstructured":"Wan Q, Tang L, Jin K, Chen X, Li Y, Xu X. Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1\/SIRT3-FOXO3a axis. Cell Mol Biol (Noisy-le-grand). 2024;70(2):257\u201363.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"7","key":"2052_CR38","first-page":"496","volume":"25","author":"S Moradi","year":"2023","unstructured":"Moradi S, Khazaei M, Rashidi Z. Synergistic Effects of Capsaicin and Quercetin Improved Induced Premature Ovarian Failure in Rat. Cell J. 2023;25(7):496\u2013507.","journal-title":"Cell J"},{"issue":"2","key":"2052_CR39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/rmb2.12323","volume":"19","author":"A Nishigaki","year":"2020","unstructured":"Nishigaki A, Kido T, Kida N, Kakita-Kobayashi M, Tsubokura H, Hisamatsu Y, et al. Resveratrol protects mitochondrial quantity by activating SIRT1\/PGC-1\u03b1 expression during ovarian hypoxia. Reprod Med Biol. 2020;19(2):189\u201397.","journal-title":"Reprod Med Biol"},{"key":"2052_CR40","doi-asserted-by":"crossref","unstructured":"Hepp M, Werion A, De Greef A, de Ville de Goyet C, de Bournonville M, Behets C et al. Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1\u03b1, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto\u2019s Thyroiditis. Int J Mol Sci. 2021;22(8).","DOI":"10.3390\/ijms22083806"},{"issue":"1","key":"2052_CR41","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s10020-025-01155-z","volume":"31","author":"Y Chen","year":"2025","unstructured":"Chen Y, Shan S, Xue Q, Ren Y, Wu Q, Chen J, et al. Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3\/HIF-1\u03b1. Mol Med. 2025;31(1):100.","journal-title":"Mol Med"},{"key":"2052_CR42","doi-asserted-by":"crossref","unstructured":"Yang T, Liu X, Zhou Y, Du L, Fu Y, Luo Y et al. Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1\/ERK\/HIF-1\u03b1 pathway through in silico analysis and experimental validation. J Ethnopharmacol. 2024;318(Pt A):116898.","DOI":"10.1016\/j.jep.2023.116898"},{"key":"2052_CR43","doi-asserted-by":"publisher","first-page":"114515","DOI":"10.1016\/j.biopha.2023.114515","volume":"161","author":"T Jin","year":"2023","unstructured":"Jin T, Zhang Y, Botchway BOA, Huang M, Lu Q, Liu X. Quercetin activates the Sestrin2\/AMPK\/SIRT1 axis to improve amyotrophic lateral sclerosis. Biomed Pharmacother. 2023;161:114515.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2052_CR44","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s40104-024-01078-5","volume":"15","author":"H Duan","year":"2024","unstructured":"Duan H, Wang F, Wang K, Yang S, Zhang R, Xue C, et al. Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1\/ROS\/AMPK signaling pathway. J Anim Sci Biotechnol. 2024;15(1):119.","journal-title":"J Anim Sci Biotechnol"},{"issue":"3","key":"2052_CR45","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11626-020-00439-4","volume":"56","author":"S Liu","year":"2020","unstructured":"Liu S, Li L, Li M, Zhang J. Effect of miR-26b-5p on cis-diamine dichloroplatinum-induced ovarian granulosa cell injury by targeting MAP3K9. Vitro Cell Dev Biol Anim. 2020;56(3):213\u201321.","journal-title":"Vitro Cell Dev Biol Anim"},{"issue":"5","key":"2052_CR46","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10815-022-02462-8","volume":"39","author":"Z Zhao","year":"2022","unstructured":"Zhao Z, Fan Q, Zhu Q, He R, Li Y, Liu C, et al. Decreased fatty acids induced granulosa cell apoptosis in patients with diminished ovarian reserve. J Assist Reprod Genet. 2022;39(5):1105\u201314.","journal-title":"J Assist Reprod Genet"},{"key":"2052_CR47","doi-asserted-by":"publisher","first-page":"172560","DOI":"10.1016\/j.ejphar.2019.172560","volume":"860","author":"AV Sirotkin","year":"2019","unstructured":"Sirotkin AV, \u0160tochma\u013eov\u00e1 A, Alexa R, K\u00e1dasi A, Bauer M, Grossmann R, et al. Quercetin directly inhibits basal ovarian cell functions and their response to the stimulatory action of FSH. Eur J Pharmacol. 2019;860:172560.","journal-title":"Eur J Pharmacol"},{"key":"2052_CR48","doi-asserted-by":"crossref","unstructured":"Cai WY, Luo X. Investigation of Fructus Ligustri Lucidi for Premature Ovarian Insufficiency based on a Network Pharmacology and Experiment Verifications. Comb Chem High Throughput Screen. 2024.","DOI":"10.2174\/0113862073321308240808075854"},{"issue":"6","key":"2052_CR49","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/03601234.2019.1586034","volume":"54","author":"A Kolesarova","year":"2019","unstructured":"Kolesarova A, Roychoudhury S, Klinerova B, Packova D, Michalcova K, Halenar M, et al. Dietary bioflavonoid quercetin modulates porcine ovarian granulosa cell functions in vitro. J Environ Sci Health B. 2019;54(6):533\u20137.","journal-title":"J Environ Sci Health B"},{"key":"2052_CR50","doi-asserted-by":"publisher","first-page":"176339","DOI":"10.1016\/j.ejphar.2024.176339","volume":"966","author":"M Cai","year":"2024","unstructured":"Cai M, Li Q, Cao Y, Huang Y, Yao H, Zhao C, et al. Quercetin activates autophagy to protect rats ovarian granulosa cells from H(2)O(2)-induced aging and injury. Eur J Pharmacol. 2024;966:176339.","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2052_CR51","doi-asserted-by":"publisher","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","volume":"5","author":"DR McIlwain","year":"2013","unstructured":"McIlwain DR, Berger T, Mak TW. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 2013;5(4):a008656.","journal-title":"Cold Spring Harb Perspect Biol"}],"container-title":["Journal of Ovarian Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13048-026-02052-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-026-02052-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13048-026-02052-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:06:38Z","timestamp":1776812798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13048-026-02052-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2052"],"URL":"https:\/\/doi.org\/10.1186\/s13048-026-02052-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6972937\/v1","asserted-by":"object"}]},"ISSN":["1757-2215"],"issn-type":[{"value":"1757-2215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"25 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Animal Welfare and Ethics Committee of Jinan University (Approval No. IACUC-20241101-11).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"157"}}