{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T05:05:34Z","timestamp":1794632734681,"version":"4.9.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AESI PI15CIII\/00029"],"award-info":[{"award-number":["AESI PI15CIII\/00029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mammographic density (MD) is an established biomarker of breast cancer (BC) risk. However, its relationship to BC pathological subtypes remains unclear. This study aimed to investigate this association and assess whether it differs by body mass index (BMI) and menopausal status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MD percentage was assessed in the diagnostic mammograms of the contralateral breast of 714 BC patients recruited from eight Spanish hospitals. Participants completed an epidemiological questionnaire, and hospital researchers collected clinical and pathological data. Standardized prevalences (SPs) and standardized prevalence ratios (SPRs) for each BC pathological subtype across MD categories were estimated based on multinomial logistic regression models, both overall and stratified by BMI and menopausal status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean MD was 26.1% (SD\u2009=\u200917.3). Although no statistically significant differences were detected, women with MD\u2009\u2265\u200950% had a 13% lower SP of hormone receptor positive tumors (SPR\u2009=\u20090.87; 95% CI 0.67\u20131.13), a 36% higher SP of human epidermal growth factor receptor 2 positive (HER2+) tumors (SPR\u2009=\u20091.36; 95% CI 0.72\u20132.58), and a 23% higher SP of triple negative (TN) tumors (SPR\u2009=\u20091.23; 95% CI 0.47\u20133.22), compared to those with MD\u2009&lt;\u200910%. These patterns were mainly observed in pre\/perimenopausal women and in those with BMI\u2009\u2265\u200925\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High MD might be mainly associated with the development of more aggressive and non-hormone-dependent cancers, such as HER2+\u2009and TN BC, especially among pre\/perimenopausal an overweight women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13058-025-02142-2","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:13:00Z","timestamp":1761315180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index"],"prefix":"10.1186","volume":"27","author":[{"given":"Julia","family":"Fern\u00e1ndez-Morata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Poll\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Fern\u00e1ndez de Larrea-Baz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Pach\u00f3n-Olmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Castell\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Llobet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostina","family":"Stradella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Cantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ram\u00f3n y Cajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Santisteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Segu\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Santaballa Bertr\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Granja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Camps-Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabela","family":"Recalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Nu\u00f1ez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Calvo Verges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"P\u00e9rez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pastor-Barriuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Lope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"2142_CR1","unstructured":"Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, Pi\u00f1eros M, Znaor A, Soerjomataram I, Bray F (2024). Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer; 2024. https:\/\/gco.iarc.who.int\/today."},{"key":"2142_CR2","unstructured":"ECIS. ECIS - European Cancer Information System; 2025. https:\/\/ecis.jrc.ec.europa.eu\/."},{"key":"2142_CR3","unstructured":"REDECAN. Red Espa\u00f1ola de Registros de C\u00e1ncer. La prevalencia del c\u00e1ncer en Espa\u00f1a a 31\u201312\u20132020; 2021. https:\/\/redecan.org\/es\/proyectos\/10\/la-prevalencia-del-cancer-en-espana-a-31-12-2020."},{"key":"2142_CR4","doi-asserted-by":"publisher","unstructured":"OECD\/European Commission. EU Country Cancer Profile: Spain 2025, EU Country Cancer Profiles, OECD Publishing, Paris; 2025. https:\/\/doi.org\/10.1787\/1f6a5051-en.","DOI":"10.1787\/1f6a5051-en"},{"key":"2142_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1056\/NEJMoa062790","volume":"356","author":"NF Boyd","year":"2007","unstructured":"Boyd NF, Guo H, Martin LJ, Sun L, Stone J, Fishell E, et al. Mammographic density and the risk and detection of breast cancer. N Engl J Med. 2007;356:227\u201336.","journal-title":"N Engl J Med"},{"key":"2142_CR6","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/S1470-2045(05)70390-9","volume":"6","author":"NF Boyd","year":"2005","unstructured":"Boyd NF, Rommens JM, Vogt K, Lee V, Hopper JL, Yaffe MJ, et al. Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol. 2005;6:798\u2013808.","journal-title":"Lancet Oncol"},{"key":"2142_CR7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.breast.2022.09.007","volume":"66","author":"FTH Bodewes","year":"2022","unstructured":"Bodewes FTH, van Asselt AA, Dorrius MD, Greuter MJW, de Bock GH. Mammographic breast density and the risk of breast cancer: a systematic review and meta-analysis. Breast. 2022;66:62\u20138.","journal-title":"Breast"},{"key":"2142_CR8","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1158\/1055-9965.EPI-20-0358","volume":"29","author":"MCS Bissell","year":"2020","unstructured":"Bissell MCS, Kerlikowske K, Sprague BL, Tice JA, Gard CC, Tossas KY, et al. Breast cancer population attributable risk proportions associated with body mass index and breast density by race\/ethnicity and menopausal status. Cancer Epidemiol Biomarkers Prev. 2020;29:2048\u201356.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2142_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s10549-014-2901-2","volume":"144","author":"CW Huo","year":"2014","unstructured":"Huo CW, Chew GL, Britt KL, Ingman WV, Henderson MA, Hopper JL, et al. Mammographic density-a review on the current understanding of its association with breast cancer. Breast Cancer Res Treat. 2014;144:479\u2013502.","journal-title":"Breast Cancer Res Treat"},{"key":"2142_CR10","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.jrms_962_21","volume":"27","author":"D-M Ye","year":"2022","unstructured":"Ye D-M, Yu T. The epidemiologic factors associated with breast density: a review. J Res Med Sci. 2022;27:53.","journal-title":"J Res Med Sci"},{"key":"2142_CR11","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.1158\/0008-5472.CAN-18-0502","volume":"78","author":"MM Gaudet","year":"2018","unstructured":"Gaudet MM, Gierach GL, Carter BD, Luo J, Milne RL, Weiderpass E, et al. Pooled analysis of nine cohorts reveals breast cancer risk factors by tumor molecular subtype. Cancer Res. 2018;78:6011\u201321.","journal-title":"Cancer Res"},{"key":"2142_CR12","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, S\u00f8rlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747\u201352.","journal-title":"Nature"},{"key":"2142_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s10549-019-05300-1","volume":"177","author":"MS Shawky","year":"2019","unstructured":"Shawky MS, Huo CW, Henderson MA, Redfern A, Britt K, Thompson EW. A review of the influence of mammographic density on breast cancer clinical and pathological phenotype. Breast Cancer Res Treat. 2019;177:251\u201376.","journal-title":"Breast Cancer Res Treat"},{"key":"2142_CR14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s10549-012-2362-4","volume":"137","author":"S Antoni","year":"2013","unstructured":"Antoni S, Sasco AJ, dos Santos Silva I, McCormack V. Is mammographic density differentially associated with breast cancer according to receptor status? A meta-analysis. Breast Cancer Res Treat. 2013;137:337\u201347.","journal-title":"Breast Cancer Res Treat"},{"key":"2142_CR15","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.crad.2023.04.008","volume":"78","author":"S Bai","year":"2023","unstructured":"Bai S, Song D, Chen M, Lai X, Xu J, Dong F. The association between mammographic density and breast cancer molecular subtypes: a systematic review and meta-analysis. Clin Radiol. 2023;78:622\u201332.","journal-title":"Clin Radiol"},{"key":"2142_CR16","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10549-019-05325-6","volume":"177","author":"E Li","year":"2019","unstructured":"Li E, Guida JL, Tian Y, Sung H, Koka H, Li M, et al. Associations between mammographic density and tumor characteristics in Chinese women with breast cancer. Breast Cancer Res Treat. 2019;177:527\u201336.","journal-title":"Breast Cancer Res Treat"},{"key":"2142_CR17","doi-asserted-by":"publisher","first-page":"pkaa092","DOI":"10.1093\/jncics\/pkaa092","volume":"5","author":"Y Tian","year":"2021","unstructured":"Tian Y, Guida JL, Koka H, Li E-N, Zhu B, Sung H, et al. Quantitative mammographic density measurements and molecular subtypes in chinese women with breast cancer. JNCI Cancer Spectr. 2021;5:pkaa092.","journal-title":"JNCI Cancer Spectr."},{"key":"2142_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1129-9","volume":"21","author":"Y Shieh","year":"2019","unstructured":"Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, et al. Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype. Breast Cancer Res. 2019;21:48.","journal-title":"Breast Cancer Res"},{"key":"2142_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10549-020-06049-8","volume":"187","author":"G Kleinstern","year":"2021","unstructured":"Kleinstern G, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Bertrand KA, et al. Association of mammographic density measures and breast cancer \u201cintrinsic\u201d molecular subtypes. Breast Cancer Res Treat. 2021;187:215\u201324.","journal-title":"Breast Cancer Res Treat"},{"key":"2142_CR20","doi-asserted-by":"publisher","first-page":"6456","DOI":"10.1002\/cam4.4158","volume":"10","author":"AM McCarthy","year":"2021","unstructured":"McCarthy AM, Friebel-Klingner T, Ehsan S, He W, Welch M, Chen J, et al. Relationship of established risk factors with breast cancer subtypes. Cancer Med. 2021;10:6456\u201367.","journal-title":"Cancer Med"},{"key":"2142_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/2193-1801-2-242","volume":"2","author":"M Poll\u00e1n","year":"2013","unstructured":"Poll\u00e1n M, Llobet R, Miranda-Garc\u00eda J, Ant\u00f3n J, Casals M, Mart\u00ednez I, et al. Validation of DM-scan, a computer-assisted tool to assess mammographic density in full-field digital mammograms. Springerplus. 2013;2:242.","journal-title":"Springerplus"},{"key":"2142_CR22","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.5858\/134.7.e48","volume":"134","author":"MEH Hammond","year":"2010","unstructured":"Hammond MEH, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, et al. American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med. 2010;134:e48-72.","journal-title":"Arch Pathol Lab Med"},{"key":"2142_CR23","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1200\/JCO.2013.50.9984","volume":"31","author":"AC Wolff","year":"2013","unstructured":"Wolff AC, Hammond MEH, Hicks DG, Dowsett M, McShane LM, Allison KH, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists clinical practice guideline update. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31:3997\u20134013.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"2142_CR24","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.5858\/arpa.2018-0902-SA","volume":"142","author":"AC Wolff","year":"2018","unstructured":"Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, et al. Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology\/college of American pathologists clinical practice guideline focused update. Arch Pathol Lab Med. 2018;142:1364\u201382.","journal-title":"Arch Pathol Lab Med"},{"key":"2142_CR25","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/aje\/kwh221","volume":"160","author":"S Greenland","year":"2004","unstructured":"Greenland S. Model-based estimation of relative risks and other epidemiologic measures in studies of common outcomes and in case-control studies. Am J Epidemiol. 2004;160:301\u20135.","journal-title":"Am J Epidemiol"},{"key":"2142_CR26","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.jclinepi.2006.12.001","volume":"60","author":"AR Localio","year":"2007","unstructured":"Localio AR, Margolis DJ, Berlin JA. Relative risks and confidence intervals were easily computed indirectly from multivariable logistic regression. J Clin Epidemiol. 2007;60:874\u201382.","journal-title":"J Clin Epidemiol"},{"key":"2142_CR27","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1158\/1055-9965.EPI-16-0881","volume":"26","author":"BL Edwards","year":"2017","unstructured":"Edwards BL, Atkins KA, Stukenborg GJ, Novicoff WM, Larson KN, Cohn WF, et al. The association of mammographic density and molecular breast cancer subtype. Cancer Epidemiol Biomarkers Prev. 2017;26:1487\u201392.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2142_CR28","doi-asserted-by":"publisher","unstructured":"Kumar N, Ehsan S, Banerjee S, Perez CF, Lhuilier I, Neuner J, et al. The associations of breast density, hormone use, family history, reproductive, and lifestyle factors with triple-negative breast cancer: a systematic review and meta-analysis; 2023. https:\/\/doi.org\/10.2139\/ssrn.4567979","DOI":"10.2139\/ssrn.4567979"},{"key":"2142_CR29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/CEJ.0000000000000353","volume":"27","author":"J Shin","year":"2018","unstructured":"Shin J, Lee JE, Ko HY, Nguyen TL, Nam SJ, Hopper JL, et al. Association between mammographic density and tumor marker-defined breast cancer subtypes: a case-control study. Eur J Cancer Prev. 2018;27:239\u201347.","journal-title":"Eur J Cancer Prev"},{"key":"2142_CR30","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1158\/1055-9965.EPI-08-0805","volume":"18","author":"H Ma","year":"2009","unstructured":"Ma H, Luo J, Press MF, Wang Y, Bernstein L, Ursin G. Is there a difference in the association between percent mammographic density and subtypes of breast cancer? Luminal A and triple-negative breast cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:479\u201385.