{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:49:02Z","timestamp":1784760542670,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Massive gastrointestinal bleeding in children is uncommon. Dieulafoy lesion is an uncommon disease which may lead to massive and repeated upper gastrointestinal hemorrhage. We report two cases of gastric Dieulafoy lesion successfully treated with either band ligation or endoscopic hemoclipping.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p><jats:italic>First case report:<\/jats:italic> A previously healthy 18-month-old female infant with <jats:italic>E. coli<\/jats:italic> sepsis, pneumonia and respiratory failure with bilateral pneumothorax requiring chest drainage. Over a few days, the patient presented hematemesis and melena with progressively worsening anemia. The esophagogastroduodenoscopy revealed an arterial vessel with eroded apex located between the body and the fundus of the stomach. Two elastic bands were applied which resulted in resolution of hematemesis and melena and improvement of the anemia.<\/jats:p>\n<jats:p><jats:italic>Second case report:<\/jats:italic> A 8-year-old male was admitted to our department with sudden massive hematemesis and melena. Clinical examination revealed anemia (hemoglobin, 6.8\u2009g\/dl). Esophagogastroduodenoscopy revealed a mucosal erosion with visible vessel located along the small curvature, close to the antrum. Three hemostatic clips were placed on the Dieulafoy lesion and hemostasis was obtained.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>we showed that, similar to gastric DL in adult patients,, gastric DL in pediatric patients can be successfully treated with endoscopic therapy, and both hemoclipping and band ligation are suitable techniques.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13052-020-0814-8","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T13:02:21Z","timestamp":1587301341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dieulafoy lesion: two pediatric case reports"],"prefix":"10.1186","volume":"46","author":[{"given":"Giovanni","family":"Di Nardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Zenzeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Ciccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Catzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito Domenico","family":"Corleto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"814_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.5152\/tjg.2014.3419","volume":"25","author":"F \u00dcnal","year":"2014","unstructured":"\u00dcnal F, \u00c7ak\u0131r M, Baran M, Duygulu \u015e, Aydo\u011fdu S. Application of endoscopic hemoclips for nonvariceal upper gastrointestinal bleeding in children. Turk J Gastroenterol. 2014;25:147\u201351.","journal-title":"Turk J Gastroenterol"},{"key":"814_CR2","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S0046-8177(88)80006-6","volume":"19","author":"TL Miko","year":"1988","unstructured":"Miko TL, Thom\u00e1zy VA. The caliber persistent artery of the stomach: a unifying approach to gastric aneurysm, Dieulafoy\u2019s lesion, and submucosal arterial malformation. Hum Pathol. 1988;19:914\u201321.","journal-title":"Hum Pathol"},{"key":"814_CR3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.4253\/wjge.v7.i4.295","volume":"7","author":"B Nojkov","year":"2015","unstructured":"Nojkov B, Cappell MS. Gastrointestinal bleeding from Dieulafoy's lesion: clinical presentation, endoscopic findings, and endoscopic therapy. World J Gastrointest Endosc. 2015;7:295\u2013307.","journal-title":"World J Gastrointest Endosc"},{"key":"814_CR4","doi-asserted-by":"publisher","first-page":"432517","DOI":"10.1155\/2012\/432517","volume":"2012","author":"JL Senger","year":"2012","unstructured":"Senger JL, Kanthan R. The evolution of Dieulafoy\u2019s lesion since 1897: then and now-a journey through the lens of a pediatric lesion with literature review. Gastroenterol Res Pract. 