{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:00:27Z","timestamp":1783702827973,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"DOI":"10.1186\/s13052-026-02229-2","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T14:15:02Z","timestamp":1773670502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional study of peripheral blood CD8\u2009+\u2009T cells in Epstein-Barr virus-associated infectious mononucleosis"],"prefix":"10.1186","volume":"52","author":[{"given":"Meng","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-4977","authenticated-orcid":false,"given":"Weifang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"2229_CR1","doi-asserted-by":"crossref","unstructured":"Kirchmeier D, Deng Y, Rieble L et al. Epstein-Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues. JCI Insight. 2024;9(20).","DOI":"10.1172\/jci.insight.173489"},{"key":"2229_CR2","doi-asserted-by":"publisher","first-page":"105443","DOI":"10.1016\/j.meegid.2023.105443","volume":"112","author":"M Liu","year":"2023","unstructured":"Liu M, Wang R, Xie Z. T cell-mediated immunity during Epstein-Barr virus infections in children. Infect Genet Evol. 2023;112:105443.","journal-title":"Infect Genet Evol"},{"issue":"1","key":"2229_CR3","first-page":"64","volume":"32","author":"Y Li","year":"2024","unstructured":"Li Y, Xi FY, Zhang WH, et al. [Analysis of virus-specific CD4\u2009+\u2009T cells and CD8\u2009+\u2009T cells in patients with liver damage caused by EB virus infection]. Chin J Hepatol. 2024;32(1):64\u201371.","journal-title":"Chin J Hepatol"},{"issue":"19","key":"2229_CR4","first-page":"1478","volume":"37","author":"HX Guo","year":"2022","unstructured":"Guo HX, Hu YJ, Yin FR, et al. [Clinical and laboratory results of 270 children with infectious mononucleosis]. Chin J Practical Pediatr. 2022;37(19):1478\u201381.","journal-title":"Chin J Practical Pediatr"},{"key":"2229_CR5","doi-asserted-by":"crossref","unstructured":"Cai X, Ebell MH, Haines L. Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis. J Am Board Fam Med. 2021 Nov-Dec;34(6):1141\u201356.","DOI":"10.3122\/jabfm.2021.06.210217"},{"key":"2229_CR6","doi-asserted-by":"publisher","first-page":"5133","DOI":"10.2147\/IJGM.S483185","volume":"17","author":"X He","year":"2024","unstructured":"He X, Hou H, Jiang Y, Huang X. Association Between Indices of Peripheral Blood Inflammation and Cavitary Pulmonary Tuberculosis. Int J Gen Med. 2024;17:5133\u201342.","journal-title":"Int J Gen Med"},{"key":"2229_CR7","unstructured":"You JM. [A case of infectious mononucleosis in children with acute hemolytic anemia]. A case of infectious mononucleosis in children with acute hemolytic anemia. 2024 (01):E2512\u20132512."},{"issue":"1","key":"2229_CR8","doi-asserted-by":"publisher","first-page":"2247887","DOI":"10.1080\/16078454.2023.2247887","volume":"28","author":"H Yang","year":"2023","unstructured":"Yang H, Cao Y, Liu J, et al. Clinical characteristics and prognostic factors of 75 cases with acquired hemophagocytic syndrome. Hematology. 2023;28(1):2247887.","journal-title":"Hematology"},{"issue":"1","key":"2229_CR9","doi-asserted-by":"publisher","first-page":"e2023023","DOI":"10.4084\/MJHID.2023.023","volume":"15","author":"EM P\u00e1ez-Guill\u00e1n","year":"2023","unstructured":"P\u00e1ez-Guill\u00e1n EM, Campos-Franco J, Alende R, Gonzalez-Quintela A. Hematological Abnormalities Beyond Lymphocytosis During Infectious Mononucleosis: Epstein-Barr Virus-Induced Thrombocytopenia. Mediterr J Hematol Infect Dis. 2023;15(1):e2023023.","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"7","key":"2229_CR10","first-page":"1259","volume":"14","author":"HX Huang","year":"2022","unstructured":"Huang HX, Zhang YH, Wang C. [Diagnostic value of combined detection of immunoglobulin and hs-CRP in infectious mononucleosis]. J Mol Diagnosis Ther. 2022;14(7):1259\u201362.","journal-title":"J Mol Diagnosis Ther"},{"key":"2229_CR11","doi-asserted-by":"publisher","first-page":"1109762","DOI":"10.3389\/fped.2023.1109762","volume":"11","author":"R Shen","year":"2023","unstructured":"Shen R, Zhou Y, Zhang L, Yang S. The value of bile acid spectrum in the evaluation of hepatic injury in children with infectious mononucleosis caused by Epstein Barr virus infection. Front Pediatr. 2023;11:1109762.","journal-title":"Front Pediatr"},{"issue":"12","key":"2229_CR12","doi-asserted-by":"publisher","first-page":"e16506","DOI":"10.1111\/ene.16506","volume":"31","author":"C Li","year":"2024","unstructured":"Li C, Gu L, Shi FY, et al. Serum liver enzymes and risk of stroke: Systematic review with meta-analyses and Mendelian randomization studies. Eur J Neurol. 2024;31(12):e16506.","journal-title":"Eur J Neurol"},{"issue":"1","key":"2229_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13052-020-00949-7","volume":"47","author":"J Shi","year":"2021","unstructured":"Shi J, Chu C, Yu M, et al. Clinical warning of hemophagocytic syndrome caused by Epstein-Barr virus. Ital J Pediatr. 2021;47(1):3.","journal-title":"Ital J Pediatr"},{"issue":"1","key":"2229_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13052-023-01457-0","volume":"49","author":"T Shi","year":"2023","unstructured":"Shi T, Ding Q, Liu X, et al. Concordance of adenosine deaminase with immunoglobulins and lymphocyte subsets in EBV-related diseases. Ital J Pediatr. 