{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:44:33Z","timestamp":1785332673863,"version":"3.55.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines","award":["24ZXZKSY00050"],"award-info":[{"award-number":["24ZXZKSY00050"]}]},{"name":"National High-level Chinese Medicine Hospital Clinical Study Specific Funding","award":["DZMG-LJRC0008"],"award-info":[{"award-number":["DZMG-LJRC0008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"DOI":"10.1186\/s13054-025-05666-3","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:47:16Z","timestamp":1759754836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Xuebijing injection reduces 28-day mortality in patients with septic shock"],"prefix":"10.1186","volume":"29","author":[{"given":"Jing","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingji","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lufeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"10","key":"5666_CR1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1164\/rccm.202310-1785OC","volume":"209","author":"B Teja","year":"2024","unstructured":"Teja B, Berube M, Pereira TV, Law AC, Schanock C, Pang B, et al. Effectiveness of fludrocortisone plus hydrocortisone versus hydrocortisone alone in septic shock: a systematic review and network meta-analysis of randomized controlled trials. Am J Respir Crit Care Med. 2024;209(10):1219\u201328.","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"5666_CR2","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1001\/jamainternmed.2023.0780","volume":"183","author":"S Liu","year":"2023","unstructured":"Liu S, Yao C, Xie J, Liu H, Wang H, Lin Z, et al. Effect of an herbal-based injection on 28-day mortality in patients with sepsis: the EXIT-SEP randomized clinical trial. JAMA Intern Med. 2023;183(7):647\u201355.","journal-title":"JAMA Intern Med"},{"issue":"9","key":"5666_CR3","doi-asserted-by":"publisher","first-page":"e735","DOI":"10.1097\/CCM.0000000000003842","volume":"47","author":"Y Song","year":"2019","unstructured":"Song Y, Yao C, Yao Y, Han H, Zhao X, et al. XueBiJing injection versus placebo for critically ill patients with severe Community-Acquired pneumonia: A randomized controlled trial. Crit Care Med. 2019;47(9):e735\u201343.","journal-title":"Crit Care Med"},{"issue":"8","key":"5666_CR4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"issue":"5","key":"5666_CR5","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/s41401-023-01224-1","volume":"45","author":"C Cheng","year":"2024","unstructured":"Cheng C, Ren C, Li MZ, Liu YH, Yao RQ, Yu Y, et al. Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation. Acta Pharmacol Sin. 2024;45(5):1077\u201392.","journal-title":"Acta Pharmacol Sin"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-025-05666-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13054-025-05666-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-025-05666-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:04:31Z","timestamp":1765371871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13054-025-05666-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5666"],"URL":"https:\/\/doi.org\/10.1186\/s13054-025-05666-3","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"28 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Dongzhimen Hospital, Beijing University of Chinese Medicine (Approval number: 2023DZMEC-294-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have read and approved the final version of the manuscript and consent to its submission and publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Lufeng Ma and Zhiqiao Feng are employed by Tianjin Chasesun Pharmaceutical Co., Ltd., the manufacturer of Xuebijing, and had no role in the study design, data analysis, or manuscript preparation. The other authors report no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"419"}}