{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:18:40Z","timestamp":1783138720435,"version":"3.54.6"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recent studies in septic patients showed that adverse effects of hydroxyethyl starches (HESs) possibly outweigh their benefits in severely impaired physiological haemostasis. It remains unclear whether this also applies to patient populations that are less vulnerable. In this meta-analysis, we evaluated the impact of various HES generations on safety and efficacy endpoints in patients undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the PubMed, Embase and Cochrane Central Register of Controlled Trials databases for randomised controlled trials (RCTs) in the English or German language comparing the use of HES to any other colloid or crystalloid during open heart surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Blood loss and transfusion requirements were higher for older starches with mean molecular weights more than 200\u00a0kDa compared to other volume substitutes. In contrast, this effect was not observed with latest-generation tetrastarches (130\/0.4), which performed even better when compared to albumin (blood loss of tetrastarch versus albumin: standardised mean difference (SMD), \u22120.34; 95% CI, \u22120.63, \u22120.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02; versus gelatin: SMD, \u22120.06; 95% CI, \u22120.20, 0.08;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.39; versus crystalloids: SMD, \u22120.05; 95% CI, \u22120.20, 0.10;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.54). Similar results were found for transfusion needs. Lengths of stay in the intensive care unit or hospital were significantly shorter with tetrastarches compared to gelatin (intensive care unit: SMD, \u22120.10; 95% CI, \u22120.15, \u22120.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0002) and crystalloids (hospital: SMD, \u22120.52; 95% CI, \u22120.90, \u22120.14;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this meta-analysis of RCTs, we could not identify safety issues with tetrastarches compared with other colloid or crystalloid solutions in terms of blood loss, transfusion requirements or hospital length of stay in patients undergoing cardiac surgery. The safety data on coagulation with older starches raise some issues that need to be addressed in future trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13054-014-0656-0","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T07:18:22Z","timestamp":1417677502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The impact of hydroxyethyl starches in cardiac surgery: a meta-analysis"],"prefix":"10.1186","volume":"18","author":[{"given":"Matthias","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Fellahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"656_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/ALN.0b013e3181a7ec82","volume":"111","author":"M Westphal","year":"2009","unstructured":"Westphal M, James MF, Kozek-Langenecker SA, Stocker R, Guidet B, Van Aken H: Hydroxyethyl starches: different products-different effects. Anesthesiology. 2009, 111: 187-202. 10.1097\/ALN.0b013e3181a7ec82.","journal-title":"Anesthesiology"},{"key":"656_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1213\/ANE.0b013e31827175da","volume":"116","author":"PJ Van Der Linden","year":"2013","unstructured":"Van Der Linden PJ, James M, Mythen M, Weiskopf RB: Safety of modern starches used during surgery. Anesth Analg. 2013, 116: 35-48. 10.1213\/ANE.0b013e31827175da.","journal-title":"Anesth Analg"},{"key":"656_CR3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/ALN.0b013e31827e5569","volume":"118","author":"C Martin","year":"2013","unstructured":"Martin C, Jacob M, Vicaut E, Guidet B, Van Aken H, Kurz A: Effect of waxy maize-derived hydroxyethyl starch 130\/0.4 on renal function in surgical patients. Anesthesiology. 2013, 118: 387-394. 10.1097\/ALN.0b013e31827e5569.","journal-title":"Anesthesiology"},{"key":"656_CR4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1093\/bja\/aet303","volume":"112","author":"MA Gillies","year":"2014","unstructured":"Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM: Incidence of postoperative death and acute kidney injury associated with i.v. 6% hydroxyethyl starch use: systematic review and meta-analysis. Br J Anaesth. 