{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:07:00Z","timestamp":1783724820662,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Serious bacterial infection (SBI) remains an important cause of morbidity and mortality in preterm infants. The objective of this study was to evaluate the dynamically increased value of the red cell distribution width (RDW) in the diagnosis of SBI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective study enrolled 334 preterm infants with birth weight less than 1500\u2009g. The initial RDW and the maximum value of RDW during hospitalization were extracted from the MIMIC-III database (version 1.4). Infants were categorized into four groups according to baseline RDW value and \u0394RDW (\u0394RDW\u2009=\u2009RDW at maximum- RDW at baseline). Logistic regression analysis was used to assess the risk of developing SBI in each group. A receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of RDW at baseline alone, \u0394RDW alone, and in combination.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Infants with increased RDW at baseline (&gt;\u200917%) and \u0394RDW &gt;\u20092% exhibited the highest risk of developing SBI, whereas the patients with normal RDW level at baseline (\u2264 17%) and \u0394RDW\u22642% (the reference group) had the lowest risk. This association remained unaltered even after adjustment in multivariable models. Basing on ROC curve analysis, the area under the curve predicted by the combination of RDW at baseline and \u0394RDW for SBI was 0.81 (95% CI, 0.76\u20130.87). Sensitivity and specificity were 78.16 and 72.47% respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We observed that combination of elevated RDW at baseline and dynamic increases during hospitalization is significantly associated with SBI. Therefore, that combination could be a promising independent diagnostic indicator of SBI in newborns.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-021-00994-w","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T11:02:53Z","timestamp":1614423773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection"],"prefix":"10.1186","volume":"47","author":[{"given":"Bin-Fang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Zhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"issue":"10","key":"994_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B0-72-160537-0\/50004-9","volume":"27","author":"BJ Stoll","year":"2006","unstructured":"Stoll BJ. Neonatal infections: a global perspective. 2006. Infectious Diseases of the Fetus & Newborn Infant. 2006;27(10):27\u201357. https:\/\/doi.org\/10.1016\/B0-72-160537-0\/50004-9.","journal-title":"Infectious Diseases of the Fetus & Newborn Infant"},{"key":"994_CR2","doi-asserted-by":"publisher","unstructured":"Jung H, Cho, Hye-Kyung. Central line-associated bloodstream infections in neonates. Korean Journal of Pediatrics. 2019;62(3):79\u201384.https:\/\/doi.org\/10.3345\/kjp.2018.07003","DOI":"10.3345\/kjp.2018.07003"},{"key":"994_CR3","doi-asserted-by":"publisher","unstructured":"Desalew A, Sintayehu Y, Teferi N, Amare F, Geda B, Worku T, et al. Cause and predictors ofneonatal mortality among neonates admitted to neonatal intensive care units of public hospitals in eastern Ethiopia: a facility-based prospective follow-up study. 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Informed consent was waived because all data are from a publicly available database.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}