2012;2012:432517.","journal-title":"Gastroenterol Res Pract"},{"key":"814_CR5","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1097\/MPG.0b013e3181ee9f89","volume":"51","author":"M Itani","year":"2010","unstructured":"Itani M, Alsaied T, Charafeddine L, Yazbeck N. Dieulafoy\u2019s lesion in children. J Pediatr Gastroenterol Nutr. 2010;51:672\u20134.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"814_CR6","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.3748\/wjg.v13.i32.4333","volume":"13","author":"S Nagri","year":"2007","unstructured":"Nagri S, Anand S, Arya Y. Clinical presentation and endoscopic management of Dieulafoy\u2019s lesions in an urban community hospital. World J Gastroenterol. 2007;13:4333\u20135.","journal-title":"World J Gastroenterol"},{"key":"814_CR7","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.gie.2011.05.027","volume":"74","author":"E Dulic-Lakovic","year":"2011","unstructured":"Dulic-Lakovic E, Dulic M, Hubner D, Fuchssteiner H, Pachofszky T, Stadler B, Maieron A, Schwaighofer H, P\u00fcsp\u00f6k A, Haas T, Gahbauer G, Datz C, Ordubadi P, Holz\u00e4pfel A, Gschwantler M, Austrian Dieulafoy-bleeding Study Group. Bleeding Dieulafoy lesions of the small bowel: a systematic study on the epidemiology and efficacy of enteroscopic treatment. Gastrointest Endosc. 2011;74:573\u201380.","journal-title":"Gastrointest Endosc"},{"key":"814_CR8","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1053\/j.gastro.2007.06.008","volume":"133","author":"GS Raju","year":"2007","unstructured":"Raju GS, Gerson L, Das A, Lewis B. American Gastroenterological Association (AGA) institute medical position statement on obscure gastrointestinal bleeding. Gastroenterology. 2007;133:1694\u20136.","journal-title":"Gastroenterology"},{"key":"814_CR9","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1007\/BF01296613","volume":"36","author":"HF Reilly","year":"1991","unstructured":"Reilly HF, Al-kawas FH. Dieulafoy\u2019s lesion-diagnosis and management. Dig Dis Sci. 1991;36:1702\u20137.","journal-title":"Dig Dis Sci"},{"key":"814_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0016-5107(87)71486-2","volume":"33","author":"FH Al-Kawas","year":"1987","unstructured":"Al-Kawas FH, O\u2019keefe J. Nd: YAG laser treatment of a bleeding Dieulafoy\u2019s lesion. Gastrointest Endosc. 1987;33:38\u20139.","journal-title":"Gastrointest Endosc"},{"key":"814_CR11","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5946\/ce.2015.48.2.112","volume":"48","author":"HK Jeon","year":"2015","unstructured":"Jeon HK, Kim GH. Endoscopic Management of Dieulafoy\u2019s lesion. Clin Endosc. 2015;48:112\u201320.","journal-title":"Clin Endosc"},{"key":"814_CR12","first-page":"937839","volume":"2015","author":"C Salakos","year":"2015","unstructured":"Salakos C, Kafritsa P, de Verney Y, Sageorgi A, Zavras N. Massive gastric hemorrhage due to Dieulafoy\u2019s lesion in a preterm neonate: a case report and literature review of the lesion in neonates. Case Rep Pediatr. 2015;2015:937839.","journal-title":"Case Rep Pediatr"},{"key":"814_CR13","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jpeds.2019.05.020","volume":"213","author":"AK Coit","year":"2019","unstructured":"Coit AK, Pisharody U, Kamitsuka M. Dieulafoy lesion: an unusual cause of excessive gastric bleeding in a neonate. J Pediatr. 2019;213:244\u2013244.e1.","journal-title":"J Pediatr"},{"key":"814_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s13256-016-1083-4","volume":"10","author":"T Emura","year":"2016","unstructured":"Emura T, Hosoda K, Harai S, Oyachi N, Suzuki T, Takada K, Kobayashi K, Ikeda H. Dieulafoy lesion in a two-year-old boy: a case report. J Med Case Rep. 2016;10:293.","journal-title":"J Med Case Rep"},{"key":"814_CR15","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1007\/s12098-016-2093-3","volume":"83","author":"PG Chandane","year":"2016","unstructured":"Chandane PG, Javia M. Enteric fever presenting as hemorrhagic shock due to bleeding from Dieulafoy\u2019s lesion. Indian J Pediatr. 