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We intended to investigate the demographic and clinical features of pediatric patients with headache and\/or dizziness and responses to head-up tilt test (HUTT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The demographic data and medical records of children and adolescents, with a primary complaint of headache and\/or dizziness and undergoing HUTT between January 2001 and June 2023, were retrospectively reviewed and analyzed. Children and adolescents with headache and\/or dizziness secondary to fever, trauma, or other obvious etiology were excluded. For those with positive responses to HUTT, the symptom score and HUTT responses were collected after treatment at follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among 2709 patients with unexplained headache and\/or dizziness, 1080 (39.87%) cases presented positive responses to HUTT, whereas 1629 (60.13%) cases had negative responses. Among patients with positive responses, 930 (34.33%) cases presented a response of vasovagal syncope, 143 (5.28%) cases of postural orthostatic tachycardia syndrome, and 7 (0.26%) cases of orthostatic hypertension. Multivariate Logistic regression analysis demonstrated that females, older age, and low body mass index percentile increased the risk of being positive responses. At follow-up, HUTT results of 236 patients were collected, among which 131 (55.51%) cases turned negative HUTT responses and had headache\/dizziness symptoms improved after treatment targeted autonomic dysfunction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>HUTT can be applied to evaluate the autonomic function of children and adolescents with headache and\/or dizziness and assess the treatment responses in those patients with autonomic dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13052-025-01976-y","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:34:03Z","timestamp":1748468043000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Demographic and clinical characteristics of children and adolescents with headache and\/or dizziness and hemodynamic responses to head-up tilt test"],"prefix":"10.1186","volume":"51","author":[{"given":"Runmei","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-0654","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"8","key":"1976_CR1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s13312-013-0213-y","volume":"50","author":"D Mishra","year":"2013","unstructured":"Mishra D, Sharma A, Juneja M, Singh K. 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All participants or their responsible guardians were asked for and gave their written consent after being informed about the nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Studies involving animals must include a statement on ethics approval"}},{"value":"The authors declare that they have no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"161"}}