{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:38:46Z","timestamp":1792787926489,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100022831","name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","doi-asserted-by":"publisher","award":["Sa\u011fl\u0131k Bilimleri \u00dcniversitesi"],"award-info":[{"award-number":["Sa\u011fl\u0131k Bilimleri \u00dcniversitesi"]}],"id":[{"id":"10.13039\/100022831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003010","name":"Ege \u00dcniversitesi","doi-asserted-by":"publisher","award":["Ege \u00dcniversitesi"],"award-info":[{"award-number":["Ege \u00dcniversitesi"]}],"id":[{"id":"10.13039\/501100003010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ital J Pediatr"],"DOI":"10.1186\/s13052-026-02299-2","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:57:56Z","timestamp":1792727876000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can mesenchymal stem cell and retinoic acid therapies more effectively reduce lung damage due to bronchopulmonary dysplasia?"],"prefix":"10.1186","volume":"52","author":[{"given":"Senem Alkan","family":"\u00d6zdemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda","family":"A\u00e7\u0131kg\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Sarper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurur","family":"Garip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"\u00d6zer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclperi","family":"\u00d6ktem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2299_CR1","doi-asserted-by":"crossref","unstructured":"Gilfillan M, Bhandari A, Bhandari V. Diagnosis and management of bronchopulmonary dysplasia BMJ. 2021;375:n1974.","DOI":"10.1136\/bmj.n1974"},{"issue":"S 01","key":"2299_CR2","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1055\/s-0042-1758867","volume":"39","author":"L Bonadies","year":"2022","unstructured":"Bonadies L, Moschino L, Valerio E, Giordano G, Manzoni P, Baraldi E. Early Biomarkers of Bronchopulmonary Dysplasia: A Quick Look to the State of the Art. Am J Perinatol. 2022;39(S 01):S26\u201330.","journal-title":"Am J Perinatol"},{"issue":"2","key":"2299_CR3","first-page":"14","volume":"23","author":"K Giusto","year":"2021","unstructured":"Giusto K, Wanczyk H, Jensen T, Finck C. Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies. Dis Model Mech. 2021;23(2):14.","journal-title":"Dis Model Mech"},{"issue":"39","key":"2299_CR4","doi-asserted-by":"publisher","first-page":"e35056","DOI":"10.1097\/MD.0000000000035056","volume":"102","author":"X Wang","year":"2023","unstructured":"Wang X, Wang S, Chen M, Lv Y, Chen X, Yang C. The value of hematocrit for predicting bronchopulmonary dysplasia in very low birth weight preterm infants. Med (Baltim). 2023;102(39):e35056.","journal-title":"Med (Baltim)"},{"issue":"2","key":"2299_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/17476348.2023.2183842","volume":"17","author":"C Harris","year":"2023","unstructured":"Harris C, Greenough A. The prevention and management strategies for neonatal chronic lung disease. Expert Rev Respir Med. 2023;17(2):143\u201354.","journal-title":"Expert Rev Respir Med"},{"issue":"2","key":"2299_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/stcltm\/szab011","volume":"11","author":"M Benny","year":"2022","unstructured":"Benny M, Courchia B, Shrager S, Sharma M, Chen P, et al. Comparative Effects of Bone Marrow-derived Versus Umbilical Cord Tissue Mesenchymal Stem Cells in an Experimental Model of Bronchopulmonary Dysplasia. Stem Cells Transl Med. 2022;11(2):189\u201399.","journal-title":"Stem Cells Transl Med"},{"issue":"7","key":"2299_CR7","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1093\/stcltm\/szae033","volume":"15","author":"E Purcell","year":"2024","unstructured":"Purcell E, Shah J, Powell C, Nguyen T, Zhou L, et al. Umbilical cord blood-derived therapy for preterm lung injury: a systematic review and meta-analysis. Stem Cells Transl Med. 2024;15(7):606\u201324.","journal-title":"Stem Cells Transl Med"},{"key":"2299_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/sctm.18-0273","volume":"9","author":"A