2016;83:1200\u20132.","journal-title":"Indian J Pediatr"},{"key":"814_CR16","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.1016\/j.jpedsurg.2011.06.015","volume":"46","author":"E Polonkai","year":"2011","unstructured":"Polonkai E, Nagy A, Cs\u00edzy I, Moln\u00e1r C, Roszer T, Balla G, J\u00f3zsa T. Pyloric atresia associated with Dieulafoy lesion and gastric dysmotility in a neonate. J Pediatr Surg. 2011;46:E19\u201323.","journal-title":"J Pediatr Surg"},{"key":"814_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2147\/CEG.S122784","volume":"10","author":"TU Y\u0131lmaz","year":"2017","unstructured":"Y\u0131lmaz TU, Kozan R. Duodenal and jejunal Dieulafoy's lesions: optimal management. Clin Exp Gastroenterol. 2017;10:275\u201383.","journal-title":"Clin Exp Gastroenterol"},{"key":"814_CR18","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jpedsurg.2008.09.033","volume":"44","author":"G Marangoni","year":"2009","unstructured":"Marangoni G, Cresswell AB, Faraj W, Shaikh H, Bowles MJ. An uncommon cause of life threatening gastrointestinal bleeding: 2 synchronous Dieulafoy lesions. J Pediatr Surg. 2009;44:441\u20133.","journal-title":"J Pediatr Surg"},{"key":"814_CR19","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/s00464-008-0255-8","volume":"23","author":"H Alis","year":"2009","unstructured":"Alis H, Oner OZ, Kalayci MU, Dolay K, Kapan S, Soylu A, Aygun E. Is endoscopic band ligation superior to injection therapy for Dieulafoy lesion? Surg Endosc. 2009;23:1465\u20139.","journal-title":"Surg Endosc"},{"key":"814_CR20","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1308\/003588410X12699663905311","volume":"92","author":"M Baxter","year":"2010","unstructured":"Baxter M, Aly EH. Dieulafoy\u2019s lesion: current trends in diagnosis and management. An R Coll Surg Engl. 2010;92:548\u201354.","journal-title":"An R Coll Surg Engl"},{"key":"814_CR21","doi-asserted-by":"publisher","first-page":"a1","DOI":"10.1055\/s-0034-1393172","volume":"47","author":"IM Gralnek","year":"2015","unstructured":"Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, Rotondano G, Hucl T, Dinis-Ribeiro M, Marmo R, Racz I, Arezzo A, Hoffmann RT, Lesur G, de Franchis R, Aabakken L, Veitch A, Radaelli F, Salgueiro P, Cardoso R, Maia L, Zullo A, Cipolletta L, Hassan C. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2015;47:a1\u201346.","journal-title":"Endoscopy"},{"key":"814_CR22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1055\/s-2004-825661","volume":"36","author":"CH Park","year":"2004","unstructured":"Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Kim SJ. A prospective, randomized trial of endoscopic band ligation versus endoscopic hemoclip placement for bleeding gastric Dieulafoy\u2019s lesions. Endoscopy. 2004;36:677\u201381.","journal-title":"Endoscopy"},{"key":"814_CR23","first-page":"315","volume":"47","author":"BK Ki","year":"2014","unstructured":"Ki BK, Soon MY, Sei JY. Endoscopy for Nonvariceal upper gastrointestinal bleeding. Clin Endosc. 2014;47:315\u20139.","journal-title":"Clin Endosc"},{"key":"814_CR24","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1067\/mge.2000.108040","volume":"52","author":"IK Chung","year":"2000","unstructured":"Chung IK, Kim EJ, Lee MS, Kim HS, Park SH, Lee MH, Kim SJ, Cho MS. Bleeding Dieulafoy\u2019s lesions and the choice of endoscopic method: comparing the hemostatic efficacy of mechanical and injection methods. Gastrointest Endosc. 2000;52:721\u20134.","journal-title":"Gastrointest Endosc"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-020-0814-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-020-0814-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-020-0814-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T23:23:41Z","timestamp":1618788221000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijponline.biomedcentral.com\/articles\/10.1186\/s13052-020-0814-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,19]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["814"],"URL":"https:\/\/doi.org\/10.1186\/s13052-020-0814-8","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,19]]},"assertion":[{"value":"6 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"informed written consent was obtained from the patient\u2019s parents for publication of this report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}