{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:37:06Z","timestamp":1765280226792,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU 2371\/1-1"],"award-info":[{"award-number":["RU 2371\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014584","name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Scand J Trauma Resusc Emerg Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Mechanical chest compression devices are accepted alternatives for cardiopulmonary resuscitation (CPR) under specific circumstances. Current devices lack prospective and comparative data on their specific cardiovascular effects and potential for severe thoracic injuries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To compare CPR effectiveness and thoracic injuries of two mechanical chest compression devices in pigs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>Prospective randomised trial.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Animals<\/jats:title>\n                <jats:p>Eighteen male German landrace pigs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ventricular fibrillation was induced in anaesthetised and instrumented pigs and the animals were randomised into two intervention groups. Mechanical CPR was initiated by means of LUCAS\u2122 2 (mCCD1) or Corpuls\u2122 cpr (mCCD2) device. Advanced life support was applied for a maximum of 10\u2009cycles and animals achieving ROSC were monitored for 8\u2009h. Ventilation\/perfusion measurements were performed and blood gas analyses were taken. Thoracic injuries were assessed via a standardised damage score.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Five animals of the mCCD1 group and one animal of the mCCD2 group achieved ROSC (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). Only the mCCD1 animals survived until the end of the monitoring period (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). MCCD1 animals showed less pulmonary shunt (<jats:italic>p<\/jats:italic>\u2009=\u20090.025) and higher normal V\/Q (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) during CPR. MCCD2 animals showed significantly more severe thoracic injuries (<jats:italic>p<\/jats:italic>\u2009=\u20090.046).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The LUCAS 2 device shows superior resuscitation outcomes and less thoracic injuries compared to Corpuls cpr when used for experimental CPR in juvenile pigs. Researchers should be aware that different mCCDs for experimental studies may significantly influence the respective outcome of resuscitation studies and affect comparability of different trials. Controlled human and animal CPR studies and a standardised post-resuscitation injury evaluation could help to confirm potential hazards.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Trial approval number: G16\u20131-042-E4.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13049-021-00892-4","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T19:02:35Z","timestamp":1622919755000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Standardized post-resuscitation damage assessment of two mechanical chest compression devices: a prospective randomized large animal trial"],"prefix":"10.1186","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-6052","authenticated-orcid":false,"given":"Robert","family":"Ruemmler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"Duenges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Renz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik Kristoffer","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"key":"892_CR1","first-page":"113","volume":"3","author":"D Treffer","year":"2019","unstructured":"Treffer D, Wei\u00dfleder A, G\u00e4ssler H, Decken S, Hauptkorn M, Helm M. Functionality and operational fitness of mechanical chest compression devices. Anasthesiologie und Intensivmedizin. 2019;3:113\u201321.","journal-title":"Anasthesiologie und Intensivmedizin"},{"issue":"3","key":"892_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0300-9572(02)00271-X","volume":"55","author":"S Steen","year":"2002","unstructured":"Steen S, Liao Q, Pierre L, Paskevicius A, Sj\u00f6berg T. Evaluation of LUCAS, a new device for automatic mechanical compression and active decompression resuscitation. Resuscitation. 2002;55(3):285\u201399. https:\/\/doi.org\/10.1016\/S0300-9572(02)00271-X.","journal-title":"Resuscitation."},{"issue":"1","key":"892_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/17482941.2012.735675","volume":"15","author":"J Fox","year":"2013","unstructured":"Fox J, Fiechter R, Gerstl P, Url A, Wagner H, L\u00fcscher TF, et al. 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Mechanical chest compression with LUCAS device does not improve clinical outcome in out-of-hospital cardiac arrest patients: a systematic review and meta-analysis. Medicine (Baltimore). 2019;98(44):e17550. https:\/\/doi.org\/10.1097\/MD.0000000000017550.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"892_CR6","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13054-019-2389-6","volume":"23","author":"N Zhu","year":"2019","unstructured":"Zhu N, Chen Q, Jiang Z, Liao F, Kou B, Tang H, et al. A meta-analysis of the resuscitative effects of mechanical and manual chest compression in out-of-hospital cardiac arrest patients. 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G16\u20131-042-E4).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The LUCAS\u2122 2 and the Corpuls\u2122 cpr device were provided unconditionally by the respective manufacturers for animal research utilisation. All authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}