2014, 112: 25-34. 10.1093\/bja\/aet303.","journal-title":"Br J Anaesth"},{"key":"656_CR5","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00228-011-1008-5","volume":"67","author":"X Shi","year":"2011","unstructured":"Shi X, Zou Z, He X, Xu H, Yuan H, Liu H: Hydroxyethyl starch for cardiovascular surgery: a systematic review of randomized controlled trials. Eur J Clin Pharmacol. 2011, 67: 767-782. 10.1007\/s00228-011-1008-5.","journal-title":"Eur J Clin Pharmacol"},{"key":"656_CR6","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1213\/ANE.0b013e31820ad3b7","volume":"112","author":"SL Shafer","year":"2011","unstructured":"Shafer SL: Shadow of doubt. Anesth Analg. 2011, 112: 498-500. 10.1213\/ANE.0b013e31820ad3b7.","journal-title":"Anesth Analg"},{"key":"656_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1191\/0267659104pf705oa","volume":"19","author":"MA Ali","year":"2004","unstructured":"Ali MA, Saleh M: Selection of optimal quantity of hydroxyethyl starch in the cardiopulmonary bypass prime. Perfusion. 2004, 19: 41-45. 10.1191\/0267659104pf705oa.","journal-title":"Perfusion"},{"key":"656_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jtcvs.2012.04.009","volume":"144","author":"RJ Navickis","year":"2012","unstructured":"Navickis RJ, Haynes GR, Wilkes MM: Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: a meta-analysis of randomized trials. J Thorac Cardiovasc Surg. 2012, 144: 223-230. 10.1016\/j.jtcvs.2012.04.009.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"656_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","volume":"8","author":"D Moher","year":"2010","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, the PRISMA Group: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010, 8: 336-341. 10.1016\/j.ijsu.2010.02.007.","journal-title":"Int J Surg"},{"key":"656_CR10","doi-asserted-by":"crossref","unstructured":"Deeks JJ, Altman DG, Bradburn MJ: Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd edition. Edited by Egger M, Smith GD, Altman DG. London: BMJ Publishing Group; 2001:285\u2013312.","DOI":"10.1002\/9780470693926.ch15"},{"key":"656_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3109\/0886022X.2012.747139","volume":"35","author":"FG Akkucuk","year":"2013","unstructured":"Akkucuk FG, Kanbak M, Ayhan B, Celebioglu B, Aypar U: The effect of HES (130\/0.4) usage as the priming solution on renal function in children undergoing cardiac surgery. Ren Fail. 2013, 35: 210-215. 10.3109\/0886022X.2012.747139.","journal-title":"Ren Fail"},{"key":"656_CR12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0267659107086656","volume":"22","author":"RH Boks","year":"2007","unstructured":"Boks RH, Wijers MJ, Hofland J, Takkenberg JJ, Bogers AJ: Low molecular starch versus gelatin plasma expander during CPB: Does it make a difference?. Perfusion. 2007, 22: 333-337. 10.1177\/0267659107086656.","journal-title":"Perfusion"},{"key":"656_CR13","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s001010050181","volume":"44","author":"H Brock","year":"1995","unstructured":"Brock H, Rapf B, Necek S, Gabriel C, Peterlik C, P\u00f6lz W, Schimetta W, Bergmann H: Comparison of postoperative volume therapy in heart surgery patients [Article in German]. Anaesthesist. 1995, 44: 486-492. 10.1007\/s001010050181.","journal-title":"Anaesthesist"},{"key":"656_CR14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S1053-0770(96)80095-4","volume":"10","author":"D Brutocao","year":"1996","unstructured":"Brutocao D, Bratton SL, Thomas JR, Schrader PF, Coles PG, Lynn AM: Comparison of hetastarch with albumin for postoperative volume expansion in children after cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 1996, 10: 348-351. 10.1016\/S1053-0770(96)80095-4.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"656_CR15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4103\/0971-9784.95072","volume":"15","author":"M Chakravarthy","year":"2012","unstructured":"Chakravarthy M, Muniraj G, Patil S, Suryaprakash S, Mitra S, Shivalingappa B: A randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130\/0.4) undergoing off pump coronary artery bypass surgery. Ann Card Anaesth. 2012, 15: 105-110. 