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This investigation delineated the spectrum and sequelae of MSK involvement in c-SLE patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective analysis included SLE patients aged\u2009\u2264\u200918\u00a0years treated at a tertiary center between 2009 and 2019. Data were extracted from electronic health records.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The cohort comprised 321 SLE patients (mean age 13.2\u2009\u00b1\u20092.5\u00a0years, 91.3% female). MSK manifestations were observed in 134 (41.7%) individuals, with joint pain universally present, followed by joint swelling in 32.1% and morning stiffness in 9.7%. Arthritis was documented in 52 (38.8%) patients, whereas 82 (61.2%) had arthralgia. Symmetrical joint involvement was observed in 96 (71.7%) subjects. The knees, wrists, and fingers were most commonly affected, with incidences of 43.3%, 40.3%, and 33.6%, respectively. Neither erosive arthritis nor Jaccoud\u2019s arthropathy was detected. MSK symptoms were significantly correlated with older age at diagnosis, the presence of non-scarring alopecia, neuropsychiatric manifestations, and elevated SLE disease activity index scores at diagnosis. Over a median follow-up of 53.6\u00a0months (IQR 26.1\u201384.6), five patients developed septic arthritis or osteomyelitis, and avascular necrosis was identified in 16 (4.9%) patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Nearly half of c-SLE patients demonstrated MSK manifestations, chiefly characterized by symmetrical involvement of both large and small joints without evidence of erosive arthritis or Jaccoud\u2019s arthropathy. Avascular necrosis is a critical concern and warrants close monitoring.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13052-024-01725-7","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T15:02:40Z","timestamp":1723820560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Musculoskeletal manifestations in childhood-onset systemic lupus erythematosus: an in-depth exploration"],"prefix":"10.1186","volume":"50","author":[{"given":"Maynart","family":"Sukharomana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siritida","family":"Vonginyoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuntawan","family":"Piyaphanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0506-6039","authenticated-orcid":false,"given":"Sirirat","family":"Charuvanij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"1725_CR1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1191\/0961203303lu2021oa","volume":"13","author":"A Zoma","year":"2004","unstructured":"Zoma A. 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