{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:46:35Z","timestamp":1785815195774,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005026","name":"Stichting tegen Kanker","doi-asserted-by":"publisher","award":["2012-216"],"award-info":[{"award-number":["2012-216"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13058-016-0709-1","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T02:14:06Z","timestamp":1463451246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation"],"prefix":"10.1186","volume":"18","author":[{"given":"Annelot","family":"Baert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Depuydt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Van Maerken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Poppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fransiska","family":"Malfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenneke","family":"van den Ende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"De Nobele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Perletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"De Leeneer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B. M.","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Vral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"709_CR1","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1126\/science.1251827","volume":"343","author":"FJ Couch","year":"2014","unstructured":"Couch FJ, Nathanson KL, Offit K. Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science. 2014;343:1466\u201370.","journal-title":"Science."},{"key":"709_CR2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.yexcr.2012.11.013","volume":"319","author":"KW Caestecker","year":"2013","unstructured":"Caestecker KW, Van de Walle GR. The role of BRCA1 in DNA double-strand repair: past and present. Exp Cell Res. 2013;319:575\u201387.","journal-title":"Exp Cell Res."},{"key":"709_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nrc3181","volume":"12","author":"R Roy","year":"2012","unstructured":"Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer. 2012;12:68\u201378.","journal-title":"Nat Rev Cancer."},{"key":"709_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000077460","volume":"104","author":"P Pfeiffer","year":"2004","unstructured":"Pfeiffer P, Goedecke W, Kuhfittig-Kulle S, Obe G. Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations. Cytogenet Genome Res. 2004;104:7\u201313.","journal-title":"Cytogenet Genome Res."},{"key":"709_CR5","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/path.4205","volume":"230","author":"WD Foulkes","year":"2013","unstructured":"Foulkes WD, Shuen AY. In brief: BRCA1and BRCA2. J Pathol. 2013;230:347\u20139.","journal-title":"J Pathol."},{"key":"709_CR6","doi-asserted-by":"publisher","first-page":"11384","DOI":"10.1158\/0008-5472.CAN-05-2156","volume":"65","author":"I Cousineau","year":"2005","unstructured":"Cousineau I, Abaji C, Belmaaza A. BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: Implications for sister chromatid cohesion, genome stability, and carcinogenesis. Cancer Res. 2005;65:11384\u201391.","journal-title":"Cancer Res."},{"key":"709_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/ng837","volume":"30","author":"RI Yarden","year":"2002","unstructured":"Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. BRCA1 regulates the G2\/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet. 2002;30:285\u20139.","journal-title":"Nat Genet."},{"key":"709_CR8","doi-asserted-by":"publisher","first-page":"e5660","DOI":"10.1136\/bmj.e5660","volume":"345","author":"A Pijpe","year":"2012","unstructured":"Pijpe A, Andrieu N, Easton DF, Kesminiene A, Cardis E, Nogu\u00e8s C, et al. Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1\/2 mutations: retrospective cohort study (GENE-RAD-RISK). BMJ. 2012;345:e5660.","journal-title":"BMJ."},{"key":"709_CR9","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10549-011-1655-3","volume":"130","author":"J Lecarpentier","year":"2011","unstructured":"Lecarpentier J, Nogu\u00e8s C, Mouret-Fourme E, Stoppa-Lyonnet D, Lasset C, Caron O, et al. Variation in breast cancer risk with mutation position, smoking, alcohol, and chest X-ray history, in the French National BRCA1\/2 carrier cohort (GENEPSO). Breast Cancer Res Treat. 2011;130:927\u201338.","journal-title":"Breast Cancer Res Treat."