{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:52:13Z","timestamp":1788245533630,"version":"build-2803163510"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG-28775"],"award-info":[{"award-number":["IG-28775"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Dipartimenti di Eccellenza \u2013 L. 232\/2016"],"award-info":[{"award-number":["Dipartimenti di Eccellenza \u2013 L. 232\/2016"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"DOI":"10.1186\/s13058-026-02236-5","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:07:00Z","timestamp":1775563620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptomic deconvolution reveals prognostic immune signatures and immunotherapy-responsive subtypes in male breast cancer"],"prefix":"10.1186","volume":"28","author":[{"given":"Valentina","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Bucalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Porzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Scafetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Cerbelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Zanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Tibiletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Carnevali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Calistri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Arcangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Zampiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capalbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Masala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"d\u2019Amati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ottini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"issue":"10","key":"2236_CR1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrc3806","volume":"14","author":"L Ottini","year":"2014","unstructured":"Ottini L. Male breast cancer: a rare disease that might uncover underlying pathways of breast cancer. Nat Rev Cancer. 2014;14(10):643. https:\/\/doi.org\/10.1038\/nrc3806.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2236_CR2","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/cancers16030579","volume":"16","author":"V Valentini","year":"2024","unstructured":"Valentini V, Bucalo A, Conti G, Celli L, Porzio V, Capalbo C, Silvestri V, Ottini L. Gender-Specific genetic predisposition to breast cancer: BRCA genes and beyond. Cancers (Basel). 2024;16(3):579. https:\/\/doi.org\/10.3390\/cancers16030579.","journal-title":"Cancers (Basel)"},{"issue":"14","key":"2236_CR3","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1200\/JCO.21.02112","volume":"40","author":"S Li","year":"2022","unstructured":"Li S, Silvestri V, Leslie G, Rebbeck TR, Neuhausen SL, Hopper JL, Nielsen HR, Lee A, Yang X, McGuffog L, Parsons MT, Andrulis IL, Arnold N, Belotti M, Borg \u00c5, Buecher B, Buys SS, Caputo SM, Chung WK, Colas C, Colonna SV, Cook J, Daly MB, de la Hoya M, de Pauw A, Delhomelle H, Eason J, Engel C, Evans DG, Faust U, Fehm TN, Fostira F, Fountzilas G, Frone M, Garcia-Barberan V, Garre P, Gauthier-Villars M, Gehrig A, Glendon G, Goldgar DE, Golmard L, Greene MH, Hahnen E, Hamann U, Hanson H, Hassan T, Hentschel J, Horvath J, Izatt L, Janavicius R, Jiao Y, John EM, Karlan BY, Kim SW, Konstantopoulou I, Kwong A, Laug\u00e9 A, Lee JW, Lesueur F, Mebirouk N, Meindl A, Mouret-Fourme E, Musgrave H, Ngeow Yuen Yie J, Niederacher D, Park SK, Pedersen IS, Ramser J, Ramus SJ, Rantala J, Rashid MU, Reichl F, Ritter J, Rump A, Santamari\u00f1a M, Saule C, Schmidt G, Schmutzler RK, Senter L, Shariff S, Singer CF, Southey MC, Stoppa-Lyonnet D, Sutter C, Tan Y, Teo SH, Terry MB, Thomassen M, Tischkowitz M, Toland AE, Torres D, Vega A, Wagner SA, Wang-Gohrke S, Wappenschmidt B, Weber BHF, Yannoukakos D, Spurdle AB, Easton DF, Chenevix-Trench G, Ottini L, Antoniou AC. Cancer risks associated with BRCA1 and BRCA2 pathogenic variants. J Clin Oncol. 2022;40(14):1529\u201341. https:\/\/doi.org\/10.1200\/JCO.21.02112.","journal-title":"J Clin Oncol"},{"key":"2236_CR4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ejca.2023.04.022","volume":"188","author":"A Bucalo","year":"2023","unstructured":"Bucalo A, Conti G, Valentini V, Capalbo C, Bruselles A, Tartaglia M, Bonanni B, Calistri D, Coppa A, Cortesi L, Giannini G, Gismondi V, Manoukian S, Manzella L, Montagna M, Peterlongo P, Radice P, Russo A, Tibiletti MG, Turchetti D, Viel A, Zanna I, Palli D, Silvestri V, Ottini L. Male breast cancer risk associated with pathogenic variants in genes other than BRCA1\/2: an Italian case-control study. Eur J Cancer. 2023;188:183\u201391. https:\/\/doi.org\/10.1016\/j.ejca.2023.04.022.","journal-title":"Eur J Cancer"},{"issue":"12","key":"2236_CR5","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1080\/14656566.2020.1763305","volume":"21","author":"BA Duso","year":"2020","unstructured":"Duso BA, Trapani D, Marra A, D\u2019Amico P, Guerini Rocco E, Fusco N, Mazzarella L, Criscitiello C, Esposito A, Curigliano G. Pharmacological management of male breast cancer. Expert Opin Pharmacother. 