{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:49:09Z","timestamp":1793159349157,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"DOI":"10.1186\/s13052-025-02077-6","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:18:56Z","timestamp":1752538736000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The clinical analysis and indications for exchange transfusion in 158 children with pertussis characterized by marked leukocytosis"],"prefix":"10.1186","volume":"51","author":[{"given":"Gaihuan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-1782","authenticated-orcid":false,"given":"Chuan","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"2077_CR1","doi-asserted-by":"publisher","unstructured":"Wan M, Zhang G, Yi H. Unraveling the resurgence of pertussis: insights into epidemiology and global health strategies. Pulmonol 2024 Nov-Dec;30(6):503\u20135. https:\/\/doi.org\/10.1016\/j.pulmoe.2024.04.009","DOI":"10.1016\/j.pulmoe.2024.04.009"},{"issue":"7","key":"2077_CR2","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1093\/cid\/civ472","volume":"61","author":"K Winter","year":"2015","unstructured":"Winter K, Zipprich J, Harriman K, Murray EL, Gornbein J, Hammer SJ, Yeganeh N, Adachi K, Cherry JD. Risk factors associated with infant deaths from pertussis: A Case-Control study. Clin Infect Dis. 2015;61(7):1099\u2013106. https:\/\/doi.org\/10.1093\/cid\/civ472.","journal-title":"Clin Infect Dis"},{"issue":"7","key":"2077_CR3","doi-asserted-by":"publisher","first-page":"ftw087","DOI":"10.1093\/femspd\/ftw087","volume":"74","author":"NH Carbonetti","year":"2016","unstructured":"Carbonetti NH. Pertussis leukocytosis: mechanisms, clinical relevance and treatment. Pathog Dis. 2016;74(7):ftw087. https:\/\/doi.org\/10.1093\/femspd\/ftw087.","journal-title":"Pathog Dis"},{"issue":"4","key":"2077_CR4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/PCC.0b013e31828a70fe","volume":"14","author":"JT Berger","year":"2013","unstructured":"Berger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R, Meert KL, Newth CJ, Berg RA, Heidemann S, Harrison R, Pollack M, Dalton H, Harvill E, Karanikas A, Liu T, Burr JS, Doctor A, Dean JM, Jenkins TL, Nicholson CE, Eunice Kennedy Shriver National Institute of Child Health. Human development (NICHD) collaborative pediatric critical care research network (CPCCRN). critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med. 2013;14(4):356\u201365. https:\/\/doi.org\/10.1097\/PCC.0b013e31828a70fe.","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"2077_CR5","first-page":"245","volume":"70","author":"A Bouziri","year":"2010","unstructured":"Bouziri A, Hamdi A, Khaldi A, Smaoui H, Kechrid A, Menif K, Ben Jaballah N. La Coqueluche maligne: Une maladie Sous diagnostiqu\u00e9e [Malignant pertussis: an underdiagnosed illness]. Med Trop (Mars). 2010;70(3):245\u20138.","journal-title":"Med Trop (Mars)"},{"issue":"2","key":"2077_CR6","doi-asserted-by":"publisher","first-page":"e264","DOI":"10.1542\/peds.114.2.e264","volume":"114","author":"MJ Romano","year":"2004","unstructured":"Romano MJ, Weber MD, Weisse ME, Siu BL. Pertussis pneumonia, hypoxemia, hyperleukocytosis, and pulmonary hypertension: improvement in oxygenation after a double volume exchange transfusion. Pediatrics. 2004;114(2):e264\u20136. https:\/\/doi.org\/10.1542\/peds.114.2.e264.","journal-title":"Pediatrics"},{"issue":"3","key":"2077_CR7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/jpc.13427","volume":"53","author":"MS Kazantzi","year":"2017","unstructured":"Kazantzi MS, Prezerakou A, Kalamitsou SN, Ilia S, Kalabalikis PK, Papadatos J, Sdougka MM, Briassoulis G, Tsolia MN. Characteristics of Bordetella pertussis infection among infantsand children admitted to paediatric intensive care units in greece: A multicentre, 11-year study. J Paediatr Child Health. 2017;53(3):257\u201362. https:\/\/doi.org\/10.1111\/jpc.13427.","journal-title":"J Paediatr Child Health"},{"issue":"17","key":"2077_CR8","doi-asserted-by":"publisher","first-page":"e0549","DOI":"10.1097\/MD.0000000000010549","volume":"97","author":"SF Tian","year":"2018","unstructured":"Tian SF, Wang HM, Deng JK. Fatal malignant pertussis with hyperleukocytosis in a Chinese infant: A case report and literature review. Med (Baltim). 