10.4103\/0971-9784.95072.","journal-title":"Ann Card Anaesth"},{"key":"656_CR16","first-page":"584","volume":"76","author":"YS Choi","year":"2010","unstructured":"Choi YS, Shim JK, Hong SW, Kim JC, Kwak YL: Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130\/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass. Minerv Anestesiol. 2010, 76: 584-591.","journal-title":"Minerv Anestesiol"},{"key":"656_CR17","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/S0003-4975(10)60907-1","volume":"34","author":"JT Diehl","year":"1982","unstructured":"Diehl JT, Lester JL, Cosgrove DM: Clinical comparison of hetastarch and albumin in postoperative cardiac patients. Ann Thorac Surg. 1982, 34: 674-679. 10.1016\/S0003-4975(10)60907-1.","journal-title":"Ann Thorac Surg"},{"key":"656_CR18","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/S1010-7940(01)00804-1","volume":"20","author":"GP Eising","year":"2001","unstructured":"Eising GP, Niemeyer M, G\u00fcnther T, Tassani P, Pfauder M, Schad H, Lange R: Does a hyperoncotic cardiopulmonary bypass prime affect extravascular lung water and cardiopulmonary function in patients undergoing coronary artery bypass surgery?. Eur J Cardiothorac Surg. 2001, 20: 282-289. 10.1016\/S1010-7940(01)00804-1.","journal-title":"Eur J Cardiothorac Surg"},{"key":"656_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1749-8090-8-71","volume":"8","author":"HA Gurbuz","year":"2013","unstructured":"Gurbuz HA, Durukan AB, Salman N, Tavlasoglu M, Durukan E, Ucar H\u0130, Yorgancioglu C: Hydroxyethyl starch 6%, 130\/0.4 vs. a balanced crystalloid solution in cardiopulmonary bypass priming: a randomized, prospective study. J Cardiothorac Surg. 2013, 8: 71-10.1186\/1749-8090-8-71.","journal-title":"J Cardiothorac Surg"},{"key":"656_CR20","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1177\/0267659113491446","volume":"28","author":"D Kimenai","year":"2013","unstructured":"Kimenai D, Bastianen G, Daane C, Megens-Bastiaanse C, van der Meer N, Scohy T, Gerritse BM: Effect of the colloids gelatin and HES 130\/0.4 on blood coagulation in cardiac surgery patients: a randomized controlled trial. Perfusion. 2013, 28: 512-519. 10.1177\/0267659113491446.","journal-title":"Perfusion"},{"key":"656_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0003-4975(10)60707-2","volume":"37","author":"JK Kirklin","year":"1984","unstructured":"Kirklin JK, Lell WA, Kouchoukos NT: Hydroxyethyl starch versus albumin for colloid infusion following cardiopulmonary bypass in patients undergoing myocardial revascularization. Ann Thorac Surg. 1984, 37: 40-46. 10.1016\/S0003-4975(10)60707-2.","journal-title":"Ann Thorac Surg"},{"key":"656_CR22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/145749690709600114","volume":"96","author":"A Kuitunen","year":"2007","unstructured":"Kuitunen A, Suojaranta-Ylinen R, Kukkonen S, Niemi T: A comparison of the haemodynamic effects of 4% succinylated gelatin, 6% hydroxyethyl starch (200\/0.5) and 4% human albumin after cardiac surgery. Scand J Surg. 2007, 96: 72-78.","journal-title":"Scand J Surg"},{"key":"656_CR23","first-page":"31","volume":"19","author":"SJ Ley","year":"1990","unstructured":"Ley SJ, Miller K, Skov P, Preisig P: Crystalloid versus colloid fluid therapy after cardiac surgery. Heart Lung. 1990, 19: 31-40.","journal-title":"Heart Lung"},{"key":"656_CR24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0022-5223(19)34780-4","volume":"104","author":"MJ London","year":"1992","unstructured":"London MJ, Franks M, Verrier ED, Merrick SH, Levin J, Mangano DT: The safety and efficacy of ten percent pentastarch as a cardiopulmonary bypass priming solution: a randomized clinical trial. J Thorac Cardiovasc Surg. 1992, 104: 284-296.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"656_CR25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0022-5223(19)34525-8","volume":"97","author":"MJ London","year":"1989","unstructured":"London MJ, Ho JS, Triedman JK, Verrier ED, Levin J, Merrick SH, Hanley FL, Browner WS, Mangano DT: A randomized clinical trial of 10% pentastarch (low molecular weight hydroxyethyl starch) versus 5% albumin for plasma volume expansion after cardiac operations. J Thorac Cardiovasc Surg. 1989, 97: 785-797.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"656_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/j.1552-4604.1994.tb03963.x","volume":"34","author":"L Mastroianni","year":"1994","unstructured":"Mastroianni L, Low HB, Rollman J, Wagle M, Bleske B, Chow MS: A comparison of 10% pentastarch and 5% albumin in patients undergoing open-heart surgery. J Clin Pharmacol. 