2020;21(12):1493\u2013504. https:\/\/doi.org\/10.1080\/14656566.2020.1763305.","journal-title":"Expert Opin Pharmacother"},{"issue":"11","key":"2236_CR6","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1001\/jamaoncol.2019.2803","volume":"5","author":"F Wang","year":"2019","unstructured":"Wang F, Shu X, Meszoely I, Pal T, Mayer IA, Yu Z, Zheng W, Bailey CE, Shu XO. Overall mortality after diagnosis of breast cancer in men vs women. JAMA Oncol. 2019;5(11):1589\u201396. https:\/\/doi.org\/10.1001\/jamaoncol.2019.2803.","journal-title":"JAMA Oncol"},{"issue":"3","key":"2236_CR7","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s10549-010-1015-8","volume":"127","author":"M Callari","year":"2011","unstructured":"Callari M, Cappelletti V, De Cecco L, Musella V, Miodini P, Veneroni S, Gariboldi M, Pierotti MA, Daidone MG. Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer. Breast Cancer Res Treat. 2011;127(3):601\u201310. https:\/\/doi.org\/10.1007\/s10549-010-1015-8.","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"2236_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13058-016-0671-y","volume":"18","author":"V Silvestri","year":"2016","unstructured":"Silvestri V, Barrowdale D, Mulligan AM, Neuhausen SL, Fox S, Karlan BY, Mitchell G, James P, Thull DL, Zorn KK, Carter NJ, Nathanson KL, Domchek SM, Rebbeck TR, Ramus SJ, Nussbaum RL, Olopade OI, Rantala J, Yoon SY, Caligo MA, Spugnesi L, Bojesen A, Pedersen IS, Thomassen M, Jensen UB, Toland AE, Senter L, Andrulis IL, Glendon G, Hulick PJ, Imyanitov EN, Greene MH, Mai PL, Singer CF, Rappaport-Fuerhauser C, Kramer G, Vijai J, Offit K, Robson M, Lincoln A, Jacobs L, Machackova E, Foretova L, Navratilova M, Vasickova P, Couch FJ, Hallberg E, Ruddy KJ, Sharma P, Kim SW, kConFab I, Teixeira MR, Pinto P, Montagna M, Matricardi L, Arason A, Johannsson OT, Barkardottir RB, Jakubowska A, Lubinski J, Izquierdo A, Pujana MA, Balma\u00f1a J, Diez O, Ivady G, Papp J, Olah E, Kwong A, Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Nevanlinna H, Aittom\u00e4ki K, Perez Segura P, Caldes T, Van Maerken T, Poppe B, Claes KB, Isaacs C, Elan C, Lasset C, Stoppa-Lyonnet D, Barjhoux L, Belotti M, Meindl A, Gehrig A, Sutter C, Engel C, Niederacher D, Steinemann D, Hahnen E, Kast K, Arnold N, Varon-Mateeva R, Wand D, Godwin AK, Evans DG, Frost D, Perkins J, Adlard J, Izatt L, Platte R, Eeles R, Ellis S, Hamann EMBRACE, Garber U, Fostira J, Fountzilas F, Pasini G, Giannini B, Rizzolo G, Russo P, Cortesi A, Papi L, Varesco L, Palli L, Zanna D, Savarese I, Radice A, Manoukian P, Peissel S, Barile B, Bonanni M, Viel B, Pensotti A, Tommasi V, Peterlongo S, Weitzel P, Osorio JN, Benitez A, McGuffog J, Healey L, Gerdes S, Ejlertsen AM, Hansen B, Steele TV, Ding L, Tung YC, Janavicius N, Goldgar R, Buys DE, Daly SS, Bane MB, Terry A, John MB, Southey EM, Easton M, Chenevix-Trench DF, Antoniou G, Ottini AC. Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the consortium of investigators of modifiers of BRCA1\/2. Breast Cancer Res. 2016;18(1):15. https:\/\/doi.org\/10.1186\/s13058-016-0671-y.","journal-title":"Breast Cancer Res"},{"issue":"1","key":"2236_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10549-018-4921-9","volume":"173","author":"A Gucalp","year":"2019","unstructured":"Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH. Male breast cancer: a disease distinct from female breast cancer. Breast Cancer Res Treat. 2019;173(1):37\u201348. https:\/\/doi.org\/10.1007\/s10549-018-4921-9.","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"2236_CR10","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1186\/bcr3116","volume":"14","author":"I Johansson","year":"2012","unstructured":"Johansson I, Nilsson C, Berglund P, et al. Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker. Breast Cancer Res. 2012;14(1):R31. https:\/\/doi.org\/10.1186\/bcr3116.","journal-title":"Breast Cancer Res"},{"key":"2236_CR11","doi-asserted-by":"publisher","unstructured":"Hassett MJ, Somerfield MR, Baker ER, et al. Management of male breast cancer: ASCO guideline. J Clin Oncol. 2020;JCO1903120. https:\/\/doi.org\/10.1200\/JCO.19.03120.","DOI":"10.1200\/JCO.19.03120"},{"issue":"5","key":"2236_CR12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","volume":"24","author":"M Binnewies","year":"2018","unstructured":"Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018;24(5):541\u201350. https:\/\/doi.org\/10.1038\/s41591-018-0014-x.","journal-title":"Nat Med"},{"issue":"3","key":"2236_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41573-018-0007-y","volume":"18","author":"J Galon","year":"2019","unstructured":"Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. 