{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:34:12Z","timestamp":1785368052286,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001700","name":"The Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["15H05006"],"award-info":[{"award-number":["15H05006"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"The Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["19K09393"],"award-info":[{"award-number":["19K09393"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Scand J Trauma Resusc Emerg Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is limited information on the predictive accuracy of commonly used predictors, such as lactate, pH or serum potassium for the survival among out-of-hospital cardiac arrest (OHCA) patients with hypothermia. This study aimed to identify the predictive accuracy of these biomarkers for survival among OHCA patients with hypothermia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective analysis, we analyzed the data from a multicenter, prospective nationwide registry among OHCA patients transported to emergency departments in Japan (the JAAM-OHCA Registry). We included all adult (\u226518\u2009years) OHCA patients with hypothermia (\u226432.0\u2009\u00b0C) who were registered from June 2014 to December 2017 and whose blood test results on hospital arrival were recorded. We calculated the predictive accuracy of pH, lactate, and potassium for 1-month survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 34,754 patients in the JAAM-OHCA database, we included 754 patients from 66 hospitals. The 1-month survival was 5.8% (44\/754). The areas under the curve of the predictors and 95% confidence interval were as follows: pH\u20090.829 [0.767\u20130.877] and lactate 0.843 [0.793\u20130.882]. On setting the cutoff points of 6.9 in pH and 120\u2009mg\/dL (13.3\u2009mmol\/L) in lactate, the predictors had a high sensitivity (lactate: 0.91; pH\u20090.91) and a low negative likelihood ratio (lactate: 0.14; pH\u20090.13), which are suitable to exclude survival to 1\u2009month. Furthermore, in additional analysis that included only the patients with potassium values available, a cutoff point of 7.0 (mmol\/L) for serum potassium had high sensitivity (0.96) and a low negative likelihood ratio (0.09).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicated the predictive accuracy of serum lactate, pH, and potassium for 1-month survival among adult OHCA patients with hypothermia. These biomarkers may help define a more appropriate resuscitation strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13049-020-00765-2","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T03:02:39Z","timestamp":1596596559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: a prospective observational cohort study in Japan"],"prefix":"10.1186","volume":"28","author":[{"given":"Yohei","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeyuki","family":"Kiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Irisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Yoshiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Ishibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shintani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Sogabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Morooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimazu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhisa","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Iwami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"issue":"20","key":"765_CR1","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1056\/NEJMra1114208","volume":"367","author":"DJ Brown","year":"2012","unstructured":"Brown DJ, Brugger H, Boyd J, Paal P. Accidental hypothermia. N Engl J Med. 2012;367(20):1930\u20138.","journal-title":"N Engl J Med"},{"key":"765_CR2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.resuscitation.2015.07.017","volume":"95","author":"A Truhlar","year":"2015","unstructured":"Truhlar A, Deakin CD, Soar J, Khalifa GE, Alfonzo A, Bierens JJ, Brattebo G, Brugger H, Dunning J, Hunyadi-Anticevic S, et al. European Resuscitation Council Guidelines for Resuscitation 2015: Section 4. Cardiac arrest in special circumstances. Resuscitation. 