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Ursodeoxycholic acid could be beneficial in neonatal jaundice needing phototherapy.\u00a0<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We searched PubMed, EBSCO, ProQuest, and Cochrane Library up to August 21<jats:sup>st<\/jats:sup>, 2021, for articles to be reviewed. Meta-analysis using random-effects model was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eight studies involving 1116 neonates were chosen in this review; however, only five studies were included for meta-analysis. Phototherapy duration was significantly lower in the interventional group with high heterogeneities. Subgroup analysis of the phototherapy duration based on the risk of bias resulted in a shorter duration (mean difference (MD)\u2009=\u2009\u201317.82; 95% CI\u2009=\u2009\u201320.17 to \u201315.47; <jats:italic>p<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.001) with low heterogeneity in the treatment group. Secondary outcome focusing on mean total serum bilirubin showed a lower mean total serum bilirubin in 48\u00a0h post-treatment (MD\u2009=\u2009\u20130.43; 95% CI\u2009=\u2009\u20130.64 to \u20130.22; <jats:italic>p<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.0001) with low heterogeneities in Asian countries.\u201d<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Ursodeoxycholic acid might be considered as a novel adjuvant therapy in neonatal indirect hyperbilirubinemia to shorten the phototherapy duration and lower the mean total serum bilirubin.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-022-01372-w","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T10:02:45Z","timestamp":1666000965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of ursodeoxycholic acid in neonatal indirect hyperbilirubinemia: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1186","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-6146","authenticated-orcid":false,"given":"Glen","family":"Lazarus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrell","family":"Francie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-1069","authenticated-orcid":false,"given":"Rosalina Dewi","family":"Roeslani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-5616","authenticated-orcid":false,"given":"Siti Rizny Fitriana","family":"Saldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-5841","authenticated-orcid":false,"given":"Hanifah","family":"Oswari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"issue":"8","key":"1372_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","volume":"2","author":"BO Olusanya","year":"2018","unstructured":"Olusanya BO, Kaplan M, Hansen TWR. 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