2019;18(3):197\u2013218. https:\/\/doi.org\/10.1038\/s41573-018-0007-y.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"2236_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41523-022-00486-y","volume":"8","author":"Y Abdou","year":"2022","unstructured":"Abdou Y, Goudarzi A, Yu JX, Upadhaya S, Vincent B, Carey LA. Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors. NPJ Breast Cancer. 2022;8(1):121. https:\/\/doi.org\/10.1038\/s41523-022-00486-y.","journal-title":"NPJ Breast Cancer"},{"issue":"10","key":"2236_CR15","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1001\/jamaoncol.2016.1061","volume":"2","author":"SE Stanton","year":"2016","unstructured":"Stanton SE, Adams S, Disis ML. Variation in the incidence and magnitude of tumor-infiltrating lymphocytes in breast cancer subtypes: a systematic review. JAMA Oncol. 2016;2(10):1354\u201360. https:\/\/doi.org\/10.1001\/jamaoncol.2016.1061.","journal-title":"JAMA Oncol"},{"issue":"4","key":"2236_CR16","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nrclinonc.2015.215","volume":"13","author":"P Savas","year":"2016","unstructured":"Savas P, Salgado R, Denkert C, Sotiriou C, Darcy PK, Smyth MJ, Loi S. Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nat Rev Clin Oncol. 2016;13(4):228\u201341. https:\/\/doi.org\/10.1038\/nrclinonc.2015.215.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"2236_CR17","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.1038\/s41467-023-41318-2","volume":"14","author":"H Sun","year":"2023","unstructured":"Sun H, Zhang L, Wang Z, Gu D, Zhu M, Cai Y, Li L, Tang J, Huang B, Bosco B, Li N, Wu L, Wu W, Li L, Liang Y, Luo L, Liu Q, Zhu Y, Sun J, Shi L, Xia T, Yang C, Xu Q, Han X, Zhang W, Liu J, Meng D, Shao H, Zheng X, Li S, Pan H, Ke J, Jiang W, Zhang X, Han X, Chu J, An H, Ge J, Pan C, Wang X, Li K, Wang Q, Ding Q. Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer. Nat Commun. 2023;14(1):5590. https:\/\/doi.org\/10.1038\/s41467-023-41318-2.","journal-title":"Nat Commun"},{"issue":"1","key":"2236_CR18","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3390\/ijms24010818","volume":"24","author":"I Brcic","year":"2023","unstructured":"Brcic I, Kluba AM, Godschachner TM, Suppan C, Regitnig P, Dandachi N, Lax SF, Bali\u0107 M. Tumor microenvironment in male breast carcinoma with emphasis on tumor infiltrating lymphocytes and PD-L1 expression. Int J Mol Sci. 2023;24(1):818. https:\/\/doi.org\/10.3390\/ijms24010818.","journal-title":"Int J Mol Sci"},{"issue":"18","key":"2236_CR19","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.3390\/cancers13184515","volume":"13","author":"V Zelli","year":"2021","unstructured":"Zelli V, Silvestri V, Valentini V, Bucalo A, Rizzolo P, Zanna I, Bianchi S, Coppa A, Giannini G, Cortesi L, Calistri D, Tibiletti MG, Fox SB, Fab K, Palli D, Ottini L. Transcriptome of male breast cancer matched with germline profiling reveals novel molecular subtypes with possible clinical relevance. Cancers (Basel). 2021;13(18):4515. https:\/\/doi.org\/10.3390\/cancers13184515.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"2236_CR20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/annonc\/mdu450","volume":"26","author":"R Salgado","year":"2015","unstructured":"Salgado R, Denkert C, Demaria S, Sirtaine N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL, Penault-Llorca F, Perez EA, Thompson EA, Symmans WF, Richardson AL, Brock J, Criscitiello C, Bailey H, Ignatiadis M, Floris G, Sparano J, Kos Z, Nielsen T, Rimm DL, Allison KH, Reis-Filho JS, Loibl S, Sotiriou C, Viale G, Badve S, Adams S, Willard-Gallo K, Loi S, International TILs Working Group 2014. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an international TILs working group 2014. Ann Oncol. 2015;26(2):259\u201371. https:\/\/doi.org\/10.1093\/annonc\/mdu450.","journal-title":"Ann Oncol"},{"key":"2236_CR21","doi-asserted-by":"publisher","first-page":"1092201","DOI":"10.3389\/fonc.2022.1092201","volume":"12","author":"V Valentini","year":"2023","unstructured":"Valentini V, Silvestri V, Bucalo A, Conti G, Karimi M, Di Francesco L, Pomati G, Mezi S, Cerbelli B, Pignataro MG, Nicolussi A, Coppa A, D\u2019Amati G, Giannini G, Ottini L. Molecular profiling of male breast cancer by multigene panel testing: implications for precision oncology. Front Oncol. 