{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:32:24Z","timestamp":1789957944099,"version":"4.0.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Congenital cytomegalovirus (cCMV) infection, resulting from non-primary maternal infection or reactivation during pregnancy, can cause serious fetal abnormalities, complications in the immediate neonatal period, and severe sequelae later in childhood. Maternal non-primary cytomegalovirus infection in pregnancy is transmitted to the fetus in 0.5-2% of cases (1).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>An African full term male newbornwas delivered by emergency caesarean section. Due to signs of asphyxia at birth and clinical moderate encephalopathy, he underwent therapeutic hypothermia. Continuous full video-electroencephalography monitoring showed no seizures during the first 72\u00a0h, however, soon after rewarming, he presented refractory status epilepticus due to an intracranial hemorrhage, related to severe thrombocytopenia. The patient also presented signs of sepsis (hypotension and signs of reduced perfusions). An echocardiography revealed severe cardiac failure with an ejection fraction of 33% and signs suggestive of cardiomyopathy. Research for CMV DNA Polymerase Chain Reaction (PCR) on urine, blood, cerebrospinal fluid, and nasopharyngeal secretions was positive.The mother had positive CMV IgG with negative IgM shortly before pregnancy. Serology for CMV was therefore not repeated during pregnancy, but CMV DNA performed on the Guthrie bloodspot taken at birth yielded a positive result, confirming the intrauterine transmission and congenital origin of the infection. The baby was discharged in good general condition and follow up showed a normal neurodevelopmental outcome at 9 months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although uncommon, congenital cytomegalovirus infection should be included in the differential diagnosis of intraventricular hemorrhage and cardiomyopathy. Furthermore, this case highlights the possible severity of congenital cytomegalovirus infection, even in cases of previous maternal immunity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-024-01637-6","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T15:13:02Z","timestamp":1713280382000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual cerebral intraventricular hemorrhage and cardiomyopathy related to congenital cytomegalovirus from non-primary maternal infection: a case report"],"prefix":"10.1186","volume":"50","author":[{"given":"Victoria","family":"Malherbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Celen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Carkeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Carapancea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Auriti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Piersigilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"1637_CR1","unstructured":"Schutze GE, Jacobs RF. Nelson Textbook of Pediatrics. 20th ed. 2015. pp. 1590\u20131594."},{"key":"1637_CR2","unstructured":"Townsend CL. 176 neonati con cCMV; 16 da infezione non primaria, 9\/16 esiti neurologici. Clin Infect Dis 2013."},{"key":"1637_CR3","unstructured":"Simonazzi G. 205 neonati, 30 da madri con infezione non primaria certa. 2\/30 esiti gravi. Fetal Diagn Ther; 2018."},{"key":"1637_CR4","doi-asserted-by":"publisher","first-page":"104518","DOI":"10.1016\/j.jcv.2020.104518","volume":"129","author":"PG Maltezou","year":"2020","unstructured":"Maltezou PG, Kourlaba G, Kourkouni \u0395, Luck S, Bl\u00e1zquez-Gamero D, Ville Y, et al. Maternal type of CMV infection and sequelae in infants with congenital CMV: systematic review and meta-analysis. J Clin Virol. 2020;129:104518. https:\/\/doi.org\/10.1016\/j.jcv.2020.104518. Epub 2020 Jun 27. PMID: 32622333.","journal-title":"J Clin Virol"},{"issue":"8","key":"1637_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/v10080405","volume":"10","author":"WJ Britt","year":"2018","unstructured":"Britt WJ. Maternal immunity and the natural history of congenital human cytomegalovirus infection. Viruses. 2018;10(8):405. https:\/\/doi.org\/10.3390\/v10080405","journal-title":"Viruses"},{"key":"1637_CR6","doi-asserted-by":"publisher","unstructured":"Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007 Jul-Aug;17(4):253\u2013\u200976. https:\/\/doi.org\/10.1002\/rmv.535. PMID: 17579921.","DOI":"10.1002\/rmv.535"},{"issue":"10","key":"1637_CR7","doi-asserted-by":"publisher","first-page":"e0240172","DOI":"10.1371\/journal.pone.0240172","volume":"15","author":"GJ Demmler-Harrison","year":"2020","unstructured":"Demmler-Harrison GJ, Miller JA, Houston Congenital Cytomegalovirus Longitudinal Study Group. Maternal cytomegalovirus immune status and hearing loss outcomes in congenital cytomegalovirus-infected offspring. PLoS ONE. 2020;15(10):e0240172. https:\/\/doi.org\/10.1371\/journal.pone.0240172. PMID: 33035237; PMCID: PMC7546493.","journal-title":"PLoS ONE"},{"issue":"1","key":"1637_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-020-4941-z","volume":"20","author":"L Pellegrinelli","year":"2020","unstructured":"Pellegrinelli L, Alberti L, Pariani E, Barbi M, Binda S. Diagnosing congenital cytomegalovirus infection: don\u2019t get rid of dried blood spots. BMC Infect Dis. 2020;20(1):1\u20135.","journal-title":"BMC Infect Dis"},{"issue":"3","key":"1637_CR9","doi-asserted-by":"publisher","first-page":"e205441","DOI":"10.1001\/jamapediatrics.2020.5441","volume":"175","author":"SC Dollard","year":"2021","unstructured":"Dollard SC, Dreon M, Hernandez-Alvarado N, Amin MM, Wong P, Lanzieri TM, et al. Sensitivity of dried blood spot testing for detection of congenital cytomegalovirus infection. JAMA Pediatr. 