2015;95. Ireland:148\u2013201.","journal-title":"Resuscitation"},{"key":"765_CR3","doi-asserted-by":"publisher","first-page":"S829","DOI":"10.1161\/CIRCULATIONAHA.110.971069","volume":"122","author":"TL Vanden Hoek","year":"2010","unstructured":"Vanden Hoek TL, Morrison LJ, Shuster M, Donnino M, Sinz E, Lavonas EJ, Jeejeebhoy FM, Gabrielli A. Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010;122. United States:S829\u201361.","journal-title":"Circulation"},{"key":"765_CR4","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.resuscitation.2014.04.029","volume":"85","author":"J Hilmo","year":"2014","unstructured":"Hilmo J, Naesheim T, Gilbert M. \u201cNobody is dead until warm and dead\u201d: prolonged resuscitation is warranted in arrested hypothermic victims also in remote areas--a retrospective study from northern Norway. Resuscitation. 2014;85:1204\u201311 Ireland: 2014 The authors. Published by Elsevier Ireland Ltd.","journal-title":"Resuscitation"},{"key":"765_CR5","doi-asserted-by":"crossref","unstructured":"Dobson JA, Burgess JJ. Resuscitation of severe hypothermia by extracorporeal rewarming in a child. J Trauma. 1996;40(3):483\u201385.","DOI":"10.1097\/00005373-199603000-00032"},{"issue":"1","key":"765_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1865-1380-5-9","volume":"5","author":"K Sawamoto","year":"2012","unstructured":"Sawamoto K, Tanno K, Takeyama Y, Asai Y. Successful treatment of severe accidental hypothermia with cardiac arrest for a long time using cardiopulmonary bypass - report of a case. Int J Emerg Med. 2012;5(1):9.","journal-title":"Int J Emerg Med"},{"key":"765_CR7","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1056\/NEJM199711203372103","volume":"337","author":"BH Walpoth","year":"1997","unstructured":"Walpoth BH, Walpoth-Aslan BN, Mattle HP, Radanov BP, Schroth G, Schaeffler L, Fischer AP, von Segesser L, Althaus U, Farstad M, et al. Outcome of survivors of accidental deep hypothermia and circulatory arrest treated with extracorporeal blood warming Rewarming from accidental hypothermia by extracorporeal circulation. A retrospective study. N Engl J Med. 1997;337. United States Germany:1500\u20135.","journal-title":"N Engl J Med"},{"key":"765_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S1010-7940(01)00713-8","volume":"20","author":"M Farstad","year":"2001","unstructured":"Farstad M, Andersen KS, Koller ME, Grong K, Segadal L, Husby P. Rewarming from accidental hypothermia by extracorporeal circulation. A retrospective study. Eur J Cardiothorac Surg. 2001;20. Germany:58\u201364.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"765_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0300-9572(94)90021-3","volume":"27","author":"P Mair","year":"1994","unstructured":"Mair P, Kornberger E, Furtwaengler W, Balogh D, Antretter H. Prognostic markers in patients with severe accidental hypothermia and cardiocirculatory arrest. Resuscitation. 1994;27(1):47\u201354.","journal-title":"Resuscitation"},{"issue":"14","key":"765_CR10","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1001\/jama.1990.03450140064035","volume":"264","author":"MD Schaller","year":"1990","unstructured":"Schaller MD, Fischer AP, Perret CH. Hyperkalemia. A prognostic factor during acute severe hypothermia. Jama. 1990;264(14):1842\u20135.","journal-title":"Jama"},{"key":"765_CR11","doi-asserted-by":"crossref","unstructured":"Matsuyama T, Morita S, Ehara N, Miyamae N, Okada Y, Jo T, Sumida Y, Okada N, Watanabe M, Nozawa M, et al. Characteristics and outcomes of accidental hypothermia in Japan: the J-point registry. Emerg Med J. 2018;35(11):659\u201366.","DOI":"10.1136\/emermed-2017-207238"},{"key":"765_CR12","doi-asserted-by":"crossref","unstructured":"Morita S, Matsuyama T, Ehara N, Miyamae N, Okada Y, Jo T, Sumida Y, Okada N, Watanabe M, Nozawa M, et al. Prevalence and outcomes of accidental hypothermia among elderly patients in Japan: data from the J-point registry. Geriatr Gerontol Int. 2018;18(10):1427\u201332.","DOI":"10.1111\/ggi.13502"},{"issue":"4","key":"765_CR13","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ajem.2013.12.023","volume":"32","author":"K Sawamoto","year":"2014","unstructured":"Sawamoto K, Bird SB, Katayama Y, Maekawa K, Uemura S, Tanno K, Narimatsu E. Outcome from severe accidental hypothermia with cardiac arrest resuscitated with extracorporeal cardiopulmonary resuscitation. Am J Emerg Med. 2014;32(4):320\u20134.","journal-title":"Am J Emerg Med"},{"issue":"11","key":"765_CR14","doi-asserted-by":"publisher","first-page":"e012799","DOI":"10.1136\/bmjopen-2016-012799","volume":"6","author":"JF Cohen","year":"2016","unstructured":"Cohen JF, Korevaar DA, Altman DG, Bruns DE, Gatsonis CA, Hooft L, Irwig L, Levine D, Reitsma JB, de Vet HC, et al. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. BMJ Open. 2016;6(11):e012799.","journal-title":"BMJ Open"},{"issue":"3","key":"765_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/ams2.340","volume":"5","author":"T Kitamura","year":"2018","unstructured":"Kitamura T, Iwami T, Atsumi T, Endo T, Kanna T, Kuroda Y, Sakurai A, Tasaki O, Tahara Y, Tsuruta R, et al. The profile of Japanese Association for Acute Medicine - out-of-hospital cardiac arrest registry in 2014-2015. Acute Med Surg. 2018;5(3):249\u201358.","journal-title":"Acute Med Surg"},{"key":"765_CR16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.resuscitation.2018.10.004","volume":"133","author":"T Irisawa","year":"2018","unstructured":"Irisawa T, Matsuyama T, Iwami T, Yamada T, Hayakawa K, Yoshiya K, Noguchi K, Nishimura T, Uejima T, Yagi Y, et al. The effect of different target temperatures in targeted temperature management on neurologically favorable outcome after out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM-OHCA registry). Resuscitation. 2018;133. Ireland: 2018 Elsevier B.V:82\u20137.","journal-title":"Resuscitation"},{"issue":"2","key":"765_CR17","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1161\/01.CIR.84.2.960","volume":"84","author":"RO Cummins","year":"1991","unstructured":"Cummins RO, Chamberlain DA, Abramson NS, Allen M, Baskett PJ, Becker L, Bossaert L, Delooz HH, Dick WF, Eisenberg MS, et al. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein style. A statement for health professionals from a task force of the American Heart Association, the European resuscitation council, the Heart and Stroke Foundation of Canada, and the Australian resuscitation council. Circulation. 1991;84(2):960\u201375.","journal-title":"Circulation"},{"issue":"1","key":"765_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13049-016-0210-y","volume":"24","author":"T Deslarzes","year":"2016","unstructured":"Deslarzes T, Rousson V, Yersin B, Durrer B, Pasquier M. An evaluation of the Swiss staging model for hypothermia using case reports from the literature. Scandinavian J Trauma Resuscitation Emergency Med. 2016;24(1):16.","journal-title":"Scandinavian J Trauma Resuscitation Emergency Med"},{"key":"765_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40560-019-0384-2","volume":"7","author":"Y Okada","year":"2019","unstructured":"Okada Y, Matsuyama T, Morita S, Ehara N, Miyamae N, Jo T, Sumida Y, Okada N, Watanabe M, Nozawa M, et al. The development and validation of a \u201c5A\u201d severity scale for predicting in-hospital mortality after accidental hypothermia from J-point registry data. J Intensive Care. 2019;7:27.","journal-title":"J Intensive Care"},{"key":"765_CR20","doi-asserted-by":"crossref","unstructured":"Okada Y, Matsuyama T, Morita S, Ehara N, Miyamae N, Jo T, Sumida Y, Okada N, Kitamura T, Iiduka R. Prognostic factors for patients with accidental hypothermia: a multi-institutional retrospective cohort study. Am J Emerg Med. 2018;37(4):565\u201370.","DOI":"10.1016\/j.ajem.2018.06.025"},{"key":"765_CR21","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.resuscitation.2015.06.013","volume":"93","author":"G Debaty","year":"2015","unstructured":"Debaty G, Moustapha I, Bouzat P, Maignan M, Blancher M, Rallo A, Brun J, Chavanon O, Danel V, Carpentier F, et al. Outcome after severe accidental hypothermia in the French Alps: A 10-year review. Resuscitation. 2015;93. Ireland: 2015 Elsevier Ireland Ltd:118\u201323.","journal-title":"Resuscitation"},{"key":"765_CR22","unstructured":"Japan Meteorological Agency Website. https:\/\/www.jma.go.jp\/jma\/indexe.html. Accessed 17 Dec 2019."},{"key":"765_CR23","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1161\/01.CIR.0000147236.85306.15","volume":"110","author":"I Jacobs","year":"2004","unstructured":"Jacobs I, Nadkarni V, Bahr J, Berg RA, Billi JE, Bossaert L, Cassan P, Coovadia A, D\u2019Este K, Finn J, et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Councils of Southern Africa). Circulation. 