2018;97(17):e0549. https:\/\/doi.org\/10.1097\/MD.0000000000010549.","journal-title":"Med (Baltim)"},{"issue":"3","key":"2077_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/INF.0000000000001710","volume":"37","author":"JD Cherry","year":"2018","unstructured":"Cherry JD, Wendorf K, Bregman B, Lehman D, Nieves D, Bradley JS, Mason WH, Sande-Lopez L, Lopez M, Federman M, Chen T, Blumberg D, Johnston S, Schwenk HT, Weintrub P, Quinn KK, Winter K, Harriman K. An observational study of severe pertussis in 100 infants\u2009\u2264\u2009120 days of age. Pediatr Infect Dis J. 2018;37(3):202\u20135. https:\/\/doi.org\/10.1097\/INF.0000000000001710.","journal-title":"Pediatr Infect Dis J"},{"issue":"7","key":"2077_CR10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3390\/toxins11070373","volume":"11","author":"K Scanlon","year":"2019","unstructured":"Scanlon K, Skerry C, Carbonetti N. Association of pertussis toxin with severe pertussis disease. Toxins (Basel). 2019;11(7):373. https:\/\/doi.org\/10.3390\/toxins11070373.","journal-title":"Toxins (Basel)"},{"issue":"8","key":"2077_CR11","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/PCC.0000000000000851","volume":"17","author":"L Straney","year":"2016","unstructured":"Straney L, Schibler A, Ganeshalingham A, Alexander J, Festa M, Slater A, MacLaren G, Schlapbach LJ, Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation and the Australian and New Zealand Intensive Care Society Paediatric Study Group. Burden and outcomes of severe pertussis infection in critically ill infants. Pediatr Crit Care Med. 2016;17(8):735\u201342. https:\/\/doi.org\/10.1097\/PCC.0000000000000851.","journal-title":"Pediatr Crit Care Med"},{"issue":"9","key":"2077_CR12","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1586\/14760584.2014.935766","volume":"13","author":"JD Cherry","year":"2014","unstructured":"Cherry JD, Paddock CD. Pathogenesis and histopathology of pertussis: implications for immunization. Expert Rev Vaccines. 2014;13(9):1115\u201323. https:\/\/doi.org\/10.1586\/14760584.2014.935766.","journal-title":"Expert Rev Vaccines"},{"issue":"3","key":"2077_CR13","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/INF.0b013e31818c9032","volume":"28","author":"DL Haberling","year":"2009","unstructured":"Haberling DL, Holman RC, Paddock CD, Murphy TV. Infant and maternal risk factors for pertussis-related infant mortality in the united states, 1999 to 2004. Pediatr Infect Dis J. 2009;28(3):194\u20138. https:\/\/doi.org\/10.1097\/INF.0b013e31818c9032.","journal-title":"Pediatr Infect Dis J"},{"issue":"8","key":"2077_CR14","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.4049\/jimmunol.171.8.4011","volume":"171","author":"S Chantakru","year":"2003","unstructured":"Chantakru S, Wang WC, van den Heuvel M, Bashar S, Simpson A, Chen Q, Croy BA, Evans SS. Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones. J Immunol. 2003;171(8):4011\u20139. https:\/\/doi.org\/10.4049\/jimmunol.171.8.4011.","journal-title":"J Immunol"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-025-02077-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-025-02077-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-025-02077-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:18:57Z","timestamp":1752538737000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijponline.biomedcentral.com\/articles\/10.1186\/s13052-025-02077-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2077"],"URL":"https:\/\/doi.org\/10.1186\/s13052-025-02077-6","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This retrospective study used data from routine clinical examinations, with personal identifiable information removed. As the study did not involve additional interventions or experimental operations, the ethics committee approved the waiver of informed consent. The study was approved by the Ethics Committee of the Children\u2019s Hospital of Chongqing Medical University and complies with the ethical standards of the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"224"}}