{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:12:34Z","timestamp":1748491954879,"version":"3.41.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007950","name":"Tanta University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007950","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Lysosomal storage disorders (LSDs) result from an accumulation of specific substrates, due to the inability to break them down leading to cellular dysfunction in multiple organs, including the heart constituting an important and treatable cause of cardiomyopathy. Given the role of oxidative stress in many inborn errors of metabolism, many studies are evaluating oxidative stress and hence the role of antioxidants in patients with LSDs. The aim of this study: was to study the possible effects of Coenzyme Q10 as a cardioprotective and an antioxidant drug in patients with LSDs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This study was a prospective case-control study conducted on 30 patients with LSDs and an equal number of healthy subjects of matched age and sex served as a control group at the unit of Medical Genetics and inborn errors of metabolism at the Pediatric Department of Tanta University Hospital. All subjects included were subjected to full history taking, complete physical examination, assessing serum level of N-terminal pro-brain natriuretic peptide (NT-proBNP) &amp; serum malondialdehyde (MDA), along with comprehensive cardiac evaluation that was done using tissue doppler imaging and speckling tracking echo. Then the patient group was subdivided into two subgroups, half of the patients received Co enzyme Q10 (CoQ10) while the other half received a placebo for 24 weeks followed by cardiac evaluation and reassessment of serum MDA and NT-proBNP for both patient subgroups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Patients with LSDs had significantly higher levels of serum MDA than controls denoting higher oxidative stress, <jats:italic>P<\/jats:italic>-value\u2009&lt;\u20090.001. CoQ10 resulted in significant beneficial reduction of serum MDA (15%) &amp;NT-proBNP (30%) in the group of patients who received CoQ10, <jats:italic>P<\/jats:italic>-value\u2009&lt;\u20090.001 and improvement of cardiac functional parameters in patients with LSDs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These findings suggest that CoQ10 may have a role in reducing oxidative stress and so may prevent the development of cardiomyopathy in patients with LSDs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>This study was performed after approval from the Ethical Committee, Faculty of Medicine, Tanta University, Egypt (approval code 33255\/07\/19) and after obtaining written informed consent from children guardians. Also, this trial was registered on Pan African clinical trials registry with the number PACTR, \u2018PACTR202107466690046\u2019. Registered 04 July 2021.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13052-025-02008-5","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:40:34Z","timestamp":1748468434000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardioprotective effects of CoQ10 in pediatric patients with lysosomal storage disorders"],"prefix":"10.1186","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-7875","authenticated-orcid":false,"given":"Yasmine","family":"Abuzaid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada Abdul Moemn","family":"Suliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama Abd Rab El Rasool","family":"Toulba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abd El Basset Abo","family":"Elezz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alshimaa","family":"Badraldeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Dawoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"45","key":"2008_CR1","doi-asserted-by":"publisher","first-page":"34304","DOI":"10.1074\/jbc.C110.165480","volume":"285","author":"JL Eichelsdoerfer","year":"2010","unstructured":"Eichelsdoerfer JL, Evans JA, Slaugenhaupt SA, Cuajungco MP. Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel. J Biol Chem. 2010;285(45):34304\u20138.","journal-title":"J Biol Chem"},{"issue":"1","key":"2008_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1750-1172-5-16","volume":"5","author":"MT Vanier","year":"2010","unstructured":"Vanier MT. Niemann-Pick disease type C. Orphanet J Rare Dis. 2010;5(1):16.","journal-title":"Orphanet J Rare Dis"},{"key":"2008_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/B978-0-12-394447-4.20019-9","volume":"2","author":"R Shrestha","year":"2016","unstructured":"Shrestha R, Kaplan J, Ward DM. Conventional and secretory lysosomes. Encyclopedia Cell Biology. 2016;2:225\u201334.","journal-title":"Encyclopedia Cell Biology"},{"issue":"1","key":"2008_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.gene.2014.09.054","volume":"555","author":"MF Coutinho","year":"2015","unstructured":"Coutinho MF, Matos L, Alves S. From bedside to cell biology: A century of history on lysosomal dysfunction. Gene. 2015;555(1):50\u20138.","journal-title":"Gene"},{"key":"2008_CR5","doi-asserted-by":"crossref","unstructured":"Nair V, Belanger EC, Veinot JP. Lysosomal storage disorders affecting the heart: a review. Cardiovascular Pathology. 2019;39(2019):12\u201324.","DOI":"10.1016\/j.carpath.2018.11.002"},{"issue":"2014","key":"2008_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijchv.2013.10.002","volume":"2","author":"P Mueller","year":"2013","unstructured":"Mueller P, Attenhofer Jost CH, Rohrbach M, Valsangiacomo Buechel ER, Seifert B, Balmer C, et al. Cardiac disease in children and young adults with various lysosomal storage diseases: comparison of echocardiographic and ECG changes among clinical groups. IJC Heart Vessels. 2013;2(2014):1\u20137.","journal-title":"IJC Heart Vessels"},{"issue":"2","key":"2008_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s40142-018-0135-z","volume":"6","author":"DA Laney","year":"2018","unstructured":"Laney DA, Gupta D, Wechsler SB. Getting to the heart of the matter: lysosomal storage diseases that manifest a cardiac phenotype. Curr Genet Med Rep. 2018;6(2):28\u201342.","journal-title":"Curr Genet Med Rep"},{"issue":"2","key":"2008_CR8","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4274\/jpr.galenos.2018.21548","volume":"6","author":"E Canda","year":"2019","unstructured":"Canda E, K\u00f6se M, Ka\u011fn\u0131c\u0131 M, Dondurmac\u0131 M, U\u00e7ar SK, S\u00f6zmen E, et al. Evaluation of cardiovascular involvement and cytokine levels in patients with mucopolysaccharidosis. J Pediatr Res. 2019;6(2):121\u20138.","journal-title":"J Pediatr Res"},{"key":"2008_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cca.2017.01.007","volume":"466","author":"B Donida","year":"2017","unstructured":"Donida B, Jacques CED, Mescka CP, Rodrigues DGB, Marchetti DP, Ribas G, et al. Oxidative damage and redox in lysosomal storage disorders: biochemical markers. Clin Chim Acta. 2017;466:46\u201353.","journal-title":"Clin Chim Acta"},{"issue":"8","key":"2008_CR10","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.3390\/jcm9082596","volume":"9","author":"KM Stepien","year":"2020","unstructured":"Stepien KM, Roncaroli F, Turton N, Hendriksz CJ, Roberts M, Heaton RA, et al. Mechanisms of mitochondrial dysfunction in lysosomal storage disorders: A review. J Clin Med. 2020;9(8):2596.","journal-title":"J Clin Med"},{"key":"2008_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cca.2015.08.002","volume":"450","author":"YK Yang","year":"2015","unstructured":"Yang YK, Wang LP, Chen L, Yao XP, Yang KQ, Gao LG, et al. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin Chim Acta. 2015;450:83\u20139.","journal-title":"Clin Chim Acta"},{"issue":"18","key":"2008_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21186695","volume":"21","author":"I Hargreaves","year":"2020","unstructured":"Hargreaves I, Heaton RA, Mantle D. Disorders of human coenzyme q10 metabolism: an overview. Int J Mol Sci. 2020;21(18):1\u201313.","journal-title":"Int J Mol Sci"},{"issue":"3\u20134","key":"2008_CR13","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000046889","volume":"10","author":"M Ebadi","year":"2001","unstructured":"Ebadi M, Govitrapong P, Sharma S, Muralikrishnan D, Shavali S, Pellett L, et al. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of Parkinson\u2019s disease. Neurosignals. 2001;10(3\u20134):224\u201353.","journal-title":"Neurosignals"},{"issue":"1\u20132","key":"2008_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bbamem.2003.11.012","volume":"1660","author":"M Turunen","year":"2004","unstructured":"Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Et Biophys Acta (BBA)-Biomembranes. 2004;1660(1\u20132):171\u201399.","journal-title":"Biochim Et Biophys Acta (BBA)-Biomembranes"},{"issue":"3","key":"2008_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s10545-013-9668-1","volume":"37","author":"L Matalonga","year":"2014","unstructured":"Matalonga L, Arias A, Coll MJ, Garcia-Villoria J, Gort L, Ribes A. Treatment effect of coenzyme Q 10 and an antioxidant cocktail in fibroblasts of patients with Sanfilippo disease. J Inherit Metab Dis. 2014;37(3):439\u201346.","journal-title":"J Inherit Metab Dis"},{"key":"2008_CR16","first-page":"1","volume":"11","author":"H Li","year":"2016","unstructured":"Li H, Yin X, Sun D, Xia K, Kang C, Chu S, et al. Sensing and Bio-Sensing research detection of NT-pro BNP using Fl uorescent protein modi Fi ed by Streptavidin as a label in immunochromatographic assay. SBSR. 2016;11:1\u20137.","journal-title":"SBSR"},{"issue":"7352","key":"2008_CR17","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1136\/bmj.324.7352.1498","volume":"324","author":"FDR Hobbs","year":"2002","unstructured":"Hobbs FDR, Davis RC, Roalfe AK, Hare R, Davies MK, Kenkre JE. Reliability of N-terminal pro-brain natriuretic peptide assay in diagnosis of heart failure: cohort study in representative and high risk community populations. BMJ. 2002;324(7352):1498.","journal-title":"BMJ"},{"issue":"1\u20132","key":"2008_CR18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0005-2760(94)90100-7","volume":"1215","author":"K Kotani","year":"1994","unstructured":"Kotani K, Maekawa M, Kanno T, Kondo A, Toda N, Manabe M. Distribution of immunoreactive malondialdehyde-modified low-density lipoprotein in human serum. Biochim Biophys Acta. 1994;1215(1\u20132):121\u20135.","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"2008_CR19","first-page":"CD004426","volume":"2012","author":"G Pfeffer","year":"2012","unstructured":"Pfeffer G, Majamaa K, Turnbull DM, Thorburn D, Chinnery PF. Treatment for mitochondrial disorders. Cochrane Database Syst Rev. 2012;2012(4):CD004426.","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"2008_CR20","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1017\/S1047951121000226","volume":"31","author":"A Badreldeen","year":"2021","unstructured":"Badreldeen A, El Razaky O, Erfan A, El-Bendary A, El Amrousy D. Comparative study of the efficacy of Captopril, Simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial. Cardiol Young. 2021;31(8):1315\u201322.","journal-title":"Cardiol Young"},{"issue":"7","key":"2008_CR21","doi-asserted-by":"publisher","first-page":"e29496","DOI":"10.1002\/pbc.29496","volume":"69","author":"D El Amrousy","year":"2022","unstructured":"El Amrousy D, El-Afify D, Khedr R, Ibrahim AM. Omega 3 fatty acids can reduce early doxorubicin\u2010induced cardiotoxicity in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2022;69(7):e29496.","journal-title":"Pediatr Blood Cancer"},{"issue":"12","key":"2008_CR22","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"RM Lang","year":"2005","unstructured":"Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American society of echocardiography\u2019s guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European association of echocardiograp. J Am Soc Echocardiogr. 2005;18(12):1440\u201363.","journal-title":"J Am Soc Echocardiogr"},{"issue":"8","key":"2008_CR23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.recesp.2013.12.011","volume":"67","author":"G Kocabay","year":"2014","unstructured":"Kocabay G, Muraru D, Peluso D, Cucchini U, Mihaila S, Padayattil-Jose S, et al. Normal left ventricular mechanics by two-dimensional speckle-tracking echocardiography. Reference values in healthy adults. Rev Esp Cardiol (Engl Ed). 