},{"key":"709_CR10","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1200\/JCO.2005.03.3126","volume":"24","author":"N Andrieu","year":"2006","unstructured":"Andrieu N, Easton DF, Chang-Claude J, Rookus MA, Brohet R, Cardis E, et al. Effect of chest x-rays on the risk of breast cancer among BRCA1\/2 Mutation Carriers in the International BRCA1\/2 Carrier Cohort Study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators\u2019 Group. J Clin Oncol. 2006;24:3361\u20136.","journal-title":"J Clin Oncol."},{"key":"709_CR11","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10549-008-9892-9","volume":"112","author":"J Gronwald","year":"2008","unstructured":"Gronwald J, Pijpe A, Byrski T, Huzarski T, Stawicka M, Cybulski C, et al. Early radiation exposures and BRCA1-associated breast cancer in young women from Poland. Breast Cancer Res Treat. 2008;112:581\u20134.","journal-title":"Breast Cancer Res Treat."},{"key":"709_CR12","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1158\/1055-9965.EPI-13-0189","volume":"22","author":"EM John","year":"2013","unstructured":"John EM, McGuire V, Thomas D, Haile R, Ozcelik H, Milne RL, et al. Diagnostic chest X-rays and breast cancer risk before age 50\u00a0years for BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev. 2013;22:1547\u201356.","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"709_CR13","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/S1470-2045(06)70624-6","volume":"7","author":"SA Narod","year":"2006","unstructured":"Narod SA, Lubinski J, Ghadirian P, Lynch HT, Moller P, Foulkes WD, et al. Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Lancet Oncol. 2006;7:402\u20136.","journal-title":"Lancet Oncol."},{"key":"709_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s10549-014-3063-y","volume":"147","author":"V Giannakeas","year":"2014","unstructured":"Giannakeas V, Lubinski J, Gronwald J, Moller P, Armel S, Lynch HT, et al. Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a prospective study. Breast Cancer Res Treat. 2014;147:113\u20138.","journal-title":"Breast Cancer Res Treat."},{"key":"709_CR15","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1158\/1055-9965.EPI-06-0176","volume":"15","author":"D Goldfrank","year":"2006","unstructured":"Goldfrank D, Chuai S, Bernstein JL, Ramon y Cajal T, Lee JB, Alonso MC, et al. Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2. Cancer Epidemiol Biomarkers Prev. 2006;15:2311\u20133.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"709_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ctrv.2014.12.002","volume":"41","author":"JC Drooger","year":"2015","unstructured":"Drooger JC, Hooning MJ, Seynaeve CM, Baaijens MH, Obdeijn IM, Sleijfer S, et al. Diagnostic and therapeutic ionizing radiation and the risk of a first and second primary breast cancer, with special attention for BRCA1 and BRCA2 mutation carriers: a critical review of the literature. Cancer Treat Rev. 2015;41:187\u201396.","journal-title":"Cancer Treat Rev."},{"key":"709_CR17","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/bjc.2011.567","volume":"106","author":"F Cardinale","year":"2012","unstructured":"Cardinale F, Bruzzi P, Bolognesi C. Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis. Br J Cancer. 2012;106:780\u201390.","journal-title":"Br J Cancer."},{"key":"709_CR18","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/sj.bjc.6602912","volume":"94","author":"Z Kote-Jarai","year":"2006","unstructured":"Kote-Jarai Z, Salmon A, Mengitsu T, Copeland M, Ardern-Jones A, Locke I, et al. Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers. Br J Cancer. 2006;94:308\u201310.","journal-title":"Br J Cancer."},{"key":"709_CR19","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3109\/09553002.2012.711500","volume":"88","author":"M Frankenberg-Schwager","year":"2012","unstructured":"Frankenberg-Schwager M, Gregus A. Chromosomal instability induced by mammography X-rays in primary human fibroblasts from BRCA1 and BRCA2 mutation carriers. Int J Radiat Biol. 2012;88:846\u201357.","journal-title":"Int J Radiat Biol."},{"key":"709_CR20","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.ijrobp.2009.10.020","volume":"76","author":"B Ernestos","year":"2010","unstructured":"Ernestos B, Nikolaos P, Koulis G, Eleni R, Konstantinos B, Alexandra G, et al. Increased chromosomal radiosensitivity in women carrying BRCA1\/BRCA2 mutations assessed with the G2 assay. Int J Radiat Oncol Biol Phys. 2010;76:1199\u2013205.","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"709_CR21","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1002\/ijc.22915","volume":"121","author":"J Barwell","year":"2007","unstructured":"Barwell J, Pangon L, Georgiou A, Kesterton I, Langman C, Arden-Jones A, et al. Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility. Int J Cancer. 2007;121:1631\u20136.","journal-title":"Int J Cancer."},{"key":"709_CR22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/ijc.10109","volume":"561","author":"TA Buchholz","year":"2002","unstructured":"Buchholz TA, Wu X, Hussain A, Tucker SL, Mills GB, Haffty B, et al. Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. Int J Cancer. 2002;561:557\u201361.","journal-title":"Int J Cancer."},{"key":"709_CR23","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cbi.2010.03.046","volume":"188","author":"JM Hair","year":"2010","unstructured":"Hair JM, Terzoudi GI, Hatzi VI, Lehockey KA, Srivastava D, Wang W, et al. BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions. Chem Biol Interact. 2010;188:350\u20138.","journal-title":"Chem Biol Interact."},{"key":"709_CR24","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3109\/09553002.2010.501836","volume":"86","author":"G Sioftanos","year":"2010","unstructured":"Sioftanos G, Ismail A, F\u00f6hse L, Shanley S, Worku M, Short SC. BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity. Int J Radiat Biol. 2010;86:1095\u2013105.","journal-title":"Int J Radiat Biol."},{"key":"709_CR25","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.1038\/ncomms6496","volume":"5","author":"S Pathania","year":"2014","unstructured":"Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, et al. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014;5:5496.","journal-title":"Nat Commun."},{"key":"709_CR26","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.dnarep.2008.08.001","volume":"7","author":"E Febrer","year":"2008","unstructured":"Febrer E, Mestres M, Caball\u00edn MR, Barrios L, Ribas M, Guti\u00e9rrez-Enr\u00edquez S, et al. Mitotic delay in lymphocytes from BRCA1 heterozygotes unable to reduce the radiation-induced chromosomal damage. DNA Repair (Amst). 2008;7:1907\u201311.","journal-title":"DNA Repair (Amst)"},{"key":"709_CR27","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s12017-013-8231-4","volume":"15","author":"K Claes","year":"2013","unstructured":"Claes K, Depuydt J, Taylor AM, Last JI, Baert A, Schietecatte P, et al. Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives. Neuromolecular Med. 2013;15:447\u201357.","journal-title":"Neuromolecular Med."},{"key":"709_CR28","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s10549-010-1017-6","volume":"127","author":"S Guti\u00e9rrez-Enr\u00edquez","year":"2011","unstructured":"Guti\u00e9rrez-Enr\u00edquez S, Ram\u00f3n Y, Cajal T, Alonso C, Corral A, Carrasco P, et al. Ionizing radiation or mitomycin-induced micronuclei in lymphocytes of BRCA1 or BRCA2 mutation carriers. Breast Cancer Res Treat. 2011;127:611\u201322.","journal-title":"Breast Cancer Res Treat."},{"key":"709_CR29","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s11433-010-4022-1","volume":"53","author":"N Li","year":"2010","unstructured":"Li N, Zhang H, Wang Y, Hao J. BRCA1 and its phosphorylation involved in caffeine-inhibitable event upstream of G2 checkpoint. Sci China Phys Mech Astron. 2010;53:1281\u20135.","journal-title":"Sci China Phys Mech Astron."},{"key":"709_CR30","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.radonc.2011.09.021","volume":"101","author":"GE Pantelias","year":"2011","unstructured":"Pantelias GE, Terzoudi GI. A standardized G2-assay for the prediction of individual radiosensitivity. Radiother Oncol. 2011;101:28\u201334.","journal-title":"Radiother Oncol."},{"key":"709_CR31","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/gcc.10221","volume":"37","author":"K Claes","year":"2003","unstructured":"Claes K, Poppe B, Machackova E, Coene I, Foretova L, De Paepe A, et al. Differentiating pathogenic mutations from polymorphic alterations in the splice sites of BRCA1 and BRCA2. Genes Chromosom Cancer. 2003;37:314\u201320.","journal-title":"Genes Chromosom Cancer."},{"key":"709_CR32","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/humu.22739","volume":"36","author":"K Leeneer De","year":"2015","unstructured":"De Leeneer K, Hellemans J, Steyaert W, Lefever S, Vereecke I, Debals E, et al. Flexible, scalable, and efficient targeted resequencing on a benchtop sequencer for variant detection in clinical practice. Hum Mutat. 2015;36:379\u201387.","journal-title":"Hum Mutat."