Moreira","year":"2020","unstructured":"Moreira A, Winter C, Joy J, Winter L, Jones M, Noronha M, Porter M, Quim K, Corral A, Alayli Y, et al. Intranasal delivery of human umbilical cord wharton\u2019s jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia. Stem Cells Transl Med. 2020;9:221\u201334.","journal-title":"Stem Cells Transl Med"},{"issue":"23","key":"2299_CR9","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1080\/14767058.2020.1856809","volume":"35","author":"S Alkan Ozdemir","year":"2022","unstructured":"Alkan Ozdemir S, Ozdemir N, Aksan O, K\u0131nal\u0131 B, Bilici G\u00fcler G, Erbil G, Ozer E, Ozer E. Effect of humic acid on oxidative stress and neuroprotection in hypoxic-ischemic brain injury: part 1. J Matern Fetal Neonatal Med. 2022;35(23):4580\u20139.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"11","key":"2299_CR10","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1002\/jemt.22413","volume":"77","author":"MM Moreira","year":"2014","unstructured":"Moreira MM, Bradaschia-Correa V, Marques ND, Ferreira LB, Arana-Chavez VE. Ultrastructural and immunohistochemical study of the effect of sodium alendronate in the progression of experimental periodontitis in rats. Microsc Res Tech. 2014;77(11):902\u20139.","journal-title":"Microsc Res Tech"},{"key":"2299_CR11","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.2147\/JIR.S448394","volume":"17","author":"S Li","year":"2024","unstructured":"Li S, Liang S, Xie S, Chen H, Huang H, He Q, Zhang H, Wang X. Investigation of the miRNA-mRNA Regulatory Circuits and Immune Signatures Associated with Bronchopulmonary Dysplasia. J Inflamm Res. 2024;17:1467\u201380.","journal-title":"J Inflamm Res"},{"issue":"2","key":"2299_CR12","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/sctm.18-0273","volume":"9","author":"A Moreira","year":"2020","unstructured":"Moreira A, Winter C, Joy J, Winter L, Jones M, Noronha M, Porter M, Quim K, Corral A, Alayli Y, Seno T, Mustafa S, Hornsby P, Ahuja S. Intranasal delivery of human umbilical cord Wharton\u2019s jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia. Stem Cells Transl Med. 2020;9(2):221\u201334.","journal-title":"Stem Cells Transl Med"},{"key":"2299_CR13","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1056\/NEJMoa032089","volume":"350","author":"TF Yeh","year":"2004","unstructured":"Yeh TF, Lin YJ, Lin HC, Huang CC, Hsieh WS, Lin CH, Tsai CH. Outcomes at School Age after Postnatal Dexamethasone Therapy for Lung Disease of Prematurity. N Engl J Med. 2004;350:1304\u201313.","journal-title":"N Engl J Med"},{"key":"2299_CR14","doi-asserted-by":"publisher","first-page":"L861","DOI":"10.1152\/ajplung.00099.2014","volume":"308","author":"A Hou","year":"2015","unstructured":"Hou A, Fu J, Yang H, Zhu Y, Pan Y, Xu S, Xue X. Hyperoxia Stimulates the Transdifferentiation of Type II Alveolar Epithelial Cells in Newborn Rats. Am J Physiol Lung Cell Mol Physiol. 2015;308:L861\u201372.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2299_CR15","first-page":"20","volume":"21","author":"P Terragni","year":"2015","unstructured":"Terragni P, Ranieri VM, Brazzi L. Novel approaches to minimize ventilator-induced lung injury. Curr Opin Crit Care. 2015;21:20\u20135.","journal-title":"Curr Opin Crit Care"},{"key":"2299_CR16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1136\/thoraxjnl-2011-201059","volume":"67","author":"GF Curley","year":"2012","unstructured":"Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O\u2019Brien T, O\u2019Toole D, Laffey JG. Mesenchymal Stem Cells Enhance Recovery and Repair Following Ventilator-Induced Lung Injury in the Rat. Thorax. 