{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:26:59Z","timestamp":1788964019310,"version":"build-2803163510"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL155020"],"award-info":[{"award-number":["T32HL155020"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL155020"],"award-info":[{"award-number":["T32HL155020"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL155020"],"award-info":[{"award-number":["T32HL155020"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL155020"],"award-info":[{"award-number":["T32HL155020"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL127101"],"award-info":[{"award-number":["K24HL127101"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K23GM128005"],"award-info":[{"award-number":["K23GM128005"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R21AT005119"],"award-info":[{"award-number":["R21AT005119"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patient-level data from the Thiamine in Septic Shock Trial (NCT01070810) and the Thiamine for Renal Protection in Septic Shock Trial (NCT03550794) were combined in this analysis. The primary outcome for the current study was survival without the receipt of renal replacement therapy (RRT). Analyses were performed on the overall cohort and the thiamine-deficient cohort (thiamine\u2009&lt;\u20098\u00a0nmol\/L).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Totally, 158 patients were included. Overall, thiamine administration was associated with higher odds of being alive and RRT-free (adjusted odds ratio [aOR]: 2.05 [95% confidence interval (CI) 1.08\u20133.90]) and not needing RRT (aOR: 2.59 [95% CI 1.01\u20136.62]). In the thiamine-deficient group, thiamine administration was associated with higher odds of being alive and RRT-free (aOR: 8.17 [95% CI 1.79\u201337.22]) and surviving to hospital discharge (aOR: 6.84 [95% CI 1.54\u201330.36]). There was a significant effect modification by baseline thiamine deficiency for alive and RRT-free (interaction, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and surviving to hospital discharge (<jats:italic>p<\/jats:italic>\u2009=\u20090.019).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In the combined analysis of two previous randomized trials, thiamine administration was associated with higher odds of being alive and RRT-free at hospital discharge in patients with septic shock. This signal was stronger in patients with thiamine deficiency.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13054-024-04818-1","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T10:02:12Z","timestamp":1707213732000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Thiamine administration in septic shock: a post hoc analysis of two randomized trials"],"prefix":"10.1186","volume":"28","author":[{"given":"Jacob","family":"Vine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max S.","family":"Kravitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne V.","family":"Grossestreuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshman","family":"Balaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon B.","family":"Leland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Berlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Moskowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Donnino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"4818_CR1","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1513\/AnnalsATS.201608-656BC","volume":"14","author":"A Moskowitz","year":"2017","unstructured":"Moskowitz A, Andersen LW, Cocchi MN, Karlsson M, Patel PV, Donnino MW. Thiamine as a renal protective agent in septic shock. A secondary analysis of a randomized, double-blind, placebo-controlled trail. Ann Am Thorac Soc.2017;14:737\u201341.","journal-title":"Ann Am Thorac Soc"},{"key":"4818_CR2","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1164\/rccm.202301-0034OC","volume":"208","author":"A Moskowitz","year":"2023","unstructured":"Moskowitz A, Berg KM, Grossestreuer AV, Balaji L, Liu X, Cocchi  MN. Thiamine for renal protection in septic shock (TRPSS): a randomized, placebo-controlled, clinical trial. Am J Respir Crit Care Med. 2023;208:570\u20138.","journal-title":"Am J Respir Crit Care Med"},{"key":"4818_CR3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1056\/NEJMra032401","volume":"351","author":"RW Schrier","year":"2004","unstructured":"Schrier RW, Wang W. Acute renal failure and sepsis. 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Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin. 2001;17:219\u201337.","journal-title":"Crit Care Clin"},{"key":"4818_CR7","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.jcrc.2010.03.003","volume":"25","author":"MW Donnino","year":"2010","unstructured":"Donnino MW, Carney E, Cocchi MN, Barbash I, Chase M, Joyce  N. Thiamine deficiency in critically ill patients with sepsis. J Crit Care. 2010;25:576\u201381.","journal-title":"J Crit Care"},{"key":"4818_CR8","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1097\/MCO.0b013e32834b8911","volume":"14","author":"W Manzanares","year":"2011","unstructured":"Manzanares W, Hardy G. Thiamine supplementation in the critically ill. 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Intensive Care Med. 2022;48:16\u201324.","DOI":"10.1007\/s00134-021-06558-0"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-024-04818-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13054-024-04818-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-024-04818-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T17:12:22Z","timestamp":1734541942000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/s13054-024-04818-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4818"],"URL":"https:\/\/doi.org\/10.1186\/s13054-024-04818-1","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"7 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The two RCTs, the Thiamine in Septic Shock Trial (TSS) (NCT01070810) and the Thiamine for Renal Protection in Septic Shock Trial (TRPSS) (NCT03550794), were approved by local Institutional Review Boards and overseen by Data Safety and Monitoring Boards. All study participants or their legal representatives were asked for written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}