{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:08:31Z","timestamp":1792688911381,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spontaneous cerebellar hemorrhage (sCH) is a severe condition, due to the limited space in the posterior fossa. The temporal dynamics of cerebral physiological variables such as intracranial pressure (ICP), pressure reactivity index (PRx), cerebral perfusion pressure (CPP), \u201coptimal\u201d CPP (CPPopt), and CPP deviation from CPPopt (\u0394CPPopt) and associations with functional outcome remain insufficiently characterized in sCH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively analyzed 94 adult sCH patients treated at the neurointensive care (NIC) unit in Uppsala University Hospital, Sweden, between 2008 and 2024, with collected high resolution monitoring data. The association between insult intensity-duration, temporal dynamics, and interactions with cerebrovascular autoregulation of the cerebral physiological variables with Glasgow Outcome Scale at discharge (GODS) were analyzed in outcome heatmaps. Formal statistical analyses between % of good monitoring time (%GMT) of the cerebral physiological variables within\/outside certain thresholds were analyzed in relation to GODS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the exploratory analyses, ICP\u2009&gt;\u200915 mmHg demonstrated a descriptive trend toward unfavorable outcome irrespective of duration, particularly the first two days post-injury. Still, the association lacked significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.85). Sustained PRx elevations\u2009&gt;\u20090.2 showed a descriptive trend toward worse outcome, with expanding vulnerability over time. However, this association was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.26). CPP\u2009&lt;\u200980 mmHg was associated with worse outcome, particularly if PRx was elevated. In addition, CPP\u2009&lt;\u200960 mmHg was associated with worse outcome, while CPP\u2009&gt;\u200980 mmHg was associated with favorable outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02, respectively). Negative \u0394CPPopt for longer durations and if PRx was elevated correlated with lower GODS. \u0394CPPopt &lt; -5 mmHg was associated with worse outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cerebral physiological monitoring provides important prognostic information in sCH. Optimal targets differ from supratentorial acute brain injuries, with an apparent benefit of higher CPP in sCH. ICP, CPP, and \u0394CPPopt remain central, warranting larger multi-center studies to define sCH-specific targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13054-026-06136-0","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:48:08Z","timestamp":1781117288000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal dynamics of ICP, PRx, CPP, and CPPopt in relation to functional outcome in spontaneous cerebellar hemorrhage"],"prefix":"10.1186","volume":"30","author":[{"given":"Rozerin","family":"Kevci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"H\u00e5nell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilin","family":"Sida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modar","family":"Alhamdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fartein","family":"Velle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Lew\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fahlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor Svedung","family":"Wettervik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"6136_CR1","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.jocn.2011.11.025","volume":"19","author":"NS Dahdaleh","year":"2012","unstructured":"Dahdaleh NS, Dlouhy BJ, Viljoen SV, Capuano AW, Kung DK, Torner JC, et al. 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