{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:36:12Z","timestamp":1793860572217,"version":"4.6.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13054-019-2560-0","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T09:03:41Z","timestamp":1565946221000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Capillary refill time variation induced by passive leg raising predicts capillary refill time response to volume expansion"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-1648","authenticated-orcid":false,"given":"Matthias","family":"Jacquet-Lagr\u00e8ze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourredine","family":"Bouhamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Portran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Baudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lilot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fornier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Fellahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"issue":"12","key":"2560_CR1","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","volume":"40","author":"Maurizio Cecconi","year":"2014","unstructured":"Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, et al. Consensus on circulatory shock and hemodynamic monitoring. Task Force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014;40:1795\u2013815.","journal-title":"Intensive Care Medicine"},{"key":"2560_CR2","unstructured":"Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock. Crit Care Med. 2017;1."},{"key":"2560_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1164\/rccm.200109-016OC","volume":"166","author":"D De Backer","year":"2002","unstructured":"De Backer D, Creteur J, Preiser J, Dubois M, Vincent J. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166:98\u2013104.","journal-title":"Am J Respir Crit Care Med"},{"key":"2560_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","volume":"18","author":"M Garcia-Alvarez","year":"2014","unstructured":"Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014;18:503.","journal-title":"Crit Care"},{"key":"2560_CR5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jcrc.2016.05.007","volume":"35","author":"A Brunauer","year":"2016","unstructured":"Brunauer A, Kok\u00f6fer A, Bataar O, Gradwohl-Matis I, Dankl D, Bakker J, et al. Changes in peripheral perfusion relate to visceral organ perfusion in early septic shock: a pilot study. J Crit Care. 2016;35:105\u20139.","journal-title":"J Crit Care"},{"key":"2560_CR6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1213\/ANE.0b013e31821569f9","volume":"113","author":"A Pickard","year":"2011","unstructured":"Pickard A, Karlen W, Ansermino JM. Capillary refill time: is it still a useful clinical sign? Anesth Analg. 2011;113:120\u20133.","journal-title":"Anesth Analg"},{"issue":"7","key":"2560_CR7","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1007\/s00134-014-3326-4","volume":"40","author":"H. Ait-Oufella","year":"2014","unstructured":"Ait-Oufella H, Bige N, Boelle PY, Pichereau C, Alves M, Bertinchamp R, et al. Capillary refill time exploration during septic shock. Intensive Care Med. 2014;40:958\u201364.","journal-title":"Intensive Care Medicine"},{"issue":"9","key":"2560_CR8","doi-asserted-by":"publisher","first-page":"e0138155","DOI":"10.1371\/journal.pone.0138155","volume":"10","author":"Susannah Fleming","year":"2015","unstructured":"Fleming S, Gill P, Jones C, Taylor JA, Van den Bruel A, Heneghan C, et al. The diagnostic value of capillary refill time for detecting serious illness in children: a systematic review and meta-analysis. PLoS One. 2015;10.","journal-title":"PLOS ONE"},{"key":"2560_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jcrc.2011.05.024","volume":"27","author":"G Hernandez","year":"2012","unstructured":"Hernandez G, Pedreros C, Veas E, Bruhn A, Romero C, Rovegno M, et al. Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study. J Crit Care. 2012;27:283\u20138.","journal-title":"J Crit Care"},{"issue":"3","key":"2560_CR10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00134-015-4184-4","volume":"42","author":"Edmilson Bastos de Moura","year":"2016","unstructured":"de Moura EB, Amorim FF, da Cruz Santana AN, Kanhouche G, de Souza Godoy LG, de Jesus Almeida L, et al. Skin mottling score as a predictor of 28-day mortality in patients with septic shock. Intensive Care Med. 2016;42:479\u201380.","journal-title":"Intensive Care Medicine"},{"key":"2560_CR11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00134-011-2163-y","volume":"37","author":"H Ait-Oufella","year":"2011","unstructured":"Ait-Oufella H, Lemoinne S, Boelle PY, Galbois A, Baudel JL, Lemant J, et al. Mottling score predicts survival in septic shock. Intensive Care Med. 2011;37:801\u20137.","journal-title":"Intensive Care Med"},{"key":"2560_CR12","doi-asserted-by":"crossref","unstructured":"Hernandez G, Bruhn A, Castro R, Regueira T. The holistic view on perfusion monitoring in septic shock. Curr Opin Crit Care. 2012.","DOI":"10.1097\/MCC.0b013e3283532c08"},{"key":"2560_CR13","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/cc12727","volume":"17","author":"MW D\u00fcnser","year":"2013","unstructured":"D\u00fcnser MW, Takala J, Brunauer A, Bakker J. Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach. Crit Care. 2013;17:326.","journal-title":"Crit Care"},{"key":"2560_CR14","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1164\/rccm.201408-1575LE","volume":"191","author":"ME van Genderen","year":"2015","unstructured":"van Genderen ME, Engels N, van der Valk RJP, Lima A, Klijn E, Bakker J, et al. Early peripheral perfusion-guided fluid therapy in patients with septic shock. Am J Respir Crit Care Med. 2015;191:477\u201380.","journal-title":"Am J Respir Crit Care Med"},{"key":"2560_CR15","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1001\/jama.2019.0071","volume":"321","author":"G Hern\u00e1ndez","year":"2019","unstructured":"Hern\u00e1ndez G, Ospina-Tasc\u00f3n GA, Damiani LP, Estenssoro E, Dubin A, Hurtado J, et al. Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA-SHOCK randomized clinical trial. JAMA. 2019;321:654\u201364.","journal-title":"JAMA."},{"issue":"4","key":"2560_CR16","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00134-012-2793-8","volume":"39","author":"Andrius Pranskunas","year":"2012","unstructured":"Pranskunas A, Koopmans M, Koetsier PM, Pilvinis V, Boerma EC. Microcirculatory blood flow as a tool to select ICU patients eligible for fluid therapy. Intensive Care Med. 2013;39(4):612-9.","journal-title":"Intensive Care Medicine"},{"key":"2560_CR17","doi-asserted-by":"crossref","unstructured":"Monnet X, Marik P, Teboul J-L. Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis. Intensive Care Med. 2016.","DOI":"10.1186\/s13613-016-0216-7"},{"key":"2560_CR18","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1007\/s00134-010-1966-6","volume":"36","author":"J Pottecher","year":"2010","unstructured":"Pottecher J, Deruddre S, Teboul J-L, Georger J-F, Laplace C, Benhamou D, et al. Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients. Intensive Care Med. 2010;36:1867\u201374.","journal-title":"Intensive Care Med"},{"key":"2560_CR19","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/s13063-016-1515-x","volume":"17","author":"V Pettil\u00e4","year":"2016","unstructured":"Pettil\u00e4 V, Merz T, Wilkman E, Perner A, Karlsson S, Lange T, et al. Targeted tissue perfusion versus macrocirculation-guided standard care in patients with septic shock (TARTARE-2S): study protocol and statistical analysis plan for a randomized controlled trial. Trials. 2016;17:384.","journal-title":"Trials."},{"key":"2560_CR20","doi-asserted-by":"crossref","unstructured":"Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ. 2015:h5527.","DOI":"10.1136\/bmj.h5527"},{"key":"2560_CR21","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J, Willatts S, De Mendon\u00e7a A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707\u201310.","journal-title":"Intensive Care Med"},{"key":"2560_CR22","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","volume":"270","author":"JR Le Gall","year":"1993","unstructured":"Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study. JAMA. 1993;270:2957\u201363.","journal-title":"JAMA."},{"key":"2560_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13054-014-0708-5","volume":"19","author":"X Monnet","year":"2015","unstructured":"Monnet X, Teboul J-L. Passive leg raising: five rules, not a drop of fluid! Crit Care Lond Engl. 2015;19:18.","journal-title":"Crit Care Lond Engl"},{"key":"2560_CR24","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/096228029800700405","volume":"7","author":"NA Obuchowski","year":"1998","unstructured":"Obuchowski NA. Sample size calculations in studies of test accuracy. Stat Methods Med Res. 1998;7:371\u201392.","journal-title":"Stat Methods Med Res"},{"key":"2560_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/0735-6757(94)90196-1","volume":"12","author":"LH Brown","year":"1994","unstructured":"Brown LH, Prasad NH, Whitley TW. Adverse lighting condition effects on the assessment of capillary refill. Am J Emerg Med. 1994;12:46\u20137.","journal-title":"Am J Emerg Med"},{"key":"2560_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ajem.2007.06.026","volume":"26","author":"B Anderson","year":"2008","unstructured":"Anderson B, Kelly A-M, Kerr D, Clooney M, Jolley D. Impact of patient and environmental factors on capillary refill time in adults. Am J Emerg Med. 2008;26:62\u20135.","journal-title":"Am J Emerg