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It has been suggested that temporal changes in MBD may impact future invasive breast cancer risk, but this has not been studied among women with BBD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We undertook a nested case\u2013control study within a cohort of 15,395 women with BBD in Kaiser Permanente Northwest (KPNW; 1970\u20132012, followed through mid-2015). Cases (<jats:italic>n<\/jats:italic>\u2009=\u2009261) developed invasive breast cancer\u2009&gt;\u20091\u00a0year after BBD diagnosis, whereas controls (<jats:italic>n<\/jats:italic>\u2009=\u2009249) did not have breast cancer by the case diagnosis date. Cases and controls were individually matched on BBD diagnosis age and plan membership duration. Standardized %MBD change (per 2\u00a0years), categorized as stable\/any increase (\u2265\u20090%), minimal decrease\u00a0of less than 5% or a\u00a0decrease\u00a0greater than or equal to 5%, was determined from baseline and follow-up mammograms. Associations between MBD change and breast cancer risk were examined using adjusted unconditional logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 64.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009329) of BBD patients had non-proliferative and 35.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009181) had proliferative disease with\/without atypia. Women with an MBD decrease (\u2264\u2009\u2212\u20095%) were less likely to develop breast cancer (Odds Ratio (OR) 0.64; 95% Confidence Interval (CI) 0.38, 1.07) compared with women with minimal decreases. Associations were stronger among women\u2009\u2265\u200950\u00a0years at BBD diagnosis (OR 0.48; 95% CI 0.25, 0.92) and with proliferative BBD (OR 0.32; 95% CI 0.11, 0.99).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>Assessment of temporal MBD changes may inform risk monitoring among women with BBD, and strategies to actively reduce MBD may help decrease future breast cancer risk.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13058-024-01764-2","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:04:09Z","timestamp":1711458249000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease"],"prefix":"10.1186","volume":"26","author":[{"given":"Maeve","family":"Mullooly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin Aiello","family":"Bowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ire A.","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roni T.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Richert-Boe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa M.","family":"Kimes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonine D.","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Rohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Abubakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen L.","family":"Gierach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"1764_CR1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1056\/NEJMra035692","volume":"353","author":"RJ Santen","year":"2005","unstructured":"Santen RJ, Mansel R. 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