2023;12:1092201. https:\/\/doi.org\/10.3389\/fonc.2022.1092201.","journal-title":"Front Oncol"},{"issue":"3","key":"2236_CR22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1056\/NEJMoa2202809","volume":"387","author":"J Cortes","year":"2022","unstructured":"Cortes J, Rugo HS, Cescon DW, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Perez-Garcia J, Iwata H, Masuda N, Torregroza Otero M, Gokmen E, Loi S, Guo Z, Zhou X, Karantza V, Pan W, Schmid P. KEYNOTE-355 Investigators. Pembrolizumab plus chemotherapy in advanced Triple-Negative breast cancer. N Engl J Med. 2022;387(3):217\u201326. https:\/\/doi.org\/10.1056\/NEJMoa2202809.","journal-title":"N Engl J Med"},{"key":"2236_CR23","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara K, Shahmoradgoli M, Mart\u00ednez E, Vegesna R, Kim H, Torres-Garcia W, Trevi\u00f1o V, Shen H, Laird PW, Levine DA, Carter SL, Getz G, Stemke-Hale K, Mills GB, Verhaak RG. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612. https:\/\/doi.org\/10.1038\/ncomms3612.","journal-title":"Nat Commun"},{"issue":"7","key":"2236_CR24","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, Diehn M, Alizadeh AA. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol. 2019;37(7):773\u201382. https:\/\/doi.org\/10.1038\/s41587-019-0114-2.","journal-title":"Nat Biotechnol"},{"issue":"1","key":"2236_CR25","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","volume":"17","author":"E Becht","year":"2016","unstructured":"Becht E, Giraldo NA, Lacroix L, Buttard B, Elarouci N, Petitprez F, Selves J, Laurent-Puig P, Saut\u00e8s-Fridman C, Fridman WH, de Reyni\u00e8s A. Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol. 2016;17(1):218. https:\/\/doi.org\/10.1186\/s13059-016-1070-5.","journal-title":"Genome Biol"},{"issue":"1","key":"2236_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13073-020-0721-z","volume":"12","author":"J Fu","year":"2020","unstructured":"Fu J, Li K, Zhang W, Wan C, Zhang J, Jiang P, Liu XS. Large-scale public data reuse to model immunotherapy response and resistance. Genome Med. 2020;12(1):21. https:\/\/doi.org\/10.1186\/s13073-020-0721-z.","journal-title":"Genome Med"},{"issue":"1","key":"2236_CR27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41467-018-02856-2","volume":"9","author":"TM Severson","year":"2018","unstructured":"Severson TM, Kim Y, Joosten SEP, Schuurman K, van der Groep P, Moelans CB, Ter Hoeve ND, Manson QF, Martens JW, van Deurzen CHM, Barbe E, Hedenfalk I, Bult P, Smit VTHBM, Linn SC, van Diest PJ, Wessels L, Zwart W. Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer. Nat Commun. 2018;9(1):482. https:\/\/doi.org\/10.1038\/s41467-018-02856-2.","journal-title":"Nat Commun"},{"issue":"7418","key":"2236_CR28","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nature11412","volume":"490","author":"Cancer Genome Atlas Network","year":"2012","unstructured":"Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61\u201370. https:\/\/doi.org\/10.1038\/nature11412.","journal-title":"Nature"},{"issue":"12","key":"2236_CR29","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1093\/bioinformatics\/btl117","volume":"22","author":"R Suzuki","year":"2006","unstructured":"Suzuki R, Shimodaira H. Pvclust: an R package for assessing the uncertainty in hierarchical clustering. Bioinformatics. 2006;22(12):1540\u20132. https:\/\/doi.org\/10.1093\/bioinformatics\/btl117.","journal-title":"Bioinformatics"},{"issue":"7","key":"2236_CR30","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1093\/bioinformatics\/btv693","volume":"32","author":"DM Gendoo","year":"2016","unstructured":"Gendoo DM, Ratanasirigulchai N, Schr\u00f6der MS, Par\u00e9 L, Parker JS, Prat A, Haibe-Kains B. Genefu: an R\/Bioconductor package for computation of gene expression-based signatures in breast cancer. Bioinformatics. 2016;32(7):1097\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btv693.","journal-title":"Bioinformatics"},{"key":"2236_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.breast.2018.04.017","volume":"40","author":"I Zanna","year":"2018","unstructured":"Zanna I, Silvestri V, Palli D, Magrini A, Rizzolo P, Saieva C, Zelli V, Bendinelli B, Vezzosi V, Valentini V, Bianchi S, Ottini L, Masala G. Smoking and FGFR2 rs2981582 variant independently modulate male breast cancer survival: A population-based study in Tuscany, Italy. Breast. 2018;40:85\u201391. https:\/\/doi.org\/10.1016\/j.breast.2018.04.017.","journal-title":"Breast"},{"issue":"6","key":"2236_CR32","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s11523-018-0610-1","volume":"13","author":"QF Manson","year":"2018","unstructured":"Manson QF, Ter Hoeve ND, Buerger H, Moelans CB, van Diest PJ. PD-1 and PD-L1 expression in male breast cancer in comparison with female breast cancer. Target Oncol. 2018;13(6):769\u201377. https:\/\/doi.org\/10.1007\/s11523-018-0610-1.","journal-title":"Target Oncol"},{"key":"2236_CR33","doi-asserted-by":"publisher","first-page":"101980","DOI":"10.1016\/j.tranon.2024.101980","volume":"45","author":"Y Li","year":"2024","unstructured":"Li Y, Guo Y, Chen F, Cui Y, Chen X, Shi G. Male breast cancer differs from female breast cancer in molecular features that affect prognoses and drug responses. Transl Oncol. 