1994, 34: 34-40. 10.1002\/j.1552-4604.1994.tb03963.x.","journal-title":"J Clin Pharmacol"},{"key":"656_CR27","unstructured":"Mehta Y, Dhar A, Sujatha, Meharwal Z, Trehan N: Comparison of new HES (130\/0.4) and HES (200\/0.5) in OPCAB surgery. J Anaesthesiol Clin Pharmacol 2007, 23:273\u2013278.,"},{"key":"656_CR28","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1097\/00003246-198312000-00009","volume":"11","author":"RA Moggio","year":"1983","unstructured":"Moggio RA, Rha CC, Somberg ED, Praeger PI, Pooley RW, Reed GE: Hemodynamic comparison of albumin and hydroxyethyl starch in postoperative cardiac surgery patients. Crit Care Med. 1983, 11: 943-945. 10.1097\/00003246-198312000-00009.","journal-title":"Crit Care Med"},{"key":"656_CR29","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00101-003-0568-x","volume":"52","author":"GP Molter","year":"2003","unstructured":"Molter GP, Solt\u00e9sz S, Larsen R, Baumann-Noss S, Biedler A, Silomon M: Haemodynamic effects following preoperative hypervolemic haemodilution with hypertonic hyperoncotic colloid solutions in coronary artery bypass graft surgery [Article in German]. Anaesthesist. 2003, 52: 905-918. 10.1007\/s00101-003-0568-x.","journal-title":"Anaesthesist"},{"key":"656_CR30","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4103\/0019-5049.63653","volume":"54","author":"K Muralidhar","year":"2010","unstructured":"Muralidhar K, Garg R, Mohanty S, Banakal S: Influence of colloid infusion on coagulation during off-pump coronary artery bypass grafting. Indian J Anaesth. 2010, 54: 147-153. 10.4103\/0019-5049.63653.","journal-title":"Indian J Anaesth"},{"key":"656_CR31","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1213\/01.ane.0000200285.20510.b6","volume":"102","author":"TT Niemi","year":"2006","unstructured":"Niemi TT, Suojaranta-Ylinen RT, Kukkonen SI, Kuitunen AH: Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesth Analg. 2006, 102: 998-1006. 10.1213\/01.ane.0000200285.20510.b6.","journal-title":"Anesth Analg"},{"key":"656_CR32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/145749690809700310","volume":"97","author":"T Niemi","year":"2008","unstructured":"Niemi T, Schramko A, Kuitunen A, Kukkonen S, Suojaranta-Ylinen R: Haemodynamics and acid-base equilibrium after cardiac surgery: comparison of rapidly degradable hydroxyethyl starch solutions and albumin. Scand J Surg. 2008, 97: 259-265.","journal-title":"Scand J Surg"},{"key":"656_CR33","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/S0003-4975(10)60683-2","volume":"36","author":"CR Saunders","year":"1983","unstructured":"Saunders CR, Carlisle L, Bick RL: Hydroxyethyl starch versus albumin in cardiopulmonary bypass prime solutions. Ann Thorac Surg. 1983, 36: 532-539. 10.1016\/S0003-4975(10)60683-2.","journal-title":"Ann Thorac Surg"},{"key":"656_CR34","first-page":"117","volume":"13","author":"N Saxena","year":"1997","unstructured":"Saxena N: A Comparison of hetastarch, albumin and Ringer lactate for volume replacement in coronary artery bypass surgery. J Anaesth Clin Pharmacol. 1997, 13: 117-120.","journal-title":"J Anaesth Clin Pharmacol"},{"key":"656_CR35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1213\/ane.0b013e31818c1282","volume":"108","author":"AA Schramko","year":"2009","unstructured":"Schramko AA, Suojaranta-Ylinen RT, Kuitunen AH, Kukkonen SI, Niemi TT: Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Anesth Analg. 2009, 108: 30-36. 10.1213\/ane.0b013e31818c1282.","journal-title":"Anesth Analg"},{"key":"656_CR36","first-page":"24","volume":"5","author":"S Shahbazi","year":"2011","unstructured":"Shahbazi S, Zeighami D, Allahyary E, Alipour A, Esmaeeli M, Ghaneie M: Effect of colloid versus crystalloid administration of cardiopulmonary bypass prime solution on tissue and organ perfusion. Int Cardiovasc Res J. 2011, 5: 24-31.","journal-title":"Int Cardiovasc Res J"},{"key":"656_CR37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1177\/026765919801300503","volume":"13","author":"I Tigchelaar","year":"1998","unstructured":"Tigchelaar I, Gallandat HRC, Boonstra PW, van Oeveren W: Comparison of three plasma expanders used as priming fluids in cardiopulmonary bypass patients. Perfusion. 