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2142_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3380","volume":"15","author":"M Poll\u00e1n","year":"2013","unstructured":"Poll\u00e1n M, Ascunce N, Ederra M, Murillo A, Erdoz\u00e1in N, Al\u00e9s-Mart\u00ednez J, et al. Mammographic density and risk of breast cancer according to tumor characteristics and mode of detection: a Spanish population-based case-control study. Breast Cancer Res. 2013;15:R9.","journal-title":"Breast Cancer Res"},{"key":"2142_CR32","doi-asserted-by":"publisher","first-page":"5391","DOI":"10.3390\/cancers13215391","volume":"13","author":"M Archer","year":"2021","unstructured":"Archer M, Dasari P, Evdokiou A, Ingman WV. Biological mechanisms and therapeutic opportunities in mammographic density and breast cancer risk. Cancers. 2021;13:5391.","journal-title":"Cancers"},{"key":"2142_CR33","doi-asserted-by":"publisher","first-page":"31550","DOI":"10.18632\/oncotarget.6912","volume":"7","author":"AJ Ironside","year":"2016","unstructured":"Ironside AJ, Jones JL. Stromal characteristics may hold the key to mammographic density: the evidence to date. Oncotarget. 2016;7:31550\u201362.","journal-title":"Oncotarget"},{"key":"2142_CR34","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.prp.2018.12.023","volume":"215","author":"S Radenkovic","year":"2019","unstructured":"Radenkovic S, Konjevic G, Gavrilovic D, Stojanovic-Rundic S, Plesinac-Karapandzic V, Stevanovic P, et al. PSTAT3 expression associated with survival and mammographic density of breast cancer patients. Pathol Res Pract. 2019;215:366\u201372.","journal-title":"Pathol Res Pract"},{"key":"2142_CR35","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1158\/1055-9965.EPI-14-1136","volume":"24","author":"KA Bertrand","year":"2015","unstructured":"Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, et al. Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics. Cancer Epidemiol Biomarkers Prev. 2015;24:798\u2013809.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2142_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1158\/1940-6207.CAPR-15-0282","volume":"9","author":"GL Gierach","year":"2016","unstructured":"Gierach GL, Patel DA, Pfeiffer RM, Figueroa JD, Linville L, Papathomas D, et al. Relationship of terminal duct lobular unit involution of the breast with area and volume mammographic densities. Cancer Prev Res. 2016;9:149\u201358.","journal-title":"Cancer Prev Res"},{"key":"2142_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0922-6","volume":"19","author":"K Ghosh","year":"2017","unstructured":"Ghosh K, Vierkant RA, Frank RD, Winham S, Visscher DW, Pankratz VS, et al. Association between mammographic breast density and histologic features of benign breast disease. Breast Cancer Res. 2017;19:134.","journal-title":"Breast Cancer Res"},{"key":"2142_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3170","volume":"14","author":"XR Yang","year":"2012","unstructured":"Yang XR, Figueroa JD, Falk RT, Zhang H, Pfeiffer RM, Hewitt SM, et al. Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers. Breast Cancer Res. 2012;14:R64.","journal-title":"Breast Cancer Res"},{"key":"2142_CR39","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1007\/s12094-024-03469-6","volume":"26","author":"I Calvo","year":"2024","unstructured":"Calvo I, Gonz\u00e1lez-Rodr\u00edguez M, Neria F, Gallegos I, Garc\u00eda-S\u00e1nchez L, S\u00e1nchez-G\u00f3mez R, et al. An analysis of the association between breast density and body mass index with breast cancer molecular subtypes in early breast cancer: data from a Spanish population. Clin Transl Oncol. 2024;26:2541\u20138.","journal-title":"Clin Transl Oncol"}],"updated-by":[{"DOI":"10.1186\/s13058-025-02169-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000}}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-025-02142-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13058-025-02142-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-025-02142-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:28:46Z","timestamp":1762957726000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/s13058-025-02142-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2142"],"URL":"https:\/\/doi.org\/10.1186\/s13058-025-02142-2","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"11 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s13058-025-02169-5","URL":"https:\/\/doi.org\/10.1186\/s13058-025-02169-5","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Research Ethics and Animal Welfare Committee of the ISCIII.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"187"}}