{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:56:29Z","timestamp":1790034989847,"version":"4.0.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005296","name":"Universit\u00e4tsklinikum Regensburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Scand J Trauma Resusc Emerg Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Veno-arterial extracorporeal membrane oxygenation (VA ECMO) has served as a crucial intervention for critically ill patients with persistent cardiopulmonary failure. A standardized approach improves VA ECMO outcomes, which is why ECMO is currently limited to specialized centers. However, transferring critically ill patients to these ECMO centers is not without risk. Portable ECMO devices allow implantation in out-of-center settings prior to transportation. Despite efforts to standardize decision-making, significant variability remains, particularly in out-of-center (OoC) settings with limited data. Due to persistently high mortality, accurate indications are needed to optimize outcomes. This study aims to identify key factors associated with favorable outcomes in OoC VA ECMO and to develop practical decision-making tools for clinicians in these settings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We retrospectively investigated the outcomes of VA ECMO implantation in out-of-center settings between 2006 and 2022 at our institution. Parameters assessed prior to VA ECMO implantation, including organ failure count, mean arterial pressure (MAP), and laboratory data, were analyzed. Follow-up data were collected to evaluate functional (Eastern Cooperative Oncology Group [ECOG] performance status) and neurological (cerebral performance category score [CPC]) (outcomes. Statistical analyses were performed using non-parametric methods and SHAP importance analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 56.5% (195 of 345 patients) who underwent VA ECMO implantation in OoC survived, and 43.8% had a favorable neurological outcome (CPC 1). 37.6% of patients had good functional outcomes (ECOG 0\u20131). Patients with a MAP\u2009&gt;\u200954\u00a0mmHg had better long-term functional outcomes, and those with a MAP\u2009&gt;\u200964\u00a0mmHg had better mid-term neurological outcomes. Poor outcomes were associated with reduced coagulation activity and increased thrombogenicity. Renal and multi-organ failure prior to VA ECMO implantation were associated with poor neurological and functional outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Through importance analyses, we identified key and secondary factors associated with favorable outcomes in OoC VA ECMO. The extent and severity of organ failure prior to VA ECMO implantation are crucial in determining outcomes. Hemodynamic status, as reflected by MAP, along with organ failure prior to VA-ECMO implantation, significantly influences neurological and functional outcomes. Patients with better hemodynamic stability and coagulation profiles had significantly improved chances of survival with favorable neurological and functional outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13049-025-01401-7","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T12:41:49Z","timestamp":1747053709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term outcomes of out-of-center veno-arterial ECMO cannulation for cardiopulmonary failure: investigation of prognostic parameters for a decision support tool \u2013 a 16-year retrospective study"],"prefix":"10.1186","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-6208","authenticated-orcid":false,"given":"Walter","family":"Petermichl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Philipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Foltan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Stadlbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter-Paul","family":"Ellmauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Merten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Blecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ulm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"issue":"5","key":"1401_CR1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/0002-9610(78)90119-8","volume":"135","author":"JH Gibbon","year":"1978","unstructured":"Gibbon JH. The development of the