{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:42:20Z","timestamp":1768646540289,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hypertrophic cardiomyopathy (HCM) in newborns is a rare condition with heterogeneous etiologies. While the relationship between hyperinsulinism and cardiac hypertrophy (CH) is known, hyperinsulinism has not been reported as cause of HCM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the case of cardiac hypertrophy (CH) in an Extremely Low Birth Weight (ELBW) infant; this patient underwent insulin therapy after the onset of persistent hyperglycemia due to parenteral nutrition (PN), supporting the hypothesis of a role of iatrogenic hyperinsulinemia in the development of HCM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The present case underlines the importance of a close cardiological follow-up in infants undergoing insulin infusion for an alteration in the glucose metabolism.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-022-01216-7","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T07:02:52Z","timestamp":1644303772000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?"],"prefix":"10.1186","volume":"48","author":[{"given":"Guglielmo","family":"Salvatori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-6082","authenticated-orcid":false,"given":"Giulia","family":"Brindisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Colantonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Zicari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"issue":"1","key":"1216_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00431-019-03521-6","volume":"179","author":"ND Paauw","year":"2020","unstructured":"Paauw ND, Stegeman R, de Vroede MAMJ, Termote JUM, Freund MW, Breur JMPJ. Neonatal cardiac hypertrophy: the role of hyperinsulinism-a review of literature. Eur J Pediatr. 2020;179(1):39\u201350.","journal-title":"Eur J Pediatr"},{"issue":"6","key":"1216_CR2","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1016\/j.jtcvs.2011.10.020","volume":"142","author":"BJ Gersh","year":"2011","unstructured":"American College of Cardiology Foundation\/American Heart Association Task Force on Practice; American Association for Thoracic Surgery; American Society of Echocardiography; American Society of Nuclear Cardiology; Heart Failure Society of America; Heart Rhythm Society; Society for Cardiovascular Angiography and Interventions; Society of Thoracic Surgeons, Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, et al. 2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines. J Thorac Cardiovasc Surg. 2011;142(6):e153\u2013203.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1216_CR3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4103\/0974-2069.99622","volume":"5","author":"H Chubb","year":"2012","unstructured":"Chubb H, Simpson JM. The use of Z-scores in paediatric cardiology. Ann Pediatr Cardiol. 2012;5:179\u201384.","journal-title":"Ann Pediatr Cardiol"},{"key":"1216_CR4","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1017\/S1047951100005217","volume":"9","author":"PE Daubeney","year":"1999","unstructured":"Daubeney PE, Blackstone EH, Weintraub RG, et al. Relationship of the dimension of cardiac structures to body size: an echocardiographic study in normal infants and children. Cardiol Young. 1999;9:402\u201310.","journal-title":"Cardiol Young"},{"key":"1216_CR5","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/heartjnl-2011-300531","volume":"98","author":"JP Moak","year":"2012","unstructured":"Moak JP, Kaski JP. Hypertrophic cardiomyopathy in children. Heart. 2012;98:1044\u201354.","journal-title":"Heart"},{"issue":"4","key":"1216_CR6","doi-asserted-by":"publisher","first-page":"F351","DOI":"10.1136\/archdischild-2012-302546","volume":"98","author":"TT Huang","year":"2013","unstructured":"Huang TT, et al. Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism. Arch Dis Child Fetal Neonatal Ed. 2013;98(4):F351\u20134.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"1","key":"1216_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/00003081-200003000-00004","volume":"43","author":"EA Reece","year":"2000","unstructured":"Reece EA, Homko CJ. Why do diabetic women deliver malformed infants? Clin Obstet Gynecol. 