2004;110. United States:3385\u201397.","journal-title":"Circulation"},{"key":"765_CR24","doi-asserted-by":"publisher","first-page":"e3999","DOI":"10.1136\/bmj.e3999","volume":"345","author":"S Mallett","year":"2012","unstructured":"Mallett S, Halligan S, Thompson M, Collins GS, Altman DG. Interpreting diagnostic accuracy studies for patient care. BMJ. 2012;345:e3999.","journal-title":"BMJ"},{"key":"765_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.resuscitation.2018.02.026","volume":"126","author":"M Pasquier","year":"2018","unstructured":"Pasquier M, Hugli O, Paal P, Darocha T, Blancher M, Husby P, Silfvast T, Carron PN, Rousson V. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: the HOPE score. Resuscitation. 2018;126:58\u201364.","journal-title":"Resuscitation"},{"key":"765_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.resuscitation.2018.03.028","volume":"127","author":"RS Saczkowski","year":"2018","unstructured":"Saczkowski RS, Brown DJA, Abu-Laban RB, Fradet G, Schulze CJ, Kuzak ND. Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: an individual patient data meta-analysis. Resuscitation. 2018;127:51\u20137.","journal-title":"Resuscitation"},{"issue":"9","key":"765_CR27","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3949\/ccjm.82a.14098","volume":"82","author":"AJ Reddy","year":"2015","unstructured":"Reddy AJ, Lam SW, Bauer SR, Guzman JA. Lactic acidosis: clinical implications and management strategies. Cleve Clin J Med. 2015;82(9):615\u201324.","journal-title":"Cleve Clin J Med"},{"issue":"2","key":"765_CR28","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/0735-6757(85)90033-6","volume":"3","author":"DL Carden","year":"1985","unstructured":"Carden DL, Martin GB, Nowak RM, Foreback CC, Tomlanovich MC. Lactic acidosis as a predictor of downtime during cardiopulmonary arrest in dogs. Am J Emerg Med. 1985;3(2):120\u20134.","journal-title":"Am J Emerg Med"},{"key":"765_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.resuscitation.2018.08.018","volume":"132","author":"C Sandroni","year":"2018","unstructured":"Sandroni C, De Santis P, D'Arrigo S. Capnography during cardiac arrest. Resuscitation. 2018;132:73\u20137.","journal-title":"Resuscitation"},{"key":"765_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0002-9343(84)80002-9","volume":"77","author":"RS Brown","year":"1984","unstructured":"Brown RS. Potassium homeostasis and clinical implications. Am J Med. 1984;77. United States:3\u201310.","journal-title":"Am J Med"},{"key":"765_CR31","doi-asserted-by":"publisher","unstructured":"Shida H, Matsuyama T, Iwami T, Okabayashi S, Yamada T, Hayakawa K, Yoshiya K, Irisawa T, Noguchi K, Nishimura T, et al. Serum potassium level on hospital arrival and survival after out-of-hospital cardiac arrest: the CRITICAL study in Osaka, Japan. Eur Heart J Acute Cardiovasc Care. 2019. https:\/\/doi.org\/10.1177\/2048872619848883.","DOI":"10.1177\/2048872619848883"},{"issue":"3","key":"765_CR32","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/0003-4975(91)90929-K","volume":"52","author":"LK von Segesser","year":"1991","unstructured":"von Segesser LK, Garcia E, Turina M. Perfusion without systemic heparinization for rewarming in accidental hypothermia. Ann Thorac Surg. 1991;52(3):560\u20131.","journal-title":"Ann Thorac Surg"}],"container-title":["Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13049-020-00765-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13049-020-00765-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13049-020-00765-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T20:10:43Z","timestamp":1628107843000},"score":1,"resource":{"primary":{"URL":"https:\/\/sjtrem.biomedcentral.com\/articles\/10.1186\/s13049-020-00765-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,5]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["765"],"URL":"https:\/\/doi.org\/10.1186\/s13049-020-00765-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-32325\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-32325\/v1","asserted-by":"object"}]},"ISSN":["1757-7241"],"issn-type":[{"value":"1757-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,5]]},"assertion":[{"value":"28 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee of Kyoto University and each participating institution approved this study protocol (R1045), and written informed consent was waived.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"75"}}