1998, 13: 297-303. 10.1177\/026765919801300503.","journal-title":"Perfusion"},{"key":"656_CR38","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/BF03019102","volume":"51","author":"PJ Van der Linden","year":"2004","unstructured":"Van der Linden PJ, de Hert SG, Daper A, Trenchant A, Schmartz D, Defrance P, Kimbimbi P: 3.5% urea-linked gelatin is as effective as 6% HES 200\/0.5 for volume management in cardiac surgery patients. Can J Anaesth. 2004, 51: 236-241. 10.1007\/BF03019102.","journal-title":"Can J Anaesth"},{"key":"656_CR39","first-page":"679","volume":"49","author":"TS Yen","year":"2008","unstructured":"Yen TS, Chan KC, Cheng YJ: Intraoperative coagulation was more interfered by HES 200\/0.5 than normal saline in off-pump coronary artery bypass surgery. J Cardiovasc Surg. 2008, 49: 679-684.","journal-title":"J Cardiovasc Surg"},{"key":"656_CR40","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1213\/01.ANE.0000096006.60716.F6","volume":"98","author":"AH Kuitunen","year":"2004","unstructured":"Kuitunen AH, Hynynen MJ, Vahtera E, Salmenper\u00e4 MT: Hydroxyethyl starch as a priming solution for cardiopulmonary bypass impairs hemostasis after cardiac surgery. Anesth Analg. 2004, 98: 291-297. 10.1213\/01.ANE.0000096006.60716.F6.","journal-title":"Anesth Analg"},{"key":"656_CR41","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/S0003-4975(10)60908-3","volume":"34","author":"DA Palanzo","year":"1982","unstructured":"Palanzo DA, Parr GV, Bull AP, Williams DR, O\u2019Neill MJ, Waldhausen JA: Hetastarch as a prime for cardiopulmonary bypass. Ann Thorac Surg. 1982, 34: 680-683. 10.1016\/S0003-4975(10)60908-3.","journal-title":"Ann Thorac Surg"},{"key":"656_CR42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1749-8090-3-45","volume":"3","author":"O Tiryakio\u011flu","year":"2008","unstructured":"Tiryakio\u011flu O, Y\u0131ld\u0131z G, Vural H, Goncu T, Ozyaz\u0131c\u0131oglu A, Yavuz \u015e: Hydroxyethyl starch versus Ringer solution in cardiopulmonary bypass prime solutions (a randomized controlled trial). J Cardiothorac Surg. 2008, 3: 45-10.1186\/1749-8090-3-45.","journal-title":"J Cardiothorac Surg"},{"key":"656_CR43","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/CCM.0b013e3181958c81","volume":"37","author":"C Hanart","year":"2009","unstructured":"Hanart C, Khalife M, de Vill\u00e9 A, Otte F, de Hert S, Van der Linden PJ: Perioperative volume replacement in children undergoing cardiac surgery: albumin versus hydroxyethyl starch 130\/0.4. Crit Care Med. 2009, 37: 696-701. 10.1097\/CCM.0b013e3181958c81.","journal-title":"Crit Care Med"},{"key":"656_CR44","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.jtcvs.2009.02.035","volume":"138","author":"M Hecht-Dolnik","year":"2009","unstructured":"Hecht-Dolnik M, Barkan H, Taharka A, Loftus J: Hetastarch increases the risk of bleeding complications in patients after off-pump coronary bypass surgery: a randomized clinical trial. J Thorac Cardiovasc Surg. 2009, 138: 703-711. 10.1016\/j.jtcvs.2009.02.035.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"656_CR45","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.athoracsur.2004.08.002","volume":"79","author":"E Iriz","year":"2005","unstructured":"Iriz E, Kolbakir F, Akar H, Adam B, Keceligil HT: Comparison of hydroxyethyl starch and ringer lactate as a prime solution regarding S-100\u03b2 protein levels and informative cognitive tests in cerebral injury. Ann Thorac Surg. 2005, 79: 666-671. 10.1016\/j.athoracsur.2004.08.002.","journal-title":"Ann Thorac Surg"},{"key":"656_CR46","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/00000542-200307000-00010","volume":"99","author":"SM Kasper","year":"2003","unstructured":"Kasper SM, Meinert P, Kampe S, G\u00f6rg C, Geisen C, Mehlhorn U, Diefenbach C: Large-dose hydroxyethyl starch 130\/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200\/0.5 at recommended doses. Anesthesiology. 2003, 99: 42-47. 10.1097\/00000542-200307000-00010.","journal-title":"Anesthesiology"},{"key":"656_CR47","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1253\/circj.CJ-11-0404","volume":"75","author":"JS Lee","year":"2011","unstructured":"Lee JS, Ahn SW, Song JW, Shim JK, Yoo KJ, Kwak YL: Effect of hydroxyethyl starch 130\/0.4 on blood loss and coagulation in patients with recent exposure to dual antiplatelet therapy undergoing off-pump coronary artery bypass graft surgery. Circ J. 2011, 75: 2397-2402. 