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However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bi-centric prospective study included patients with sepsis with or without shock and prolonged CRT\u2009&gt;\u20093\u00a0s despite initial resuscitation. Clinicians in charge of the patients were free to infuse either saline 500\u00a0mL or human serum albumin 20% 100\u00a0mL over 15\u00a0min. Global hemodynamic parameters as well as peripheral tissue perfusion were analyzed after 1 (H1) and 4\u00a0h (H4). The primary endpoint was CRT normalization (&lt;\u20093\u00a0s) at H1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      62 patients were screened, and 50 patients (13 sepsis and 37 septic shock) were included, 21 in the saline group and 29 in the albumin group. SOFA score was 8 [5\u201311], and SAPS II was 53 [45\u201370]. Median age was 68 [60\u201376] years with a higher proportion of men (74%). The primary sources of infection were respiratory (54%) and abdominal (24%). At baseline, comorbidities, clinical and biological characteristics were similar between groups\n                      <jats:bold>.<\/jats:bold>\n                      At H1, CRT normalization (&lt;\u20093\u00a0s) was more frequent in patients receiving albumin as compared to patients treated by saline (63 vs 29%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). The decrease in fingertip CRT was more important in the albumin group when compared to saline group (\u2212 1.0 [\u2212 0.3; \u2212 1.5] vs \u2212 0.2 [\u2212 0.1; \u2212 1.1] seconds,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04) as well as decrease in mottling score. At H4, beneficial effects of albumin on peripheral tissue perfusion were maintained and urinary output trended to be higher in the albumin group (1.1 [0.5\u20131.8] vs 0.7 [0.5\u20130.9] ml\/kg\/h,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.08). Finally, arterial lactate level did not significantly change between H0 and H4 in the saline group but significantly decreased in the albumin group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with resuscitated sepsis, albumin infusion might lead to greater improvement of tissue hypoperfusion compared to saline. ClinicalTrials.gov Identifier: NCT05094856.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13054-024-04827-0","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:06:07Z","timestamp":1707271567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study"],"prefix":"10.1186","volume":"28","author":[{"given":"Paul","family":"Gabarre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Desnos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louai","family":"Missri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Urbina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bonny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Baudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Berard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Montil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Guidet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Voiriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Joffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Maury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafid","family":"Ait-Oufella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"issue":"10219","key":"4827_CR1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. 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