{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:56:57Z","timestamp":1781650617977,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ovarian Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endometriosis is a common cause of infertility and is frequently associated with recurrent implantation failure in assisted reproductive technologies. Impaired endometrial receptivity, mediated by altered transcription factors, adhesion molecules, and extracellular matrix components, has been proposed as a contributing mechanism. This study aimed to evaluate compartment-specific immunohistochemical expression patterns of HOXA-10, HOXA-11, CD44, \u03b21 integrin, ECM-1, and focal adhesion kinase (FAK) in women with endometriosis-related implantation failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective case\u2013control study was conducted at the IVF Unit of Gazi University Faculty of Medicine. The study group consisted of 34 infertile women with surgically confirmed endometriosis and recurrent IVF failure, subdivided into pre-receptive and receptive phases based on histological dating, while fertile women without infertility or endometriosis served as controls. Endometrial biopsies were obtained during the implantation window. Immunohistochemical expression was evaluated using semi-quantitative compartment-specific scoring, with ImageJ-based analysis used as supportive. Appropriate non-parametric statistical analyses were applied, and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant intergroup differences were observed for stromal HOXA-10 or HOXA-11 expression between control, pre-receptive, and receptive groups. Glandular CD44 positivity was significantly increased in the receptive group compared with controls, while no significant difference was detected between pre-receptive and receptive phases after multiple comparison correction. \u03b21 integrin expression did not demonstrate consistent phase-specific differences. In contrast, strong glandular ECM-1 expression was significantly reduced in both pre-receptive and receptive groups compared with controls, whereas stromal ECM-1 expression remained unchanged. Stromal FAK expression was significantly increased in both pre-receptive and receptive groups relative to controls, with no significant difference between these phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endometriosis-related implantation failure is associated with distinct, compartment-specific alterations in endometrial receptivity markers that appear largely independent of physiological implantation timing. Reduced glandular ECM-1 expression and persistent stromal FAK accumulation suggest disease-specific epithelial\u2013stromal dysregulation rather than delayed or shifted receptivity. Altered glandular CD44 expression in the receptive phase likely reflects endometriosis-associated epithelial adhesion changes rather than a phase-specific marker of functional receptivity. These findings highlight the importance of compartment-focused evaluation of endometrial receptivity in endometriosis-related infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>This study was retrospectively conducted and was not registered in a clinical trial registry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13048-026-02072-3","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:58:22Z","timestamp":1776671902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial HOXA-10, HOXA-11, \u00df-1 integrin, ECM-1, FAK, and CD44 immunohistochemical expressions in endometriosis-related recurrent IVF failure: a retrospective case-control study"],"prefix":"10.1186","volume":"19","author":[{"given":"Esin \u015eahin","family":"Toruk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Acar","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclistan Sanem","family":"Sar\u0131ba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"4","key":"2072_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/humupd\/dmm011","volume":"13","author":"K Diedrich","year":"2007","unstructured":"Diedrich K, et al. The role of the endometrium and embryo in human implantation. Hum Reprod Update. 2007;13(4):365\u201377.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"2072_CR2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2174\/1566524016666160225153659","volume":"16","author":"JI Ahn","year":"2016","unstructured":"Ahn JI, et al. cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis. Curr Mol Med. 2016;16(3):276\u201387.","journal-title":"Curr Mol Med"},{"issue":"1","key":"2072_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2017.05.031","volume":"108","author":"BA Lessey","year":"2017","unstructured":"Lessey BA, Kim JJ. Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why. 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