{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:19:30Z","timestamp":1762658370791,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R15CA170111"],"award-info":[{"award-number":["R15CA170111"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13058-017-0886-6","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T11:54:08Z","timestamp":1503057248000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)"],"prefix":"10.1186","volume":"19","author":[{"given":"Susan R.","family":"Sturgeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Richard","family":"Pilsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen F.","family":"Arcaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Ikuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Mi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayha","family":"Chopra-Tandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam R.","family":"Karpf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina G.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Schairer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raji","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Reckhow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"886_CR1","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1056\/NEJMra072067","volume":"358","author":"M Esteller","year":"2008","unstructured":"Esteller M. Epigenetics in cancer. N Engl J Med. 2008;358:1148\u201359. doi:\n                    10.1056\/NEJMra072067\n                    \n                  .","journal-title":"N Engl J Med"},{"key":"886_CR2","doi-asserted-by":"publisher","first-page":"6883","DOI":"10.1093\/nar\/11.19.6883","volume":"11","author":"MA Gama-Sosa","year":"1983","unstructured":"Gama-Sosa MA, Slagel VA, Trewyn RW, Oxenhandler R, Kuo KC, Gehrke CW, Ehrlich M. The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res. 1983;11:6883\u201394.","journal-title":"Nucleic Acids Res"},{"key":"886_CR3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1021\/ac0489420","volume":"77","author":"L Song","year":"2005","unstructured":"Song L, James SR, Kazim L, Karpf AR. Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Chem. 2005;77:504\u201310. doi:\n                    10.1021\/ac0489420\n                    \n                  .","journal-title":"Anal Chem"},{"key":"886_CR4","first-page":"187","volume":"214","author":"TH Bestor","year":"1998","unstructured":"Bestor TH. The host defence function of genomic methylation patterns. Novartis Found Symp. 1998;214:187\u201395. discussion 195-9, 228-32.","journal-title":"Novartis Found Symp"},{"key":"886_CR5","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1093\/nar\/gnh032","volume":"32","author":"AS Yang","year":"2004","unstructured":"Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 2004;32:e38. doi:\n                    10.1093\/nar\/gnh032\n                    \n                  .","journal-title":"Nucleic Acids Res"},{"key":"886_CR6","first-page":"45","volume":"1","author":"M Karimi","year":"2006","unstructured":"Karimi M, Johansson S, Ekstrom TJ. Using LUMA: a luminometric-based assay for global DNA-methylation. Epigenetics. 2006;1:45\u20138.","journal-title":"Epigenetics"},{"key":"886_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13148-015-0104-2","volume":"7","author":"K van Veldhoven","year":"2015","unstructured":"van Veldhoven K, Polidoro S, Baglietto L, Severi G, Sacerdote C, Panico S, Mattiello A, Palli D, Masala G, Krogh V, et al. Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis. Clin Epigenetics. 2015;7:67. doi:\n                    10.1186\/s13148-015-0104-2\n                    \n                  . eCollection 2015.","journal-title":"Clin Epigenetics"},{"key":"886_CR8","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10549-014-3209-y","volume":"148","author":"G Severi","year":"2014","unstructured":"Severi G, Southey MC, English DR, Jung CH, Lonie A, McLean C, Tsimiklis H, Hopper JL, Giles GG, Baglietto L. Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer. Breast Cancer Res Treat. 2014;148:665\u201373. doi:\n                    10.1007\/s10549-014-3209-y\n                    \n                  .","journal-title":"Breast Cancer Res Treat"},{"key":"886_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1471-2105-13-86","volume":"13","author":"EA Houseman","year":"2012","unstructured":"Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012;13:86. doi:\n                    10.1186\/1471-2105-13-86\n                    \n                  .","journal-title":"BMC Bioinformatics"},{"key":"886_CR10","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/jnci\/djt090","volume":"105","author":"M Garcia-Closas","year":"2013","unstructured":"Garcia-Closas M, Gail MH, Kelsey KT, Ziegler RG. Searching for blood DNA methylation markers of breast cancer risk and early detection. J Natl Cancer Inst. 2013;105:678\u201380. doi:\n                    10.1093\/jnci\/djt090\n                    \n                  .","journal-title":"J Natl Cancer Inst"},{"key":"886_CR11","doi-asserted-by":"publisher","unstructured":"Choi JY, James SR, Link PA, McCann SE, Hong CC, Davis W, Nesline MK, Ambrosone CB, Karpf AR. Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis. 2009. doi:\n                    10.1093\/carcin\/bgp143\n                    \n                  . PMID: 1958413","DOI":"10.1093\/carcin\/bgp143"},{"key":"886_CR12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/carcin\/bgt342","volume":"35","author":"LA Deroo","year":"2014","unstructured":"Deroo LA, Bolick SC, Xu Z, Umbach DM, Shore D, Weinberg CR, Sandler DP, Taylor JA. Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the sister study. Carcinogenesis. 2014;35:333\u20138. doi:\n                    10.1093\/carcin\/bgt342\n                    \n                  .","journal-title":"Carcinogenesis"},{"key":"886_CR13","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1158\/0008-5472.CAN-11-3157","volume":"72","author":"K Brennan","year":"2012","unstructured":"Brennan K, Garcia-Closas M, Orr N, Fletcher O, Jones M, Ashworth A, Swerdlow A, Thorne H, KConFab Investigators, Riboli E, et al. Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk. Cancer Res. 2012;72:2304\u201313. doi:\n                    10.1158\/0008-5472.CAN-11-3157\n                    \n                  .","journal-title":"Cancer Res"},{"key":"886_CR14","doi-asserted-by":"publisher","unstructured":"Wu HC, Delgado-Cruzata L, Flom JD, Perrin M, Liao Y, Ferris J, Santella RM, Terry MB. Repetitive element DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the BCFR. Carcinogenesis. 2012. doi:\n                    10.1093\/carcin\/bgs201\n                    \n                  .","DOI":"10.1093\/carcin\/bgs201"},{"key":"886_CR15","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1096\/fj.11-197251","volume":"26","author":"X Xu","year":"2012","unstructured":"Xu X, Gammon MD, Hernandez-Vargas H, Herceg Z, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J. DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study. FASEB J. 2012;26:2657\u201366. doi:\n                    10.1096\/fj.11-197251\n                    \n                  .","journal-title":"FASEB J"},{"key":"886_CR16","first-page":"2489","volume":"30","author":"YH Cho","year":"2010","unstructured":"Cho YH, Yazici H, Wu HC, Terry MB, Gonzalez K, Qu M, Dalay N, Santella RM. Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients. Anticancer Res. 2010;30:2489\u201396.","journal-title":"Anticancer Res"},{"key":"886_CR17","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1093\/hmg\/ddp033","volume":"18","author":"JM Flanagan","year":"2009","unstructured":"Flanagan JM, Munoz-Alegre M, Henderson S, Tang T, Sun P, Johnson N, Fletcher O, Dos Santos Silva I, Peto J, Boshoff C, et al. Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum Mol Genet. 2009;18:1332\u201342. doi:\n                    10.1093\/hmg\/ddp033\n                    \n                  .","journal-title":"Hum Mol Genet"},{"key":"886_CR18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cca.2012.01.024","volume":"413","author":"N Kitkumthorn","year":"2012","unstructured":"Kitkumthorn N, Tuangsintanakul T, Rattanatanyong P, Tiwawech D, Mutirangura A. LINE-1 methylation in the peripheral blood mononuclear cells of cancer patients. Clin Chim Acta. 2012;413:869\u201374. doi:\n                    10.1016\/j.cca.2012.01.024\n                    \n                  .","journal-title":"Clin Chim Acta"},{"key":"886_CR19","doi-asserted-by":"publisher","first-page":"e2656","DOI":"10.1371\/journal.pone.0002656","volume":"3","author":"M Widschwendter","year":"2008","unstructured":"Widschwendter M, Apostolidou S, Raum E, Rothenbacher D, Fiegl H, Menon U, Stegmaier C, Jacobs IJ, Brenner H. Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study. PLoS One. 2008;3:e2656. doi:\n                    10.1371\/journal.pone.0002656\n                    \n                  .","journal-title":"PLoS One"},{"key":"886_CR20","doi-asserted-by":"publisher","unstructured":"Delgado-Cruzata L, Wu HC, Perrin M, Liao Y, Kappil MA, Ferris JS, Flom JD, Yazici H, Santella RM, Terry MB. Global DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the breast cancer family registry. Epigenetics. 2012;7:868-74. doi:\n                    10.4161\/epi.20830\n                    \n                  . Epub 2012 Jun 18.","DOI":"10.4161\/epi.20830"},{"key":"886_CR21","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1038\/bjc.2014.223","volume":"110","author":"A Kuchiba","year":"2014","unstructured":"Kuchiba A, Iwasaki M, Ono H, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Tsugane S, Yoshida T. Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women. Br J Cancer. 2014;110:2765\u201371. doi:\n                    10.1038\/bjc.2014.223\n                    \n                  .","journal-title":"Br J Cancer"},{"key":"886_CR22","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1158\/1940-6207.CAPR-12-0316","volume":"5","author":"K Brennan","year":"2012","unstructured":"Brennan K, Flanagan JM. Is there a link between genome-wide hypomethylation in blood and cancer risk? Cancer Prev Res (Phila). 