heart-lung apparatus. Am J Surg Mai. 1978;135(5):608\u201319.","journal-title":"Am J Surg Mai"},{"issue":"25","key":"1401_CR2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/j.jacc.2014.03.046","volume":"63","author":"D Abrams","year":"2014","unstructured":"Abrams D, Combes A, Brodie D. Extracorporeal Membrane Oxygenation in Cardiopulmonary Disease in Adults. J Am Coll Cardiol Juli. 2014;63(25):2769\u201378.","journal-title":"J Am Coll Cardiol Juli"},{"issue":"18","key":"1401_CR3","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1136\/heartjnl-2017-311928","volume":"105","author":"J Ali","year":"2019","unstructured":"Ali J, Vuylsteke A. Extracorporeal membrane oxygenation: indications, technique and contemporary outcomes. Heart. 2019;105(18):1437\u201343.","journal-title":"Heart"},{"issue":"3","key":"1401_CR4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.5694\/j.1326-5377.2009.tb02735.x","volume":"191","author":"SJ Lindstrom","year":"2009","unstructured":"Lindstrom SJ, Pellegrino VA, Butt WW. Extracorporeal membrane oxygenation. Med J Aust. 2009;191(3):178\u201382.","journal-title":"Med J Aust"},{"key":"1401_CR5","doi-asserted-by":"crossref","unstructured":"Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, u.\u00a0a. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. The Lancet. Oktober 2009;374(9698):1351\u201363.","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"1401_CR6","unstructured":"Extracorporeal Life Support Organization (ELSO) Guidelines for Adult Cardiac Failure. 2013."},{"issue":"1","key":"1401_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1542\/peds.84.1.43","volume":"84","author":"RK Kanter","year":"1989","unstructured":"Kanter RK, Tompkins JM. Adverse events during interhospital transport: physiologic deterioration associated with pretransport severity of illness. Pediatrics Juli. 1989;84(1):43\u20138.","journal-title":"Pediatrics Juli"},{"key":"1401_CR8","doi-asserted-by":"crossref","unstructured":"R\u00fcckert F, Steinke T, Fl\u00f6ther L, Bucher M, Metz D, Frantz S, u.\u00a0a. Predictors for quality of life of patients with a portable out-of-centre-implanted extracorporeal membrane oxygenation device. Interact Cardiovasc Thorac Surg. 31. Dezember 2016;ivw398.","DOI":"10.1093\/icvts\/ivw398"},{"key":"1401_CR9","doi-asserted-by":"crossref","unstructured":"Rasp\u00e9 C, R\u00fcckert F, Metz D, Hofmann B, Neitzel T, Stiller M, u.\u00a0a. Inter-hospital transfer of ECMO-assisted patients with a portable miniaturized ECMO device: 4 years of experience. Perfusion. Januar 2015;30(1):52\u20139.","DOI":"10.1177\/0267659114531611"},{"key":"1401_CR10","doi-asserted-by":"crossref","unstructured":"Deinzer J, Philipp A, Kmiec L, Li J, Wiesner S, Blecha S, u.\u00a0a. Mortality on extracorporeal membrane oxygenation: Evaluation of independent risk factors and causes of death during venoarterial and venovenous support. Perfusion. November 2024;39(8):1648\u201356.","DOI":"10.1177\/02676591231212997"},{"key":"1401_CR11","unstructured":"Christine Stead, MHSA. ELSO-Web-page: Understanding The ECMO Team Members & Their Roles [Internet]. 2024 [zitiert 21. Oktober 2024]. Verf\u00fcgbar unter: https:\/\/www.elso.org\/aboutus\/contact.aspx"},{"key":"1401_CR12","unstructured":"Brodie D, Lorusso R, MacLaren G, Peek G, Thiagarajan R, Vewrcaemst L, u.\u00a0a., Herausgeber. Extracorporeal life support: the ELSO Red book. 6th edition. Ann Arbor, Michigan: Extracorporeal Life Support Organization; 2022. 779 S."},{"issue":"4","key":"1401_CR13","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.ccc.2017.07.001","volume":"33","author":"J Jones-Akhtarekhavari","year":"2017","unstructured":"Jones-Akhtarekhavari J, Tribble TA, Zwischenberger JB. Developing an Extracorporeal Membrane Oxygenation Program. Crit Care Clin Oktober. 2017;33(4):767\u201375.","journal-title":"Crit Care Clin Oktober"},{"key":"1401_CR14","doi-asserted-by":"crossref","unstructured":"Banga S, Challa A, Patel AR, Singh S, Emani VK. The Patient Selection Criteria for Veno-arterial Extracorporeal Mechanical Oxygenation. Cureus [Internet]. 20. September 2019 [zitiert 21. Oktober 2024]; Verf\u00fcgbar unter: https:\/\/www.cureus.com\/articles\/23285-the-patient-selection-criteria-for-veno-arterial-extracorporeal-mechanical-oxygenation","DOI":"10.7759\/cureus.5709"},{"key":"1401_CR15","doi-asserted-by":"crossref","unstructured":"Chung SY, Sheu JJ, Lin YJ, Sun CK, Chang LT, Chen YL, u.