2012;67:496\u2013501.","journal-title":"Thorax"},{"key":"2299_CR17","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1164\/rccm.200902-0242OC","volume":"180","author":"M Aslam","year":"2009","unstructured":"Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S. Bone Marrow Stromal Cells Attenuate Lung Injury in a Murine Model of Neonatal Chronic Lung Disease. Am J Respir Crit Care Med. 2009;180:1122\u201330.","journal-title":"Am J Respir Crit Care Med"},{"key":"2299_CR18","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1042\/CBI20110447","volume":"36","author":"X Zhang","year":"2012","unstructured":"Zhang X, Wang H, Shi Y, Peng W, Zhang S, Zhang W, Xu J, Mei Y, Feng Z. Role of Bone marrow-derived mesenchymal stem cells in the prevention of hyperoxia-induced lung injury in newborn mice. Cell Biol Int. 2012;36:589\u201394.","journal-title":"Cell Biol Int"},{"key":"2299_CR19","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1164\/rccm.200902-0179OC","volume":"180","author":"T van Haaften","year":"2009","unstructured":"van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, et al. Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats. Am J Respir Crit Care Med. 2009;180:1131\u201342.","journal-title":"Am J Respir Crit Care Med"},{"key":"2299_CR20","doi-asserted-by":"crossref","unstructured":"Peluzzo AM, Autieri MV Challenging the Paradigm: Anti-Inflammatory Interleukins and Angiogenesis., Cells, Abiramalatha T, Ramaswamy VV, Bandyopadhyay T, Somanath SH, Shaik NB, Pullattayil AK, Weiner GM. Interventions to prevent Bronchopulmonary Dysplasia in preterm infants: An umbrella review of systematic reviews and meta-analyses JAMA Pediatr. 2022;176(5):502\u2013516.","DOI":"10.1001\/jamapediatrics.2021.6619"},{"key":"2299_CR21","first-page":"2628","volume":"10","author":"CM Chen","year":"2018","unstructured":"Chen CM, Chou HC. Human Mesenchymal Stem Cells Attenuate Hyperoxia-Induced Lung Injury through Inhibition of the Renin-Angiotensin System in Newborn Rats. Am J Transl Res. 2018;10:2628.","journal-title":"Am J Transl Res"},{"key":"2299_CR22","first-page":"1","volume":"40","author":"Y Wang","year":"2020","unstructured":"Wang Y, Long W, Cao Y, Li J, You L, snd Fan Y. Mesenchymal Stem cell-derived secretomes for therapeutic potential of premature infant diseases. Biosci Rep. 2020;40:1\u201312.","journal-title":"Biosci Rep"},{"key":"2299_CR23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3390\/cells11030587","volume":"11","author":"AM Peluzzo","year":"2022","unstructured":"Peluzzo AM, Autieri MV. Challenging the Paradigm: Anti-Inflammatory Interleukins and Angiogenesis. Cells. 2022;11:587.","journal-title":"Cells"},{"issue":"1","key":"2299_CR24","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.bbadis.2016.11.006","volume":"1863","author":"AV Shinde","year":"2017","unstructured":"Shinde AV, Humeres C, Frangogiannis NG. The role of \u03b1-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biophys Acta Mol Basis Dis. 2017;1863(1):298\u2013309.","journal-title":"Biophys Acta Mol Basis Dis"},{"issue":"9","key":"2299_CR25","doi-asserted-by":"publisher","first-page":"L824","DOI":"10.1152\/ajplung.00350.2015","volume":"1","author":"KH Sun","year":"2016","unstructured":"Sun KH, Chang Y, Reed N, Sheppard D. \u03b1-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGF\u03b2 activation or collagen production across multiple models of organ fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016;1(9):L824\u201336.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2299_CR26","doi-asserted-by":"crossref","unstructured":"K BR, Malathi NNS. (2014).Evaluation of myofibroblasts by expression of alpha smooth muscle actin: a marker in fibrosis, dysplasia and carcinoma. J Clin of Diagn Res. 8(4);ZC14\u20137.","DOI":"10.7860\/JCDR\/2014\/7820.4231"},{"issue":"3","key":"2299_CR27","first-page":"667","volume":"18","author":"N Anggorowati","year":"2017","unstructured":"Anggorowati N, Ratna Kurniasari C, Damayanti K, Cahyanti T, Widodo I, Ghozali A, Romi MM, Sari DC, Arfian N. Histochemical and Immunohistochemical Study of \u03b1-SMA, Collagen, and PCNA in Epithelial Ovarian Neoplasm. Asian Pac J Cancer Prev. 2017;18(3):667\u201371.","journal-title":"Asian Pac J Cancer Prev"},{"key":"2299_CR28","first-page":"206","volume":"58","author":"S G\u00fclasi","year":"2016","unstructured":"G\u00fclasi S, Atici A, Yilmaz SN, Polat A, Yilmaz M, et al. Mesenchymal Stem Cell Treatment in Hyperoxia-Induced Lung Injury in Newborn Rats. Pediatr Int Off J Jpn Pediatr Soc. 2016;58:206\u201313.","journal-title":"Pediatr Int Off J Jpn Pediatr Soc"},{"key":"2299_CR29","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1136\/thoraxjnl-2012-202323","volume":"68","author":"M Pierro","year":"2013","unstructured":"Pierro M, Ionescu L, Montemurro T, Vadivel A, Weissmann G, et al. Short-Term, Long-Term and Paracrine Effect of Human Umbilical Cord-Derived Stem Cells in Lung Injury Prevention and Repair in Experimental Bronchopulmonary Dysplasia. Thorax. 