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Proven invasive candidiasis with at least 2 BDG determinations were considered.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the study population of 103 patients (age 47 [35\u201362] years, SAPS II score 67 [52\u201377]) 68 bloodstream and 35 intrabdominal infections were recorded. Serial measurements showed that in 54 patients BDG decreased over time (BDG downslope group) while in 49 did not (N-BDG downslope group). <jats:italic>Candida albicans<\/jats:italic> was the pathogen most frequently isolated (61%) followed by <jats:italic>C. parapsilosis<\/jats:italic> (17%) and <jats:italic>C. glabrata<\/jats:italic> (12%), in absence of any inter-group difference. Invasive candidiasis related mortality was lower in BDG downslope than in N-BDG downslope group (17% vs 53%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The multivariate Cox regression analysis showed the association of septic shock at infection occurrence and chronic liver disease with invasive candidiasis mortality (HR [95% CI] 3.24 [1.25\u20138.44] <jats:italic>p<\/jats:italic>\u2009=\u20090.02 and 7.27 [2.33\u201322.66] <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, respectively) while a BDG downslope was the only predictor of survival (HR [95% CI] 0.19 [0.09\u20130.43] <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The area under the receiver operator characteristic curve for the performance of BDG downslope as predictor of good clinical outcome was 0.74 (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and our model showed that a BDG downslope &gt;\u200970% predicted survival with both specificity and positive predictive value of 100%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A decrease in serum BDG was associated with reduced mortality and a steep downslope predicted survival with high specificity in invasive candidiasis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13054-024-05022-x","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T07:02:53Z","timestamp":1720767773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic value of serial (1,3)-\u03b2-d-glucan measurements in ICU patients with invasive candidiasis"],"prefix":"10.1186","volume":"28","author":[{"given":"Simone","family":"Carelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Posteraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Torelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Carolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sole","family":"Vallecoccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikardo","family":"Xhemalaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Lucio","family":"Cutuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa Sofia","family":"Tanzarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Dell\u2019Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Cammarota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Caroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Luca","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"De Pascale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"5022_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13054-016-1313-6","volume":"20","author":"T Calandra","year":"2016","unstructured":"Calandra T, Roberts JA, Antonelli M, Bassetti M, Vincent J-L. 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