{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:43:27Z","timestamp":1791582207213,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Neuromuscular diseases include a large group of heterogeneous and rare pathologies that affect different components of the motor unit. It is essential to optimize resources to know the prevalence of comorbidities in the most frequent groups to establish an early multidisciplinary approach in a specialized setting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patients and methods<\/jats:title>\n                <jats:p>Retrospective descriptive study of pediatric and adolescent patients with neuromuscular diseases (NMDs). The Inclusion criteria were NMDs patients with motor neuron involvement divided into three groups, depending on the affected component of the motor unit. Group I: involvement of the motor neuron; Group II: peripheral neuropathies; Group III: myopathies. Demographic variables, association with comorbidities, need for respiratory support, and rehabilitative treatment were collected in each group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ninety-six patients who met the inclusion criteria were studied. In group I, when compared to the other two groups, a higher incidence of scoliosis (68.3%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.011), deformity of the rib cage (31.3%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.0001), chronic respiratory insufficiency (62.5%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001) and bronchial aspiration (12.5%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.03) was detected. In this group, 50%of the patients required non-invasive mechanical ventilation (<jats:italic>p<\/jats:italic>\u00a0=\u20090.0001). The in-hospital requirement for respiratory physiotherapy was higher in group I (75%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001). We observed a higher incidence of scoliosis in Group III compared to Group II.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Neuromuscular diseases with motor neuron involvement present more comorbidities and require an early approach after diagnosis to improve prognosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-021-01176-4","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T14:04:23Z","timestamp":1637071463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Experience in neuromuscular diseases in children and adolescents and their comorbidities in a tertiary hospital"],"prefix":"10.1186","volume":"47","author":[{"given":"J. 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