},{"key":"709_CR33","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/210913a0","volume":"210","author":"MS Sasaki","year":"1966","unstructured":"Sasaki MS, Norman A. Proliferation of human lymphocytes in culture. Nature. 1966;210:913\u20134.","journal-title":"Nature."},{"key":"709_CR34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.4049\/jimmunol.120.3.955","volume":"120","author":"JL Bernheim","year":"1978","unstructured":"Bernheim JL, Dorian RE, Mendelsohn J. DNA synthesis and proliferation of human lymphocytes in vitro. I. Cell kinetics of response to phytohemagglutinin. J Immunol. 1978;120:955\u201362.","journal-title":"J Immunol"},{"key":"709_CR35","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1038\/sj.onc.1205520","volume":"21","author":"K Claes","year":"2002","unstructured":"Claes K, Vandesompele J, Poppe B, Dahan K, Coene I, De Paepe A, et al. Pathological splice mutations outside the invariant AG\/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5\u2032 end of the BRCA1 gene. Oncogene. 2002;21:4171\u20135.","journal-title":"Oncogene."},{"key":"709_CR36","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/ejhg.2011.100","volume":"19","author":"JC Th\u00e9ry","year":"2011","unstructured":"Th\u00e9ry JC, Krieger S, Gaildrat P, R\u00e9villion F, Buisine MP, Killian A, et al. Contribution of bioinformatics predictions and functional splicing assays to the interpretation of unclassified variants of the BRCA genes. Eur J Hum Genet. 2011;19:1052\u20138.","journal-title":"Eur J Hum Genet."},{"key":"709_CR37","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1111\/j.1742-4658.2010.07735.x","volume":"277","author":"RJ Linger","year":"2010","unstructured":"Linger RJ, Kruk PA. BRCA1 16\u00a0years later: risk-associated BRCA1 mutations and their functional implications. FEBS J. 2010;277:3086\u201396.","journal-title":"FEBS J."},{"key":"709_CR38","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10549-015-3459-3","volume":"152","author":"T Vaclov\u00e1","year":"2015","unstructured":"Vaclov\u00e1 T, G\u00f3mez-L\u00f3pez G, Seti\u00e9n F, Garc\u00eda Bueno JM, Mac\u00edas JA, Barroso A, et al. DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers. Breast Cancer Res Treat. 2015;152:271\u201382. doi: 10.1007\/s10549-015-3459-3 .","journal-title":"Breast Cancer Res Treat."},{"key":"709_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1159\/000442442","volume":"25","author":"EKJ Pauwels","year":"2016","unstructured":"Pauwels EKJ, Foray N, Bourguignon MH. Breast cancer induced by X-ray mammography screening? A review based on recent understanding of low-dose radiobiology. Med Princ Pract. 2016;25:101\u20139. doi: 10.1159\/000442442 .","journal-title":"Med Princ Pract."},{"key":"709_CR40","doi-asserted-by":"publisher","first-page":"A123","DOI":"10.1088\/0952-4746\/29\/2A\/S08","volume":"29","author":"GJ Heyes","year":"2009","unstructured":"Heyes GJ, Mill AJ, Charles MW. Mammography-oncogenicity at low doses. J Radiol Prot. 2009;29:A123\u201332.","journal-title":"J Radiol Prot."},{"key":"709_CR41","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3109\/09553002.2013.782447","volume":"89","author":"J Depuydt","year":"2013","unstructured":"Depuydt J, Baert A, Vandersickel V, Thierens H, Vral A. Relative biological effectiveness of mammography X-rays at the level of DNA and chromosomes in lymphocytes. Int J Radiat Biol. 2013;89:532\u20138.","journal-title":"Int J Radiat Biol."},{"key":"709_CR42","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s10549-014-2888-8","volume":"144","author":"IM Obdeijn","year":"2014","unstructured":"Obdeijn IM, Winter-Warnars GA, Mann RM, Hooning MJ, Hunink MGM, Tilanus-Linthorst MM. Should we screen BRCA1 mutation carriers only with MRI? A multicenter study. Breast Cancer Res Treat. 2014;144:577\u201382.","journal-title":"Breast Cancer Res Treat."},{"key":"709_CR43","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.1073\/pnas.0307761101","volume":"101","author":"KE Rieger","year":"2004","unstructured":"Rieger KE, Hong WJ, Tusher VG, Tang J, Tibshirani R, Chu G. Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Proc Natl Acad Sci U S A. 2004;101:6635\u201340.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"709_CR44","doi-asserted-by":"publisher","first-page":"7334","DOI":"10.1038\/sj.onc.1203165","volume":"18","author":"N Foray","year":"1999","unstructured":"Foray N, Randrianarison V, Marot D, Perricaudet M, Lenoir G, Feunteun J. Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. Oncogene. 