Med"},{"key":"2560_CR27","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/S0196-0644(88)80675-9","volume":"17","author":"DL Schriger","year":"1988","unstructured":"Schriger DL, Baraff L. Defining normal capillary refill: variation with age, sex, and temperature. Ann Emerg Med. 1988;17:932\u20135.","journal-title":"Ann Emerg Med"},{"issue":"4","key":"2560_CR28","doi-asserted-by":"publisher","first-page":"R204","DOI":"10.1186\/cc10421","volume":"15","author":"Xavier Monnet","year":"2011","unstructured":"Monnet X, Persichini R, Ktari M, Jozwiak M, Richard C, Teboul J-L. Precision of the transpulmonary thermodilution measurements. Crit Care. 2011;15:R204.","journal-title":"Critical Care"},{"key":"2560_CR29","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/ALN.0000000000001824","volume":"127","author":"M Jacquet-Lagr\u00e8ze","year":"2017","unstructured":"Jacquet-Lagr\u00e8ze M, Izaute G, Fellahi J-L. Diagnostic accuracy studies: the methodologic approach matters! Anesthesiology. 2017;127:728\u20139.","journal-title":"Anesthesiology."},{"key":"2560_CR30","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/01.PCC.0000090293.32810.4E","volume":"4","author":"K Maitland","year":"2003","unstructured":"Maitland K, Pamba A, Newton CRJC, Levin M. Response to volume resuscitation in children with severe malaria. Pediatr Crit Care Med. 2003;4:426\u201331.","journal-title":"Pediatr Crit Care Med"},{"key":"2560_CR31","doi-asserted-by":"crossref","unstructured":"De Backer D, Ortiz JA, Salgado D. Coupling microcirculation to systemic hemodynamics. Curr Opin Crit Care. 2010;16:250\u20134.","DOI":"10.1097\/MCC.0b013e3283383621"},{"key":"2560_CR32","doi-asserted-by":"crossref","unstructured":"De Backer D, Donadello K, Sakr Y, Ospina-Tascon G, Salgado D, Scolletta S, et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med. 2013;41:791\u20139.","DOI":"10.1097\/CCM.0b013e3182742e8b"},{"key":"2560_CR33","doi-asserted-by":"crossref","unstructured":"Garc\u00eda MIM, Romero MG, Cano AG, Aya HD, Rhodes A, Grounds RM, et al. Dynamic arterial elastance as a predictor of arterial pressure response to fluid administration: a validation study. Crit Care. 2014;18:626.","DOI":"10.1186\/s13054-014-0626-6"},{"key":"2560_CR34","doi-asserted-by":"crossref","unstructured":"Gu\u00e9rin L, Teboul J-L, Persichini R, Dres M, Richard C, Monnet X. Effects of passive leg raising and volume expansion on mean systemic pressure and venous return in shock in humans. Crit Care. 2015;19.","DOI":"10.1186\/s13054-015-1115-2"},{"issue":"6","key":"2560_CR35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10286-015-0286-x","volume":"25","author":"Eva Klijn","year":"2015","unstructured":"Klijn E, Niehof S, Johan Groeneveld AB, Lima AP, Bakker J, van Bommel J. Postural change in volunteers: sympathetic tone determines microvascular response to cardiac preload and output increases. Clin Auton Res. 2015;25:347\u201354.","journal-title":"Clinical Autonomic Research"},{"key":"2560_CR36","doi-asserted-by":"crossref","unstructured":"Mallat J, Lazkani A, Lemyze M, Pepy F, Meddour M, Gasan G, et al. Repeatability of blood gas parameters, PCO2 gap, and PCO2 gap to arterial-to-venous oxygen content difference in critically ill adult patients. Medicine (Baltimore). 2015;94.","DOI":"10.1097\/MD.0000000000000415"},{"issue":"1","key":"2560_CR37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1088\/0967-3334\/37\/1\/83","volume":"37","author":"L L Blaxter","year":"2015","unstructured":"Blaxter LL, Morris DE, Crowe JA, Henry C, Hill S, Sharkey D, et al. An automated quasi-continuous capillary refill timing device. Physiol Meas. 2016;37:83\u201399.","journal-title":"Physiological Measurement"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-019-2560-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13054-019-2560-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-019-2560-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T19:15:50Z","timestamp":1597432550000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/s13054-019-2560-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,16]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2560"],"URL":"https:\/\/doi.org\/10.1186\/s13054-019-2560-0","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736456347.793579972","asserted-by":"object"}]},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,16]]},"assertion":[{"value":"1 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Comit\u00e9 de Protection des Personnes Lyon Sud-Est II ANSM: 2014-A01034-43.\n                      \n                      : NCT02248025.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The corresponding author has created a medtech company called DICARTECH which is developing a device to assess capillary refill time. All other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"281"}}