2014;67(8):651\u20138.","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"8","key":"2008_CR24","doi-asserted-by":"publisher","first-page":"572","DOI":"10.3109\/07853890008998837","volume":"32","author":"K Frank","year":"2000","unstructured":"Frank K, Kranias EG. Phospholamban and cardiac contractility. Ann Med. 2000;32(8):572\u20138.","journal-title":"Ann Med"},{"issue":"11","key":"2008_CR25","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1074\/jbc.M114.630319","volume":"290","author":"N Abrol","year":"2015","unstructured":"Abrol N, de Tombe PP, Robia SL. Acute inotropic and lusitropic effects of cardiomyopathic R9C mutation of phospholamban. J Biol Chem. 2015;290(11):7130\u201340.","journal-title":"J Biol Chem"},{"issue":"1","key":"2008_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13395-021-00280-7","volume":"11","author":"H Xu","year":"2021","unstructured":"Xu H, Van Remmen H. The sarcoendoplasmic reticulum calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies. Skelet Muscle. 2021;11(1):25.","journal-title":"Skelet Muscle"},{"issue":"6","key":"2008_CR27","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.3390\/jcm9061923","volume":"9","author":"RA Heaton","year":"2020","unstructured":"Heaton RA, Heales S, Rahman K, Sexton DW, Hargreaves I. The effect of cellular coenzyme Q10 deficiency on lysosomal acidification. J Clin Med. 2020;9(6):1923.","journal-title":"J Clin Med"},{"key":"2008_CR28","doi-asserted-by":"crossref","unstructured":"Maladkar M. Coenzyme Q10: the cardiac Bio-energizer in cardiovascular diseases. J Cardiol Cardiovasc Ther. 2016;1(2).","DOI":"10.19080\/JOCCT.2016.01.555560"},{"issue":"3\u20134","key":"2008_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000360101","volume":"5","author":"J Garrido-Maraver","year":"2014","unstructured":"Garrido-Maraver J, Cordero MD, Oropesa-\u00c1vila M, Fern\u00e1ndez Vega A, De La Mata M, Delgado Pav\u00f3n A, et al. Coenzyme Q10 therapy. Mol Syndromol. 2014;5(3\u20134):187\u201397.","journal-title":"Mol Syndromol"},{"issue":"2","key":"2008_CR30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.atherosclerosis.2011.10.027","volume":"221","author":"L Gao","year":"2012","unstructured":"Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L. Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials. Atherosclerosis. 2012;221(2):311\u20136.","journal-title":"Atherosclerosis"},{"issue":"2","key":"2008_CR31","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.molmed.2016.12.003","volume":"23","author":"N Plotegher","year":"2017","unstructured":"Plotegher N, Duchen MR. Mitochondrial dysfunction and neurodegeneration in lysosomal storage disorders. Trends Mol Med. 2017;23(2):116\u201334.","journal-title":"Trends Mol Med"},{"key":"2008_CR32","doi-asserted-by":"crossref","unstructured":"Navas P, Cascajo MV, Alc\u00e1zar-Fabra M, Hern\u00e1ndez-Camacho JD, S\u00e1nchez-Cuesta A, Rodr\u00edguez ABC et al. Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging. Vol. 47, BioFactors. John Wiley and Sons Inc 2021;551\u201369.","DOI":"10.1002\/biof.1733"},{"key":"2008_CR33","unstructured":"Horman V, Hargreaves I. Secondary coenzyme Q10 deficiency: Causes and consequence. In: Coenzyme Q10: Uses, Health Effects and Role in Disease. 2018;89\u2013110."},{"key":"2008_CR34","unstructured":"Singh Z, Karthigesu IP, Singh P. Kaur R. Use of malondialdehyde as a biomarker for assessing oxidative stress in different disease pathologies: a review. Iran J Public Health. 2015;43(Supple 3 SE-Review Article(s))."},{"key":"2008_CR35","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1590\/S0100-40422009000100032","volume":"32","author":"D Grotto","year":"2009","unstructured":"Grotto D, Maria LS, Valentini J, Paniz C, Schmitt G, Garcia SC, et al. Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification. Quim Nova. 2009;32:169\u201374.","journal-title":"Quim Nova"},{"issue":"2","key":"2008_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ymgme.2011.02.016","volume":"103","author":"L Filippon","year":"2011","unstructured":"Filippon L, Vanzin CS, Biancini GB, Pereira IN, Manfredini V, Sitta A, et al. Oxidative stress in patients with mucopolysaccharidosis type II before and during enzyme replacement therapy. Mol Genet Metab. 