10.1253\/circj.CJ-11-0404.","journal-title":"Circ J"},{"key":"656_CR48","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/0267659111426920","volume":"27","author":"S Lou","year":"2012","unstructured":"Lou S, Bian L, Long C, Wang Z, Ma J, Zhou B: Does 6% hydroxyethyl starch 130\/0.4 impact differently on blood glucose than 4% gelatin in patients receiving open heart surgery?. Perfusion. 2012, 27: 113-118. 10.1177\/0267659111426920.","journal-title":"Perfusion"},{"key":"656_CR49","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1778-428X.2012.01169.x","volume":"12","author":"KP Mulavisala","year":"2012","unstructured":"Mulavisala KP, Kulkarni V, Mudunuri R, Viswanath VR, Byalal JR, Gopal PB, Kulkarni SS: Hydroxyethyl starch 130\/0.4 versus modified succinylated gelatin for volume expansion in pediatric cardiac surgery patients: the effects on perioperative bleeding and transfusion needs. Transfus Altern Transfus Med. 2012, 12: 51-58. 10.1111\/j.1778-428X.2012.01169.x.","journal-title":"Transfus Altern Transfus Med"},{"key":"656_CR50","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1177\/0218492309338101","volume":"17","author":"JS Ooi","year":"2009","unstructured":"Ooi JS, Ramzisham AR, Zamrin MD: Is 6% hydroxyethyl starch 130\/0.4 safe in coronary artery bypass graft surgery?. Asian Cardiovasc Thorac Ann. 2009, 17: 368-372. 10.1177\/0218492309338101.","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"656_CR51","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1093\/bja\/aeq084","volume":"104","author":"A Schramko","year":"2010","unstructured":"Schramko A, Suojaranta-Ylinen R, Kuitunen A, Raivio P, Kukkonen S, Niemi T: Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Br J Anaesth. 2010, 104: 691-697. 10.1093\/bja\/aeq084.","journal-title":"Br J Anaesth"},{"key":"656_CR52","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1213\/01.ANE.0000175216.53374.27","volume":"101","author":"PJ Van der Linden","year":"2005","unstructured":"Van der Linden PJ, de Hert SG, Deraedt D, Cromheecke S, de Decker K, de Paep R, Rodrigus I, Daper A, Trenchant A: Hydroxyethyl starch 130\/0.4 versus modified fluid gelatin for volume expansion in cardiac surgery patients: the effects on perioperative bleeding and transfusion needs. Anesth Analg. 2005, 101: 629-634. 10.1213\/01.ANE.0000175216.53374.27.","journal-title":"Anesth Analg"},{"key":"656_CR53","doi-asserted-by":"publisher","first-page":"428","DOI":"10.5830\/CVJA-2012-026","volume":"23","author":"SM Alavi","year":"2012","unstructured":"Alavi SM, Ahmadi BB, Baharestani B, Babaei T: Comparison of the effects of gelatin, Ringer\u2019s solution and a modern hydroxylethyl starch solution after coronary artery bypass graft surgery. Cardiovasc J Afr. 2012, 23: 428-431. 10.5830\/CVJA-2012-026.","journal-title":"Cardiovasc J Afr"},{"key":"656_CR54","first-page":"111","volume":"103","author":"C Ertmer","year":"2012","unstructured":"Ertmer C, Wulf H, van Aken H, Friederich P, Mahl C, Bepperling F, Westphal M, Gogarten W: Efficacy and safety of 10% HES 130\/0.4 versus 10% HES 200\/0.5 for plasma volume expansion in cardiac surgery patients. Minerva Med. 2012, 103: 111-122.","journal-title":"Minerva Med"},{"key":"656_CR55","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/BF03019870","volume":"47","author":"HRC Gallandat","year":"2000","unstructured":"Gallandat HRC, Siemons AW, Baus D, van Rooyen-Butijn WT, Haagenaars JA, van Oeveren W, Bepperling F: A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery. Can J Anaesth. 2000, 47: 1207-1215. 10.1007\/BF03019870.","journal-title":"Can J Anaesth"},{"key":"656_CR56","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1053\/jcan.2001.21964","volume":"15","author":"K J\u00e4rvel\u00e4","year":"2001","unstructured":"J\u00e4rvel\u00e4 K, Koskinen M, Kaukinen S, K\u00f6\u00f6bi T: Effects of hypertonic saline (7.5%) on extracellular fluid volumes compared with normal saline (0.9%) and 6% hydroxyethyl starch after aortocoronary bypass graft surgery. J Cardiothorac Vasc Anest. 2001, 15: 210-215. 