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Nevertheless, many patients cannot be successfully weaned from VA ECMO support and 1-year mortality remains high. A systematic approach could help to optimize clinical management in favor of weaning by identifying important factors in individual patients. Here, we provide an overview of pivotal factors that potentially prevent successful weaning of VA ECMO. We present this through a rigorous approach following the relatable acronym ABCDE, in order to facilitate widespread use in daily practice.<\/jats:p>","DOI":"10.1186\/s13054-022-04089-8","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:04:24Z","timestamp":1657879464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The ABCDE approach to difficult weaning from venoarterial extracorporeal membrane oxygenation"],"prefix":"10.1186","volume":"26","author":[{"given":"Christiaan L.","family":"Meuwese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brodie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk W.","family":"Donker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"issue":"7\u20138","key":"4089_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s12471-021-01552-z","volume":"29","author":"CL Meuwese","year":"2021","unstructured":"Meuwese CL, Hermens JA, de Haan M, Braithwaite SA, Ramjankhan F, Buijsrogge MP, et al. 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DB receives research support from ALung Technologies. He has been on the medical advisory boards for Abiomed, Xenios, Medtronic, Inspira, and Cellenkos. He is the President-elect of the Extracorporeal Life Support Organization (ELSO) and the Chair of the Executive Committee of the International ECMO Network (ECMONet). DWD reports personal fees from Getinge-Maquet, Xenios NovaLung Fresenius, and Abiomed and research funding from \u2018Stichting Gezondheidszorg Spaarneland (SGS)\u2019 foundation, and consultancy and research cooperation with Getinge-Maquet.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"216"}}