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It remains unclear, if these requirements can be fulfilled by volatile sedations in intensive care medicine in an efficient manner. Therefore, this study aimed to assess the time to extubation and secondary the workload required.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a prospective randomized single-center trial at a tertiary university hospital to evaluate the postoperative management of open valve surgery patients. The study was randomized with regard to the use of volatile sedation compared to propofol sedation. Sedation was discontinued 60\u00a0min after admission for critical postoperative monitoring.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We observed a significantly earlier extubation (91\u2009\u00b1\u200939\u00a0min vs. 167\u2009\u00b1\u200977\u00a0min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), eye-opening (86\u2009\u00b1\u200928\u00a0min vs. 151\u2009\u00b1\u200971\u00a0min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and command compliance (93\u2009\u00b1\u200938\u00a0min vs. 164\u2009\u00b1\u200975\u00a0min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) using volatile sedation, which in turn was associated with a significantly increased workload of a median of 9:56\u00a0min (\u00b1\u20094:16\u00a0min) set-up time. We did not observe any differences in complications. Cardiopulmonary bypass time did not differ between the groups 101 (IQR 81; 113) versus 112 (IQR 79; 136) minutes <jats:italic>p<\/jats:italic>\u2009=\u20090.36.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Using volatile sedation is associated with few minutes additional workload in assembling and enables a significantly accelerated evaluation of vulnerable patient groups. Volatile sedation has considerable advantages and emerges as a safe sedation technique in our vulnerable study population.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>: Clinical trials registration (NCT04958668) was completed on 1 July 2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13054-024-04899-y","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:02:03Z","timestamp":1712314923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial"],"prefix":"10.1186","volume":"28","clinical-trial-number":[{"clinical-trial-number":"nct04958668","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Armin Niklas","family":"Flinspach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian J\u00fcrgen","family":"Raimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Pfaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zacharowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Neef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Hannah","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"issue":"4","key":"4899_CR1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1213\/ANE.0000000000001588","volume":"124","author":"H Liu","year":"2017","unstructured":"Liu H, Ji F, Peng K, Applegate RL, Fleming N. 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An informed consent was obtained from each individual patient or their legal representative in advance.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"A.N.F. received speaker fees from P.J. Dahlhausen & Co. GmbH, Cologne, Germany, received the Sedana Medical Research Grant 2020 and Thieme Teaching Award 2022. E.H.A. received a research Grant from the German Research Foundation (AD 592\/1-1). F.J.R. received speaker fees from Helios Germany, university hospital W\u00fcrzburg and Keller Medical GmbH. FJR received financial support by HemoSonics LLC, pharma-consult Petersohn and Boehringer Ingelheim. V.N. received speaker fees from Sysmex and Pharmacosmos. K.Z. has received honoraria for participation in advisory board meetings for Haemonetics and Vifor and received speaker fees from CSL Behring, Masimo, Pharmacosmos, Boston Scientific, Salus, iSEP, Edwards and GE Healthcare. He is the Principal Investigator of the EU-Horizon 2020 project ENVISION (Intelligent plug-and-play digital tool for real-time surveillance of COVID-19 patients and smart decision-making in Intensive Care Units) and Horizon Europe 2021 project COVend (Biomarker and AI-supported FX06 therapy to prevent progression from mild and moderate to severe stages of COVID-19). The Department of Anaesthesiology, Intensive Care Medicine & Pain Therapy of the University Hospital Frankfurt, Goethe University received support from B. Braun Melsungen, CSL Behring, Fresenius Kabi, and Vifor Pharma for the implementation of Frankfurt\u2019s Patient Blood Management program. M.P. and P.K. declare that there are no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"111"}}