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Understanding trends in MBD by age and parity in women with BBD is essential to the clinical management and prevention of breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the Early Determinants of Mammographic Density (EDMD) study, a prospective follow-up study of women born in 1959\u20131967, we evaluated MBD in 676 women. We used linear regression with generalized estimating equations to examine associations between self-reported BBD and MBD (percent density, dense area, and non-dense area), assessed through a computer-assisted method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A prior BBD diagnosis (median age at diagnosis 32\u2009years) was reported by 18% of our cohort. The median time from BBD diagnosis to first available study mammogram was 9.4\u2009years (range 1.1\u201327.6\u2009years). Women with BBD had a 3.44% higher percent MBD (standard error (SE) = 1.56,<jats:italic>p<\/jats:italic>-value\u2009=\u20090.03) on their first available mammogram than women without BBD. Compared with parous women without BBD, nulliparous women with BBD and women with a BBD diagnosis prior to first birth had 7\u20138% higher percent MBD (<jats:italic>\u03b2<\/jats:italic>= 7.25, SE = 2.43,<jats:italic>p<\/jats:italic>-value&lt;\u20090.01 and \u03b2 = 7.84, SE = 2.98,<jats:italic>p<\/jats:italic>-value\u2009=\u20090.01, respectively), while there was no difference in MBD in women with a BBD diagnosis after the first birth (<jats:italic>\u03b2<\/jats:italic>= \u22120.22, SE = 2.40,<jats:italic>p<\/jats:italic>-value\u2009=\u20090.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with self-reported BBD had higher mammographic breast density than women without BBD; the association was limited to women with BBD diagnosed before their first birth.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13058-021-01426-7","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T07:02:49Z","timestamp":1619420569000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Benign breast disease and changes in mammographic breast density"],"prefix":"10.1186","volume":"23","author":[{"given":"Laura L.","family":"Reimers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Tehranifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin B.","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"Flom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-5033","authenticated-orcid":false,"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"issue":"9","key":"1426_CR1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/jnci\/87.9.670","volume":"87","author":"NF Boyd","year":"1995","unstructured":"Boyd NF, Byng JW, Jong RA, Fishell EK, Little LE, Miller AB, Lockwood GA, Tritchler DL, Yaffe MJ. 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