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The generalized SSSS is recommended to be admitted and treated with intravenous antibiotics. However, there were limited reports on whether personal and clinical factors can have impacts on the duration of intravenous antibiotic application for pediatric patients with generalized SSSS.\n                    <\/jats:p>\n                    <jats:p>\n                      We performed a study to assess the factors affecting intravenous antibiotic treatment course of SSSS patients. Additionally, the positive culture rates of\n                      <jats:italic>S.aureus<\/jats:italic>\n                      in different samples and the antibiotic-resistant profile were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred nineteen patients with generalized SSSS were included. Gender, age, area, season, maximum axillary temperature, white blood cell (WBC) count, C-reactive protein (CRP) level, types of intravenous antibiotics, and types of external antibiotics were recorded as the baseline. Simple linear regression was applied in the univariate analysis to determine the variables with statistical significance and then these variables were further examined in multivariate linear regression model. The positive culture rates of\n                      <jats:italic>S.aureus in<\/jats:italic>\n                      different sample sources were calculated and the drug sensitivity results were statistically compared by pairwise Chi square test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to the multiple linear regression, older ages (\u03b2\u2009=\u2009\u2212\u20090.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and external application of fusidic acid (\u03b2\u2009=\u2009\u2212\u20091.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were associated with shorter treatment course, elevated leukocytes (\u03b2\u2009=\u20090.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and CRP level (\u03b2\u2009=\u20091.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) were associated with longer treatment course. The positive culture rates of periorificial swabs, throat swabs, and blood samples were 54.55, 30.77, and 5.97% respectively. The resistant rates of levofloxacin (8.33%), gentamycin (8.33%), tetracycline (25%), oxacillin (8.33%), vancomycin (0%) were significantly lower than the ones of erythromycin (100%), trimethoprim-sulfamethoxazole (TMP\/SMX) (83.33%), clindamycin (91.67%), penicillin G(100%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Elevated leukocytes and CRP level indicated prolonged intravenous antibiotic treatment course. Older ages and external application of fusidic acid helped to reduce the treatment course. Compared with blood samples, the culture positive rates of\n                      <jats:italic>S.aureus<\/jats:italic>\n                      in periorificial and throat swabs were higher. Oxacillin and vancomycin resistance was rare and clindamycin resistance was common. Clindamycin monotherapy for SSSS should be avoided.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13052-021-01120-6","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T04:03:01Z","timestamp":1628222581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antibiotic-resistant profile and the factors affecting the intravenous antibiotic treatment course of generalized Staphylococcal Scalded Skin Syndrome: a retrospective study"],"prefix":"10.1186","volume":"47","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longnian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-5884","authenticated-orcid":false,"given":"Cong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"issue":"6","key":"1120_CR1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/j.1440-1754.2008.01316.x","volume":"44","author":"V Kapoor","year":"2008","unstructured":"Kapoor V, Travadi J, Braye S. 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This is an observational study and a waiver from the need to provide written informed consent of the caregivers were obtained from the institutional review board of The First Affiliated Hospital of Gannan Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Tao Yang, Jiangyi Wang, Junya Cao, Yun Lai, Longnian Li, Xiaoying Ye and Cong You declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"169"}}