{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:18:31Z","timestamp":1792801111058,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Hospital Research Foundation Group Fellowship","id":[{"id":"https:\/\/ror.org\/054r0wx32","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Anaesthesia and Intensive Care Trust at Austin Health","id":[{"id":"https:\/\/ror.org\/05dbj6g52","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mega-dose sodium ascorbate (NaAscorbate) appears beneficial in experimental sepsis. However, its physiological effects in patients with septic shock are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a pilot, single-dose, double-blind, randomized controlled trial. We enrolled patients with septic shock within 24\u00a0h of diagnosis. We randomly assigned them to receive a single mega-dose of NaAscorbate (30\u00a0g over 1 h followed by 30\u00a0g over 5 h) or placebo (vehicle). The primary outcome was the total 24\u00a0h urine output (UO) from the beginning of the study treatment. Secondary outcomes included the time course of the progressive cumulative UO, vasopressor dose, and sequential organ failure assessment (SOFA) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 30 patients (15 patients in each arm). The mean (95% confidence interval) total 24-h UO was 2056 (1520\u20132593) ml with placebo and 2948 (2181\u20133715) ml with NaAscorbate (mean difference 891.5, 95% confidence interval [\u2212\u20092.1 to 1785.2],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.051). Moreover, the progressive cumulative UO was greater over time on linear mixed modelling with NaAscorbate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Vasopressor dose and SOFA score changes over time showed faster reductions with NaAscorbate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.042). The sodium level, however, increased more over time with NaAscorbate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was no statistical difference in other clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with septic shock, mega-dose NaAscorbate did not significantly increase cumulative 24-h UO. However, it induced a significantly greater increase in UO and a\u00a0greater reduction in vasopressor dose and SOFA score over time. One episode of hypernatremia and one of hemolysis were observed in the NaAscorbate group. These findings support further cautious investigation of this novel intervention.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration<\/jats:italic>\n                      Australian New Zealand Clinical Trial Registry (ACTRN12620000651987), Date registered June\/5\/2020.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13054-023-04644-x","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T11:01:57Z","timestamp":1697108517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial"],"prefix":"10.1186","volume":"27","clinical-trial-number":[{"clinical-trial-number":"actrn12620000651987","registry":"10.18810\/anzctr"}],"author":[{"given":"Fumitaka","family":"Yanase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Spano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Chaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thummaporn","family":"Naorungroj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie Pei Chen","family":"Ow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugeesh R.","family":"Lankadeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive N.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashenafi H.","family":"Betrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius J. 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Written informed consent for enrolment or consent to continue and use patient data was obtained from all patients or the legally responsible person.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all patients or the legally responsible person.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"YRL, CNM and RB own a patent for the use of mega-dose sodium ascorbate in the treatment of sepsis.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"371"}}