2000;43(1):32\u201345.","journal-title":"Clin Obstet Gynecol"},{"issue":"2","key":"1216_CR8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/bdr2.1155","volume":"110","author":"HZ Nasri","year":"2018","unstructured":"Nasri HZ, Houde Ng K, Westgate MN, Hunt AT, Holmes LB. Malformations among infants of mothers with insulin-dependent diabetes: is there a recognizable pattern of abnormalities? Birth Defects Res. 2018;110(2):108\u201313.","journal-title":"Birth Defects Res"},{"issue":"3 Pt 1","key":"1216_CR9","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1097\/01.AOG.0000231688.08263.47","volume":"108","author":"J Yang","year":"2006","unstructured":"Yang J, Cummings EA, O'Connell C, Jangaard K. Fetal and neonatal outcomes of diabetic pregnancies. Obstet Gynecol. 2006;108(3 Pt 1):644\u201350.","journal-title":"Obstet Gynecol"},{"issue":"10","key":"1216_CR10","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1017\/S1047951119001884","volume":"29","author":"M Mohsin","year":"2019","unstructured":"Mohsin M, Sadqani S, Younus K, Hoodbhoy Z, Ashiqali S, Atiq M. Evaluation of cardiac function in fetuses of mothers with gestational diabetes. Cardiol Young. 2019;29(10):1264\u20137.","journal-title":"Cardiol Young"},{"issue":"8","key":"1216_CR11","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.2337\/dc05-2265","volume":"29","author":"RC Temple","year":"2006","unstructured":"Temple RC, Aldridge VJ, Murphy HR. Prepregnancy care and pregnancy outcomes in women with type 1 diabetes. Diabetes Care. 2006;29(8):1744\u20139.","journal-title":"Diabetes Care"},{"issue":"3","key":"1216_CR12","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/dme.13579","volume":"35","author":"HR Murphy","year":"2018","unstructured":"Murphy HR, Bell R, Dornhorst A, Forde R, Lewis-Barned N. Pregnancy in diabetes: challenges and opportunities for improving pregnancy outcomes. Diabet Med. 2018;35(3):292\u20139.","journal-title":"Diabet Med"},{"issue":"5","key":"1216_CR13","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S0002-9378(97)70035-8","volume":"177","author":"UM Schaefer","year":"1997","unstructured":"Schaefer UM, Songster G, Xiang A, Berkowitz K, Buchanan TA, Kjos SL. Congenital malformations in offspring of women with hyperglycemia first detected during pregnancy. Am J Obstet Gynecol. 1997;177(5):1165\u201371.","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"1216_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/echo.13811","volume":"35","author":"MR Asoglu","year":"2018","unstructured":"Asoglu MR, Gabbay-Benziv R, Turan OM, Turan S. Exposure of the developing heart to diabetic environment and early cardiac assessment: a review. Echocardiography. 2018;35(2):244\u201357.","journal-title":"Echocardiography"},{"issue":"2","key":"1216_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12265-011-9344-5","volume":"5","author":"G Breithardt","year":"2012","unstructured":"Breithardt G, Breithardt O-A. Left Bundle Branch Block, an Old\u2013New Entity. J cardiovasc Transl Res. 2012;5(2):107\u201316.","journal-title":"J cardiovasc Transl Res"},{"key":"1216_CR16","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1136\/heart.89.10.1217","volume":"89","author":"C Wren","year":"2003","unstructured":"Wren C, Birrell G, Hawthorne G. Cardiovascular malformations in infants of diabetic mothers. Heart. 2003;89:1217\u201320.","journal-title":"Heart."},{"issue":"2","key":"1216_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00246-003-0538-8","volume":"25","author":"RM Abu-Sulaiman","year":"2004","unstructured":"Abu-Sulaiman RM, Subaih B. Congenital heart disease in infants of diabetic mothers: echocardiographic study. Pediatr Cardiol. 2004;25(2):137\u201340.","journal-title":"Pediatr Cardiol"},{"issue":"18","key":"1216_CR18","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1056\/NEJMoa0803725","volume":"359","author":"K Beardsall","year":"2008","unstructured":"Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, Vanhole C, Palmer CR, van Weissenbruch M, et al. Early insulin therapy in very-low-birth-weight infants. N Engl J Med. 2008;359(18):1873\u201384.","journal-title":"N Engl J Med"},{"key":"1216_CR19","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s004310050596","volume":"156","author":"R Oberhoffer","year":"1997","unstructured":"Oberhoffer R, Hogel J, Stoz F, et al. Cardiac and extracardiac complications in infants of diabetic mothers and their relation to parameters of carbohydrate metabolism. Eur J Pediatr. 