2024;45:101980. https:\/\/doi.org\/10.1016\/j.tranon.2024.101980.","journal-title":"Transl Oncol"},{"issue":"23","key":"2236_CR34","doi-asserted-by":"publisher","first-page":"13113","DOI":"10.3390\/ijms252313113","volume":"25","author":"E Hargrove-Wiley","year":"2024","unstructured":"Hargrove-Wiley E, Obodo D, Bindeman W, Fingleton B. Elucidating Sex-Specific immune profiles in a breast cancer model. Int J Mol Sci. 2024;25(23):13113. https:\/\/doi.org\/10.3390\/ijms252313113.","journal-title":"Int J Mol Sci"},{"key":"2236_CR35","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ejca.2017.01.034","volume":"82","author":"MA Vermeulen","year":"2017","unstructured":"Vermeulen MA, Slaets L, Cardoso F, Giordano SH, Tryfonidis K, van Diest PJ, Dijkstra NH, Schr\u00f6der CP, van Asperen CJ, Linderholm B, Benstead K, Foekens R, Martens JWM, Bartlett JMS, van Deurzen CHM. Pathological characterisation of male breast cancer: results of the EORTC 10085\/TBCRC\/BIG\/NABCG international male breast cancer program. Eur J Cancer. 2017;82:219\u201327. https:\/\/doi.org\/10.1016\/j.ejca.2017.01.034.","journal-title":"Eur J Cancer"},{"issue":"1","key":"2236_CR36","doi-asserted-by":"publisher","first-page":"19142","DOI":"10.1038\/s41598-024-70184-1","volume":"14","author":"H Liu","year":"2024","unstructured":"Liu H, Dong A, Rasteh AM, Wang P, Weng J. Identification of the novel exhausted T cell CD8\u2009+\u2009markers in breast cancer. Sci Rep. 2024;14(1):19142. https:\/\/doi.org\/10.1038\/s41598-024-70184-1.","journal-title":"Sci Rep"},{"issue":"1","key":"2236_CR37","doi-asserted-by":"publisher","first-page":"12569","DOI":"10.1038\/s41598-025-97784-9","volume":"15","author":"Y Tian","year":"2025","unstructured":"Tian Y, Yang Y, He L, Yu X, Zhou H, Wang J. Exploring the tumor microenvironment of breast cancer to develop a prognostic model and predict immunotherapy responses. Sci Rep. 2025;15(1):12569. https:\/\/doi.org\/10.1038\/s41598-025-97784-9.","journal-title":"Sci Rep"},{"key":"2236_CR38","doi-asserted-by":"publisher","first-page":"1544348","DOI":"10.3389\/fimmu.2025.1544348","volume":"16","author":"F Li","year":"2025","unstructured":"Li F, Jin C, Pan Y, Zhang Z, Wang L, Deng J, Zhou Y, Guo B, Zhang S. Construction of a stromal cell-related prognostic signature based on a 101-combination machine learning framework for predicting prognosis and immunotherapy response in triple-negative breast cancer. Front Immunol. 2025;16:1544348. https:\/\/doi.org\/10.3389\/fimmu.2025.1544348.","journal-title":"Front Immunol"},{"issue":"3","key":"2236_CR39","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/modpathol.2011.174","volume":"25","author":"R Kornegoor","year":"2012","unstructured":"Kornegoor R, Verschuur-Maes AH, Buerger H, Hogenes MC, de Bruin PC, Oudejans JJ, van der Groep P, Hinrichs B, van Diest PJ. Molecular subtyping of male breast cancer by immunohistochemistry. Mod Pathol. 2012;25(3):398\u2013404. https:\/\/doi.org\/10.1038\/modpathol.2011.174.","journal-title":"Mod Pathol"},{"key":"2236_CR40","doi-asserted-by":"publisher","first-page":"104545","DOI":"10.1016\/j.breast.2025.104545","volume":"83","author":"M Li","year":"2025","unstructured":"Li M, Panet F, Barberi V, Salgado R, Oliveira M, Loi S. Biomarkers of response and resistance to immune checkpoint inhibitors in breast cancer. Breast. 2025;83:104545. https:\/\/doi.org\/10.1016\/j.breast.2025.104545.","journal-title":"Breast"},{"issue":"3","key":"2236_CR41","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.trecan.2021.12.003","volume":"8","author":"MATM van Vugt","year":"2022","unstructured":"van Vugt MATM, Parkes EE. When breaks get hot: inflammatory signaling in BRCA1\/2-mutant cancers. Trends Cancer. 2022;8(3):174\u201389. https:\/\/doi.org\/10.1016\/j.trecan.2021.12.003.","journal-title":"Trends Cancer"},{"issue":"4","key":"2236_CR42","doi-asserted-by":"publisher","first-page":"e0215381","DOI":"10.1371\/journal.pone.0215381","volume":"14","author":"WX Wen","year":"2019","unstructured":"Wen WX, Leong CO. Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1\/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer. PLoS ONE. 2019;14(4):e0215381. https:\/\/doi.org\/10.1371\/journal.pone.0215381.","journal-title":"PLoS ONE"},{"issue":"10","key":"2236_CR43","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.trecan.2024.07.009","volume":"10","author":"E Montauti","year":"2024","unstructured":"Montauti E, Oh DY, Fong L. CD4+ T cells in antitumor immunity. Trends Cancer. 2024;10(10):969\u201385. https:\/\/doi.org\/10.1016\/j.trecan.2024.07.009.","journal-title":"Trends Cancer"},{"issue":"6","key":"2236_CR44","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/s41590-023-01510-4","volume":"24","author":"M K\u00fcnzli","year":"2023","unstructured":"K\u00fcnzli M, Masopust D. CD4+ T cell memory. Nat Immunol. 