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Patients were categorized into a DSAI group (33 cases) and a non-DSAI group (98 cases). Data analyzed included age, gender, pediatric intensive care unit (PICU) admission, surgical delay, initial symptoms, highest pre-hospital fever, inflammatory markers, pathogen type (MSSA\/MRSA), bacteremia, antibiotic duration, postoperative fever length, surgeries (\u2265\u20092), hospital stay, and prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>DSAI primarily affected the lungs, brain, and thorax, with femur and hip joints being the most involved OAI sites. Fever (45.45%) and limb swelling\/pain (42.42%) were common symptoms. The DSAI group showed significantly higher CRP levels, bacteremia incidence, MRSA infections, PICU admissions, surgical delays, \u2265\u20092 surgeries, longer postoperative fever, prolonged hospital stays, and worse prognosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No significant differences were found in age, gender, pre-admission time, initial symptoms, highest fever, WBC count, ESR, antibiotic duration, or neutrophil percentage (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Logistic regression identified bacteremia (OR: 32.232, 95% CI: [2.558-406.068], <jats:italic>P<\/jats:italic>\u2009=\u20090.007), CRP\u2009&gt;\u2009162.375\u00a0mg\/L (OR: 7.499, 95% CI: [2.044\u201327.513], <jats:italic>P<\/jats:italic>\u2009=\u20090.002), and surgical delay\u2009&gt;\u20099.50 days (OR: 7.462, 95% CI: [1.828\u201330.459], <jats:italic>P<\/jats:italic>\u2009=\u20090.005) as independent risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>DSAI complicates OAI, leading to a severe course and poor prognosis. High vigilance and early intervention are crucial for pediatric patients with these risk factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13052-025-02007-6","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:38:05Z","timestamp":1748468285000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of clinical characteristics and risk factors for Staphylococcus aureus disseminated infection secondary to acute osteoarticular infections in children"],"prefix":"10.1186","volume":"51","author":[{"given":"Yingtie","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"3","key":"2007_CR1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.idc.2015.05.012","volume":"29","author":"JC Arnold","year":"2015","unstructured":"Arnold JC, Bradley JS. 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