10.1053\/jcan.2001.21964.","journal-title":"J Cardiothorac Vasc Anest"},{"key":"656_CR57","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1399-6576.1993.tb03783.x","volume":"37","author":"A Kuitunen","year":"1993","unstructured":"Kuitunen A, Hynynen M, Salmenper\u00e4 M, Heinonen J, Vahtera E, Verkkala K, Myllyl\u00e4 G: Hydroxyethyl starch as a prime for cardiopulmonary bypass: effects of two different solutions on haemostasis. Acta Anaesthesiol Scand. 1993, 37: 652-658. 10.1111\/j.1399-6576.1993.tb03783.x.","journal-title":"Acta Anaesthesiol Scand"},{"key":"656_CR58","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4077\/CJP.2012.BAA028","volume":"55","author":"HL Liou","year":"2012","unstructured":"Liou HL, Shih CC, Chao YF, Lin NT, Lai ST, Wang SH, Chen HI: Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass. Chin J Physiol. 2012, 55: 210-218. 10.4077\/CJP.2012.BAA028.","journal-title":"Chin J Physiol"},{"key":"656_CR59","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1097\/CCM.0b013e3181f3e08c","volume":"38","author":"S Magder","year":"2010","unstructured":"Magder S, Potter BJ, Varennes BD, Doucette S, Fergusson D: Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med. 2010, 38: 2117-2124. 10.1097\/CCM.0b013e3181f3e08c.","journal-title":"Crit Care Med"},{"key":"656_CR60","first-page":"91","volume":"60","author":"J Vanhoonacker","year":"2009","unstructured":"Vanhoonacker J, Ongenae M, Vanoverschelde H, Donadoni R: Hydroxyethyl starch 130\/0.4 versus modified fluid gelatin for cardiopulmonary bypass priming: the effects on postoperative bleeding and volume expansion needs after elective CABG. Acta Anaesthesiol Belg. 2009, 60: 91-97.","journal-title":"Acta Anaesthesiol Belg"},{"key":"656_CR61","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0267659107077903","volume":"22","author":"WW Yap","year":"2007","unstructured":"Yap WW, Young D, Pathi V: Effects of gelatine and medium molecular weight starch as priming fluid in cardiopulmonary bypass-a randomised controlled trial. Perfusion. 2007, 22: 57-61. 10.1177\/0267659107077903.","journal-title":"Perfusion"},{"key":"656_CR62","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1055\/s-0038-1649964","volume":"74","author":"J Treib","year":"1995","unstructured":"Treib J, Haass A, Pindur G, Seyfert UT, Treib W, Grauer MT, Wenzel E, Schimrigk K: HES 200\/0.5 is not HES 200\/0.5: influence of the C2\/C6 hydroxyethylation ratio of hydroxyethyl starch (HES) on hemorheology, coagulation and elimination kinetics. Thromb Haemost. 1995, 74: 1452-1456.","journal-title":"Thromb Haemost"},{"key":"656_CR63","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1600-0609.1996.tb01337.x","volume":"56","author":"J Treib","year":"1996","unstructured":"Treib J, Haass A, Pindur G, Treib W, Wenzel E, Schimrigk K: Influence of intravascular molecular weight of hydroxyethyl starch on platelets. Eur J Haematol. 1996, 56: 168-172. 10.1111\/j.1600-0609.1996.tb01337.x.","journal-title":"Eur J Haematol"},{"key":"656_CR64","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1213\/ane.0b013e31817e6eac","volume":"107","author":"SA Kozek-Langenecker","year":"2008","unstructured":"Kozek-Langenecker SA, Jungheinrich C, Sauermann W, Van der Linden PJ: The effects of hydroxyethyl starch 130\/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials. Anesth Analg. 2008, 107: 382-390. 10.1213\/ane.0b013e31817e6eac.","journal-title":"Anesth Analg"},{"key":"656_CR65","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1097\/ALN.0b013e3182a6b387","volume":"119","author":"PJ Van der Linden","year":"2013","unstructured":"Van der Linden PJ, de Vill\u00e9 A, Hofer A, Heschl M, Gombotz H: Six percent hydroxyethyl starch 130\/0.4 (Voluven) versus 5% human serum albumin for volume replacement therapy during elective open-heart surgery in pediatric patients. Anesthesiology. 2013, 119: 1296-1309. 10.1097\/ALN.0b013e3182a6b387.","journal-title":"Anesthesiology"},{"key":"656_CR66","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/ALN.0b013e3181863117","volume":"109","author":"D Chappell","year":"2008","unstructured":"Chappell D, Jacob M, Hofmann-Kiefer K, Conzen P, Rehm M: A rational approach to perioperative fluid management. Anesthesiology. 2008, 109: 723-740. 10.1097\/ALN.0b013e3181863117.","journal-title":"Anesthesiology"},{"key":"656_CR67","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1213\/ANE.0b013e3181eaff91","volume":"112","author":"CS Hartog","year":"2011","unstructured":"Hartog CS, Bauer M, Reinhart K: The efficacy and safety of colloid resuscitation in the critically ill. Anesth Analg. 