2021;175(3):e205441. https:\/\/doi.org\/10.1001\/jamapediatrics.2020.5441. Epub 2021 Mar 1. PMID: 33523119; PMCID: PMC7851756.","journal-title":"JAMA Pediatr"},{"key":"1637_CR10","doi-asserted-by":"crossref","unstructured":"Michelle Barton A, Michael Forrester JM. Soci\u00e9t\u00e9 canadienne de p\u00e9diatrie, comit\u00e9 des maladies infectieuses et d\u2019immunisation (Ontario). Mise \u00e0 jour sur l\u2019infection cong\u00e9nitale \u00e0 cytom\u00e9galovirus: la pr\u00e9vention pr\u00e9natale, le diagnostic n\u00e9onatal et la prise en charge. Paediatr Child Health. 2020.","DOI":"10.1093\/pch\/pxaa084"},{"issue":"10","key":"1637_CR11","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1056\/NEJMoa1404599","volume":"372","author":"DW Kimberlin","year":"2015","unstructured":"Kimberlin DW, Jester PM, S\u00e1nchez PJ, Ahmed A, Arav-Boger R, Michaels MG, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group, et al. Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med. 2015;372(10):933\u201343. https:\/\/doi.org\/10.1056\/NEJMoa1404599. PMID: 25738669; PMCID: PMC4401811.","journal-title":"N Engl J Med"},{"issue":"12","key":"1637_CR12","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1097\/INF.0000000000001763","volume":"36","author":"SE Luck","year":"2017","unstructured":"Luck SE, Wieringa JW, Bl\u00e1zquez-Gamero D, Henneke P, Schuster K, Butler K, et al. Congenital cytomegalovirus a European expert consensus statement on diagnosis and management. Pediatr Infect Dis J. 2017;36(12):1205\u201313.","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"1637_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.12659\/PJR.883379","volume":"77","author":"A Cabaj","year":"2012","unstructured":"Cabaj A, Bekiesi\u0144ska-Figatowska M, Madzik J. MRI patterns of hypoxic-ischemic brain injury in preterm and full term infants - classical and less common MR findings. Pol J Radiol. 2012;77(3):71\u20136.","journal-title":"Pol J Radiol"},{"key":"1637_CR14","doi-asserted-by":"publisher","unstructured":"Stoykova Z, Ivanova L, Cvetkova S, Yordanova D. Congenital Cytomegalovirus Infection - Lessons from a Clinical Case. Folia Med (Plovdiv). 2020;62(2):403\u2013407. https:\/\/doi.org\/10.3897\/folmed.62.e49840. PMID: 32666770.","DOI":"10.3897\/folmed.62.e49840"},{"key":"1637_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3389\/fped.2017.00134","volume":"5","author":"I Mack","year":"2017","unstructured":"Mack I, Burckhardt MA, Heininger U, Pr\u00fcfer F, Schulzke S, Wellmann S. Symptomatic congenital cytomegalovirus infection in children of Seropositive Women. Front Pediatr. 2017;5:134. https:\/\/doi.org\/10.3389\/fped.2017.00134. PMID: 28649563; PMCID: PMC5465240.","journal-title":"Front Pediatr"},{"key":"1637_CR16","doi-asserted-by":"crossref","unstructured":"Arnouts L, Van Mechelen K, Laroche S, Meuwissen M, Boudewyns A, Martens M, Mahieu L. Non-primary CMV infection not always innocent. A case-report and literature review. Acta Clin Belg. 2022;77(1):96\u2013100. doi: 10.1080\/17843286.2020.1773651. Epub 2020 Jun 3. PMID: 32491959.","DOI":"10.1080\/17843286.2020.1773651"},{"key":"1637_CR17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41420-023-01408-y","volume":"9","author":"SK Yadav","year":"2023","unstructured":"Yadav SK, Gawargi FI, Hasan MH, et al. Differential effects of CMV infection on the viability of cardiac cells. Cell Death Discov. 2023;9:111. https:\/\/doi.org\/10.1038\/s41420-023-01408-y","journal-title":"Cell Death Discov"},{"issue":"2","key":"1637_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.carpath.2008.12.001","volume":"19","author":"J Ritter","year":"2010","unstructured":"Ritter J, Tang-Feldman Y, Lochhead R, Estrada M, Lochhead S, Yu C, et al. In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. Cardiovasc Pathol. 2010;19(2):83\u201393. https:\/\/doi.org\/10.1016\/j.carpath.2008.12.001","journal-title":"Cardiovasc Pathol"},{"issue":"14","key":"1637_CR19","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1001\/jama.2010.423","volume":"303","author":"SB Boppana","year":"2010","unstructured":"Boppana SB, Ross SA, Novak Z, et al. Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. JAMA. 2010;303(14):1375\u201382. https:\/\/doi.org\/10.1001\/jama.2010.423","journal-title":"JAMA"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-024-01637-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-024-01637-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-024-01637-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T15:16:17Z","timestamp":1713280577000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijponline.biomedcentral.com\/articles\/10.1186\/s13052-024-01637-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,16]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1637"],"URL":"https:\/\/doi.org\/10.1186\/s13052-024-01637-6","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,16]]},"assertion":[{"value":"4 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient\u2019s parents for publication of this case report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"71"}}