1997;156:262\u20135.","journal-title":"Eur J Pediatr"},{"key":"1216_CR20","first-page":"359","volume":"54","author":"MM Massin","year":"1999","unstructured":"Massin MM, Van Elmbt G, Soyeur D. Reversible hypertrophic cardiomyopathy in congenital hyperinsulinism. Acta Cardiol. 1999;54:359\u201361.","journal-title":"Acta Cardiol"},{"key":"1216_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/8904_2011_86","volume":"4","author":"EH Jeninga","year":"2012","unstructured":"Jeninga EH, de Vroede M, Hamers N, et al. A patient with congenital generalized lipodystrophy due to a novel mutation in BSCL2: indications for secondary mitochondrial dysfunction. JIMD Rep. 2012;4:47\u201354.","journal-title":"JIMD Rep"},{"key":"1216_CR22","doi-asserted-by":"publisher","first-page":"F351","DOI":"10.1136\/archdischild-2012-302546","volume":"98","author":"T Huang","year":"2013","unstructured":"Huang T, Kelly A, Becker SA, et al. Hypertrophic cardio- myopathy in neonates with congenital hyperinsulinism. Arch Dis Child Fetal Neonatal Ed. 2013;98:F351\u20134.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"1216_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000151643","volume":"94","author":"WW Hay Jr","year":"2008","unstructured":"Hay WW Jr. Strategies for feeding the preterm infant. Neonatology. 2008;94(4):245\u201354.","journal-title":"Neonatology"},{"issue":"10079","key":"1216_CR24","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1016\/S0140-6736(17)30552-4","volume":"389","author":"JE Harding","year":"2017","unstructured":"Harding JE, Cormack BE, Alexander T, Alsweiler JM, Bloomfield FH. Advances in nutrition of the newborn infant. Lancet. 2017;389(10079):1660\u20138.","journal-title":"Lancet"},{"issue":"4","key":"1216_CR25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000083863","volume":"87","author":"SM Ng","year":"2005","unstructured":"Ng SM, May JE, Emmerson AJ. Continuous insulin infusion in hyperglycaemic extremely-low-birth-weight neonates. Biol Neonate. 2005;87(4):269\u201372.","journal-title":"Biol Neonate"},{"issue":"5","key":"1216_CR26","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1542\/peds.2006-0628","volume":"118","author":"SP Hays","year":"2006","unstructured":"Hays SP, Smith EO, Sunehag AL. Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants. Pediatrics. 2006;118(5):1811\u20138.","journal-title":"Pediatrics"},{"issue":"11","key":"1216_CR27","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1001\/jamapediatrics.2015.1667","volume":"169","author":"HJ Stensvold","year":"2015","unstructured":"Stensvold HJ, Strommen K, Lang AM, Abrahamsen TG, Steen EK, Pripp AH, et al. Early enhanced parenteral nutrition, hyperglycemia, and death among extremely low-birth-weight infants. JAMA Pediatr. 2015;169(11):1003\u201310.","journal-title":"JAMA Pediatr"},{"key":"1216_CR28","first-page":"e45","volume":"44","author":"PJ Thureen","year":"1999","unstructured":"Thureen PJ. Early aggressive nutrition in the neonate. Neo Rev. 1999;44:e45\u201355.","journal-title":"Neo Rev"},{"issue":"3","key":"1216_CR29","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/MPG.0000000000000894","volume":"61","author":"C Aldana-Valenzuela","year":"2015","unstructured":"Aldana-Valenzuela C. Early aggressive nutrition in premature infants: is this the best approach? J Pediatr Gastroenterol Nutr. 2015;61(3):269\u201370.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1216_CR30","first-page":"74","volume":"91","author":"V Kairamkonda","year":"2006","unstructured":"Kairamkonda V. Does continuous insulin infusion improve glycaemic control and nutrition in hyperglycaemic very low birth weight infants? Arch Dis Child. 2006;91:74\u201383.","journal-title":"Arch Dis Child"},{"issue":"2","key":"1216_CR31","first-page":"123","volume":"16","author":"G Dawid","year":"2010","unstructured":"Dawid G, Wegrzynowski J, Kwiatek M, Biczysko-Mokosa A, Petriczko E, Horodnicka-Jozwa A. A fetal dilated and hypertrophic cardiomyopathy associated with maternal gestational diabetes--a case report. Pediatr Endocrinol Diabetes Metab. 2010;16(2):123\u20135.","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"issue":"12","key":"1216_CR32","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1111\/j.1651-2227.2008.01022.x","volume":"97","author":"M Chaudhari","year":"2008","unstructured":"Chaudhari M, Brodlie M, Hasan A. Hypertrophic cardiomyopathy and transposition of great arteries associated with maternal diabetes and presumed gestational diabetes. Acta Paediatr. 