2011, 112: 156-164. 10.1213\/ANE.0b013e3181eaff91.","journal-title":"Anesth Analg"},{"key":"656_CR68","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/CCM.0b013e3181bc80f1","volume":"38","author":"DN Lobo","year":"2010","unstructured":"Lobo DN, Stanga Z, Aloysius MM, Wicks C, Nunes QM, Ingram KL, Risch L, Allison SP: Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers. Crit Care Med. 2010, 38: 464-470. 10.1097\/CCM.0b013e3181bc80f1.","journal-title":"Crit Care Med"},{"key":"656_CR69","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1007\/s00101-003-0557-0","volume":"52","author":"M Jacob","year":"2003","unstructured":"Jacob M, Rehm M, Orth V, L\u00f6tsch M, Brechtelsbauer H, Weninger E, Finsterer U: Exact measurement of the volume effect of 6% hydoxyethyl starch 130\/0.4 (Voluven) during acute preoperative normovolemic hemodilution [Article in German]. Anaesthesist. 2003, 52: 896-904. 10.1007\/s00101-003-0557-0.","journal-title":"Anaesthesist"},{"key":"656_CR70","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/00003246-199704000-00013","volume":"25","author":"L Riddez","year":"1997","unstructured":"Riddez L, Hahn RG, Brismar B, Strandberg A, Svens\u00e9n C, Hedenstierna G: Central and regional hemodynamics during acute hypovolemia and volume substitution in volunteers. Crit Care Med. 1997, 25: 635-640. 10.1097\/00003246-199704000-00013.","journal-title":"Crit Care Med"},{"key":"656_CR71","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/BF01704717","volume":"17","author":"JF Baron","year":"1991","unstructured":"Baron JF, De Kegel D, Prost AC, Mundler O, Arthaud M, Basset G, Maistre G, Masson F, Carayon A, Landault C, Barr\u00e9 E, Viars P: Low molecular weight hydroxyethyl starch 6% compared to albumin 4% during intentional hemodilution. Intensive Care Med. 1991, 17: 141-148. 10.1007\/BF01704717.","journal-title":"Intensive Care Med"},{"key":"656_CR72","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1056\/NEJMoa1204242","volume":"367","author":"A Perner","year":"2012","unstructured":"Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, \u00c5neman A, Madsen KR, M\u00f8ller MH, Elkj\u00e6r JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, S\u00f8e-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kj\u00e6ldgaard AL, Fabritius ML, Mondrup F, Pott FC, M\u00f8ller TP, et al: Hydroxyethyl starch 130\/0.42 versus Ringer\u2019s acetate in severe sepsis. N Engl J Med. 2012, 367: 124-134. 10.1056\/NEJMoa1204242. A published erratum appears in N Engl J Med 2012, 367:481","journal-title":"N Engl J Med"},{"key":"656_CR73","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1056\/NEJMoa1209759","volume":"367","author":"JA Myburgh","year":"2012","unstructured":"Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA, CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group: Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012, 367: 1901-1911. 10.1056\/NEJMoa1209759.","journal-title":"N Engl J Med"},{"key":"656_CR74","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/ACO.0b013e328328d1b6","volume":"22","author":"D Chappell","year":"2009","unstructured":"Chappell D, Westphal M, Jacob M: The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness. Curr Opin Anaesthesiol. 2009, 22: 155-162. 10.1097\/ACO.0b013e328328d1b6.","journal-title":"Curr Opin Anaesthesiol"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-014-0656-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13054-014-0656-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-014-0656-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-014-0656-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T12:07:58Z","timestamp":1728907678000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/s13054-014-0656-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":74,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["656"],"URL":"https:\/\/doi.org\/10.1186\/s13054-014-0656-0","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725264792.793514803","asserted-by":"object"}]},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]},"assertion":[{"value":"8 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"656"}}