{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:01:23Z","timestamp":1793196083587,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Benign acute childhood myositis (BACM) is a self-limited syndrome associated with viral infections characterized by symmetric lower extremity pain typically affecting school-aged children. Evolution in rhabdomyolysis and kidney damage is rarely reported.<\/jats:p>\n                <jats:p>Despite this, the acute presentation commonly concerns both parents and health care providers, often leading to unnecessary workup.<\/jats:p>\n                <jats:p>The aim of the study was to determine the features and outcome of a large series of children with BACM identifying a management pathway for pediatricians in Emergency Department (ED).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a retrospective study of patients with BACM managed in 2 Italian pediatric ED during a period of 8 and a half years.<\/jats:p>\n                <jats:p>Demographic data, clinical, and laboratory results were extracted from electronic medical records.<\/jats:p>\n                <jats:p>Recurrence, complications, treatments, and outcomes were also recorded.<\/jats:p>\n                <jats:p>Descriptive statistics were produced for first-episode patients and for those with recurrence of myositis. A comparison between groups was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred and thirteen patients with BACM were identified. Ninety-two children (65 males) had a single episode, while ten (nine males) had recurrence. The mean age at presentation was 6.0\u2009years (range 2\u201313,2).<\/jats:p>\n                <jats:p>All patients had normal neurological examination and no one developed myoglobinuria, or renal failure. At first evaluation median CK level was 1413 UI\/l (normal values &lt;\u2009150\u2009U\/L).<\/jats:p>\n                <jats:p>Median CK of \u201crecurrent\u201d patients was higher than \u201cnon-recurrent\u201d (2330 vs 1150\u2009U\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p>\n                <jats:p>Viral studies were positive in 51\/74 cases, with high prevalence of Influenza viruses.<\/jats:p>\n                <jats:p>Ninety-six patients (85%) were hospitalized with a median of 4\u2009days. No patients had any residual muscular impairment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>BACM has an excellent prognosis. Severe pathological conditions can be excluded with a complete history and clinical examination and simple blood and urine tests, avoiding unnecessary diagnostic investigations. Most patients may be discharged home from ED recommending hydration, rest, analgesics and careful follow-up.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-021-01002-x","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T13:02:57Z","timestamp":1615294977000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Management and outcome of benign acute childhood myositis in pediatric emergency department"],"prefix":"10.1186","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-0181","authenticated-orcid":false,"given":"Giacomo","family":"Brisca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pirlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Romanengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pistorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gaiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Panicucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Piccotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"1002_CR1","doi-asserted-by":"publisher","unstructured":"Mackay MT, Kornberg AJ, Shield LK, Dennett X. 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