2023;24(6):903\u201314. https:\/\/doi.org\/10.1038\/s41590-023-01510-4.","journal-title":"Nat Immunol"},{"key":"2236_CR45","doi-asserted-by":"publisher","first-page":"2584243","DOI":"10.1155\/2018\/2584243","volume":"2018","author":"A Aponte-L\u00f3pez","year":"2018","unstructured":"Aponte-L\u00f3pez A, Fuentes-Panan\u00e1 EM, Cortes-Mu\u00f1oz D, Mu\u00f1oz-Cruz S. Mast Cell, the neglected member of the tumor microenvironment: role in breast cancer. J Immunol Res. 2018;2018:2584243. https:\/\/doi.org\/10.1155\/2018\/2584243.","journal-title":"J Immunol Res"},{"issue":"8","key":"2236_CR46","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1158\/0008-5472.CAN-21-3424","volume":"82","author":"MT Majorini","year":"2022","unstructured":"Majorini MT, Colombo MP, Lecis D. Few, but efficient: the role of mast cells in breast cancer and other solid tumors. Cancer Res. 2022;82(8):1439\u201347. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-3424.","journal-title":"Cancer Res"},{"issue":"11","key":"2236_CR47","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1158\/0008-5472.CAN-19-3596","volume":"80","author":"MT Majorini","year":"2020","unstructured":"Majorini MT, Cancila V, Rigoni A, Botti L, Dugo M, Triulzi T, De Cecco L, Fontanella E, Jachetti E, Tagliabue E, Chiodoni C, Tripodo C, Colombo MP, Lecis D. Infiltrating mast Cell-Mediated stimulation of Estrogen receptor activity in breast cancer cells promotes the luminal phenotype. Cancer Res. 2020;80(11):2311\u201324. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-3596.","journal-title":"Cancer Res"},{"issue":"3","key":"2236_CR48","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.biocel.2004.09.001","volume":"37","author":"I Puxeddu","year":"2005","unstructured":"Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F. Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol. 2005;37(3):628\u201336. https:\/\/doi.org\/10.1016\/j.biocel.2004.09.001.","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"2236_CR49","doi-asserted-by":"publisher","first-page":"e450","DOI":"10.1002\/ctm2.450","volume":"11","author":"D Yang","year":"2021","unstructured":"Yang D, Guo P, He T, Powell CA. Role of endothelial cells in tumor microenvironment. Clin Transl Med. 2021;11(6):e450. https:\/\/doi.org\/10.1002\/ctm2.450.","journal-title":"Clin Transl Med"},{"key":"2236_CR50","doi-asserted-by":"publisher","first-page":"1367875","DOI":"10.3389\/fimmu.2024.1367875","volume":"15","author":"P Leone","year":"2024","unstructured":"Leone P, Malerba E, Susca N, Favoino E, Perosa F, Brunori G, Prete M, Racanelli V. Endothelial cells in tumor microenvironment: insights and perspectives. Front Immunol. 2024;15:1367875. https:\/\/doi.org\/10.3389\/fimmu.2024.1367875.","journal-title":"Front Immunol"},{"issue":"6","key":"2236_CR51","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/ijc.28146","volume":"133","author":"JW Franses","year":"2013","unstructured":"Franses JW, Drosu NC, Gibson WJ, Chitalia VC, Edelman ER. Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis. Int J Cancer. 2013;133(6):1334\u201344. https:\/\/doi.org\/10.1002\/ijc.28146.","journal-title":"Int J Cancer"},{"issue":"4","key":"2236_CR52","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.jtcvs.2012.12.064","volume":"146","author":"KK Singh","year":"2013","unstructured":"Singh KK, Shukla PC, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S. BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis. J Thorac Cardiovasc Surg. 2013;146(4):949\u2013e9604. https:\/\/doi.org\/10.1016\/j.jtcvs.2012.12.064.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"13","key":"2236_CR53","doi-asserted-by":"publisher","first-page":"e14481","DOI":"10.14814\/phy2.14481","volume":"8","author":"S Singh","year":"2020","unstructured":"Singh S, Nguyen H, Michels D, Bazinet H, Matkar PN, Liu Z, Esene L, Adam M, Bugyei-Twum A, Mebrahtu E, Joseph J, Ehsan M, Chen HH, Qadura M, Singh KK. BReast cancer susceptibility gene 2 deficiency exacerbates oxidized LDL-induced DNA damage and endothelial apoptosis. Physiol Rep. 2020;8(13):e14481. https:\/\/doi.org\/10.14814\/phy2.14481.","journal-title":"Physiol Rep"},{"key":"2236_CR54","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fmed.2017.00103","volume":"4","author":"MR Galdiero","year":"2017","unstructured":"Galdiero MR, Varricchi G, Seaf M, Marone G, Levi-Schaffer F, Marone G. Bidirectional mast Cell-Eosinophil interactions in inflammatory disorders and cancer. Front Med (Lausanne). 2017;4:103. https:\/\/doi.org\/10.3389\/fmed.2017.00103.","journal-title":"Front Med (Lausanne)"},{"issue":"9","key":"2236_CR55","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3390\/biomedicines9091087","volume":"9","author":"A Poncin","year":"2021","unstructured":"Poncin A, Onesti CE, Josse C, Boulet D, Thiry J, Bours V, Jerusalem G. Immunity and breast cancer: focus on eosinophils. Biomedicines. 