\u00a0a. Outcome of patients with profound cardiogenic shock after cardiopulmonary resuscitation and prompt extracorporeal membrane oxygenation support. A single-center observational study. Circ J Off J Jpn Circ Soc. 2012;76(6):1385\u201392.","DOI":"10.1253\/circj.CJ-11-1015"},{"key":"1401_CR16","doi-asserted-by":"crossref","unstructured":"Combes A, Leprince P, Luyt CE, Bonnet N, Trouillet JL, L\u00e9ger P, u.\u00a0a. Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock. Crit Care Med. Mai 2008;36(5):1404\u201311.","DOI":"10.1097\/CCM.0b013e31816f7cf7"},{"key":"1401_CR17","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Solano J, Sousa-Casasnovas I, Bell\u00f3n-Cano JM, Garc\u00eda-Carre\u00f1o J, Ju\u00e1rez-Fern\u00e1ndez M, D\u00edez-Delhoyo F, u.\u00a0a. Lactate levels as a prognostic predict in cardiogenic shock under venoarterial extracorporeal membrane oxygenation support. Rev Esp Cardiol Engl Ed. Juli 2022;75(7):595\u2013603.","DOI":"10.1016\/j.rec.2021.08.020"},{"key":"1401_CR18","doi-asserted-by":"crossref","unstructured":"Rivers J, Pilcher D, Kim J, Bartos JA, Burrell A. Extracorporeal membrane oxygenation for the treatment of massive pulmonary embolism. An analysis of the ELSO database. Resuscitation. Oktober 2023;191:109940.","DOI":"10.1016\/j.resuscitation.2023.109940"},{"key":"1401_CR19","doi-asserted-by":"crossref","unstructured":"Arlt M, Philipp A, Voelkel S, Schopka S, Husser O, Hengstenberg C, u.\u00a0a. Early experiences with miniaturized extracorporeal life-support in the catheterization laboratory. Eur J Cardiothorac Surg. 1. November 2012;42(5):858\u201363.","DOI":"10.1093\/ejcts\/ezs176"},{"key":"1401_CR20","doi-asserted-by":"crossref","unstructured":"Puehler T, Philipp A, Schmid C, Luchner A. Implantation of a new extracorporeal life support system during resuscitation in complicated percutaneous coronary intervention with occlusion of the left main artery. Eur Heart J. 2. Oktober 2010;31(20):2499\u20132499.","DOI":"10.1093\/eurheartj\/ehq231"},{"key":"1401_CR21","doi-asserted-by":"crossref","unstructured":"Lunz D, Philipp A, M\u00fcller T, Pfister K, Foltan M, Rupprecht L, u.\u00a0a. Ischemia-related vascular complications of percutaneously initiated venoarterial extracorporeal membrane oxygenation: Indication setting, risk factors, manifestation and outcome. J Crit Care. August 2019;52:58\u201362.","DOI":"10.1016\/j.jcrc.2019.04.002"},{"key":"1401_CR22","doi-asserted-by":"crossref","unstructured":"Wiest C, Philipp A, Foltan M, Lunz D, Merten C, Blecha S, u.\u00a0a. Does cerebral near-infrared spectroscopy (NIRS) help to predict futile cannulation in extracorporeal cardiopulmonary resuscitation (ECPR)? Resuscitation. November 2021;168:186\u201390.","DOI":"10.1016\/j.resuscitation.2021.08.008"},{"key":"1401_CR23","unstructured":"Prime B. PRIME, B. ECLS Circuit. ELSO Anticoagulation Guideline. 2014. 2014. ELSO Anticoagulation Guideline 2014."},{"key":"1401_CR24","doi-asserted-by":"crossref","unstructured":"Fisser C, Reichenb\u00e4cher C, M\u00fcller T, Schneckenpointner R, Malfertheiner MV, Philipp A, u.\u00a0a. Incidence and Risk Factors for Cannula-Related Venous Thrombosis After Venovenous Extracorporeal Membrane Oxygenation in Adult Patients With Acute Respiratory Failure. Crit Care Med. April 2019;47(4):e332\u20139.","DOI":"10.1097\/CCM.0000000000003650"},{"key":"1401_CR25","doi-asserted-by":"crossref","unstructured":"Burgos LM, Seoane L, Diez M, Baro Vila RC, Furmento JF, Vrancic M, u.\u00a0a. Multiparameters Associated to Successful Weaning from VA ECMO in Adult Patients with Cardiogenic Shock or Cardiac Arrest: Systematic Review and Meta-Analysis. Ann Card Anaesth. Januar 2023;26(1):4\u201311.","DOI":"10.4103\/aca.aca_79_22"},{"key":"1401_CR26","doi-asserted-by":"crossref","unstructured":"Ajam K, Gold LS, Beck SS, Damon S, Phelps R, Rea TD. Reliability of the Cerebral Performance Category to classify neurological status among survivors of ventricular fibrillation arrest: a cohort study. Scand J Trauma Resusc Emerg Med. 15. Juni 2011;19:38.","DOI":"10.1186\/1757-7241-19-38"},{"key":"1401_CR27","doi-asserted-by":"crossref","unstructured":"Risco JR, Kelly AG, Holloway