2023;49(1):49.","journal-title":"Ital J Pediatr"},{"key":"2229_CR15","doi-asserted-by":"publisher","first-page":"1339920","DOI":"10.3389\/fped.2024.1339920","volume":"12","author":"C Gao","year":"2024","unstructured":"Gao C, Cao L, Mei X. Clinical analysis of infectious mononucleosis complicated with acute acalculous cholecystitis. Front Pediatr. 2024;12:1339920.","journal-title":"Front Pediatr"},{"key":"2229_CR16","doi-asserted-by":"crossref","unstructured":"Desimio MG, Covino DA, Rivalta B et al. The Role of NK Cells in EBV Infection and Related Diseases: Current Understanding and Hints for Novel Therapies. Cancers (Basel). 2023;15(6).","DOI":"10.3390\/cancers15061914"},{"issue":"5","key":"2229_CR17","first-page":"326","volume":"41","author":"B Gemici Karaaslan","year":"2024","unstructured":"Gemici Karaaslan B, Rosain J, Bustamante J, K\u0131yk\u0131m A. Interferon Gamma in Sickness Predisposing to Mycobacterial Infectious Diseases. Balkan Med J. 2024;41(5):326\u201332.","journal-title":"Balkan Med J"},{"issue":"5","key":"2229_CR18","first-page":"292","volume":"51","author":"YY Li","year":"2024","unstructured":"Li YY, Yang J, Zhong XM. [Progress on inflammatory bowel disease associated with IL-10 signaling pathway deficiency]. Int J Pediatr. 2024;51(5):292\u20136.","journal-title":"Int J Pediatr"},{"issue":"10","key":"2229_CR19","doi-asserted-by":"publisher","first-page":"8019","DOI":"10.1007\/s00432-023-04696-0","volume":"149","author":"PM Wang","year":"2023","unstructured":"Wang PM, Zhang ZW, Zhang S, et al. Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis. J Cancer Res Clin Oncol. 2023;149(10):8019\u201326.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"8","key":"2229_CR20","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.4049\/jimmunol.1700412","volume":"200","author":"K Kanai","year":"2018","unstructured":"Kanai K, Park AM, Watanabe A, et al. Murine \u03b3-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin. J Immunol. 2018;200(8):2703\u201313.","journal-title":"J Immunol"},{"issue":"2","key":"2229_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1556\/030.65.2018.047","volume":"66","author":"EN Filatova","year":"2019","unstructured":"Filatova EN, Sakharnov NA, Knyazev DI, Utkin OV. Changes in mRNA expression of members of TGFB1-associated pathways in human leukocytes during EBV infection. Acta Microbiol Immunol Hung. 2019;66(2):247\u201354.","journal-title":"Acta Microbiol Immunol Hung"},{"issue":"4","key":"2229_CR22","first-page":"2673","volume":"22","author":"H Wang","year":"2020","unstructured":"Wang H, Xiang Y, Li X, et al. High lymphocyte\u2013to\u2013monocyte ratio is associated with low \u03b1\u2013fetoprotein expression in patients with hepatitis B virus\u2013associated hepatocellular carcinoma. Mol Med Rep. 2020;22(4):2673\u201384.","journal-title":"Mol Med Rep"},{"key":"2229_CR23","doi-asserted-by":"publisher","first-page":"110127","DOI":"10.1016\/j.cbi.2022.110127","volume":"366","author":"J Sankar","year":"2022","unstructured":"Sankar J, Arora S, Joshi G, Kumar R. Pore-forming proteins and their role in cancer and inflammation: Mechanistic insights and plausible druggable targets. Chem Biol Interact. 2022;366:110127.","journal-title":"Chem Biol Interact"},{"key":"2229_CR24","doi-asserted-by":"crossref","unstructured":"Tibbs E, Cao X. Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease. Cancers (Basel). 2022;14(6).","DOI":"10.3390\/cancers14061436"},{"issue":"2","key":"2229_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/apm.13094","volume":"129","author":"H Gang","year":"2021","unstructured":"Gang H, Peng D, Hu Y, et al. Interleukin-9-secreting CD4(+) T cells regulate CD8(+) T cells cytotoxicity in patients with acute coronary syndromes. Apmis. 2021;129(2):91\u2013102.","journal-title":"Apmis"},{"issue":"8","key":"2229_CR26","first-page":"584","volume":"21","author":"YP Han","year":"2013","unstructured":"Han YP, Li J, Jiang LF, et al. [Hepatitis B e antigen from chronic hepatitis B patients induces Th1\/Th2 cytokine imbalance in vitro]. Chin J Hepatol. 2013;21(8):584\u20139.","journal-title":"Chin J Hepatol"},{"issue":"4","key":"2229_CR27","first-page":"220","volume":"33","author":"SS Yuan","year":"2015","unstructured":"Yuan SS, Xiang TX, Tao XP, et al. [The effects of hepatitis B e antigen on Toll-like receptor 9 and CD8 activated costimulatory molecules expressions on human peripheral blood mononuclear cells]. Chin J Infect Dis. 2015;33(4):220\u20134.","journal-title":"Chin J Infect Dis"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-026-02229-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-026-02229-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-026-02229-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:38:53Z","timestamp":1776908333000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13052-026-02229-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2229"],"URL":"https:\/\/doi.org\/10.1186\/s13052-026-02229-2","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]},"assertion":[{"value":"1 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The project was approved by the Medical Ethics Committee of Suda University Affiliated Hospital (No.2023CS219). The guardian of the child is aware of the corresponding situation and signs and authorizes the informed consent form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"65"}}