2011;103(2):121\u20137.","journal-title":"Mol Genet Metab"},{"issue":"December","key":"2008_CR37","first-page":"100667","volume":"25","author":"RV Kartha","year":"2020","unstructured":"Kartha RV, Terluk MR, Brown R, Travis A, Mishra UR, Rudser K, et al. Patients with gaucher disease display systemic oxidative stress dependent on therapy status. Mol Genet Metab Rep. 2020;25(December):100667.","journal-title":"Mol Genet Metab Rep"},{"issue":"31","key":"2008_CR38","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.2174\/1381612824666181112112857","volume":"24","author":"M Bakhshayeshkaram","year":"2018","unstructured":"Bakhshayeshkaram M, Lankarani KB, Mirhosseini N, Tabrizi R, Akbari M, Dabbaghmanesh MH, et al. The effects of coenzyme Q10 supplementation on metabolic profiles of patients with chronic kidney disease: A systematic review and Meta-analysis of randomized controlled trials. Curr Pharm Des. 2018;24(31):3710\u201323.","journal-title":"Curr Pharm Des"},{"issue":"3","key":"2008_CR39","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.pharmthera.2009.07.003","volume":"124","author":"A Kumar","year":"2009","unstructured":"Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther. 2009;124(3):259\u201368.","journal-title":"Pharmacol Ther"},{"issue":"2","key":"2008_CR40","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/antiox10020276","volume":"10","author":"Q Chen","year":"2021","unstructured":"Chen Q, Qi S, Hocum-Stone L, Lesnefsky E, Kelly RF, McFalls EO. Preventing myocardial injury following non-cardiac surgery: a potential role for preoperative antioxidant therapy with ubiquinone. Antioxidants. 2021;10(2):276.","journal-title":"Antioxidants"},{"key":"2008_CR41","doi-asserted-by":"crossref","unstructured":"Chen FL, Chang PS, Lin YC, Lin PT. A pilot clinical study of liquid ubiquinol supplementation on cardiac function in pediatric dilated cardiomyopathy. Nutrients. 2018;10(11).","DOI":"10.3390\/nu10111697"},{"issue":"6","key":"2008_CR42","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jchf.2014.06.008","volume":"2","author":"SA Mortensen","year":"2014","unstructured":"Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: A randomized double-blind trial. JACC Heart Fail. 2014;2(6):641\u20139.","journal-title":"JACC Heart Fail"},{"issue":"5","key":"2008_CR43","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1017\/S1047951109990795","volume":"19","author":"A Kocharian","year":"2009","unstructured":"Kocharian A, Shabanian R, Rafiei-Khorgami M, Kiani A, Heidari-Bateni G. Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy. Cardiol Young. 2009;19(5):501\u20136.","journal-title":"Cardiol Young"},{"issue":"3","key":"2008_CR44","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/hdi.12022","volume":"17","author":"S Turk","year":"2013","unstructured":"Turk S, Baki A, Solak Y, Kayrak M, Atalay H, Gaipov A, et al. Coenzyme Q10 supplementation and diastolic heart functions in Hemodialysis patients: A randomized double-blind placebo-controlled trial. Hemodial Int. 2013;17(3):374\u201381.","journal-title":"Hemodial Int"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-025-02008-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-025-02008-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-025-02008-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:40:41Z","timestamp":1748468441000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijponline.biomedcentral.com\/articles\/10.1186\/s13052-025-02008-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2008"],"URL":"https:\/\/doi.org\/10.1186\/s13052-025-02008-5","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"13 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008, and have been approved by the institutional committees of Faculty of Medicine, Tanta University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"163"}}