{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:46:13Z","timestamp":1790102773762,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral cleansing for reducing CAUTI in comatose patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this randomized controlled trial, eligible patients in our hospital were enrolled and allocated randomly to the experimental group (expanded periurethral cleansing protocol; n\u2009=\u2009225) or the control group (usual periurethral cleansing protocol; n\u2009=\u2009221). The incidence of CAUTI on days 3, 7, and 10 after catheter insertion were compared, and the pathogen results and influencing factors were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidences of CAUTI in the experimental and control groups on days 3, 7, and 10 were (5\/225, 2.22% <jats:italic>vs<\/jats:italic>. 7\/221, 3.17%, <jats:italic>P<\/jats:italic>\u2009=\u20090.54), (12\/225, 5.33% <jats:italic>vs<\/jats:italic>. 18\/221, 8.14%, <jats:italic>P<\/jats:italic>\u2009=\u20090.24), and (23\/225, 10.22% <jats:italic>vs.<\/jats:italic> 47\/221, 21.27%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), respectively; <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Candida albicans<\/jats:italic> were the most common species in the two groups. The incidences of bacterial CAUTI and fungal CAUTI in the two groups were 11\/225, 4.89% <jats:italic>vs.<\/jats:italic> 24\/221, 10.86%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and (10\/225, 4.44% <jats:italic>vs.<\/jats:italic> 14\/221, 6.33%, <jats:italic>P<\/jats:italic>\u2009=\u20090.38), respectively. The incidences of polymicrobial CAUTI in the two groups were 2\/225 (0.89%) and 9\/221 (4.07%), respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). The percentages of CAUTI-positive females in the two groups were 9.85% (13\/132) and 29.52% (31\/105), respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The proportion of CAUTI-positive patients with diabetes in the experimental and control groups was 17.72% (14\/79), which was lower than the 40.85% (29\/71) in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Expanded periurethral cleansing could reduce the incidence of CAUTI, especially those caused by bacteria and multiple pathogens, in comatose patients with short-term catheterization (\u2264\u200910 days). Female patients and patients with diabetes benefit more from the expanded periurethral cleansing protocol for reducing CAUTI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13054-024-04947-7","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T18:01:59Z","timestamp":1715623319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial"],"prefix":"10.1186","volume":"28","author":[{"given":"Xingsong","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"issue":"13","key":"4947_CR1","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1056\/NEJMoa1306801","volume":"370","author":"SS Magill","year":"2014","unstructured":"Magill SS, Edwards JR, Bamberg W, et al. 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