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This multicentre, randomized, feasibility trial was conducted to test the hypothesis that a restrictive protocol targeting non-resuscitation fluids reduces the overall volume administered compared with usual care.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Adults with septic shock in six Swedish ICUs were randomized within 12\u00a0h of ICU admission to receive either protocolized reduction of non-resuscitation fluids or usual care. The primary outcome was the total volume of fluid administered within three days of inclusion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median (IQR) total volume of fluid in the first three days, was 6008\u00a0ml (interquartile range [IQR] 3960\u20138123) in the restrictive fluid group (n\u2009=\u200944), and 9765\u00a0ml (IQR 6804\u201312,401) in the control group (n\u2009=\u200948); corresponding to a Hodges\u2013Lehmann median difference of 3560\u00a0ml [95% confidence interval 1614\u20135302]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Outcome data on all-cause mortality, days alive and free of mechanical ventilation and acute kidney injury or ischemic events in the ICU within 90\u00a0days of inclusion were recorded in 98\/98 (100%), 95\/98 (98%) and 95\/98 (98%) of participants respectively. Cognition and health-related quality of life at six months were recorded in 39\/52 (75%) and 41\/52 (79%) of surviving participants, respectively. Ninety out of 134 patients (67%) of eligible patients were randomized, and 15\/98 (15%) of the participants experienced at least one protocol violation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Protocolized reduction of non-resuscitation fluids in patients with septic shock resulted in a large decrease in fluid administration compared with usual care. A trial using this design to test if reducing non-resuscitation fluids improves outcomes is feasible.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov, NCT05249088, 18 February 2022. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05249088\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05249088<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13054-024-04952-w","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T09:01:44Z","timestamp":1715936504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial"],"prefix":"10.1186","volume":"28","author":[{"given":"Anja","family":"Lind\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sp\u00e5ngfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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