2021;9(9):1087. https:\/\/doi.org\/10.3390\/biomedicines9091087.","journal-title":"Biomedicines"},{"issue":"5","key":"2236_CR56","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.surg.2020.07.052","volume":"169","author":"K Chouliaras","year":"2021","unstructured":"Chouliaras K, Tokumaru Y, Asaoka M, Oshi M, Attwood KM, Yoshida K, Ishikawa T, Takabe K. Prevalence and clinical relevance of tumor-associated tissue eosinophilia (TATE) in breast cancer. Surgery. 2021;169(5):1234\u20139. https:\/\/doi.org\/10.1016\/j.surg.2020.07.052.","journal-title":"Surgery"},{"issue":"1","key":"2236_CR57","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10549-012-2062-0","volume":"134","author":"L Ottini","year":"2012","unstructured":"Ottini L, Silvestri V, Rizzolo P, Falchetti M, Zanna I, Saieva C, Masala G, Bianchi S, Manoukian S, Barile M, Peterlongo P, Varesco L, Tommasi S, Russo A, Giannini G, Cortesi L, Viel A, Montagna M, Radice P, Palli D. Clinical and pathologic characteristics of BRCA-positive and BRCA-negative male breast cancer patients: results from a collaborative multicenter study in Italy. Breast Cancer Res Treat. 2012;134(1):411\u20138. https:\/\/doi.org\/10.1007\/s10549-012-2062-0.","journal-title":"Breast Cancer Res Treat"},{"key":"2236_CR58","doi-asserted-by":"publisher","first-page":"1514147","DOI":"10.1155\/2024\/1514147","volume":"2024","author":"FF Hasan","year":"2024","unstructured":"Hasan FF, Fadhil MH, Almukhtar ZK. Assessment of tissue eosinophilic infiltration in invasive mammary carcinoma. Int J Breast Cancer. 2024;2024:1514147. https:\/\/doi.org\/10.1155\/2024\/1514147.","journal-title":"Int J Breast Cancer"},{"issue":"1","key":"2236_CR59","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1158\/1055-9965.EPI-11-0775","volume":"21","author":"N Mavaddat","year":"2012","unstructured":"Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O\u2019Malley F, John EM, Janavicius R, Tihomirova L, Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Ben\u00edtez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, Peock HEBON, Frost S, Evans D, Brewer DG, Walker C, Rogers L, Side MT, Houghton LE, Weaver CEMBRACE, Godwin J, Schmutzler AK, Wappenschmidt RK, Meindl B, Kast A, Arnold K, Niederacher N, Sutter D, Deissler C, Gadzicki H, Preisler-Adams D, Varon-Mateeva S, Sch\u00f6nbuchner R, Gevensleben I, Stoppa-Lyonnet H, Belotti D, Barjhoux M L, GEMO Study Collaborators, Isaacs C, Peshkin BN, Caldes T, de la Hoya M, Ca\u00f1adas C, Heikkinen T, Heikkil\u00e4 P, Aittom\u00e4ki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D\u2019Andrea E, Yan M, Fox S, kConFab I, Rebbeck TR, Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, SWE -BRCA, Steele C, Neuhausen L, Nussbaum SL, Beattie R, Odunsi M, Sucheston K, Gayther L, Nathanson SA, Gross K, Walsh J, Karlan C, Chenevix-Trench B, Easton G, Antoniou DF. Consortium of investigators of modifiers of BRCA1\/2. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the consortium of investigators of modifiers of BRCA1\/2 (CIMBA). Cancer Epidemiol Biomarkers Prev. 2012;21(1):134\u201347. https:\/\/doi.org\/10.1158\/1055-9965.EPI-11-0775.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2236_CR60","doi-asserted-by":"publisher","first-page":"1295257","DOI":"10.3389\/fimmu.2023.1295257","volume":"14","author":"U Basak","year":"2023","unstructured":"Basak U, Sarkar T, Mukherjee S, Chakraborty S, Dutta A, Dutta S, Nayak D, Kaushik S, Das T, Sa G. Tumor-associated macrophages: an effective player of the tumor microenvironment. Front Immunol. 2023;14:1295257. https:\/\/doi.org\/10.3389\/fimmu.2023.1295257.","journal-title":"Front Immunol"},{"key":"2236_CR61","doi-asserted-by":"publisher","first-page":"116930","DOI":"10.1016\/j.biopha.2024.116930","volume":"177","author":"W Zhang","year":"2024","unstructured":"Zhang W, Wang M, Ji C, Liu X, Gu B, Dong T. Macrophage polarization in the tumor microenvironment: emerging roles and therapeutic potentials. Biomed Pharmacother. 2024;177:116930. https:\/\/doi.org\/10.1016\/j.biopha.2024.116930.","journal-title":"Biomed Pharmacother"},{"key":"2236_CR62","doi-asserted-by":"publisher","first-page":"560074","DOI":"10.3389\/fimmu.2020.560074","volume":"11","author":"MY Hachim","year":"2020","unstructured":"Hachim MY, Hachim IY, Talaat IM, Yakout NM, Hamoudi R. M1 polarization markers are upregulated in Basal-Like breast cancer molecular subtype and associated with favorable patient outcome. Front Immunol. 2020;11:560074. https:\/\/doi.org\/10.3389\/fimmu.2020.560074.","journal-title":"Front Immunol"},{"issue":"1","key":"2236_CR63","doi-asserted-by":"publisher","first-page":"6966","DOI":"10.1038\/s41467-023-42382-4","volume":"14","author":"J Barbazan","year":"2023","unstructured":"Barbazan J, P\u00e9rez-Gonz\u00e1lez C, G\u00f3mez-Gonz\u00e1lez M, Dedenon M, Richon S, Latorre E, Serra M, Mariani P, Descroix S, Sens P, Trepat X, Vignjevic DM. Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction. Nat Commun. 2023;14(1):6966. https:\/\/doi.org\/10.1038\/s41467-023-42382-4.","journal-title":"Nat Commun"},{"issue":"3","key":"2236_CR64","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.breast.2012.07.008","volume":"22","author":"K Kr\u00fcger","year":"2013","unstructured":"Kr\u00fcger K, Stefansson IM, Collett K, Arnes JB, Aas T, Akslen LA. Microvessel proliferation by co-expression of endothelial Nestin and Ki-67 is associated with a basal-like phenotype and aggressive features in breast cancer. Breast. 2013;22(3):282\u20138. https:\/\/doi.org\/10.1016\/j.breast.2012.07.008.","journal-title":"Breast"},{"key":"2236_CR65","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-3-030-47189-7_10","volume":"1270","author":"BC \u00d6zdemir","year":"2021","unstructured":"\u00d6zdemir BC. Androgen signaling in the tumor microenvironment. Adv Exp Med Biol. 2021;1270:169\u201383. https:\/\/doi.org\/10.1007\/978-3-030-47189-7_10.","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"2236_CR66","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1530\/ERC-16-0138","volume":"24","author":"CP Liao","year":"2017","unstructured":"Liao CP, Chen LY, Luethy A, Kim Y, Kani K, MacLeod AR, Gross ME. Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. Endocr Relat Cancer. 2017;24(4):157\u201370. https:\/\/doi.org\/10.1530\/ERC-16-0138.","journal-title":"Endocr Relat Cancer"},{"issue":"8","key":"2236_CR67","first-page":"2132","volume":"60","author":"T Chen","year":"2000","unstructured":"Chen T, Wang LH, Farrar WL. Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res. 2000;60(8):2132\u20135. PMID: 10786674.","journal-title":"Cancer Res"},{"key":"2236_CR68","doi-asserted-by":"publisher","first-page":"1416941","DOI":"10.3389\/fimmu.2024.1416941","volume":"15","author":"J Zhao","year":"2024","unstructured":"Zhao J, Wang Q, Tan AF, Loh CJL, Toh HC. Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor. Front Immunol. 2024;15:1416941. https:\/\/doi.org\/10.3389\/fimmu.2024.1416941. PMID: 38863718; PMCID: PMC11165033.","journal-title":"Front Immunol"},{"key":"2236_CR69","doi-asserted-by":"publisher","unstructured":"Hu YM, Zhao F, Graff JN, Chen C, Zhao X, Thomas GV, Wu H, Kardosh A, Mills GB, Alumkal JJ, Moran AE, Xia Z. Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages. BioRxiv [Preprint]. 2024 May 14:2024.05.08.593181. https:\/\/doi.org\/10.1101\/2024.05.08.593181","DOI":"10.1101\/2024.05.08.593181"},{"issue":"1","key":"2236_CR70","doi-asserted-by":"publisher","first-page":"100930","DOI":"10.1016\/j.tranon.2020.100930","volume":"14","author":"S Nersesian","year":"2021","unstructured":"Nersesian S, Schwartz SL, Grantham SR, MacLean LK, Lee SN, Pugh-Toole M, Boudreau JE. NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis. Transl Oncol. 2021;14(1):100930. https:\/\/doi.org\/10.1016\/j.tranon.2020.100930.","journal-title":"Transl Oncol"},{"issue":"6","key":"2236_CR71","doi-asserted-by":"publisher","first-page":"e738","DOI":"10.1016\/j.clbc.2021.02.003","volume":"21","author":"L Bouzidi","year":"2021","unstructured":"Bouzidi L, Triki H, Charfi S, Kridis WB, Derbel M, Ayadi L, Sellami-Boudawara T, Cherif B. Prognostic value of natural killer cells besides Tumor-Infiltrating lymphocytes in breast cancer tissues. Clin Breast Cancer. 2021;21(6):e738\u201347. https:\/\/doi.org\/10.1016\/j.clbc.2021.02.003.","journal-title":"Clin Breast Cancer"},{"key":"2236_CR72","doi-asserted-by":"publisher","first-page":"1200282","DOI":"10.3389\/fimmu.2023.1200282","volume":"14","author":"Z Liu","year":"2023","unstructured":"Liu Z, Ding M, Qiu P, Pan K, Guo Q. Natural killer cell-related prognostic risk model predicts prognosis and treatment outcomes in triple-negative breast cancer. Front Immunol. 2023;14:1200282. https:\/\/doi.org\/10.3389\/fimmu.2023.1200282.","journal-title":"Front Immunol"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13058-026-02236-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-026-02236-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-026-02236-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:29:00Z","timestamp":1778722140000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13058-026-02236-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2236"],"URL":"https:\/\/doi.org\/10.1186\/s13058-026-02236-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7572724\/v1","asserted-by":"object"}]},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For each participant, informed consent to participate in the study was obtained. The study was approved by the Local Ethical Committee (Sapienza University of Rome, Prot. 669\/17).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}