2008;97(12):1755\u20137.","journal-title":"Acta Paediatr"},{"key":"1216_CR33","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0022-3476(80)80862-6","volume":"96","author":"JA Breitweser","year":"1980","unstructured":"Breitweser JA, Meyer RA, Sperling MA, et al. Cardiac septal hypertrophy in hyperinsulinemic infants. J Pediatr. 1980;96:535\u20139.","journal-title":"J Pediatr"},{"issue":"5","key":"1216_CR34","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.yjmcc.2010.02.012","volume":"48","author":"M Kruger","year":"2010","unstructured":"Kruger M, Babicz K, von Frieling-Salewsky M, Linke WA. Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy. J Mol Cell Cardiol. 2010;48(5):910\u20136.","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"1216_CR35","first-page":"H787","volume":"291","author":"AM Samuelsson","year":"2006","unstructured":"Samuelsson AM, Bollano E, Mobini R, Larsson BM, Omerovic E, Fu M, et al. Hyperinsulinemia: effect on cardiac mass\/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Phys Heart Circ Phys. 2006;291(2):H787\u201396.","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"11","key":"1216_CR36","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.numecd.2009.01.008","volume":"19","author":"AS Moreira","year":"2009","unstructured":"Moreira AS, Teixeira Teixeira M, da Silveira OF, Pereira RO, de Oliveira S-JG, Garcia de Souza EP, et al. Left ventricular hypertrophy induced by overnutrition early in life. Nutr Metab Cardiovasc Dis. 2009;19(11):805\u201310.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"1216_CR37","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1590\/S0001-37652003000400006","volume":"75","author":"CA Mandarim-de-Lacerda","year":"2003","unstructured":"Mandarim-de-Lacerda CA. Stereological tools in biomedical research. Anais da Academia Brasileira de Ciencias. 2003;75(4):469\u201386.","journal-title":"Anais da Academia Brasileira de Ciencias"},{"issue":"12","key":"1216_CR38","doi-asserted-by":"publisher","first-page":"e50077","DOI":"10.1371\/journal.pone.0050077","volume":"7","author":"D Jankovic","year":"2012","unstructured":"Jankovic D, Winhofer Y, Promintzer-Schifferl M, Wohlschlager-Krenn E, Anderwald CH, Wolf P, et al. Effects of insulin therapy on myocardial lipid content and cardiac geometry in patients with type-2 diabetes mellitus. Plos One. 2012;7(12):e50077.","journal-title":"Plos One"},{"key":"1216_CR39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0002-9343(88)90398-1","volume":"85","author":"RS Bar","year":"1988","unstructured":"Bar RS, Boes M, Dake BL, et al. Insulin, insulin-like growth factors, and vascular endothelium. Am J Med. 1988;85:59\u201370.","journal-title":"Am J Med"},{"key":"1216_CR40","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1006\/jmcc.1999.1036","volume":"31","author":"J Ren","year":"1999","unstructured":"Ren J, Samson WK, Sowers JR. Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological im- plications in heart disease. J Mol Cell Cardiol. 1999;31:2049\u201361.","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"1216_CR41","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/eurheartj\/ehl416","volume":"28","author":"S Ullmo","year":"2007","unstructured":"Ullmo S, Vial Y, Di Bernardo S, Roth-Kleiner M, Mivelaz Y, Sekarski N, et al. Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study. Eur Heart J. 2007;28(11):1319\u201325.","journal-title":"Eur Heart J"},{"key":"1216_CR42","doi-asserted-by":"crossref","unstructured":"Topcuoglu S, Karatekin G, Yavuz T, Arman D, Kaya A, Gursoy T, Oval\u0131 F. The relationship between the oxidative stress and the cardiac hypertrophy in infants of diabetic mothers. Diab Res Clin Pract. 2015;109(1):104.","DOI":"10.1016\/j.diabres.2015.04.022"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-022-01216-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-022-01216-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-022-01216-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T17:14:35Z","timestamp":1666372475000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijponline.biomedcentral.com\/articles\/10.1186\/s13052-022-01216-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1216"],"URL":"https:\/\/doi.org\/10.1186\/s13052-022-01216-7","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,8]]},"assertion":[{"value":"2 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the family for the publication of this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24"}}