{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T14:30:28Z","timestamp":1775053828360,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13052-015-0132-8","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T14:18:05Z","timestamp":1427811485000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection"],"prefix":"10.1186","volume":"41","author":[{"given":"Fabio","family":"Natale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Bizzarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Cardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelia","family":"Gaeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Villani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Liuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"De Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"132_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0022-3476(03)00192-6","volume":"143","author":"DW Kimberlin","year":"2003","unstructured":"Kimberlin DW, Lin CY, S\u00e1nchez PJ, Demmler GJ, Dankner W, Shelton M, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr. 2003;143:16\u201325.","journal-title":"J Pediatr"},{"issue":"Suppl 4","key":"132_CR2","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.1016\/j.jcv.2009.08.012","volume":"46","author":"SE Oliver","year":"2009","unstructured":"Oliver SE, Cloud GA, S\u00e1nchez PJ, Demmler GJ, Dankner W, Shelton M, et al. Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. J Clin Virol. 2009;46 Suppl 4:S22\u20136.","journal-title":"J Clin Virol"},{"key":"132_CR3","first-page":"208","volume":"14","author":"M Stronati","year":"2013","unstructured":"Stronati M, Lombardi G, Garofoli F, Villani P, Regazzi M. Pharmacokinetics, pharmacodynamics and clinical use of valganciclovir in newborns with symptomatic congenital cytomegalovirus infection. Curr Drug Metab. 2013;14:208\u201315.","journal-title":"Curr Drug Metab"},{"key":"132_CR4","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1086\/528376","volume":"197","author":"DW Kimberlin","year":"2008","unstructured":"Kimberlin DW, Acosta EP, S\u00e1nchez PJ, Sood S, Agrawal V, Homans J, et al. Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. J Infect Dis. 2008;197:836\u201345.","journal-title":"J Infect Dis"},{"key":"132_CR5","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1128\/CMR.00007-10","volume":"23","author":"R Nau","year":"2010","unstructured":"Nau R, S\u00f6rgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fluid\/blood\u2013brain barrier for treatment of central nervous system infections. Clin Microbiol Rev. 2010;23:858\u201383.","journal-title":"Clin Microbiol Rev"},{"key":"132_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000355638","volume":"5","author":"H Sakamoto","year":"2013","unstructured":"Sakamoto H, Hirano M, Nose K, Ueno S, Oki T, Sugimoto K, et al. A case of severe ganciclovir-induced encephalopathy. Case Rep Neurol. 2013;5:183\u20136.","journal-title":"Case Rep Neurol"},{"key":"132_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1345\/aph.1G214","volume":"40","author":"H Peyriere","year":"2006","unstructured":"Peyriere H, Jeziorsky E, Jalabert A, Cociglio M, Benketira A, Blayac JP, et al. Neurotoxicity related to valganciclovir in a child with impaired renal function: usefulness of therapeutic drug monitoring. Ann Pharmacother. 2006;40:143\u20136.","journal-title":"Ann Pharmacother"},{"key":"132_CR8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/clpt.1986.177","volume":"40","author":"C Fletcher","year":"1986","unstructured":"Fletcher C, Sawchuk R, Chinnock B, de Miranda P, Balfour Jr HH. Human pharmacokinetics of the antiviral drug DHPG. Clin Pharmacol Ther. 1986;40:281\u20136.","journal-title":"Clin Pharmacol Ther"},{"key":"132_CR9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0731-7085(99)00161-2","volume":"21","author":"F Chu","year":"1999","unstructured":"Chu F, Kiang CH, Sung ML, Huang B, Reeve RL, Tarnowski T. A rapid, sensitive HPLC method for the determination of ganciclovir in human plasma and serum. J Pharm Biomed Anal. 1999;21:657\u201367.","journal-title":"J Pharm Biomed Anal"},{"issue":"6","key":"132_CR10","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1128\/CDLI.8.6.1279-1281.2001","volume":"8","author":"JJ McSharry","year":"2001","unstructured":"McSharry JJ, McDonough A, Olson B, Talarico C, Davis M, Biron KK. Inhibition of ganciclovir-susceptible and -resistant human cytomegalovirus clinical isolates by the benzimidazole L-riboside 1263W94. Clin Diagn Lab Immunol. 2001;8(6):1279\u201381.","journal-title":"Clin Diagn Lab Immunol"},{"key":"132_CR11","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.earlhumdev.2011.08.021","volume":"87","author":"S Kadambari","year":"2011","unstructured":"Kadambari S, Williams EJ, Luck S, Griffiths PD, Sharland M. Evidence based management guidelines for the detection and treatment of congenital CMV. Early Hum Dev. 2011;87:723\u20138.","journal-title":"Early Hum Dev"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-015-0132-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13052-015-0132-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-015-0132-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-015-0132-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T09:04:58Z","timestamp":1598864698000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijponline.biomedcentral.com\/articles\/10.1186\/s13052-015-0132-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["132"],"URL":"https:\/\/doi.org\/10.1186\/s13052-015-0132-8","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]},"assertion":[{"value":"2 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"26"}}