2013;68:475\u201384.","journal-title":"Thorax"},{"key":"2299_CR30","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1164\/rccm.200410-1325OC","volume":"172","author":"EL Burnham","year":"2005","unstructured":"Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M. Increaased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med. 2005;172:854\u201360.","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"2299_CR31","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1001\/jamapediatrics.2021.6619","volume":"176","author":"T Abiramalatha","year":"2022","unstructured":"Abiramalatha T, Ramaswamy VV, Bandyopadhyay T, Somanath SH, Shaik NB, Pullattayil AK, Weiner GM. Interventions to prevent Bronchopulmonary Dysplasia in preterm infants: An umbrella review of systematic reviews and meta-analyses. JAMA Pediatr. 2022;176(5):502\u201316.","journal-title":"JAMA Pediatr"},{"issue":"3","key":"2299_CR32","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1177\/0884533616673613","volume":"32","author":"E Schwartz","year":"2017","unstructured":"Schwartz E, Zelig R, Parker A, Johnson S. Vitamin A supplementaion fort he prevention of Bronchopulmonary Dysplasia in preterm infants: An update. Nutr Clin Pract. 2017;32(3):346\u201353.","journal-title":"Nutr Clin Pract"},{"issue":"4","key":"2299_CR33","first-page":"298","volume":"8","author":"T Muehlbacher","year":"2021","unstructured":"Muehlbacher T, Bassler D, Bryant MB. Evidence for the Management of Bronchopulmonary Dysplasia in Very Preterm Infants. Child (Basel). 2021;8(4):298.","journal-title":"Child (Basel)"},{"issue":"8","key":"2299_CR34","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3390\/cells11081275","volume":"11","author":"SA Omar","year":"2022","unstructured":"Omar SA, Hafez AA, Ibrahim S, Pillai N, Abdulmageed M, et al. Stem-Cell Therapy for Bronchopulmonary Dysplasia (BPD) in Newborns. Cells. 2022;11(8):1275.","journal-title":"Cells"},{"issue":"6","key":"2299_CR35","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/j.1399-3046.2012.01709.x","volume":"16","author":"H Zhang","year":"2012","unstructured":"Zhang H, Fang J, Su H, Yang M, Lai W, Mai Y, Wu Y. Bone marrow mesenchymal stem cells attenuate lung inflammation of hyperoxic newborn rats. Pediatr Transpl. 2012;16(6):589\u201398. https:\/\/doi.org\/10.1111\/j.1399-3046.2012.01709.x. Epub 2012 Jun 28. PMID: 22738184.","journal-title":"Pediatr Transpl"},{"issue":"1","key":"2299_CR36","doi-asserted-by":"publisher","first-page":"e52419","DOI":"10.1371\/journal.pone.0052419","volume":"8","author":"YS Chang","year":"2013","unstructured":"Chang YS, Choi SJ, Ahn SY, Sung DK, Sung SI, Yoo HS, Oh WI, Park WS. Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury. PLoS ONE. 2013;8(1):e52419.","journal-title":"PLoS ONE"}],"container-title":["Italian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-026-02299-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-026-02299-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13052-026-02299-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:01:58Z","timestamp":1792785718000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13052-026-02299-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2299"],"URL":"https:\/\/doi.org\/10.1186\/s13052-026-02299-2","relation":{},"ISSN":["1824-7288"],"issn-type":[{"value":"1824-7288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"16 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This present study was approved by the Dokuz Eylul University Animal Experiments Local Ethics Committee in Izmir (Approval number: 2021\/011).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patients to publish this paper.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have no conflict of interest.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"153"}}