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The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Aims<\/jats:title>\n<jats:p>Neuroprem is an area-based prospective cohort study on the neuro-developmental outcome of very low birth weight (VLBW) infants that aims to define severe functional disability at 2\u2009years of age.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Surviving VLBW infants from an Italian network of 7 neonatal intensive care units (NICUs) were assessed for 24\u2009months through the Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and neuro-functional evaluation according to the International Classification of Disability and Health (ICF-CY). The primary outcome measure was severe functional disability at 2\u2009years of age, defined as cerebral palsy, a BSDI III cognitive composite score\u2009&lt;\u20092 standard deviation (SD) or a GMDS-R global quotients score\u2009&lt;\u20092 SD, bilateral blindness or deafness.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 211 surviving VLBW infants, 153 completed follow-up at 24\u2009months (72.5%). Thirteen patients (8.5%) developed a severe functional disability, of whom 7 presented with cerebral palsy (overall rate of 4.5%). Patients with cerebral palsy were all classified with ICF-CY scores of 3 or 4. BSDI III composite scores and GMDS-R subscales were significantly correlated with ICF-CY scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Neuroprem represents an Italian network of NICUs aiming to work together to ensure preterm neuro-developmental assessment. This study updates information on VLBW outcomes in an Italian region, showing a rate of cerebral palsy and major developmental disabilities in line with or even lower than those of similar international studies. 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