RG. Prognostication in neurology. In: Handbook of Clinical Neurology [Internet]. Elsevier; 2022 [zitiert 14. November 2024]. S. 175\u201393. Verf\u00fcgbar unter: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780323850292000038","DOI":"10.1016\/B978-0-323-85029-2.00003-8"},{"key":"1401_CR28","doi-asserted-by":"crossref","unstructured":"Uribarri A, Cruz-Gonz\u00e1lez I, Dalmau MJ, Rubia-Mart\u00edn MC, Ochoa M, S\u00e1nchez PL. Interhospital Transfer in Patients on ECMO Support. An Essential Tool for a Critical Care Network. Rev Esp Cardiol Engl Ed. Dezember 2017;70(12):1147\u20139.","DOI":"10.1016\/j.rec.2017.02.038"},{"key":"1401_CR29","doi-asserted-by":"crossref","unstructured":"Banning AS, Sabat\u00e9 M, Orban M, Gracey J, L\u00f3pez-Sobrino T, Massberg S, u.\u00a0a. Venoarterial extracorporeal membrane oxygenation or standard care in patients with cardiogenic shock complicating acute myocardial infarction: the multicentre, randomised EURO SHOCK trial. EuroIntervention. August 2023;19(6):482\u201392.","DOI":"10.4244\/EIJ-D-23-00204"},{"key":"1401_CR30","doi-asserted-by":"crossref","unstructured":"Cankar T, Krepek M, Kosmopoulos M, Rad\u0161el P, Yannopoulos D, Noc M, u.\u00a0a. Long-term Survival and Quality of Life in Non-Surgical Adult Patients Supported with Veno-Arterial Extracorporeal Oxygenation. J Clin Med. 31. Oktober 2022;11(21):6452.","DOI":"10.3390\/jcm11216452"},{"key":"1401_CR31","doi-asserted-by":"crossref","unstructured":"Ouweneel DM, Schotborgh JV, Limpens J, Sjauw KD, Engstr\u00f6m AE, Lagrand WK, u.\u00a0a. Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med. Dezember 2016;42(12):1922\u201334.","DOI":"10.1007\/s00134-016-4536-8"},{"key":"1401_CR32","doi-asserted-by":"crossref","unstructured":"Schmidt M, Burrell A, Roberts L, Bailey M, Sheldrake J, Rycus PT, u.\u00a0a. Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial-ECMO (SAVE)-score. Eur Heart J. 1. September 2015;36(33):2246\u201356.","DOI":"10.1093\/eurheartj\/ehv194"},{"key":"1401_CR33","doi-asserted-by":"crossref","unstructured":"Ryu JA, Chung CR, Cho YH, Sung K, Jeon K, Suh GY, u.\u00a0a. Neurologic Outcomes in Patients Who Undergo Extracorporeal Cardiopulmonary Resuscitation. Ann Thorac Surg. September 2019;108(3):749\u201355.","DOI":"10.1016\/j.athoracsur.2019.03.033"},{"key":"1401_CR34","doi-asserted-by":"crossref","unstructured":"Petermichl W, Philipp A, Hiller KA, Foltan M, Floerchinger B, Graf B, u.\u00a0a. Reliability of prognostic biomarkers after prehospital extracorporeal cardiopulmonary resuscitation with target temperature management. Scand J Trauma Resusc Emerg Med. Dezember 2021;29(1):147.","DOI":"10.1186\/s13049-021-00961-8"},{"issue":"6","key":"1401_CR35","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.chest.2021.08.001","volume":"160","author":"MR Anderson","year":"2021","unstructured":"Anderson MR, Shashaty MGS. Impact of Obesity in Critical Illness. Chest Dezember. 2021;160(6):2135\u201345.","journal-title":"Chest Dezember"},{"key":"1401_CR36","doi-asserted-by":"crossref","unstructured":"Vidal MG, Weisser JR, Gonzalez F, Toro MA, Loudet C, Balasini C, u.\u00a0a. Incidence and clinical effects of intra-abdominal hypertension in critically ill patients: Crit Care Med. Juni 2008;36(6):1823\u201331.","DOI":"10.1097\/CCM.0b013e31817c7a4d"},{"key":"1401_CR37","doi-asserted-by":"crossref","unstructured":"Frezza EE, Shebani KO, Robertson J, Wachtel MS. Morbid Obesity Causes Chronic Increase of Intraabdominal Pressure. Dig Dis Sci. 21. M\u00e4rz 2007;52(4):1038\u201341.","DOI":"10.1007\/s10620-006-9203-4"},{"key":"1401_CR38","doi-asserted-by":"crossref","unstructured":"Millar JE, Fanning JP, McDonald CI, McAuley DF, Fraser JF. The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology. Crit Care Lond Engl. 28. November 2016;20(1):387.","DOI":"10.1186\/s13054-016-1570-4"},{"key":"1401_CR39","unstructured":"Rudym D, Pham T, Rackley CR, Grasselli G, Anderson M, Baldwin MR, u.\u00a0a. Mortality in Patients with Obesity and Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation: The Multicenter ECMObesity Study. Am J Respir Crit Care Med. 15. September 2023;208(6):685\u201394."},{"key":"1401_CR40","doi-asserted-by":"crossref","unstructured":"Ripoll JG, ElSaban M, Nabzdyk CS, Balakrishna A, Villavicencio MA, Calderon-Rojas RD, u.