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Arachidonate 15-lipoxygenase (ALOX-15) controls production of endogenous lipid mediators, including lipoxins that regulate airway inflammation. Mutations at various positions in ALOX-15 gene can influence airway disease development. We investigated association between <jats:italic>ALOX-15,c.-292\u00a0C\u2009&gt;\u2009T <\/jats:italic>gene polymorphism and bronchiectasis unrelated to cystic fibrosis in Egyptian children. Also, lipoxin A4 (LXA4) level in bronchoalveolar lavage (BAL) was studied in relation to polymorphism genotypes and disease phenotypes determined by clinical, pulmonary functions, and radiological severity parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was an exploratory study that included 60 participants. Thirty children with non-cystic fibrosis bronchiectasis (NCFB) were compared with 30 age and sex-matched controls. <jats:italic>ALOX-15,c.-292\u00a0C\u2009&gt;\u2009T <\/jats:italic>polymorphism was genotyped using TaqMan-based Real-time PCR. LXA4 was measured in BAL using ELISA method.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was no significant difference between patients and controls regarding <jats:italic>ALOX-15,c.-292\u00a0C\u2009&gt;\u2009T<\/jats:italic> polymorphism genotypes and alleles (OR\u2009=\u20091.75; 95% CI (0.53\u20135.7), <jats:italic>P<\/jats:italic>\u2009=\u20090.35) (OR\u2009=\u20091; 95% CI (0.48-2), <jats:italic>p<\/jats:italic>\u2009=\u20091). BAL LXA4 level was significantly lower in patients, median (IQR) of 576.9 (147.6\u20131510) ng\/ml compared to controls, median (IQR) of 1675 (536.8\u20132542) (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Patients with severe bronchiectasis had a significantly lower LXA4 level (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were significant correlations with exacerbations frequency (<jats:italic>r<\/jats:italic>=-0.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and FEV1% predicted (<jats:italic>r<\/jats:italic>\u2009=\u20090.64, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Heterozygous <jats:italic>CT <\/jats:italic>genotype carriers showed higher LXA4 levels compared to other genotypes(<jats:italic>p<\/jats:italic>\u2009=\u20090.005).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Low airway LXA4 in children with NCFB is associated with severe disease phenotype and lung function deterioration. <jats:italic>CT <\/jats:italic>genotype of <jats:italic>ALOX-15,c.-292 C &gt; T <\/jats:italic>polymorphism might be a protective genetic factor against bronchiectasis development and\/or progression due to enhanced LXA4 production.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-024-01654-5","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T15:01:58Z","timestamp":1714402918000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between arachidonate lipoxygenase 15,c.-292\u00a0C\u2009&gt;\u2009T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype"],"prefix":"10.1186","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-9291","authenticated-orcid":false,"given":"Mahitab Morsy","family":"Hussein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman Mahmoud","family":"Fouda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Shehab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas Samir","family":"Nabih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mohamed","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally Raafat","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"1654_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.pedneo.2019.09.013","volume":"61","author":"M Poeta","year":"2020","unstructured":"Poeta M, Maglione M, Borrelli M, Santamaria F. 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Approval was granted by Research Ethics Committee of human experimentation, Faculty of Medicine, Ain shams university (FMASU MD 270\/2020). Informed consent was obtained from participants or their legal guardians before enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent for publication"}},{"value":"All data generated or analyzed during this study are included in this published article or its supplementary information file.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availablity"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}