2012;5:1345\u201357. doi:\n                    10.1158\/1940-6207.CAPR-12-0316\n                    \n                  .","journal-title":"Cancer Prev Res (Phila)"},{"key":"886_CR23","doi-asserted-by":"crossref","unstructured":"Hayes RB, Sigurdson A, Moore L, Peters U, Huang WY, Pinsky P, Reding D, Gelmann EP, Rothman N, Pfeiffer RM, et al. Methods for etiologic and early marker investigations in the PLCO trial. Mutat Res. 2005;592:147\u201354. PMID: 16054167.","DOI":"10.1016\/j.mrfmmm.2005.06.013"},{"key":"886_CR24","doi-asserted-by":"crossref","unstructured":"Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet. 2007;39:870\u20134. PMID: 17529973.","DOI":"10.1038\/ng2075"},{"key":"886_CR25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1471-2407-9-84","volume":"9","author":"JV Lacey Jr","year":"2009","unstructured":"Lacey Jr JV, Kreimer AR, Buys SS, Marcus PM, Chang SC, Leitzmann MF, Hoover RN, Prorok PC, Berg CD, Hartge P, et al. Breast cancer epidemiology according to recognized breast cancer risk factors in the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial cohort. BMC Cancer. 2009;9:84. doi:\n                    10.1186\/1471-2407-9-84\n                    \n                  .","journal-title":"BMC Cancer"},{"key":"886_CR26","doi-asserted-by":"publisher","unstructured":"Dugue PA, English DR, MacInnis RJ, Jung CH, Bassett JK, FitzGerald LM, Wong EM, Joo JE, Hopper JL, Southey MC, et al. Reliability of DNA methylation measures from dried blood spots and mononuclear cells using the HumanMethylation450k BeadArray. Sci Rep. 2016;6:30317. doi:\n                    10.1038\/srep30317\n                    \n                  .","DOI":"10.1038\/srep30317"},{"key":"886_CR27","doi-asserted-by":"publisher","unstructured":"Tang Q, Cheng J, Cao X, Surowy H, Burwinkel B. Blood-based DNA methylation as biomarker for breast cancer: a systematic review.Clin Epigenetics. 2016;8:115. doi:\n                    10.1186\/s13148-016-0282-6\n                    \n                  .","DOI":"10.1186\/s13148-016-0282-6"},{"key":"886_CR28","doi-asserted-by":"publisher","unstructured":"Stirzaker C, Taberlay PC, Statham AL, Clark SJ. Mining cancer methylomes: prospects and challenges. Trends Genet. 2014;30:75\u201384. doi:\n                    10.1016\/j.tig.2013.11.004\n                    \n                  .","DOI":"10.1016\/j.tig.2013.11.004"},{"key":"886_CR29","doi-asserted-by":"publisher","unstructured":"Wu HC, Delgado-Cruzata L, Flom JD, Kappil M, Ferris JS, Liao Y, Santella RM, Terry MB. Global methylation profiles in DNA from different blood cell types. Epigenetics. 2011;6. doi:\n                    10.4161\/epi.6.1.13391\n                    \n                  .","DOI":"10.4161\/epi.6.1.13391"},{"key":"886_CR30","doi-asserted-by":"publisher","unstructured":"Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics. 2011;6:828-37. doi:\n                    10.4161\/epi.6.7.16500\n                    \n                  . Epub 2011 July 1.","DOI":"10.4161\/epi.6.7.16500"},{"key":"886_CR31","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/jnci\/djt045","volume":"105","author":"Z Xu","year":"2013","unstructured":"Xu Z, Bolick SC, Deroo LA, Weinberg CR, Sandler DP, Taylor JA. Epigenome-wide association study of breast cancer using prospectively collected sister study samples. J Natl Cancer Inst. 2013;105:694\u2013700. doi:\n                    10.1093\/jnci\/djt045\n                    \n                  .","journal-title":"J Natl Cancer Inst"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-017-0886-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13058-017-0886-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-017-0886-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T13:31:45Z","timestamp":1589549505000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/s13058-017-0886-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["886"],"URL":"https:\/\/doi.org\/10.1186\/s13058-017-0886-6","relation":{},"ISSN":["1465-542X"],"issn-type":[{"type":"electronic","value":"1465-542X"}],"subject":[],"published":{"date-parts":[[2017,8,18]]},"assertion":[{"value":"24 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 information"}},{"value":"The University of Massachusetts Amherst Institutional Review Board, the Special Studies Institutional Review Board at the National Cancer Institute, and institutional review boards at the 10 participating study centers (Colorado Multiple Institutional Review Board, CB F490, MedStar Health Research Institute-Georgetown University Oncology Institutional Review Board, Pacific Health Research and Education Institute Institutional Review Board, Henry Ford Health System Institutional Review Board, University of Minnesota Twin Cities Institutional Review Board, Washington University in St. Louis Institutional Review Board, University of Pittsburgh Institutional Review Board, The University of Utah Institutional Review Board, Marshfield Clinic Research Foundation Institutional Review Board, and University of Alabama at Birmingham Institutional Review Board) approved this study. Informed consent was obtained from all study participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"94"}}