\u00a0a. Obesity and Extracorporeal Membrane Oxygenation (ECMO): Analysis of Outcomes. J Cardiothorac Vasc Anesth. Januar 2024;38(1):285\u201398.","DOI":"10.1053\/j.jvca.2023.10.025"},{"key":"1401_CR41","doi-asserted-by":"crossref","unstructured":"Sun F, Mei Y, Lv J, Li W, Hu D, Zhang G, u.\u00a0a. Average mean arterial pressure in the first 6 hours of extracorporeal cardiopulmonary resuscitation in the prediction of the prognosis of neurological outcome: a single-center retrospective study. Perfusion. November 2022;37(8):805\u201311.","DOI":"10.1177\/02676591211027118"},{"key":"1401_CR42","doi-asserted-by":"crossref","unstructured":"Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Shea L, Donnino M, u.\u00a0a. Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study*. Crit Care Med. Januar 2019;47(1):93\u2013100.","DOI":"10.1097\/CCM.0000000000003474"},{"key":"1401_CR43","doi-asserted-by":"crossref","unstructured":"Walsh M, Devereaux PJ, Garg AX, Kurz A, Turan A, Rodseth RN, u.\u00a0a. Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery. Anesthesiology. 1. September 2013;119(3):507\u201315.","DOI":"10.1097\/ALN.0b013e3182a10e26"},{"issue":"1","key":"1401_CR44","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s13019-021-01579-8","volume":"16","author":"W Petermichl","year":"2021","unstructured":"Petermichl W, Gruber M, Schoeller I, Allouch K, Graf BM, Zausig YA. The additional use of methylene blue has a decatecholaminisation effect on cardiac vasoplegic syndrome after cardiac surgery. J Cardiothorac Surg Dezember. 2021;16(1):205.","journal-title":"J Cardiothorac Surg Dezember"},{"issue":"11","key":"1401_CR45","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1055\/s-0037-1616068","volume":"86","author":"F Taylor","year":"2001","unstructured":"Taylor F, Toh CH, Hoots K, Wada H, Levi M. Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation: On behalf of the Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Thromb Haemost. 2001;86(11):1327\u201330.","journal-title":"Thromb Haemost"},{"issue":"2","key":"1401_CR46","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/jth.13911","volume":"16","author":"T Iba","year":"2018","unstructured":"Iba T, Levy JH. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. J Thromb Haemost Februar. 2018;16(2):231\u201341.","journal-title":"J Thromb Haemost Februar"},{"issue":"12","key":"1401_CR47","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1177\/0885066619871452","volume":"35","author":"NM Gourd","year":"2020","unstructured":"Gourd NM, Nikitas N. Multiple Organ Dysfunction Syndrome. J Intensive Care Med Dezember. 2020;35(12):1564\u201375.","journal-title":"J Intensive Care Med Dezember"},{"issue":"10","key":"1401_CR48","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1007\/s00520-018-4597-z","volume":"27","author":"M Sok","year":"2019","unstructured":"Sok M, Zavrl M, Greif B, Srp\u010di\u010d M. Objective assessment of WHO\/ECOG performance status. Support Care Cancer Oktober. 2019;27(10):3793\u20138.","journal-title":"Support Care Cancer Oktober"},{"key":"1401_CR49","doi-asserted-by":"crossref","unstructured":"Yukawa T, Kashiura M, Sugiyama K, Tanabe T, Hamabe Y. Neurological outcomes and duration from cardiac arrest to the initiation of extracorporeal membrane oxygenation in patients with out-of-hospital cardiac arrest: a retrospective study. Scand J Trauma Resusc Emerg Med. Dezember 2017;25(1):95.","DOI":"10.1186\/s13049-017-0440-7"}],"container-title":["Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13049-025-01401-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13049-025-01401-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13049-025-01401-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T12:42:00Z","timestamp":1747053720000},"score":1,"resource":{"primary":{"URL":"https:\/\/sjtrem.biomedcentral.com\/articles\/10.1186\/s13049-025-01401-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1401"],"URL":"https:\/\/doi.org\/10.1186\/s13049-025-01401-7","relation":{},"ISSN":["1757-7241"],"issn-type":[{"value":"1757-7241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"14 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the University of Regensburg (file number 19\u2013121.56).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"81"}}