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The use of albumin solutions for plasma volume support is controversial because of concerns of increased capillary leakage, which could aggravate the commonly seen interstitial oedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present open controlled clinical trial, an intravenous infusion of 20% albumin at 3\u2009mL\/kg was given over 30\u2009min to 15 burn patients and 15 healthy volunteers. Blood samples and urine were collected for 5\u2009h. Plasma dilution, plasma albumin and colloid osmotic pressure were compared. Mass balance calculations were used to estimate plasma volume expansion and capillary leakage of fluid and albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients were studied between 4 and 14 (median, 7) days after the burn injury, which spread over 7\u201348% (median, 15%) of the total body surface area. The albumin solution expanded the plasma volume by almost 15%, equivalent to twice the infused volume, in both groups. The urinary excretion exceeded the infused volume by a factor of 2.5. Capillary leakage of albumin occurred at a rate of 3.4\u2009\u00b1\u20091.5\u2009g\/h in burn patients and 3.7\u2009\u00b1\u20091.6\u2009g\/h in the volunteers (<jats:italic>P<\/jats:italic>\u2009=\u20090.61), which corresponded to 2.4\u2009\u00b1\u20091.0% and 2.5\u2009\u00b1\u20091.2% per hour of the intravascular pool (<jats:italic>P<\/jats:italic>\u2009=\u20090.85). The median half-life of the plasma volume expansion was 5.9 (25th\u201375th percentiles 2.7\u201311.7) h in the burn patients and 6.9 (3.4\u20138.5) h in the volunteers (<jats:italic>P<\/jats:italic>\u2009=\u20090.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Albumin 20% was an effective volume expander in patients at 1\u00a0week post-burn. No relevant differences were found between burn patients and healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2016-000996-26\/SE\">EudraCT 2016-000996-26<\/jats:ext-link>on May 31, 2016.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13054-020-02855-0","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T23:03:53Z","timestamp":1588633433000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers"],"prefix":"10.1186","volume":"24","author":[{"given":"Markus","family":"Zdolsek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folke","family":"Sj\u00f6berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Zdolsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"2855_CR1","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s00134-018-5253-2","volume":"44","author":"J M\u00e5rtensson","year":"2018","unstructured":"M\u00e5rtensson J, Bihari S, Bannard-Smith J, Glassford NJ, Lloyd-Donald P, et al. 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The trial was registered aton May 31, 2016, and also at. The first patient was studied on September 19, 2016. The presentation follows the STROBE Statement for case-control studies.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author RGH declares that he receives a research grant from Grifols for studies of 20% albumin. The other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"191"}}