1999;18:7334\u201342.","journal-title":"Oncogene."},{"key":"709_CR45","doi-asserted-by":"publisher","first-page":"127","DOI":"10.2217\/whe.12.2","volume":"8","author":"L Salmena","year":"2012","unstructured":"Salmena L, Narod S. BRCA1 haploinsufficiency: consequences for breast cancer. Womens Health (Lond Engl). 2012;8:127\u20139.","journal-title":"Womens Health (Lond Engl)"},{"key":"709_CR46","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1093\/hmg\/11.23.2805","volume":"11","author":"L Perrin-Vidoz","year":"2002","unstructured":"Perrin-Vidoz L, Sinilnikova OM, Stoppa-Lyonnet D, Lenoir GM, Mazoyer S. The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons. Hum Mol Genet. 2002;11:2805\u201314.","journal-title":"Hum Mol Genet."},{"key":"709_CR47","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/humu.20590","volume":"29","author":"O Anczuk\u00f3w","year":"2008","unstructured":"Anczuk\u00f3w O, Ware MD, Buisson M, Zetoune AB, Stoppa-Lyonnet D, Sinilnikova OM, et al. Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? Hum Mutat. 2008;29:65\u201373.","journal-title":"Hum Mutat."},{"key":"709_CR48","doi-asserted-by":"publisher","first-page":"7505","DOI":"10.1038\/ncomms8505","volume":"6","author":"M Sedic","year":"2015","unstructured":"Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, et al. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 2015;6:7505.","journal-title":"Nat Commun."},{"key":"709_CR49","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1667\/0033-7587(2001)156[0577:CAFDTS]2.0.CO;2","volume":"156","author":"H Nikjoo","year":"2001","unstructured":"Nikjoo H, O\u2019Neill P, Wilson WE, Goodhead DT. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res. 2001;156:577\u201383.","journal-title":"Radiat Res."},{"key":"709_CR50","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF01214639","volume":"25","author":"U Hagen","year":"1986","unstructured":"Hagen U. Current aspects on the radiation induced base damage in DNA. Radiat Environ Biophys. 1986;25:261\u201371.","journal-title":"Radiat Environ Biophys."},{"key":"709_CR51","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.mrrev.2009.12.007","volume":"704","author":"ME Dextraze","year":"2010","unstructured":"Dextraze ME, Gantchev T, Girouard S, Hunting D. DNA interstrand cross-links induced by ionizing radiation: an unsung lesion. Mutat Res. 2010;704:101\u20137.","journal-title":"Mutat Res."},{"key":"709_CR52","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/carcin\/bgv007","volume":"36","author":"Z Guo","year":"2015","unstructured":"Guo Z, Shu Y, Zhou H, Zhang W, Wang H. Radiogenomics helps to achieve personalized therapy by evaluating patient responses to radiation treatment. Carcinogenesis. 2015;36:307\u201317.","journal-title":"Carcinogenesis."},{"key":"709_CR53","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mrfmmm.2008.10.014","volume":"667","author":"O Popanda","year":"2009","unstructured":"Popanda O, Marquardt JU, Chang-Claude J, Schmezer P. Genetic variation in normal tissue toxicity induced by ionizing radiation. Mutat Res. 2009;667:58\u201369.","journal-title":"Mutat Res."},{"key":"709_CR54","first-page":"901","volume":"4","author":"A Vral","year":"2011","unstructured":"Vral A, Willems P, Claes K, Poppe B, Perletti G, Thierens H. Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity. Mol Med Rep. 2011;4:901\u201312.","journal-title":"Mol Med Rep."},{"key":"709_CR55","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/gcc.20515","volume":"47","author":"P Willems","year":"2008","unstructured":"Willems P, Claes K, Baeyens A, Vandersickel V, Werbrouck J, De Ruyck K, et al. Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity [published erratum appears in Genes Chromosomes Cancer. 2009;48:381]. Genes Chromosomes Cancer. 2008;47:137\u201348.","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-016-0709-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13058-016-0709-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-016-0709-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-016-0709-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T06:53:35Z","timestamp":1692341615000},"score":1,"resource":{"primary":{"URL":"http:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/s13058-016-0709-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["709"],"URL":"https:\/\/doi.org\/10.1186\/s13058-016-0709-1","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]},"article-number":"52"}}